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The map label for this gene is proC [H]

Identifier: 124025161

GI number: 124025161

Start: 409574

End: 410416

Strand: Direct

Name: proC [H]

Synonym: NATL1_04481

Alternate gene names: 124025161

Gene position: 409574-410416 (Clockwise)

Preceding gene: 124025160

Following gene: 124025166

Centisome position: 21.96

GC content: 40.21

Gene sequence:

>843_bases
TTGGAAATTTCTCTTGGGATAATTGGCCTTGGCAGTATGGCTAAGGCTATTGTTTTACCTCTTTTGGAGAGAGGTGAATA
CAATCCTCAACAAGTTTTAGGAATTGTTGGTAGGAGCTCAAGTATTGCATCTGCATTGAATGATCTTCCACAGGAAGTAA
AAGTTGTAACTAGCAAAGATCCTTTGTCTAAAGAAGTGTGGAAGGCCCCTATAAAAATATTGGCTGTAAAACCTCAACAA
TTAAGCAAAATCAAAGAATCTGTTTCGTCATTTCAATCGAATGATCAGTTCCCTAAACCGTTATTAATTTCAGTTTTAGC
TGGAATAACATTGAAAAGTCTTAAGAAAGCTTTTCCTAGACACACATGTGTAAGAGCAGTGCCTAATACCCCTTCTCTTG
TCGGCCAAGGGCTTACTGGTTTGGCGTGGCCAGATGATATGACTTCGGATCAAAAGAAAGTTGTTAGAAAGATTTTTGAA
CCTATCAGTGAAATTTACGAGTTGGAGGAGCCAAAGCTTGATTCCTTTTTGGCTTTAACTTCTTCAGGACCTGCATATAT
AGCTTTAGTTGTTGAAGCAATGGCTGATGGAGCTGTTGCCGCAGGATTACCACGACAATTATCCAATCAATTAGCTCATA
GAACTCTTTCAGGTACTGCATCTCTACTAAGAGAAAAGAATTTACACCCTGCTGAACTAAAAGATATGGTTGCCTCTCCT
GCAGGTACTACGATTAGTGCTCTTCGACACCTTGAACTTTCTGGCTTGAGATCCGCCTTAATTGAAGCAGTTGTTTTGGC
AGCGCAGAAGAGTCGTCAATTGGCTGAGGAAGTTTCGACCTAG

Upstream 100 bases:

>100_bases
AGTAATAAAGGGAATGATTTGATTTCTAAGGAAACCTCTCCTGCGCCAGAGCCTGCTTGGGGGGAGACAGTCGCTACTGC
TCTTTGAATGATTAATTAGA

Downstream 100 bases:

>100_bases
ATGATCTAAGTACGTTTGCATATAGATTTTCAAGTGAGTCAATATTTTGTTGAAGTGTATATTTTTCTTCTACTCTTAAG
CGTGCACGTCTACCTAGTTC

Product: Delta 1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MEISLGIIGLGSMAKAIVLPLLERGEYNPQQVLGIVGRSSSIASALNDLPQEVKVVTSKDPLSKEVWKAPIKILAVKPQQ
LSKIKESVSSFQSNDQFPKPLLISVLAGITLKSLKKAFPRHTCVRAVPNTPSLVGQGLTGLAWPDDMTSDQKKVVRKIFE
PISEIYELEEPKLDSFLALTSSGPAYIALVVEAMADGAVAAGLPRQLSNQLAHRTLSGTASLLREKNLHPAELKDMVASP
AGTTISALRHLELSGLRSALIEAVVLAAQKSRQLAEEVST

Sequences:

>Translated_280_residues
MEISLGIIGLGSMAKAIVLPLLERGEYNPQQVLGIVGRSSSIASALNDLPQEVKVVTSKDPLSKEVWKAPIKILAVKPQQ
LSKIKESVSSFQSNDQFPKPLLISVLAGITLKSLKKAFPRHTCVRAVPNTPSLVGQGLTGLAWPDDMTSDQKKVVRKIFE
PISEIYELEEPKLDSFLALTSSGPAYIALVVEAMADGAVAAGLPRQLSNQLAHRTLSGTASLLREKNLHPAELKDMVASP
AGTTISALRHLELSGLRSALIEAVVLAAQKSRQLAEEVST
>Mature_280_residues
MEISLGIIGLGSMAKAIVLPLLERGEYNPQQVLGIVGRSSSIASALNDLPQEVKVVTSKDPLSKEVWKAPIKILAVKPQQ
LSKIKESVSSFQSNDQFPKPLLISVLAGITLKSLKKAFPRHTCVRAVPNTPSLVGQGLTGLAWPDDMTSDQKKVVRKIFE
PISEIYELEEPKLDSFLALTSSGPAYIALVVEAMADGAVAAGLPRQLSNQLAHRTLSGTASLLREKNLHPAELKDMVASP
AGTTISALRHLELSGLRSALIEAVVLAAQKSRQLAEEVST

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=279, Percent_Identity=31.8996415770609, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI21361454, Length=277, Percent_Identity=32.129963898917, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI24797095, Length=277, Percent_Identity=32.129963898917, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24797097, Length=277, Percent_Identity=32.129963898917, Blast_Score=123, Evalue=1e-28,
Organism=Escherichia coli, GI1786585, Length=278, Percent_Identity=35.2517985611511, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17569021, Length=276, Percent_Identity=32.2463768115942, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17540664, Length=288, Percent_Identity=31.5972222222222, Blast_Score=121, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320861, Length=291, Percent_Identity=26.4604810996564, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21358587, Length=273, Percent_Identity=32.6007326007326, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=38.4615384615385, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24648116, Length=284, Percent_Identity=30.9859154929577, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29981; Mature: 29981

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEISLGIIGLGSMAKAIVLPLLERGEYNPQQVLGIVGRSSSIASALNDLPQEVKVVTSKD
CCEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCC
PLSKEVWKAPIKILAVKPQQLSKIKESVSSFQSNDQFPKPLLISVLAGITLKSLKKAFPR
CCHHHHHHCCHHHEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCH
HTCVRAVPNTPSLVGQGLTGLAWPDDMTSDQKKVVRKIFEPISEIYELEEPKLDSFLALT
HHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEC
SSGPAYIALVVEAMADGAVAAGLPRQLSNQLAHRTLSGTASLLREKNLHPAELKDMVASP
CCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
AGTTISALRHLELSGLRSALIEAVVLAAQKSRQLAEEVST
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEISLGIIGLGSMAKAIVLPLLERGEYNPQQVLGIVGRSSSIASALNDLPQEVKVVTSKD
CCEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCC
PLSKEVWKAPIKILAVKPQQLSKIKESVSSFQSNDQFPKPLLISVLAGITLKSLKKAFPR
CCHHHHHHCCHHHEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCH
HTCVRAVPNTPSLVGQGLTGLAWPDDMTSDQKKVVRKIFEPISEIYELEEPKLDSFLALT
HHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEC
SSGPAYIALVVEAMADGAVAAGLPRQLSNQLAHRTLSGTASLLREKNLHPAELKDMVASP
CCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
AGTTISALRHLELSGLRSALIEAVVLAAQKSRQLAEEVST
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]