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The map label for this gene is mutSB [H]

Identifier: 124025008

GI number: 124025008

Start: 273492

End: 275906

Strand: Direct

Name: mutSB [H]

Synonym: NATL1_02951

Alternate gene names: 124025008

Gene position: 273492-275906 (Clockwise)

Preceding gene: 124025007

Following gene: 124025009

Centisome position: 14.67

GC content: 37.72

Gene sequence:

>2415_bases
ATGGGATTAACAAAAAATCATGATGATTCTAAAAAGGCACAAATAATATCAGAGTCTTTGGATTTGCTTGAATGGCCAAC
TGTTTGTAGCCATTTGTCTACATTCGCTCTTACTCAACAAGGTCGTAAAAAATGTGAAAGCTTTGATTTGCCACGAAATC
TATCTTTAAGCCAAGAGCTATTGTCCCAAACATTAGAAATTGGGTCATTAGATAGTTCTCTTAATGAAGGAATATCTTTT
GATGGTGTTCATGATTTGGAAAATATACTTTTGATATGCTCCAAAGGAGGTATTGCTATTGGTGAGGATTTATTAAAAGT
AGCTGATACTTTAAGAGCTGCTAGAAAATTACGAAAACTAATATTTGATCAAGTGATACGTCCACGACTTTCTGAATTGC
TCAAAGATGTTGCAACTTTGCCAGATTTGCAAAAACTCCTCGAATTCGGGCTTGATGAAGGTGGGCGAATTGCAGATCGT
GCTAGCCCAAAGCTTTCTGAATTACGACGTTATAGAAATTCCGTACGTCTTCAAAGAAAAGATATTCTACAAGATATCAT
CCGGAAATATGGTGGATTACTTCAAGATAATATTATTTCAGAGAGGTATGGACGACCTGTTTTAGCGTTTAAGGCTGGGA
CTTCTGATCAAATTAAAGGAATGGTTCATGATAGTTCGGCCTCTGGAAACACGATATATGTCGAGCCCCAAGTTGTCATA
TCAATAGGAAATCGTTTAGCTAAGATAGATTCTGAAATCTCAGATGAAGAGAGGAGACTTTTAGCTGATTGGAGTAAAGA
GGTTGGTCTTAATGCAATTGTAATAGCTCATTTAGTAGAGATCCTTTTGCAAATTGAGTTTGCATTGTCTCGAGCACGTT
ATTCTAAATGGCTTAATGGGGTCCCTGCAATTCTTGATCAAGAAGAACATTCACTCTTTGAGATCAAAGATTTTCGTCAT
CCTTTATTAGTATGGAATGACTTCCATGAGAAAAAGAATACAGTAGTTCCAACTAGTTTTGATGTCGCCCCTGATTTAAA
AGTTGTTGCGATTACAGGCCCTAATACTGGAGGGAAAACAGTTGCTTTGAAAAGTATTGGTTTAGCAGTTTTAATGGCAA
AAGCGGGGTTGCTTTTGCCATGTACAGGCTCACCAAGATTACCATGGTGTAAAAATGTTTTCGCTGATATTGGTGATGAG
CAATCTTTACAGCAAAATTTGTCTACATTTAGCGGACATATTCTTCGTATAAGTCGAATACTCGACGCTATAGATGTGTT
CCCTGGTACGACTCTCGTTCTTTTAGATGAAGTTGGAGCTGGAACTGATCCAACTGAAGGCACAGCATTGGCCATGGCAC
TCCTACAGGTAATGGCTAATAGAGCAAGATTAACTATCGCGACTACTCATTTTGGACAATTAAAAGCGCTCAAATATAGT
GATTCAAGATTTGAAAATGCTTCAGTTTCTTTTGATAGTGAAACTATACAACCAACTTTTCATTTGCAATGGGGAATTCC
TGGTCGAAGTAATGCAATTGAAATTTCAAAGAGACTTGGTCTCGATGAGCAAGTAATCATAAGTGCTCAAAAATTTATCA
ATCCTGAAAGGGTTGATAATGTTAATCAAGTTATTCAAGGCTTAGAAAAACAACGCGAGCGTCAGCAATCAGCAGCTGAA
GATGCTGCTGCATTATTGGCTAAAACCGAATTACTGCATGAGGAATTACTTAATAGTTGGCAGAAACAACGTCAACAATC
GGAAGAGTTTAATGAGCAAGGAAGGTTCAAATTGGAGTCATCAATTCGTGAAGGTCAAAAAGAAGTTAGACATTTAATTA
AACGTTTGCGCGATCAAAACGCTAGTGGTGAGACAGCAAGAATTGCCGGTCAACGATTACGGCAAATAGAAAAGGGATAT
CGAAACGACAAGCGAATTAACCACACACAGAGTTGGACCCCAAAGATTGGGGAAAAAGTTAGATTGTCTTCTATTGGTAA
AGCAGGTGAAATAATTTCTTTTTCAGATGATGGAATGCAATTAACGGTGCTATGCGGAGTATTTCGAAGCAAAGTCAATT
TAACCGAAGTTGAAAGTCTTGATGGTCAAAAGGTCGAAATAAACCAAAATGTGCAAGTAAAAACTTCGCAGGTAAGAAAG
AATTTATCTTTAGTAAGAACTAAAAAAAATACCTTAGATGTAAGAGGGTTACGCGTTCATGAAGCCGAGGGGGTAATTGA
AGAAAAATTGAGAAATTGTTCCGGAGCTTTATGGGTTATTCATGGAATTGGTTCTGGAAAACTGAAAAAAGGTTTGAGGA
AATGGTTTGATTCACTTCCATATATTGAAAAAGTAGCCGATGCTGAACCTCATGATGGCGGCCCTGGATGTAGCGTTGTG
TGGATGGTTGATTGA

Upstream 100 bases:

>100_bases
TTCTTCTTTTTATTTAAAAGATACAGAAGGTAATTGGTTAGAAATGCTTTATCACCCATCAACAGGAATACCAACAAATC
AATAGACTTTAGCTAGACGA

Downstream 100 bases:

>100_bases
AATTGAGGTGAAAGTTATAAACAGTTTTTTCACTTCTTTAATTTAGCAAGGATGAATTTAAGAATTATTATTTAGTTAAT
TGATTAAAGATATTTCTAAA

Product: DNA mismatch repair protein MutS family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MGLTKNHDDSKKAQIISESLDLLEWPTVCSHLSTFALTQQGRKKCESFDLPRNLSLSQELLSQTLEIGSLDSSLNEGISF
DGVHDLENILLICSKGGIAIGEDLLKVADTLRAARKLRKLIFDQVIRPRLSELLKDVATLPDLQKLLEFGLDEGGRIADR
ASPKLSELRRYRNSVRLQRKDILQDIIRKYGGLLQDNIISERYGRPVLAFKAGTSDQIKGMVHDSSASGNTIYVEPQVVI
SIGNRLAKIDSEISDEERRLLADWSKEVGLNAIVIAHLVEILLQIEFALSRARYSKWLNGVPAILDQEEHSLFEIKDFRH
PLLVWNDFHEKKNTVVPTSFDVAPDLKVVAITGPNTGGKTVALKSIGLAVLMAKAGLLLPCTGSPRLPWCKNVFADIGDE
QSLQQNLSTFSGHILRISRILDAIDVFPGTTLVLLDEVGAGTDPTEGTALAMALLQVMANRARLTIATTHFGQLKALKYS
DSRFENASVSFDSETIQPTFHLQWGIPGRSNAIEISKRLGLDEQVIISAQKFINPERVDNVNQVIQGLEKQRERQQSAAE
DAAALLAKTELLHEELLNSWQKQRQQSEEFNEQGRFKLESSIREGQKEVRHLIKRLRDQNASGETARIAGQRLRQIEKGY
RNDKRINHTQSWTPKIGEKVRLSSIGKAGEIISFSDDGMQLTVLCGVFRSKVNLTEVESLDGQKVEINQNVQVKTSQVRK
NLSLVRTKKNTLDVRGLRVHEAEGVIEEKLRNCSGALWVIHGIGSGKLKKGLRKWFDSLPYIEKVADAEPHDGGPGCSVV
WMVD

Sequences:

>Translated_804_residues
MGLTKNHDDSKKAQIISESLDLLEWPTVCSHLSTFALTQQGRKKCESFDLPRNLSLSQELLSQTLEIGSLDSSLNEGISF
DGVHDLENILLICSKGGIAIGEDLLKVADTLRAARKLRKLIFDQVIRPRLSELLKDVATLPDLQKLLEFGLDEGGRIADR
ASPKLSELRRYRNSVRLQRKDILQDIIRKYGGLLQDNIISERYGRPVLAFKAGTSDQIKGMVHDSSASGNTIYVEPQVVI
SIGNRLAKIDSEISDEERRLLADWSKEVGLNAIVIAHLVEILLQIEFALSRARYSKWLNGVPAILDQEEHSLFEIKDFRH
PLLVWNDFHEKKNTVVPTSFDVAPDLKVVAITGPNTGGKTVALKSIGLAVLMAKAGLLLPCTGSPRLPWCKNVFADIGDE
QSLQQNLSTFSGHILRISRILDAIDVFPGTTLVLLDEVGAGTDPTEGTALAMALLQVMANRARLTIATTHFGQLKALKYS
DSRFENASVSFDSETIQPTFHLQWGIPGRSNAIEISKRLGLDEQVIISAQKFINPERVDNVNQVIQGLEKQRERQQSAAE
DAAALLAKTELLHEELLNSWQKQRQQSEEFNEQGRFKLESSIREGQKEVRHLIKRLRDQNASGETARIAGQRLRQIEKGY
RNDKRINHTQSWTPKIGEKVRLSSIGKAGEIISFSDDGMQLTVLCGVFRSKVNLTEVESLDGQKVEINQNVQVKTSQVRK
NLSLVRTKKNTLDVRGLRVHEAEGVIEEKLRNCSGALWVIHGIGSGKLKKGLRKWFDSLPYIEKVADAEPHDGGPGCSVV
WMVD
>Mature_803_residues
GLTKNHDDSKKAQIISESLDLLEWPTVCSHLSTFALTQQGRKKCESFDLPRNLSLSQELLSQTLEIGSLDSSLNEGISFD
GVHDLENILLICSKGGIAIGEDLLKVADTLRAARKLRKLIFDQVIRPRLSELLKDVATLPDLQKLLEFGLDEGGRIADRA
SPKLSELRRYRNSVRLQRKDILQDIIRKYGGLLQDNIISERYGRPVLAFKAGTSDQIKGMVHDSSASGNTIYVEPQVVIS
IGNRLAKIDSEISDEERRLLADWSKEVGLNAIVIAHLVEILLQIEFALSRARYSKWLNGVPAILDQEEHSLFEIKDFRHP
LLVWNDFHEKKNTVVPTSFDVAPDLKVVAITGPNTGGKTVALKSIGLAVLMAKAGLLLPCTGSPRLPWCKNVFADIGDEQ
SLQQNLSTFSGHILRISRILDAIDVFPGTTLVLLDEVGAGTDPTEGTALAMALLQVMANRARLTIATTHFGQLKALKYSD
SRFENASVSFDSETIQPTFHLQWGIPGRSNAIEISKRLGLDEQVIISAQKFINPERVDNVNQVIQGLEKQRERQQSAAED
AAALLAKTELLHEELLNSWQKQRQQSEEFNEQGRFKLESSIREGQKEVRHLIKRLRDQNASGETARIAGQRLRQIEKGYR
NDKRINHTQSWTPKIGEKVRLSSIGKAGEIISFSDDGMQLTVLCGVFRSKVNLTEVESLDGQKVEINQNVQVKTSQVRKN
LSLVRTKKNTLDVRGLRVHEAEGVIEEKLRNCSGALWVIHGIGSGKLKKGLRKWFDSLPYIEKVADAEPHDGGPGCSVVW
MVD

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI26638666, Length=223, Percent_Identity=29.5964125560538, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI4505253, Length=223, Percent_Identity=29.5964125560538, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI4557761, Length=264, Percent_Identity=26.5151515151515, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI4504191, Length=299, Percent_Identity=26.7558528428094, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI26638664, Length=223, Percent_Identity=30.0448430493274, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI262231786, Length=223, Percent_Identity=29.5964125560538, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI284813531, Length=167, Percent_Identity=30.5389221556886, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI36949366, Length=169, Percent_Identity=29.585798816568, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789089, Length=306, Percent_Identity=25.1633986928105, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508445, Length=242, Percent_Identity=28.099173553719, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17534743, Length=253, Percent_Identity=25.6916996047431, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17508447, Length=227, Percent_Identity=27.7533039647577, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319935, Length=272, Percent_Identity=28.3088235294118, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321912, Length=259, Percent_Identity=27.027027027027, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324482, Length=317, Percent_Identity=23.9747634069401, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320302, Length=269, Percent_Identity=23.7918215613383, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320047, Length=235, Percent_Identity=25.9574468085106, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24584320, Length=421, Percent_Identity=24.2280285035629, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24664545, Length=243, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89593; Mature: 89461

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLTKNHDDSKKAQIISESLDLLEWPTVCSHLSTFALTQQGRKKCESFDLPRNLSLSQEL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LSQTLEIGSLDSSLNEGISFDGVHDLENILLICSKGGIAIGEDLLKVADTLRAARKLRKL
HHHHHHHCCCHHHHHCCCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IFDQVIRPRLSELLKDVATLPDLQKLLEFGLDEGGRIADRASPKLSELRRYRNSVRLQRK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DILQDIIRKYGGLLQDNIISERYGRPVLAFKAGTSDQIKGMVHDSSASGNTIYVEPQVVI
HHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCHHHCEEEECCCCCCCEEEECCCEEE
SIGNRLAKIDSEISDEERRLLADWSKEVGLNAIVIAHLVEILLQIEFALSRARYSKWLNG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VPAILDQEEHSLFEIKDFRHPLLVWNDFHEKKNTVVPTSFDVAPDLKVVAITGPNTGGKT
CCHHHCCCCCCHHHHHHCCCCEEEECCHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCE
VALKSIGLAVLMAKAGLLLPCTGSPRLPWCKNVFADIGDEQSLQQNLSTFSGHILRISRI
EEHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LDAIDVFPGTTLVLLDEVGAGTDPTEGTALAMALLQVMANRARLTIATTHFGQLKALKYS
HHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEC
DSRFENASVSFDSETIQPTFHLQWGIPGRSNAIEISKRLGLDEQVIISAQKFINPERVDN
CCCCCCCCEECCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHCC
VNQVIQGLEKQRERQQSAAEDAAALLAKTELLHEELLNSWQKQRQQSEEFNEQGRFKLES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHH
SIREGQKEVRHLIKRLRDQNASGETARIAGQRLRQIEKGYRNDKRINHTQSWTPKIGEKV
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCHH
RLSSIGKAGEIISFSDDGMQLTVLCGVFRSKVNLTEVESLDGQKVEINQNVQVKTSQVRK
HHHHCCCCCCEEEECCCCCEEHHHHHHHHHCCCHHHHHCCCCCEEEECCCCEEEHHHHHH
NLSLVRTKKNTLDVRGLRVHEAEGVIEEKLRNCSGALWVIHGIGSGKLKKGLRKWFDSLP
HHHHHHCCCCCCCCCCEEEEHHCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCC
YIEKVADAEPHDGGPGCSVVWMVD
HHHHHCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
GLTKNHDDSKKAQIISESLDLLEWPTVCSHLSTFALTQQGRKKCESFDLPRNLSLSQEL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LSQTLEIGSLDSSLNEGISFDGVHDLENILLICSKGGIAIGEDLLKVADTLRAARKLRKL
HHHHHHHCCCHHHHHCCCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IFDQVIRPRLSELLKDVATLPDLQKLLEFGLDEGGRIADRASPKLSELRRYRNSVRLQRK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DILQDIIRKYGGLLQDNIISERYGRPVLAFKAGTSDQIKGMVHDSSASGNTIYVEPQVVI
HHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCHHHCEEEECCCCCCCEEEECCCEEE
SIGNRLAKIDSEISDEERRLLADWSKEVGLNAIVIAHLVEILLQIEFALSRARYSKWLNG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VPAILDQEEHSLFEIKDFRHPLLVWNDFHEKKNTVVPTSFDVAPDLKVVAITGPNTGGKT
CCHHHCCCCCCHHHHHHCCCCEEEECCHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCE
VALKSIGLAVLMAKAGLLLPCTGSPRLPWCKNVFADIGDEQSLQQNLSTFSGHILRISRI
EEHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LDAIDVFPGTTLVLLDEVGAGTDPTEGTALAMALLQVMANRARLTIATTHFGQLKALKYS
HHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEC
DSRFENASVSFDSETIQPTFHLQWGIPGRSNAIEISKRLGLDEQVIISAQKFINPERVDN
CCCCCCCCEECCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHCC
VNQVIQGLEKQRERQQSAAEDAAALLAKTELLHEELLNSWQKQRQQSEEFNEQGRFKLES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHH
SIREGQKEVRHLIKRLRDQNASGETARIAGQRLRQIEKGYRNDKRINHTQSWTPKIGEKV
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCHH
RLSSIGKAGEIISFSDDGMQLTVLCGVFRSKVNLTEVESLDGQKVEINQNVQVKTSQVRK
HHHHCCCCCCEEEECCCCCEEHHHHHHHHHCCCHHHHHCCCCCEEEECCCCEEEHHHHHH
NLSLVRTKKNTLDVRGLRVHEAEGVIEEKLRNCSGALWVIHGIGSGKLKKGLRKWFDSLP
HHHHHHCCCCCCCCCCEEEEHHCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCC
YIEKVADAEPHDGGPGCSVVWMVD
HHHHHCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]