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The map label for this gene is hemB [H]

Identifier: 124025006

GI number: 124025006

Start: 272024

End: 273022

Strand: Direct

Name: hemB [H]

Synonym: NATL1_02931

Alternate gene names: 124025006

Gene position: 272024-273022 (Clockwise)

Preceding gene: 124025005

Following gene: 124025007

Centisome position: 14.59

GC content: 38.84

Gene sequence:

>999_bases
ATGGATCTTACTTATCGGCCCCGTCGTCTTCGCAGAACAAACTCTTTAAGAGAGATGGTTCGAGAGAACACTGTCTCTGC
TTCTGACTTTATTTACCCTCTTTTTGTTCATGAAGGTTCAGATACTCAAGAAATAGCCGCGATGCCAGGTACAAGTCGCT
GGCCCATAGATGGATTGATTGATGAAGTTAAGCGTGCTTGGAATCTAGGTATTAGATGTGTCGTTATTTTTCCAAAAGTT
CCTGACGAGCAAAAAACAGAAGATGGAGCTGAATGCTTTAATGAAAAAGGTTTAATACCAAGGACTATTGAAAGATTGAA
AAAAGAGATACCGGAAATGTGTGTTATGACTGATGTTGCTTTAGATCCTTATTCTTGTGATGGTCATGATGGAATAGTTA
GTGATGACGGGATAATTTTGAATGATGCAACTGTTAATTATTTGTGTAAACAAGCTGTTGTTCAGGCACGAGCTGGAGCA
GATTTAATTGGCCCAAGTGACATGATGGATGGAAGAGTTGGAGCAATAAGAGAAGCCTTAGATGATGAAGGTTTTGAACA
TGTAGGAATAATTAGTTATACGGCAAAATATTCATCTGCATATTATGGACCGTTTAGAGAAGCTTTAGATTCTGCTCCTA
GATCAATATCTAATAAGCCTATTCCGAAAAATAAAAACACCTATCAGATGGATCCAGCTAATGCTAGGGAAGCAATAACT
GAAGCTCAGCTTGACGAACAAGAAGGATCAGACATCCTCATGGTTAAACCAGGTTTGGCTTACTTAGATATTATTTACCG
TTTAAGAGAAGAATCAGAACTACCTATCGCTGCGTATAACGTAAGTGGGGAGTACTCGATGGTCAAAGCTGCTGCTCAAA
GAGGCTGGATAGATGAAAGAGAAATTGTTTTGGAAACTTTATTGAGTTTTAAAAGAGCAGGAGCAAATCTGATCCTTACA
TATCACGCATGTGATGCCGCAGGATGGTTAAAAGAATAA

Upstream 100 bases:

>100_bases
GAAAAGCTTAGATCTGTTCGAATAGATGAACCTCGATCAAGCTGGTTCGAGAAGGCTAGGACTTAAAGGAAGTAAAATGT
AGTTATCTTGATTGGTCCAT

Downstream 100 bases:

>100_bases
TAAAGTTGATTAAGAAAATTACTAAAATTTGAACCTTCAATCAAAAGTAATGCAAAAAAAACAGTCTGAATTAAATATTG
AAAGTGTTCATCGACTCGGT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MDLTYRPRRLRRTNSLREMVRENTVSASDFIYPLFVHEGSDTQEIAAMPGTSRWPIDGLIDEVKRAWNLGIRCVVIFPKV
PDEQKTEDGAECFNEKGLIPRTIERLKKEIPEMCVMTDVALDPYSCDGHDGIVSDDGIILNDATVNYLCKQAVVQARAGA
DLIGPSDMMDGRVGAIREALDDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRSISNKPIPKNKNTYQMDPANAREAIT
EAQLDEQEGSDILMVKPGLAYLDIIYRLREESELPIAAYNVSGEYSMVKAAAQRGWIDEREIVLETLLSFKRAGANLILT
YHACDAAGWLKE

Sequences:

>Translated_332_residues
MDLTYRPRRLRRTNSLREMVRENTVSASDFIYPLFVHEGSDTQEIAAMPGTSRWPIDGLIDEVKRAWNLGIRCVVIFPKV
PDEQKTEDGAECFNEKGLIPRTIERLKKEIPEMCVMTDVALDPYSCDGHDGIVSDDGIILNDATVNYLCKQAVVQARAGA
DLIGPSDMMDGRVGAIREALDDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRSISNKPIPKNKNTYQMDPANAREAIT
EAQLDEQEGSDILMVKPGLAYLDIIYRLREESELPIAAYNVSGEYSMVKAAAQRGWIDEREIVLETLLSFKRAGANLILT
YHACDAAGWLKE
>Mature_332_residues
MDLTYRPRRLRRTNSLREMVRENTVSASDFIYPLFVHEGSDTQEIAAMPGTSRWPIDGLIDEVKRAWNLGIRCVVIFPKV
PDEQKTEDGAECFNEKGLIPRTIERLKKEIPEMCVMTDVALDPYSCDGHDGIVSDDGIILNDATVNYLCKQAVVQARAGA
DLIGPSDMMDGRVGAIREALDDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRSISNKPIPKNKNTYQMDPANAREAIT
EAQLDEQEGSDILMVKPGLAYLDIIYRLREESELPIAAYNVSGEYSMVKAAAQRGWIDEREIVLETLLSFKRAGANLILT
YHACDAAGWLKE

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=313, Percent_Identity=38.3386581469649, Blast_Score=221, Evalue=8e-58,
Organism=Escherichia coli, GI87081728, Length=327, Percent_Identity=48.9296636085627, Blast_Score=283, Evalue=8e-78,
Organism=Saccharomyces cerevisiae, GI6321398, Length=325, Percent_Identity=37.2307692307692, Blast_Score=192, Evalue=7e-50,
Organism=Drosophila melanogaster, GI21358291, Length=311, Percent_Identity=34.7266881028939, Blast_Score=195, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37092; Mature: 37092

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTYRPRRLRRTNSLREMVRENTVSASDFIYPLFVHEGSDTQEIAAMPGTSRWPIDGLI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHCEEEEEEECCCCCHHHHCCCCCCCCCHHHHH
DEVKRAWNLGIRCVVIFPKVPDEQKTEDGAECFNEKGLIPRTIERLKKEIPEMCVMTDVA
HHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
LDPYSCDGHDGIVSDDGIILNDATVNYLCKQAVVQARAGADLIGPSDMMDGRVGAIREAL
CCCCCCCCCCCEECCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHH
DDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRSISNKPIPKNKNTYQMDPANAREAIT
CCCCCCEEEEEEEEHHHCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCEEECCCHHHHHHH
EAQLDEQEGSDILMVKPGLAYLDIIYRLREESELPIAAYNVSGEYSMVKAAAQRGWIDER
HHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHH
EIVLETLLSFKRAGANLILTYHACDAAGWLKE
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MDLTYRPRRLRRTNSLREMVRENTVSASDFIYPLFVHEGSDTQEIAAMPGTSRWPIDGLI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHCEEEEEEECCCCCHHHHCCCCCCCCCHHHHH
DEVKRAWNLGIRCVVIFPKVPDEQKTEDGAECFNEKGLIPRTIERLKKEIPEMCVMTDVA
HHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
LDPYSCDGHDGIVSDDGIILNDATVNYLCKQAVVQARAGADLIGPSDMMDGRVGAIREAL
CCCCCCCCCCCEECCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHH
DDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRSISNKPIPKNKNTYQMDPANAREAIT
CCCCCCEEEEEEEEHHHCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCEEECCCHHHHHHH
EAQLDEQEGSDILMVKPGLAYLDIIYRLREESELPIAAYNVSGEYSMVKAAAQRGWIDER
HHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHH
EIVLETLLSFKRAGANLILTYHACDAAGWLKE
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]