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The map label for this gene is pyrD [H]

Identifier: 124024988

GI number: 124024988

Start: 255182

End: 256339

Strand: Reverse

Name: pyrD [H]

Synonym: NATL1_02751

Alternate gene names: 124024988

Gene position: 256339-255182 (Counterclockwise)

Preceding gene: 124024989

Following gene: 124024987

Centisome position: 13.75

GC content: 36.44

Gene sequence:

>1158_bases
TTGCCAACAACTAAAAAAAACGACTTATACAACATTCTCCTCGGTCAGCTTCTATCTCAAGACGAGGGTATTGATGCAGA
AATACTTACTAATTCAGCCCTTAATGCAATTAAATTCGCATCATTAAATAGAAACTTTCCATTAATTTCTAATATCCTTT
TAAAAGCATCAAATGATTTTCAAAGAAACAATTCAAGCTTAAATCAAATTGTTTTTGGCTCTCACTTTAAAAATCCTGTG
GGACTTGCTGCTGGATTTGACAAGAATGGCGTAGGAGCAGGTCTTTGGAATTATTTTGGATTTGGTTTCGCCGAATTGGG
AACTATTACTTGGCATGCCCAAGAAGGCAATCCAAAGCCTAGACTTTTCAGAATTGCAAAAGAGAAAGCTGCGCTGAATC
GAATGGGATTCAATAACCAAGGAGCAGAAAATTTTTTGAAAACAATCGAAAAACAGAAAATCCTTGCACCAGGGAATAGA
CCTTGTGTCCTAGGAATAAATTTAGGCAAGTCAAAAATCACTCCACTCGATGAAGCCCATATAGACTATTCTTTATCTCT
AAAACTACTGGCTCCTTTATCAGACTATGCAGTAATTAATGTTAGTTCACCTAATACCCCAGGCCTTCGTTCATTACAAG
GAACAAAACAAATAAAAAAATTAATAATCACGCTTAAAGATTTACCCAATTGTCCTCCTTTGCTTGTAAAAATTGCCCCA
GATCTTTCCAATGAAGCAATTGATGAAATTGCAAGAGTTGCGATGGAAAATGGCATCGATGGAATTATTGCAATCAATAC
AAGCTTAGATAGATTTGATTTAAAAAATCTGAAAATCAAAACTGGAAATACTCTAGGACAAGAAAATGGAGGATTAAGTG
GTCTACCCTTACAAAAAAGAGGACTAGAAGTTATTCGGAGACTAAGAAGAAGTACTGATAATGATTTACCTCTGATTGGT
GTGGGTGGAATTCATTCAGCAAGAGCGGCATGGGAAAGAATTACAGCTGGTGCCTCACTGGTTCAGATTTATACTGGGTG
GATATTTGAGGGACCAAATTTAGTTCCAGACATACTAGATGGATTAATCCAGCAAATGGAAAAACATGGATTCCGAAATA
TTAAAGAGGCCATAGGTTCCGAAGAACCATGGAAGTAA

Upstream 100 bases:

>100_bases
CTTCAATATGTCAAAGGTCATAGCGGAGAAAAGGATAATGACAGAGTCGATGCAATTGCGGTAGCTTTTTCTAAAGGTAG
GAAAATACAACTTAAAGATT

Downstream 100 bases:

>100_bases
AATACAAAAGGAATTAAATAAATTTTTATGATTATATTTTAAACTAAGACTAAGATTGTCTCAAATATAATGAACATAAA
CTTTGAAAATCATGGCGGTA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MPTTKKNDLYNILLGQLLSQDEGIDAEILTNSALNAIKFASLNRNFPLISNILLKASNDFQRNNSSLNQIVFGSHFKNPV
GLAAGFDKNGVGAGLWNYFGFGFAELGTITWHAQEGNPKPRLFRIAKEKAALNRMGFNNQGAENFLKTIEKQKILAPGNR
PCVLGINLGKSKITPLDEAHIDYSLSLKLLAPLSDYAVINVSSPNTPGLRSLQGTKQIKKLIITLKDLPNCPPLLVKIAP
DLSNEAIDEIARVAMENGIDGIIAINTSLDRFDLKNLKIKTGNTLGQENGGLSGLPLQKRGLEVIRRLRRSTDNDLPLIG
VGGIHSARAAWERITAGASLVQIYTGWIFEGPNLVPDILDGLIQQMEKHGFRNIKEAIGSEEPWK

Sequences:

>Translated_385_residues
MPTTKKNDLYNILLGQLLSQDEGIDAEILTNSALNAIKFASLNRNFPLISNILLKASNDFQRNNSSLNQIVFGSHFKNPV
GLAAGFDKNGVGAGLWNYFGFGFAELGTITWHAQEGNPKPRLFRIAKEKAALNRMGFNNQGAENFLKTIEKQKILAPGNR
PCVLGINLGKSKITPLDEAHIDYSLSLKLLAPLSDYAVINVSSPNTPGLRSLQGTKQIKKLIITLKDLPNCPPLLVKIAP
DLSNEAIDEIARVAMENGIDGIIAINTSLDRFDLKNLKIKTGNTLGQENGGLSGLPLQKRGLEVIRRLRRSTDNDLPLIG
VGGIHSARAAWERITAGASLVQIYTGWIFEGPNLVPDILDGLIQQMEKHGFRNIKEAIGSEEPWK
>Mature_384_residues
PTTKKNDLYNILLGQLLSQDEGIDAEILTNSALNAIKFASLNRNFPLISNILLKASNDFQRNNSSLNQIVFGSHFKNPVG
LAAGFDKNGVGAGLWNYFGFGFAELGTITWHAQEGNPKPRLFRIAKEKAALNRMGFNNQGAENFLKTIEKQKILAPGNRP
CVLGINLGKSKITPLDEAHIDYSLSLKLLAPLSDYAVINVSSPNTPGLRSLQGTKQIKKLIITLKDLPNCPPLLVKIAPD
LSNEAIDEIARVAMENGIDGIIAINTSLDRFDLKNLKIKTGNTLGQENGGLSGLPLQKRGLEVIRRLRRSTDNDLPLIGV
GGIHSARAAWERITAGASLVQIYTGWIFEGPNLVPDILDGLIQQMEKHGFRNIKEAIGSEEPWK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=376, Percent_Identity=39.8936170212766, Blast_Score=238, Evalue=5e-63,
Organism=Escherichia coli, GI1787177, Length=297, Percent_Identity=44.7811447811448, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI87082059, Length=151, Percent_Identity=33.112582781457, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509475, Length=321, Percent_Identity=38.9408099688474, Blast_Score=227, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6322633, Length=286, Percent_Identity=25.8741258741259, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281361352, Length=331, Percent_Identity=39.2749244712991, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI17137316, Length=331, Percent_Identity=39.2749244712991, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 42102; Mature: 41971

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTKKNDLYNILLGQLLSQDEGIDAEILTNSALNAIKFASLNRNFPLISNILLKASNDF
CCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCH
QRNNSSLNQIVFGSHFKNPVGLAAGFDKNGVGAGLWNYFGFGFAELGTITWHAQEGNPKP
HCCCCCHHEEEECCCCCCCCCEECCCCCCCCCCHHHHHHCCCHHHHCEEEEEECCCCCCC
RLFRIAKEKAALNRMGFNNQGAENFLKTIEKQKILAPGNRPCVLGINLGKSKITPLDEAH
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCCCEEEEEECCCCCCCCCCHHC
IDYSLSLKLLAPLSDYAVINVSSPNTPGLRSLQGTKQIKKLIITLKDLPNCPPLLVKIAP
CCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
DLSNEAIDEIARVAMENGIDGIIAINTSLDRFDLKNLKIKTGNTLGQENGGLSGLPLQKR
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHH
GLEVIRRLRRSTDNDLPLIGVGGIHSARAAWERITAGASLVQIYTGWIFEGPNLVPDILD
HHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHCEEECCCCCHHHHHH
GLIQQMEKHGFRNIKEAIGSEEPWK
HHHHHHHHCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PTTKKNDLYNILLGQLLSQDEGIDAEILTNSALNAIKFASLNRNFPLISNILLKASNDF
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCH
QRNNSSLNQIVFGSHFKNPVGLAAGFDKNGVGAGLWNYFGFGFAELGTITWHAQEGNPKP
HCCCCCHHEEEECCCCCCCCCEECCCCCCCCCCHHHHHHCCCHHHHCEEEEEECCCCCCC
RLFRIAKEKAALNRMGFNNQGAENFLKTIEKQKILAPGNRPCVLGINLGKSKITPLDEAH
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCCCEEEEEECCCCCCCCCCHHC
IDYSLSLKLLAPLSDYAVINVSSPNTPGLRSLQGTKQIKKLIITLKDLPNCPPLLVKIAP
CCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
DLSNEAIDEIARVAMENGIDGIIAINTSLDRFDLKNLKIKTGNTLGQENGGLSGLPLQKR
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHH
GLEVIRRLRRSTDNDLPLIGVGGIHSARAAWERITAGASLVQIYTGWIFEGPNLVPDILD
HHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHCEEECCCCCHHHHHH
GLIQQMEKHGFRNIKEAIGSEEPWK
HHHHHHHHCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]