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The map label for this gene is cobD [H]

Identifier: 124024987

GI number: 124024987

Start: 254030

End: 255112

Strand: Reverse

Name: cobD [H]

Synonym: NATL1_02741

Alternate gene names: 124024987

Gene position: 255112-254030 (Counterclockwise)

Preceding gene: 124024988

Following gene: 124024985

Centisome position: 13.68

GC content: 30.47

Gene sequence:

>1083_bases
ATGAACATAAACTTTGAAAATCATGGCGGTAATATTGAAAAAGAAGCAAGAAAATTAGGACTGTCTACAGAAAATATAAT
CGATGCAAGTGCATCAATAGTACCTTTTAAATTACCTAACAAATTAAATAATTATCTTATTAATAGTATAAAAAATAGGT
CTATAAGATCTTATCCCGATAGAAGTTATTTTGAAGTGAGAAATGCTATTTCAAAATGGCATAATATTGAGCCATCAATG
ATTTTACCTGGCAATGGAGCCTCTGAATTATTTACGTGGGCAGCAAGAGATGCAAGTCTAAATGGAATCAGTTCTTTACC
CTCTCCTGGTTTTGGAGATTATCAAAGAGCTTTAAAATGCTGGAATGCTCCTTATGTTCATAATCCTTTACCCTTATCTT
GGACAAATAACAATCCTCAATCATTCCCAATTGAACCAAAAGCAAATGTCTTGTGGATTACCAATCCACATAATCCAACT
GGTCAATTATGGAGTCGTTCTTCAATAGAAAATTTACTAGCAAATTACAAACTTGTAATTTGCGATGAAGCATTTATTTC
TCTTGTCCCTGGAGGAGAAAGTCAATCAATTATAGATTTAACAAATATATATAAGAACCTAATAGTAATAAGAAGTTTAA
CTAAATTCCTTGGTATTGCTGGATTAAGGGTTGGATATGCCGTGACAAACTCAGATAGATTATTAAAATGGAAAGAGATA
AGAGATCCATGGCCTGTAAATACGCTAGCCATCAATGCAACTAAGATGATCATGAAAGATTCTAAAATGCATAAAAAAAG
ATTAAATAAGATCCATAGATGGGTAGAAAAAGAAGGGAAATGGCTATATCAAAGTTTGTCAAGTTTCTCTACTATTAAGC
CTCTACCATCAACTACTAACTTTCAATTAATAAAAAGTGAGAGCTCTATATTAAATCTTCTTGAGAATTTAAAAAAAAGA
GGAATTATATTACGAGACTGTAGATCATTTATAAACTTAGATGAAAAATGGTTCAGAATCAGTCTTCTAAAAAGAGAACA
AAATATTCAAATTATTAATACACTAAAAGATTATATTAACTAA

Upstream 100 bases:

>100_bases
GGCCATAGGTTCCGAAGAACCATGGAAGTAAAATACAAAAGGAATTAAATAAATTTTTATGATTATATTTTAAACTAAGA
CTAAGATTGTCTCAAATATA

Downstream 100 bases:

>100_bases
TAGAATGTATTATTTCGAATATCTTTTTTTCAGGATATGAATAATCATGATTATTCATATTTAATTTCATTTCCCTAAGA
GAATTAGAATCCAATAAATT

Product: aminotransferases class-I

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MNINFENHGGNIEKEARKLGLSTENIIDASASIVPFKLPNKLNNYLINSIKNRSIRSYPDRSYFEVRNAISKWHNIEPSM
ILPGNGASELFTWAARDASLNGISSLPSPGFGDYQRALKCWNAPYVHNPLPLSWTNNNPQSFPIEPKANVLWITNPHNPT
GQLWSRSSIENLLANYKLVICDEAFISLVPGGESQSIIDLTNIYKNLIVIRSLTKFLGIAGLRVGYAVTNSDRLLKWKEI
RDPWPVNTLAINATKMIMKDSKMHKKRLNKIHRWVEKEGKWLYQSLSSFSTIKPLPSTTNFQLIKSESSILNLLENLKKR
GIILRDCRSFINLDEKWFRISLLKREQNIQIINTLKDYIN

Sequences:

>Translated_360_residues
MNINFENHGGNIEKEARKLGLSTENIIDASASIVPFKLPNKLNNYLINSIKNRSIRSYPDRSYFEVRNAISKWHNIEPSM
ILPGNGASELFTWAARDASLNGISSLPSPGFGDYQRALKCWNAPYVHNPLPLSWTNNNPQSFPIEPKANVLWITNPHNPT
GQLWSRSSIENLLANYKLVICDEAFISLVPGGESQSIIDLTNIYKNLIVIRSLTKFLGIAGLRVGYAVTNSDRLLKWKEI
RDPWPVNTLAINATKMIMKDSKMHKKRLNKIHRWVEKEGKWLYQSLSSFSTIKPLPSTTNFQLIKSESSILNLLENLKKR
GIILRDCRSFINLDEKWFRISLLKREQNIQIINTLKDYIN
>Mature_360_residues
MNINFENHGGNIEKEARKLGLSTENIIDASASIVPFKLPNKLNNYLINSIKNRSIRSYPDRSYFEVRNAISKWHNIEPSM
ILPGNGASELFTWAARDASLNGISSLPSPGFGDYQRALKCWNAPYVHNPLPLSWTNNNPQSFPIEPKANVLWITNPHNPT
GQLWSRSSIENLLANYKLVICDEAFISLVPGGESQSIIDLTNIYKNLIVIRSLTKFLGIAGLRVGYAVTNSDRLLKWKEI
RDPWPVNTLAINATKMIMKDSKMHKKRLNKIHRWVEKEGKWLYQSLSSFSTIKPLPSTTNFQLIKSESSILNLLENLKKR
GIILRDCRSFINLDEKWFRISLLKREQNIQIINTLKDYIN

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=320, Percent_Identity=23.4375, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322075, Length=269, Percent_Identity=24.907063197026, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41205; Mature: 41205

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNINFENHGGNIEKEARKLGLSTENIIDASASIVPFKLPNKLNNYLINSIKNRSIRSYPD
CCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCC
RSYFEVRNAISKWHNIEPSMILPGNGASELFTWAARDASLNGISSLPSPGFGDYQRALKC
HHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
WNAPYVHNPLPLSWTNNNPQSFPIEPKANVLWITNPHNPTGQLWSRSSIENLLANYKLVI
CCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEE
CDEAFISLVPGGESQSIIDLTNIYKNLIVIRSLTKFLGIAGLRVGYAVTNSDRLLKWKEI
ECHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEHHHC
RDPWPVNTLAINATKMIMKDSKMHKKRLNKIHRWVEKEGKWLYQSLSSFSTIKPLPSTTN
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FQLIKSESSILNLLENLKKRGIILRDCRSFINLDEKWFRISLLKREQNIQIINTLKDYIN
EEEEECHHHHHHHHHHHHHCCEEHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNINFENHGGNIEKEARKLGLSTENIIDASASIVPFKLPNKLNNYLINSIKNRSIRSYPD
CCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCC
RSYFEVRNAISKWHNIEPSMILPGNGASELFTWAARDASLNGISSLPSPGFGDYQRALKC
HHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
WNAPYVHNPLPLSWTNNNPQSFPIEPKANVLWITNPHNPTGQLWSRSSIENLLANYKLVI
CCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEE
CDEAFISLVPGGESQSIIDLTNIYKNLIVIRSLTKFLGIAGLRVGYAVTNSDRLLKWKEI
ECHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEHHHC
RDPWPVNTLAINATKMIMKDSKMHKKRLNKIHRWVEKEGKWLYQSLSSFSTIKPLPSTTN
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FQLIKSESSILNLLENLKKRGIILRDCRSFINLDEKWFRISLLKREQNIQIINTLKDYIN
EEEEECHHHHHHHHHHHHHCCEEHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]