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The map label for this gene is trpB

Identifier: 124024951

GI number: 124024951

Start: 220171

End: 221424

Strand: Reverse

Name: trpB

Synonym: NATL1_02381

Alternate gene names: 124024951

Gene position: 221424-220171 (Counterclockwise)

Preceding gene: 124024954

Following gene: 124024949

Centisome position: 11.87

GC content: 41.95

Gene sequence:

>1254_bases
GTGACAGGTACACTCCCAACACAATTTAAAGATTCGGATTTATCTCCTTTAACAAGGCCAAATGCTCTTGGTCGATTTGG
TAAGTATGGGGGGCAATATGTTCCTGAAACTTTAATACCTGCTCTTATTGAATTAGAGCAAGCTGCTAAAGAAGCATGGA
AAGATTCTTCATTCAATTCAGAACTAAATCATTTACTAAAAACATACGTAGGAAGATCAACTCCTCTTTATGAAGCCACA
AGACTAACTGAACATTACAGAAAAAATACATTAAAAGGTCCAAGGATTTGGCTTAAAAGAGAAGATTTAAATCACACAGG
CGCACACAAAATAAATAATGCACTTGGGCAAGCTCTTCTTGCGATTCGGATGGGAAAAAAAAGAATTATTGCTGAAACTG
GGGCTGGTCAGCATGGAGTTGCAACTGCGACAGTCTGCGCTCGTTTTGGATTGGAGTGCATTATCTATATGGGCAAAGAA
GATATGAGAAGACAAGCCTTAAACGTATTCCGAATGCAATTGCTTGGAGCCTCAGTGAGGCCAGTAACAAGTGGAACAGC
AACACTCAAAGATGCAACCAGCGAAGCTATTCGGGATTGGGTTACTAATGTTGAAACGACTCATTATATTCTCGGTTCAG
TTGCAGGCCCACATCCATATCCAATGTTGGTCAGAGATTTTCACGCAGTTATTGGAGAAGAAACAAAGCAACAATGTAAA
CAAGCTTTTGGGCGGTCTCCCGATGTTCTTCTTGCTTGTGTTGGTGGGGGATCGAATGCGATGGGTCTTTTCCATTCTTT
TGTTGAAGACAAAAGTGTGAGAATGATTGGAGTTGAAGCTGCGGGAGATGGAGTCGAAACAGGTCGCCATGCAGCGACAA
TTACTGAAGGAAGAGTAGGAGTTCTCCACGGCGCGATGAGTCTCTTACTACAAGACAAAGATGGGCAAGTTGAGGAGGCT
CATTCCATTAGCGCAGGTCTTGATTATCCAGGGGTTGGGCCGGAGCATAGTTACTTAAAAGAAATTGGACGTGCTGAATA
TGCTGCTGTTACTGACACTGAAGCCATAGAAGCGCTGCAATTAGTGAGTAAATTGGAAGGTATTATTCCTGCTCTAGAGA
CTGCTCATGCATTTGCCTATCTAGAAAAACTTTGCCCAACTCTCAATCATAATTCTGAAATTGTCATTAACTGCTCTGGC
AGAGGGGATAAAGACGTGAATACAGTTGCTGAAAAGCTAGGATCAGAAATATAA

Upstream 100 bases:

>100_bases
GAGTGTTACTCCCTATTGTCTTAAGAGGGTCATTAAACTCACTCCAGCCACCTTTGGACATTTTTTGCTTTTTGGCTGGT
AATTATTTTCTTAATCTAAG

Downstream 100 bases:

>100_bases
AATAACAGCTTATTAATACCTTGGAACAGATTGATCAACATCTGTGCTCCAAGCATCTATTCCTCCGACAAGATTCCAAA
CACTTTTAGCTATTCCTTGT

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTGTLPTQFKDSDLSPLTRPNALGRFGKYGGQYVPETLIPALIELEQAAKEAWKDSSFNSELNHLLKTYVGRSTPLYEAT
RLTEHYRKNTLKGPRIWLKREDLNHTGAHKINNALGQALLAIRMGKKRIIAETGAGQHGVATATVCARFGLECIIYMGKE
DMRRQALNVFRMQLLGASVRPVTSGTATLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMLVRDFHAVIGEETKQQCK
QAFGRSPDVLLACVGGGSNAMGLFHSFVEDKSVRMIGVEAAGDGVETGRHAATITEGRVGVLHGAMSLLLQDKDGQVEEA
HSISAGLDYPGVGPEHSYLKEIGRAEYAAVTDTEAIEALQLVSKLEGIIPALETAHAFAYLEKLCPTLNHNSEIVINCSG
RGDKDVNTVAEKLGSEI

Sequences:

>Translated_417_residues
MTGTLPTQFKDSDLSPLTRPNALGRFGKYGGQYVPETLIPALIELEQAAKEAWKDSSFNSELNHLLKTYVGRSTPLYEAT
RLTEHYRKNTLKGPRIWLKREDLNHTGAHKINNALGQALLAIRMGKKRIIAETGAGQHGVATATVCARFGLECIIYMGKE
DMRRQALNVFRMQLLGASVRPVTSGTATLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMLVRDFHAVIGEETKQQCK
QAFGRSPDVLLACVGGGSNAMGLFHSFVEDKSVRMIGVEAAGDGVETGRHAATITEGRVGVLHGAMSLLLQDKDGQVEEA
HSISAGLDYPGVGPEHSYLKEIGRAEYAAVTDTEAIEALQLVSKLEGIIPALETAHAFAYLEKLCPTLNHNSEIVINCSG
RGDKDVNTVAEKLGSEI
>Mature_416_residues
TGTLPTQFKDSDLSPLTRPNALGRFGKYGGQYVPETLIPALIELEQAAKEAWKDSSFNSELNHLLKTYVGRSTPLYEATR
LTEHYRKNTLKGPRIWLKREDLNHTGAHKINNALGQALLAIRMGKKRIIAETGAGQHGVATATVCARFGLECIIYMGKED
MRRQALNVFRMQLLGASVRPVTSGTATLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMLVRDFHAVIGEETKQQCKQ
AFGRSPDVLLACVGGGSNAMGLFHSFVEDKSVRMIGVEAAGDGVETGRHAATITEGRVGVLHGAMSLLLQDKDGQVEEAH
SISAGLDYPGVGPEHSYLKEIGRAEYAAVTDTEAIEALQLVSKLEGIIPALETAHAFAYLEKLCPTLNHNSEIVINCSGR
GDKDVNTVAEKLGSEI

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=389, Percent_Identity=54.4987146529563, Blast_Score=428, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321412, Length=397, Percent_Identity=59.1939546599496, Blast_Score=476, Evalue=1e-135,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_PROM1 (A2BZZ2)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014067.1
- STRING:   A2BZZ2
- GeneID:   4779575
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_02381
- eggNOG:   COG0133
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- ProtClustDB:   PRK04346
- BioCyc:   PMAR167555:NATL1_02381-MONOMER
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 45217; Mature: 45086

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTLPTQFKDSDLSPLTRPNALGRFGKYGGQYVPETLIPALIELEQAAKEAWKDSSFNS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
ELNHLLKTYVGRSTPLYEATRLTEHYRKNTLKGPRIWLKREDLNHTGAHKINNALGQALL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
AIRMGKKRIIAETGAGQHGVATATVCARFGLECIIYMGKEDMRRQALNVFRMQLLGASVR
HHHHCCHHEEEECCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCC
PVTSGTATLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMLVRDFHAVIGEETKQQCK
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHH
QAFGRSPDVLLACVGGGSNAMGLFHSFVEDKSVRMIGVEAAGDGVETGRHAATITEGRVG
HHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEECCCCHH
VLHGAMSLLLQDKDGQVEEAHSISAGLDYPGVGPEHSYLKEIGRAEYAAVTDTEAIEALQ
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHCCCCHHHHHHHH
LVSKLEGIIPALETAHAFAYLEKLCPTLNHNSEIVINCSGRGDKDVNTVAEKLGSEI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TGTLPTQFKDSDLSPLTRPNALGRFGKYGGQYVPETLIPALIELEQAAKEAWKDSSFNS
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
ELNHLLKTYVGRSTPLYEATRLTEHYRKNTLKGPRIWLKREDLNHTGAHKINNALGQALL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
AIRMGKKRIIAETGAGQHGVATATVCARFGLECIIYMGKEDMRRQALNVFRMQLLGASVR
HHHHCCHHEEEECCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCC
PVTSGTATLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMLVRDFHAVIGEETKQQCK
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHH
QAFGRSPDVLLACVGGGSNAMGLFHSFVEDKSVRMIGVEAAGDGVETGRHAATITEGRVG
HHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEECCCCHH
VLHGAMSLLLQDKDGQVEEAHSISAGLDYPGVGPEHSYLKEIGRAEYAAVTDTEAIEALQ
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHCCCCHHHHHHHH
LVSKLEGIIPALETAHAFAYLEKLCPTLNHNSEIVINCSGRGDKDVNTVAEKLGSEI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA