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The map label for this gene is gltA [H]

Identifier: 124024947

GI number: 124024947

Start: 216876

End: 218003

Strand: Reverse

Name: gltA [H]

Synonym: NATL1_02341

Alternate gene names: 124024947

Gene position: 218003-216876 (Counterclockwise)

Preceding gene: 124024949

Following gene: 124024946

Centisome position: 11.69

GC content: 41.49

Gene sequence:

>1128_bases
TTGGTTCTAAAGCCAGGCTTGGAAGGAGTTCCAGTAACCAAATCAGGGATATGCGAAATAAATGGAACAGAAGGAAGGCT
TAGCTACAGAGGTTATCCAATATCTGAGCTAGCCCAAAAGAGTAGTTTTTTAGAAACTGCATTTCTCCTGATCTGGGGAG
AACTTCCCACTGAAAATGAGCTTGAGAAATTTGAAAAGGACGTTCAAATGCATAGACGAGTGAGCTTTAGAATTAGAGAT
ATGCTCAAGTGTTTTCCAGAGTCTGGGCATCCTATGGATGCTCTTCAAGCAAGTGCTGCATCTTTGGGCCTCTTTTATTC
TCGAAGAGCAATTGATGATCCAAAATATATCTACGACGCAGTAGTGAGGTTGATTGCAAAAATTCCAACTATGGTTGCTG
CTTTCGAGCAAATAAGAAAAGGAGACGATCCAATTCAACCGCAAGATGATTTACCTTACTCTTCCAATTTCCTTTATATG
CTCACCGAGAGGGAGCCAAATCCTCTTGCAGCAAGAGTTTTCGACAGATGTTTAATTCTTCATGCCGAGCACAGTCTCAA
TGCAAGTACGTTTAGCGCAAGAGTAACTGCAAGCACATTGACTGATCCTTATGCCGTCGTCGCTTCTGCCGTTGGGACAT
TAGCCGGTCCTCTTCATGGAGGGGCCAATGAAGATGTGATAGCAATGCTAGAAGAAATTGGAAGGCCTGATGAAGCCTCT
TCATTTCTCAATGATGCAATTGCAAAAAAAAGGAAAATCATGGGCTTTGGACACAGGGAATATCGTGTCAAAGACCCTAG
AGCAACAATTTTACAAGCCTTCGCAGAGGAACTTTTCTCGGAATTTGGTAAAGATGAAATGTATGAAGTAGCCAAAGCAC
TTGAAGAAGAAGCTATTTCCAAGCTGGGGCCAAAAGGTATATTCCCAAATGTTGACTTTTATTCCGGACTTGTTTATCGA
AAGCTAGGTATTCCTCGAGATTTATTTACACCAGTTTTTGCTATTTCCAGAGTTGCTGGTTGGTTGGCTCACTGGAGAGA
ACAACTTGGAGCAAATAGAATTTTCAGACCATCACAAATTTATGAAGGAGCAAAAATGAGAAATTGGAAGCCTCTTGAAA
GCAGATAA

Upstream 100 bases:

>100_bases
TAATTCTATAAAATAAAGTTCAAGTTGAAAATTTTTCAATTGAACAGAAAATTGTTTTGCAGGAGCTAAAGCCATAGATA
ACGAAAAAAAGACAACTAAT

Downstream 100 bases:

>100_bases
TTTGAAATTTATTTTTTTCGAATTTAAAATTAATTCAAAATTACACTAACCTTGTTAATAGAACATATGTAAGAAGTGAA
TTCAGGTATAGACCTTGAAA

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MVLKPGLEGVPVTKSGICEINGTEGRLSYRGYPISELAQKSSFLETAFLLIWGELPTENELEKFEKDVQMHRRVSFRIRD
MLKCFPESGHPMDALQASAASLGLFYSRRAIDDPKYIYDAVVRLIAKIPTMVAAFEQIRKGDDPIQPQDDLPYSSNFLYM
LTEREPNPLAARVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVIAMLEEIGRPDEAS
SFLNDAIAKKRKIMGFGHREYRVKDPRATILQAFAEELFSEFGKDEMYEVAKALEEEAISKLGPKGIFPNVDFYSGLVYR
KLGIPRDLFTPVFAISRVAGWLAHWREQLGANRIFRPSQIYEGAKMRNWKPLESR

Sequences:

>Translated_375_residues
MVLKPGLEGVPVTKSGICEINGTEGRLSYRGYPISELAQKSSFLETAFLLIWGELPTENELEKFEKDVQMHRRVSFRIRD
MLKCFPESGHPMDALQASAASLGLFYSRRAIDDPKYIYDAVVRLIAKIPTMVAAFEQIRKGDDPIQPQDDLPYSSNFLYM
LTEREPNPLAARVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVIAMLEEIGRPDEAS
SFLNDAIAKKRKIMGFGHREYRVKDPRATILQAFAEELFSEFGKDEMYEVAKALEEEAISKLGPKGIFPNVDFYSGLVYR
KLGIPRDLFTPVFAISRVAGWLAHWREQLGANRIFRPSQIYEGAKMRNWKPLESR
>Mature_375_residues
MVLKPGLEGVPVTKSGICEINGTEGRLSYRGYPISELAQKSSFLETAFLLIWGELPTENELEKFEKDVQMHRRVSFRIRD
MLKCFPESGHPMDALQASAASLGLFYSRRAIDDPKYIYDAVVRLIAKIPTMVAAFEQIRKGDDPIQPQDDLPYSSNFLYM
LTEREPNPLAARVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVIAMLEEIGRPDEAS
SFLNDAIAKKRKIMGFGHREYRVKDPRATILQAFAEELFSEFGKDEMYEVAKALEEEAISKLGPKGIFPNVDFYSGLVYR
KLGIPRDLFTPVFAISRVAGWLAHWREQLGANRIFRPSQIYEGAKMRNWKPLESR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=330, Percent_Identity=29.6969696969697, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786939, Length=381, Percent_Identity=38.3202099737533, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1786527, Length=379, Percent_Identity=34.5646437994723, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17555174, Length=330, Percent_Identity=27.5757575757576, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319850, Length=323, Percent_Identity=26.625386996904, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325257, Length=344, Percent_Identity=28.4883720930233, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324328, Length=317, Percent_Identity=25.5520504731861, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24640126, Length=329, Percent_Identity=26.7477203647416, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640124, Length=329, Percent_Identity=26.7477203647416, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21356863, Length=379, Percent_Identity=26.3852242744063, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42114; Mature: 42114

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLKPGLEGVPVTKSGICEINGTEGRLSYRGYPISELAQKSSFLETAFLLIWGELPTENE
CCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
LEKFEKDVQMHRRVSFRIRDMLKCFPESGHPMDALQASAASLGLFYSRRAIDDPKYIYDA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VVRLIAKIPTMVAAFEQIRKGDDPIQPQDDLPYSSNFLYMLTEREPNPLAARVFDRCLIL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
HAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVIAMLEEIGRPDEAS
HCCCCCCCHHHHHEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHH
SFLNDAIAKKRKIMGFGHREYRVKDPRATILQAFAEELFSEFGKDEMYEVAKALEEEAIS
HHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
KLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPVFAISRVAGWLAHWREQLGANRIFRPSQI
HCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YEGAKMRNWKPLESR
HCCCCCCCCCCCCCC
>Mature Secondary Structure
MVLKPGLEGVPVTKSGICEINGTEGRLSYRGYPISELAQKSSFLETAFLLIWGELPTENE
CCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
LEKFEKDVQMHRRVSFRIRDMLKCFPESGHPMDALQASAASLGLFYSRRAIDDPKYIYDA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VVRLIAKIPTMVAAFEQIRKGDDPIQPQDDLPYSSNFLYMLTEREPNPLAARVFDRCLIL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
HAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDVIAMLEEIGRPDEAS
HCCCCCCCHHHHHEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHH
SFLNDAIAKKRKIMGFGHREYRVKDPRATILQAFAEELFSEFGKDEMYEVAKALEEEAIS
HHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
KLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPVFAISRVAGWLAHWREQLGANRIFRPSQI
HCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YEGAKMRNWKPLESR
HCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]