Click here to switch to the map view.

The map label for this gene is ndhA

Identifier: 124024946

GI number: 124024946

Start: 215682

End: 216800

Strand: Reverse

Name: ndhA

Synonym: NATL1_02331

Alternate gene names: 124024946

Gene position: 216800-215682 (Counterclockwise)

Preceding gene: 124024947

Following gene: 124024945

Centisome position: 11.63

GC content: 37.18

Gene sequence:

>1119_bases
GTGAATTCAGGTATAGACCTTGAAATGAGTTTTACCCAAGGTGTTCAAAACCTTGGTTTATCTCATGAATTAGCACACCT
TTTATGGATCCCTCTTCCAATGCTTTTAGTATTGGTATCAGCTGTCATTGGTGTATTAGTAACAGTTTGGCTTGAACGAA
AAATTTCTGCAGCAGCTCAACAAAGAATTGGGCCTGAATATGCAGGTGCACTTGGTATTCTTCAGCCAATGGCAGACGGT
TTGAAACTCTTAGTAAAAGAAGACATTATTCCAGCAAGGGCTGACAGTGTTCTTTTTACAGTTGGTCCAATATTAGTTTT
AGTGCCAGTTATTCTATCTTGGCTAATTGTTCCCTTTGGTCAAAATCTGTTAATTAGTAATGTAGGTATAGGAATATTTT
TGTGGATTGCCCTAAGTAGCATTCAACCAATTGGTTTACTGATGAGTGGCTACTCTTCCAATAATAAATATTCTTTACTA
GGTGGACTGAGAGCTGCCGCTCAATCAATTAGTTATGAAATTCCATTAGCGCTAGCAGTTTTGGCCATAGTTATGATGAG
CAATTCATTGAGCACTGTTGACATAGTTGAGCAACAAAATACTGCCGGCTTACTTAGCTGGAATATATGGCGACAACCTG
TAGGTTTTATTATTTTTTGGATCTGTGCATTAGCTGAATGCGAGAGACTACCTTTTGATTTACCAGAGGCAGAAGAAGAG
CTTGTAGCTGGTTATCAAACTGAGTATTCAGGTATGAAATTTGCTCTGTTTTACTTAGCTGGATACATCAATCTTGTTTT
ATCTGCTTTACTTGTTTCTGTTCTGTACTTGGGAGGATGGGGGTTTCCAATCTCAATTGATTGGTTTTCATCATTGATAG
GTCTTTCAATTGATAATCCATTAGTTCAAATTATTGCTGCGTCTCTTGGAATTGTAATGACAATCCTTAAGGCTTATTTA
CTGGTTTTTCTAGCAATCTTATTGAGATGGACTACTCCAAGAGTTCGGATTGATCAACTACTTGATTTAGGCTGGAAGTT
TCTTTTACCTATTTCTTTGGTCAATTTACTTGTAACTGCATCACTTAAATTGGCATTTCCGATTACATTTGGCGGATAA

Upstream 100 bases:

>100_bases
TTGGAAGCCTCTTGAAAGCAGATAATTTGAAATTTATTTTTTTCGAATTTAAAATTAATTCAAAATTACACTAACCTTGT
TAATAGAACATATGTAAGAA

Downstream 100 bases:

>100_bases
TAGAAAAGCAACACACTAGCTAGTTTTTTAAGTAAAAGTACCTACATTTAATTGAAAAAAACTGTATAATGATTACTGTA
GACATAGACCGCCGGCATCG

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNSGIDLEMSFTQGVQNLGLSHELAHLLWIPLPMLLVLVSAVIGVLVTVWLERKISAAAQQRIGPEYAGALGILQPMADG
LKLLVKEDIIPARADSVLFTVGPILVLVPVILSWLIVPFGQNLLISNVGIGIFLWIALSSIQPIGLLMSGYSSNNKYSLL
GGLRAAAQSISYEIPLALAVLAIVMMSNSLSTVDIVEQQNTAGLLSWNIWRQPVGFIIFWICALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLAGYINLVLSALLVSVLYLGGWGFPISIDWFSSLIGLSIDNPLVQIIAASLGIVMTILKAYL
LVFLAILLRWTTPRVRIDQLLDLGWKFLLPISLVNLLVTASLKLAFPITFGG

Sequences:

>Translated_372_residues
MNSGIDLEMSFTQGVQNLGLSHELAHLLWIPLPMLLVLVSAVIGVLVTVWLERKISAAAQQRIGPEYAGALGILQPMADG
LKLLVKEDIIPARADSVLFTVGPILVLVPVILSWLIVPFGQNLLISNVGIGIFLWIALSSIQPIGLLMSGYSSNNKYSLL
GGLRAAAQSISYEIPLALAVLAIVMMSNSLSTVDIVEQQNTAGLLSWNIWRQPVGFIIFWICALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLAGYINLVLSALLVSVLYLGGWGFPISIDWFSSLIGLSIDNPLVQIIAASLGIVMTILKAYL
LVFLAILLRWTTPRVRIDQLLDLGWKFLLPISLVNLLVTASLKLAFPITFGG
>Mature_372_residues
MNSGIDLEMSFTQGVQNLGLSHELAHLLWIPLPMLLVLVSAVIGVLVTVWLERKISAAAQQRIGPEYAGALGILQPMADG
LKLLVKEDIIPARADSVLFTVGPILVLVPVILSWLIVPFGQNLLISNVGIGIFLWIALSSIQPIGLLMSGYSSNNKYSLL
GGLRAAAQSISYEIPLALAVLAIVMMSNSLSTVDIVEQQNTAGLLSWNIWRQPVGFIIFWICALAECERLPFDLPEAEEE
LVAGYQTEYSGMKFALFYLAGYINLVLSALLVSVLYLGGWGFPISIDWFSSLIGLSIDNPLVQIIAASLGIVMTILKAYL
LVFLAILLRWTTPRVRIDQLLDLGWKFLLPISLVNLLVTASLKLAFPITFGG

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=34.640522875817, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1788618, Length=342, Percent_Identity=37.719298245614, Blast_Score=225, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU1C_PROM1 (A2BZY7)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014062.1
- STRING:   A2BZY7
- GeneID:   4779513
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_02331
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   IFWICAL
- ProtClustDB:   PRK06076
- BioCyc:   PMAR167555:NATL1_02331-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: 1.6.5.3

Molecular weight: Translated: 40533; Mature: 40533

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f11f228)-; HASH(0x1e7b49c4)-; HASH(0x1eee7350)-; HASH(0x1e8dcd64)-; HASH(0x1e840af4)-; HASH(0x1f351fb0)-; HASH(0x1e785bc4)-; HASH(0x1e9264cc)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSGIDLEMSFTQGVQNLGLSHELAHLLWIPLPMLLVLVSAVIGVLVTVWLERKISAAAQ
CCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYAGALGILQPMADGLKLLVKEDIIPARADSVLFTVGPILVLVPVILSWLIVPFG
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QNLLISNVGIGIFLWIALSSIQPIGLLMSGYSSNNKYSLLGGLRAAAQSISYEIPLALAV
CCHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAIVMMSNSLSTVDIVEQQNTAGLLSWNIWRQPVGFIIFWICALAECERLPFDLPEAEEE
HHHHHHCCCCCHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LVAGYQTEYSGMKFALFYLAGYINLVLSALLVSVLYLGGWGFPISIDWFSSLIGLSIDNP
HHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCHH
LVQIIAASLGIVMTILKAYLLVFLAILLRWTTPRVRIDQLLDLGWKFLLPISLVNLLVTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
SLKLAFPITFGG
HHHEEEEEECCH
>Mature Secondary Structure
MNSGIDLEMSFTQGVQNLGLSHELAHLLWIPLPMLLVLVSAVIGVLVTVWLERKISAAAQ
CCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYAGALGILQPMADGLKLLVKEDIIPARADSVLFTVGPILVLVPVILSWLIVPFG
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QNLLISNVGIGIFLWIALSSIQPIGLLMSGYSSNNKYSLLGGLRAAAQSISYEIPLALAV
CCHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAIVMMSNSLSTVDIVEQQNTAGLLSWNIWRQPVGFIIFWICALAECERLPFDLPEAEEE
HHHHHHCCCCCHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LVAGYQTEYSGMKFALFYLAGYINLVLSALLVSVLYLGGWGFPISIDWFSSLIGLSIDNP
HHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCHH
LVQIIAASLGIVMTILKAYLLVFLAILLRWTTPRVRIDQLLDLGWKFLLPISLVNLLVTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
SLKLAFPITFGG
HHHEEEEEECCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA