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The map label for this gene is murC

Identifier: 124024734

GI number: 124024734

Start: 23092

End: 24576

Strand: Reverse

Name: murC

Synonym: NATL1_00211

Alternate gene names: 124024734

Gene position: 24576-23092 (Counterclockwise)

Preceding gene: 124024736

Following gene: 124024733

Centisome position: 1.32

GC content: 30.57

Gene sequence:

>1485_bases
ATGACGAGTTATCTTTCTAACGACACTGAAGCGAAATTGAAGAAGACAAAGGAGTTACCACCTCATATTCATTTTATAGG
AATCGGAGGTATTGGTATGTCTGCTCTGGCAATGATTCTCGCTCAAAAAGGATATTCAATATCTGGCTCTGACCAGAAAA
AAAACCTAACTTTAAAAAAATTAGAAGAAAACAAAGTCCACATCTTTCCAACCCAAGTAGAATCGAATATTGATGAAATT
CTTAAAGTCCATGGGAAAAACATATTAGTTGTTAAAAGTTCAGCAATACATCGAGATAATTTAGAATTATGTAAAGCAAA
AAAATATAATTTAAAAATCAAGCATCGTTCTGAAATATTAGCCTTTTTAATTGAAGAAAAAAAATCAATAATCGTCTCAG
GTTCTCATGGTAAAACAACTACAAGTACTTACATTACAACATTATTTTCTTATGCAAATAAGAGTCCAACGGCTATCATC
GGCGGAATCGTACCTCTCTACAAAAGCAACTACAGTTTTGGTAAAAGTGAATTTTTAATCGCAGAAGCAGATGAATCAGA
TGGATCATTAGTAAAGTTTAATCCAAATATCGGATTAATCACGAATTTAGAACTTGAACATGTTGATCATTATCTAGATC
TAGAAGATTTAATAGAAACAATGAAACAGTTTGCTCAAAAGTGTGAATGCCTGATTACCAATTTTGACTGTGATAATCTT
AGAGCTAATATACATGGTTCTAAATGGTTTTCGATCCAAAAAATTATTAATATAGATTTTGCACTGATCCCGAAAGAATC
TAATGGATGTGAAATTATTGCGGAGTATTATGAAAAAGAAAAGTTTATTGATGTTATAAAAATACCTGTTCCTGGCATAC
ACAATTTAAGCAATGCAGCTGCTGCTATAGCTGCATGTAGAGTGGCTGGCATTCTTTTCAAAGATATAAAAAAAGGAATT
GAAAAATTAAAGCTACCCTCAAGAAGATTTGAATTTAAAGGATTATGGAGAAACAGATTAATAGTTGAGGATTATGCTCA
TCATCCGAGCGAAATTGATGCTGCAATATCAATTGCATCTACTATTATTGAGACAAAACATAAACTCTCAAAAATATTAC
CAAGAAGAATAGTTACGATCTTTCAGCCGCATCGATATAGTAGAACTAAAAAGTTTCAAAAGGAATTTGCAAAAACTCTA
AGTCAATCTGATTTAGTATTTATAACTCCAATTTACTCTGCTGGAGAAGATAAAATCGAAGGAATAAATAATAAGAGTAT
TGGACATGAGTTAAAAAAAATCAAACCTAACCTAGAAATATATACTCCAGATAACAATCAAAATTTGATAAAACTAATAA
AAGAAAAGACACTTGAAAACGACTTGATTTTAATTATGGGAGCAGGAGATATTAATCTAATAAGTGAAAATCTATTTTTA
GAGTTACTCAATAATAAATTAATCAGCAATGATATAGCCGCTTAA

Upstream 100 bases:

>100_bases
CGATGATCATTTTCTGTGCATTTTGAAAAATAATTGAAGCGTTAAGGAAATAAAAAGTCCAAAAACTCTCTAATTCTTTA
AAAAATGTGCCTTTATATCA

Downstream 100 bases:

>100_bases
TAAATGAATTCCATTAAATTACAGAAAAATATTTCCTTATCAAATTTCACTACTTGGGGAATAGGTGGTCCTGCAGAATG
GATTGCTCAACCAAAAAATA

Product: UDP-N-acetylmuramate-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTSYLSNDTEAKLKKTKELPPHIHFIGIGGIGMSALAMILAQKGYSISGSDQKKNLTLKKLEENKVHIFPTQVESNIDEI
LKVHGKNILVVKSSAIHRDNLELCKAKKYNLKIKHRSEILAFLIEEKKSIIVSGSHGKTTTSTYITTLFSYANKSPTAII
GGIVPLYKSNYSFGKSEFLIAEADESDGSLVKFNPNIGLITNLELEHVDHYLDLEDLIETMKQFAQKCECLITNFDCDNL
RANIHGSKWFSIQKIINIDFALIPKESNGCEIIAEYYEKEKFIDVIKIPVPGIHNLSNAAAAIAACRVAGILFKDIKKGI
EKLKLPSRRFEFKGLWRNRLIVEDYAHHPSEIDAAISIASTIIETKHKLSKILPRRIVTIFQPHRYSRTKKFQKEFAKTL
SQSDLVFITPIYSAGEDKIEGINNKSIGHELKKIKPNLEIYTPDNNQNLIKLIKEKTLENDLILIMGAGDINLISENLFL
ELLNNKLISNDIAA

Sequences:

>Translated_494_residues
MTSYLSNDTEAKLKKTKELPPHIHFIGIGGIGMSALAMILAQKGYSISGSDQKKNLTLKKLEENKVHIFPTQVESNIDEI
LKVHGKNILVVKSSAIHRDNLELCKAKKYNLKIKHRSEILAFLIEEKKSIIVSGSHGKTTTSTYITTLFSYANKSPTAII
GGIVPLYKSNYSFGKSEFLIAEADESDGSLVKFNPNIGLITNLELEHVDHYLDLEDLIETMKQFAQKCECLITNFDCDNL
RANIHGSKWFSIQKIINIDFALIPKESNGCEIIAEYYEKEKFIDVIKIPVPGIHNLSNAAAAIAACRVAGILFKDIKKGI
EKLKLPSRRFEFKGLWRNRLIVEDYAHHPSEIDAAISIASTIIETKHKLSKILPRRIVTIFQPHRYSRTKKFQKEFAKTL
SQSDLVFITPIYSAGEDKIEGINNKSIGHELKKIKPNLEIYTPDNNQNLIKLIKEKTLENDLILIMGAGDINLISENLFL
ELLNNKLISNDIAA
>Mature_493_residues
TSYLSNDTEAKLKKTKELPPHIHFIGIGGIGMSALAMILAQKGYSISGSDQKKNLTLKKLEENKVHIFPTQVESNIDEIL
KVHGKNILVVKSSAIHRDNLELCKAKKYNLKIKHRSEILAFLIEEKKSIIVSGSHGKTTTSTYITTLFSYANKSPTAIIG
GIVPLYKSNYSFGKSEFLIAEADESDGSLVKFNPNIGLITNLELEHVDHYLDLEDLIETMKQFAQKCECLITNFDCDNLR
ANIHGSKWFSIQKIINIDFALIPKESNGCEIIAEYYEKEKFIDVIKIPVPGIHNLSNAAAAIAACRVAGILFKDIKKGIE
KLKLPSRRFEFKGLWRNRLIVEDYAHHPSEIDAAISIASTIIETKHKLSKILPRRIVTIFQPHRYSRTKKFQKEFAKTLS
QSDLVFITPIYSAGEDKIEGINNKSIGHELKKIKPNLEIYTPDNNQNLIKLIKEKTLENDLILIMGAGDINLISENLFLE
LLNNKLISNDIAA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=480, Percent_Identity=31.6666666666667, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1790680, Length=413, Percent_Identity=25.4237288135593, Blast_Score=112, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PROM1 (A2BZC5)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001013850.1
- ProteinModelPortal:   A2BZC5
- SMR:   A2BZC5
- STRING:   A2BZC5
- GeneID:   4780958
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_00211
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   CLSK716070
- BioCyc:   PMAR167555:NATL1_00211-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 55598; Mature: 55467

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYLSNDTEAKLKKTKELPPHIHFIGIGGIGMSALAMILAQKGYSISGSDQKKNLTLKK
CCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEE
LEENKVHIFPTQVESNIDEILKVHGKNILVVKSSAIHRDNLELCKAKKYNLKIKHRSEIL
ECCCCEEEEECHHHCCHHHHHHHCCCEEEEEECCCCCCCCHHHHCCCCCEEEEEHHHHHH
AFLIEEKKSIIVSGSHGKTTTSTYITTLFSYANKSPTAIIGGIVPLYKSNYSFGKSEFLI
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHCCCCCCCCCEEEE
AEADESDGSLVKFNPNIGLITNLELEHVDHYLDLEDLIETMKQFAQKCECLITNFDCDNL
EECCCCCCCEEEECCCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCCC
RANIHGSKWFSIQKIINIDFALIPKESNGCEIIAEYYEKEKFIDVIKIPVPGIHNLSNAA
EECCCCCCEEEEEHEEECCEEEEECCCCCHHHHHHHHHHHHCEEEEEECCCCCCCHHHHH
AAIAACRVAGILFKDIKKGIEKLKLPSRRFEFKGLWRNRLIVEDYAHHPSEIDAAISIAS
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHCCHHCCCEEEEHHCCCCHHHHHHHHHHH
TIIETKHKLSKILPRRIVTIFQPHRYSRTKKFQKEFAKTLSQSDLVFITPIYSAGEDKIE
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHC
GINNKSIGHELKKIKPNLEIYTPDNNQNLIKLIKEKTLENDLILIMGAGDINLISENLFL
CCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHH
ELLNNKLISNDIAA
HHHHCHHHHCCCCC
>Mature Secondary Structure 
TSYLSNDTEAKLKKTKELPPHIHFIGIGGIGMSALAMILAQKGYSISGSDQKKNLTLKK
CCCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEE
LEENKVHIFPTQVESNIDEILKVHGKNILVVKSSAIHRDNLELCKAKKYNLKIKHRSEIL
ECCCCEEEEECHHHCCHHHHHHHCCCEEEEEECCCCCCCCHHHHCCCCCEEEEEHHHHHH
AFLIEEKKSIIVSGSHGKTTTSTYITTLFSYANKSPTAIIGGIVPLYKSNYSFGKSEFLI
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHCCCCCCCCCEEEE
AEADESDGSLVKFNPNIGLITNLELEHVDHYLDLEDLIETMKQFAQKCECLITNFDCDNL
EECCCCCCCEEEECCCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCCC
RANIHGSKWFSIQKIINIDFALIPKESNGCEIIAEYYEKEKFIDVIKIPVPGIHNLSNAA
EECCCCCCEEEEEHEEECCEEEEECCCCCHHHHHHHHHHHHCEEEEEECCCCCCCHHHHH
AAIAACRVAGILFKDIKKGIEKLKLPSRRFEFKGLWRNRLIVEDYAHHPSEIDAAISIAS
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHCCHHCCCEEEEHHCCCCHHHHHHHHHHH
TIIETKHKLSKILPRRIVTIFQPHRYSRTKKFQKEFAKTLSQSDLVFITPIYSAGEDKIE
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHC
GINNKSIGHELKKIKPNLEIYTPDNNQNLIKLIKEKTLENDLILIMGAGDINLISENLFL
CCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHH
ELLNNKLISNDIAA
HHHHCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA