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The map label for this gene is tmk

Identifier: 124024337

GI number: 124024337

Start: 2337690

End: 2338340

Strand: Reverse

Name: tmk

Synonym: P9303_26491

Alternate gene names: 124024337

Gene position: 2338340-2337690 (Counterclockwise)

Preceding gene: 124024338

Following gene: 124024336

Centisome position: 87.16

GC content: 53.92

Gene sequence:

>651_bases
ATGAGTGGTCGCCTTCTTGTTCTGGAGGGTATTGACGGCTGTGGCAAGACCACTCAGCTCCGTCACCTTGCCAACTGGCT
GCCACGCAGCGGTTTGATGCCTGAGGGTGCAAGGTTGCATCTCACCCGTGAGCCCGGTGGTACGGCTTTAGGTATGGCCT
TGCGCAAGTTGGTTCTTCACCCGCCTGGGGATGCCTCTCCTGAACCCCTTGCGGAACTGTTGCTGTATGCGGCTGATCGA
GCCCAGCACGTGGCTCAGTTGATCCGACCGGCGCTTGAGCAGGGGCACTGGGTACTCAGTGATCGTTTTAGTGGCTCTAC
CCTTGCTTATCAGGGTTATGGAAGAGAGTTGGATCTGGATTTGATTCAGCAACTCGAGCAGATCGCCACGGCTGGACTTG
TCCCGGACCTAACTTTTTGGTTGGAGTTGTCTGTAGAAGAAAGTTTGGTTCGGCGGGATGCAAGATCTAACGATCGAATC
GAAGCGGAAGGAGTTGATTTTTTAACCAGGGTGGCAACTGGATTTGCTGTTTTGGCTAGGGAACGATCTTGGGTGCCGTT
GCAGGCGGATCAACAAGTTGAGTCAGTTAGTTCTGCTTTAGAGAGCCAGCTGAAGCACCATTTCGGGCCTTTGCAAGAGA
GCATGCGATGA

Upstream 100 bases:

>100_bases
TGCCGGGCTTTGGGTTGTTGCTCTCCCCACCCATCGCCGCTCTATTGATGGCCCTTAGTTCAATCACCGTGGTCGTTAAC
GCTTTGGCACTGCGTACTAC

Downstream 100 bases:

>100_bases
GCCTTGAGATTGAGACGCGTGGGCTGTTTGAAGATTTGATCGCTCAGCCGTTGGCAGTTGCATTGCTGGAGGCAGCGTTG
AGTCAGGGTCGACTGGCTCC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MSGRLLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGMALRKLVLHPPGDASPEPLAELLLYAADR
AQHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLDLIQQLEQIATAGLVPDLTFWLELSVEESLVRRDARSNDRI
EAEGVDFLTRVATGFAVLARERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR

Sequences:

>Translated_216_residues
MSGRLLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGMALRKLVLHPPGDASPEPLAELLLYAADR
AQHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLDLIQQLEQIATAGLVPDLTFWLELSVEESLVRRDARSNDRI
EAEGVDFLTRVATGFAVLARERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR
>Mature_215_residues
SGRLLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGMALRKLVLHPPGDASPEPLAELLLYAADRA
QHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLDLIQQLEQIATAGLVPDLTFWLELSVEESLVRRDARSNDRIE
AEGVDFLTRVATGFAVLARERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=37.6190476190476, Blast_Score=121, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PROM3 (A2CD19)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018644.1
- ProteinModelPortal:   A2CD19
- SMR:   A2CD19
- STRING:   A2CD19
- GeneID:   4776762
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_26491
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK13974
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23860; Mature: 23728

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRLLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGMALRKLVLH
CCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
PPGDASPEPLAELLLYAADRAQHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCHH
LIQQLEQIATAGLVPDLTFWLELSVEESLVRRDARSNDRIEAEGVDFLTRVATGFAVLAR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
ERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
SGRLLVLEGIDGCGKTTQLRHLANWLPRSGLMPEGARLHLTREPGGTALGMALRKLVLH
CCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
PPGDASPEPLAELLLYAADRAQHVAQLIRPALEQGHWVLSDRFSGSTLAYQGYGRELDLD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCHH
LIQQLEQIATAGLVPDLTFWLELSVEESLVRRDARSNDRIEAEGVDFLTRVATGFAVLAR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
ERSWVPLQADQQVESVSSALESQLKHHFGPLQESMR
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA