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The map label for this gene is holB [H]

Identifier: 124024336

GI number: 124024336

Start: 2336713

End: 2337693

Strand: Reverse

Name: holB [H]

Synonym: P9303_26481

Alternate gene names: 124024336

Gene position: 2337693-2336713 (Counterclockwise)

Preceding gene: 124024337

Following gene: 124024332

Centisome position: 87.14

GC content: 55.96

Gene sequence:

>981_bases
ATGAGCCTTGAGATTGAGACGCGTGGGCTGTTTGAAGATTTGATCGCTCAGCCGTTGGCAGTTGCATTGCTGGAGGCAGC
GTTGAGTCAGGGTCGACTGGCTCCGGCATATCTCTTTTCTGGTCCAGATGGAGTGGGTCGCAGTCTGGCGGCATTGCGTT
TTCTCGAGGGCGTCATCAGCAGTGGTAAGCCGGCCCTGCGTGAACGCCGTCGTCTAGAGGCGTTCAACCATCCTGATCTG
CTTTGGGTCGAACCGACTTATCAGCATCAAGGCCGCCTGGTCCCTAAGTCCCAGGCAGAGGAAGAAGGCGTGAGCCGCCG
TTCACCCCCACAGGTGCGCCTCGAACAGATTCGGGGGGTGACAAGATTCCTAGGACGACGACCTGTTGAGGCCCCAAGGG
GCATGGTGGTGATTGAAGCGGCGGACTCTATGCCCGAAGCTGCTGCCAATGCTTTGCTTAAAACGCTGGAAGAACCAGGT
CATGGCTTGTTGATTCTGCTTTCGGCCGCTTCTGAGCGCTTGCTCACGACAATTCGTTCTCGATGCCAACAGATTCTTTT
TGCTCGTCTTGAAGGAGCAGACATGCAGACTGTTCTGGCCAGGACGAGCACAGCGGAGATGCGGTCGTCCTTGTTGGCAT
TGGATCAGCCGGAACTGGTTGCGATGGCCGCTGGTTCTCCTGGGGCGCTGTTGCAGCATTTTTGGCTCTGGCAGGCAGTT
CCAGAGGAGTTTTGGCTACGCCTTGAAGAGCGTCCCCAAAAGCCAATGGAAGCCTTAGCTCTGGCGAGGGACCTTACTGA
GGCTCTTAATGGGGAGCAGCAGCTTTGGCTGATTGATTGGTGGCAACAACATTTTTGGATCCAACGGCCTGATCCAAGAC
CACTGAAACGTTTGGAAAGGCTGCGTTCACACCTGCTGGGGTTTGTGCAACCCAGGCTGGCCTGGGAAGTGGCTTTGCTG
GAACTGATTCCTTGCGTTTAA

Upstream 100 bases:

>100_bases
CTTGGGTGCCGTTGCAGGCGGATCAACAAGTTGAGTCAGTTAGTTCTGCTTTAGAGAGCCAGCTGAAGCACCATTTCGGG
CCTTTGCAAGAGAGCATGCG

Downstream 100 bases:

>100_bases
GCGCTGGCGCGCTCTCCTTGCTTGTTTTGTGCTTCTCTGGCTTCCCTCTCTTGGCGTGCCTGGATTAGTAGGTCTTGGAA
CTCTTCGAGTTGTCCTCCTG

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSLEIETRGLFEDLIAQPLAVALLEAALSQGRLAPAYLFSGPDGVGRSLAALRFLEGVISSGKPALRERRRLEAFNHPDL
LWVEPTYQHQGRLVPKSQAEEEGVSRRSPPQVRLEQIRGVTRFLGRRPVEAPRGMVVIEAADSMPEAAANALLKTLEEPG
HGLLILLSAASERLLTTIRSRCQQILFARLEGADMQTVLARTSTAEMRSSLLALDQPELVAMAAGSPGALLQHFWLWQAV
PEEFWLRLEERPQKPMEALALARDLTEALNGEQQLWLIDWWQQHFWIQRPDPRPLKRLERLRSHLLGFVQPRLAWEVALL
ELIPCV

Sequences:

>Translated_326_residues
MSLEIETRGLFEDLIAQPLAVALLEAALSQGRLAPAYLFSGPDGVGRSLAALRFLEGVISSGKPALRERRRLEAFNHPDL
LWVEPTYQHQGRLVPKSQAEEEGVSRRSPPQVRLEQIRGVTRFLGRRPVEAPRGMVVIEAADSMPEAAANALLKTLEEPG
HGLLILLSAASERLLTTIRSRCQQILFARLEGADMQTVLARTSTAEMRSSLLALDQPELVAMAAGSPGALLQHFWLWQAV
PEEFWLRLEERPQKPMEALALARDLTEALNGEQQLWLIDWWQQHFWIQRPDPRPLKRLERLRSHLLGFVQPRLAWEVALL
ELIPCV
>Mature_325_residues
SLEIETRGLFEDLIAQPLAVALLEAALSQGRLAPAYLFSGPDGVGRSLAALRFLEGVISSGKPALRERRRLEAFNHPDLL
WVEPTYQHQGRLVPKSQAEEEGVSRRSPPQVRLEQIRGVTRFLGRRPVEAPRGMVVIEAADSMPEAAANALLKTLEEPGH
GLLILLSAASERLLTTIRSRCQQILFARLEGADMQTVLARTSTAEMRSSLLALDQPELVAMAAGSPGALLQHFWLWQAVP
EEFWLRLEERPQKPMEALALARDLTEALNGEQQLWLIDWWQQHFWIQRPDPRPLKRLERLRSHLLGFVQPRLAWEVALLE
LIPCV

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36702; Mature: 36571

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEIETRGLFEDLIAQPLAVALLEAALSQGRLAPAYLFSGPDGVGRSLAALRFLEGVIS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
SGKPALRERRRLEAFNHPDLLWVEPTYQHQGRLVPKSQAEEEGVSRRSPPQVRLEQIRGV
CCCHHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHH
TRFLGRRPVEAPRGMVVIEAADSMPEAAANALLKTLEEPGHGLLILLSAASERLLTTIRS
HHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
RCQQILFARLEGADMQTVLARTSTAEMRSSLLALDQPELVAMAAGSPGALLQHFWLWQAV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHC
PEEFWLRLEERPQKPMEALALARDLTEALNGEQQLWLIDWWQQHFWIQRPDPRPLKRLER
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHH
LRSHLLGFVQPRLAWEVALLELIPCV
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLEIETRGLFEDLIAQPLAVALLEAALSQGRLAPAYLFSGPDGVGRSLAALRFLEGVIS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
SGKPALRERRRLEAFNHPDLLWVEPTYQHQGRLVPKSQAEEEGVSRRSPPQVRLEQIRGV
CCCHHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHH
TRFLGRRPVEAPRGMVVIEAADSMPEAAANALLKTLEEPGHGLLILLSAASERLLTTIRS
HHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
RCQQILFARLEGADMQTVLARTSTAEMRSSLLALDQPELVAMAAGSPGALLQHFWLWQAV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHC
PEEFWLRLEERPQKPMEALALARDLTEALNGEQQLWLIDWWQQHFWIQRPDPRPLKRLER
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHH
LRSHLLGFVQPRLAWEVALLELIPCV
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]