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The map label for this gene is hisS

Identifier: 124024229

GI number: 124024229

Start: 2234415

End: 2235725

Strand: Reverse

Name: hisS

Synonym: P9303_25401

Alternate gene names: 124024229

Gene position: 2235725-2234415 (Counterclockwise)

Preceding gene: 124024230

Following gene: 124024228

Centisome position: 83.34

GC content: 54.77

Gene sequence:

>1311_bases
GTGACTCAGCTGCAGAGCCTGCGAGGAATGGTGGATCTATTGCCGGAACAGACGAGGTGCTGGCAGGCGGTAGAAAGCGT
TGCGCGAGATCACTTTCGTAGAGCAGGGTTGCAGGAAATTCGCACGCCTCTTCTGGAAGTGACTGAACTCTTCGCACGTG
GCATTGGTGAAGCGACGGATGTTGTTGGAAAGGAGATGTATACCTTTGTTGATCGGGGTGATCGATCCTGCACCCTTCGG
CCGGAGGGAACCGCTTCTGTTGTGCGTGCTGCTCTACAGCACGGCTTGTTGAGTCAGGGGCCACAGCGTCTTTGGTATGG
CGGTCCAATGTTTCGCTATGAGCGACCTCAGGCTGGTCGGCAACGACAGTTTTATCAGATTGGTGTGGAGTATCTCGGGG
TTGGCAGTCCTCGTAGTGATGCTGAAGTCATTGCATTGGCCTGGGCACTTCTGGTCGACTTGGGTGTGCAAGGTCTTGTT
CTGGAGATCAATAGCCTCGGCACCCTTCAGGATCGACAGAAGTATCGAGAGGAGCTTGTGGCGTGGCTAGAAGCCCGCAG
TGACCAGCTTGATGACGATTCACGCAAGCGTTTGTATACCAACCCACTGCGTATCCTTGATAGTAAAAACCCTGCAATAA
GTGAATTGTTGCAGGATGCTCCCACGCTTTTTGAGGCGCTCAGCGTGGAGAGTAAGGCCCGCTTTGAGGAGGTTCAGGTC
GACTTGGAGGCTCTCCAGATACCTTTCCAACTCAATCCTCGTCTTGTGCGCGGCCTTGACTACTACGGCCATACCGCTTT
TGAGATCACTAGCGATCAGCTTGGGGCCCAGGCCACAGTCTGCGGAGGAGGAAGATATGACGGGTTGGTTGAGCAGTTAG
GGGGGGCACCCACTCCCGCTTTTGGTTGGGCTTTTGGTATGGAGCGGTTGATGCTTTTGCTTGAGTCTGCGGCGAGTATT
AATCCAAATGGATCAGCTGCTCGCTTAACGGCTTCCACGAGGCCGGATCTTTATGTGGTGAATCGGGGAGAGCAGGCGGA
ACGAGTCGCCCTGGTCATTGCCCATCAGCTACGGGCTGCGGGGCTCGTGGTGGAGCTGGATAGTTCTGGATCTGCCTTTA
ATAAGCAGTTCAAGCGTGCCGGTCGCAGTAGGGCTACCTGGGCCTTGGTGATTGGTGATGATGAGGCCGAGCGGGGCGAG
GCACGCCTTAAGTATTTGCAGGAGGCAACAACTCAAGCCAATCCGATTCCCATCGATCAACTCCATCGACTCGACGATGT
CACTGGTCTTGTTCGTTTGGTTCGAGAATGA

Upstream 100 bases:

>100_bases
GCCAACAGTTCAGGGGCATTGCGCAACTTGTTTGGATGCCTCGTTTATCGAGCTTGGTGATCACTGGCCCGGCAGACTGC
CTACTGGTTGTTGGTGAAGA

Downstream 100 bases:

>100_bases
CTTCGTATAACTTGCTTCCCAGGCTGAGGTTCCACTTAATCTTTTGCCATGACTGAGCAGGTCTCTCCCCTCATCTTTTG
TTGAACTCGCTGTTTACAAC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATDVVGKEMYTFVDRGDRSCTLR
PEGTASVVRAALQHGLLSQGPQRLWYGGPMFRYERPQAGRQRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLV
LEINSLGTLQDRQKYREELVAWLEARSDQLDDDSRKRLYTNPLRILDSKNPAISELLQDAPTLFEALSVESKARFEEVQV
DLEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPAFGWAFGMERLMLLLESAASI
NPNGSAARLTASTRPDLYVVNRGEQAERVALVIAHQLRAAGLVVELDSSGSAFNKQFKRAGRSRATWALVIGDDEAERGE
ARLKYLQEATTQANPIPIDQLHRLDDVTGLVRLVRE

Sequences:

>Translated_436_residues
MTQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATDVVGKEMYTFVDRGDRSCTLR
PEGTASVVRAALQHGLLSQGPQRLWYGGPMFRYERPQAGRQRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLV
LEINSLGTLQDRQKYREELVAWLEARSDQLDDDSRKRLYTNPLRILDSKNPAISELLQDAPTLFEALSVESKARFEEVQV
DLEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPAFGWAFGMERLMLLLESAASI
NPNGSAARLTASTRPDLYVVNRGEQAERVALVIAHQLRAAGLVVELDSSGSAFNKQFKRAGRSRATWALVIGDDEAERGE
ARLKYLQEATTQANPIPIDQLHRLDDVTGLVRLVRE
>Mature_435_residues
TQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATDVVGKEMYTFVDRGDRSCTLRP
EGTASVVRAALQHGLLSQGPQRLWYGGPMFRYERPQAGRQRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLVL
EINSLGTLQDRQKYREELVAWLEARSDQLDDDSRKRLYTNPLRILDSKNPAISELLQDAPTLFEALSVESKARFEEVQVD
LEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPAFGWAFGMERLMLLLESAASIN
PNGSAARLTASTRPDLYVVNRGEQAERVALVIAHQLRAAGLVVELDSSGSAFNKQFKRAGRSRATWALVIGDDEAERGEA
RLKYLQEATTQANPIPIDQLHRLDDVTGLVRLVRE

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=414, Percent_Identity=47.8260869565217, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71993693, Length=467, Percent_Identity=24.1970021413276, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71993686, Length=467, Percent_Identity=24.1970021413276, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_PROM3 (A2CCR1)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018536.1
- ProteinModelPortal:   A2CCR1
- SMR:   A2CCR1
- STRING:   A2CCR1
- GeneID:   4776791
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_25401
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 48419; Mature: 48287

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATD
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHH
VVGKEMYTFVDRGDRSCTLRPEGTASVVRAALQHGLLSQGPQRLWYGGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCH
QRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLVLEINSLGTLQDRQKYREELV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHH
AWLEARSDQLDDDSRKRLYTNPLRILDSKNPAISELLQDAPTLFEALSVESKARFEEVQV
HHHHHHCCCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPA
HHHHHCCCCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHHHHCCCCCCH
FGWAFGMERLMLLLESAASINPNGSAARLTASTRPDLYVVNRGEQAERVALVIAHQLRAA
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHC
GLVVELDSSGSAFNKQFKRAGRSRATWALVIGDDEAERGEARLKYLQEATTQANPIPIDQ
CEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHH
LHRLDDVTGLVRLVRE
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQLQSLRGMVDLLPEQTRCWQAVESVARDHFRRAGLQEIRTPLLEVTELFARGIGEATD
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHH
VVGKEMYTFVDRGDRSCTLRPEGTASVVRAALQHGLLSQGPQRLWYGGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCH
QRQFYQIGVEYLGVGSPRSDAEVIALAWALLVDLGVQGLVLEINSLGTLQDRQKYREELV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHH
AWLEARSDQLDDDSRKRLYTNPLRILDSKNPAISELLQDAPTLFEALSVESKARFEEVQV
HHHHHHCCCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLEALQIPFQLNPRLVRGLDYYGHTAFEITSDQLGAQATVCGGGRYDGLVEQLGGAPTPA
HHHHHCCCCCCCCHHHHHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHHHHCCCCCCH
FGWAFGMERLMLLLESAASINPNGSAARLTASTRPDLYVVNRGEQAERVALVIAHQLRAA
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHC
GLVVELDSSGSAFNKQFKRAGRSRATWALVIGDDEAERGEARLKYLQEATTQANPIPIDQ
CEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHH
LHRLDDVTGLVRLVRE
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA