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The map label for this gene is ugd [H]

Identifier: 124024228

GI number: 124024228

Start: 2232863

End: 2234311

Strand: Reverse

Name: ugd [H]

Synonym: P9303_25391

Alternate gene names: 124024228

Gene position: 2234311-2232863 (Counterclockwise)

Preceding gene: 124024229

Following gene: 124024227

Centisome position: 83.29

GC content: 54.66

Gene sequence:

>1449_bases
ATGACTGCCTTTCCGATCCGCAACATCTGTTGCATTGGTGCGGGTTACGTAGGCGGTCCGACTATGGCGGTGATTGCCGA
TCGCTGTCCACAGATACAGGTGAACGTGGTGGACCTCAATGAGGCCCGCATTGCTGCTTGGAATGACCTTGATCTCAGCA
AACTGCCTGTGTATGAGCCTGGGTTGGATGCGGTGGTCGACCGGGCTCGCGGGCGCAATCTCACTTTCTCTACGCAGGTG
GACGCTGCGATTGCTGCTGCTGACATGGTGTTCATTTCGGTGAATACACCAACCAAAACAAAAGGGCTGGGGGCCGGTCA
GGCCAGTGATCTGCGTTGGGTGGAAGCTTGCGCTCGTCAGGTCGCTCAATCTGCGCAGGGTCACACGATTGTGGTTGAGA
AGAGCACGCTGCCAGTGCGAACCGCTGAAGTTGTGCGTTCGATTCTTGAGGCAGCTCAGCGGCAGGCGGTTGATGGAGAG
CTACCGATCAGTTTTTCTGTGTTGTCCAACCCAGAGTTCCTTGCCGAGGGCACGGCGATTCGTGATTTGGAGTCGCCGGA
CCGTGTGTTGATCGGTGGTGAAAACCCCGTTGCCATTCAGTCTTTGGCAGAGATTTATGGCCATTGGGTGCCAGTTGAGA
AAATTTTGCTTACCAATCTTTGGAGCAGTGAGCTCTCCAAGCTCACCGCCAATGCGTTTCTTGCTCAGCGCATCAGTTCC
ATTAACTCAGTGGCGGCTCTTTGCGAACACACTGGTGCGGATGTGCGTGAGGTGGCGCGCGCTATTGGAAGCGATTCTCG
CATTGGCTCCAAGTTCCTTGAAGCTGGTCCTGGGTTTGGTGGGAGTTGTTTTCAGAAAGACATCCTCAATCTGGTTTATC
TCTGTCGTCATTTTGGTTTGCCGGATGTGGCGGACTATTGGGAAAACGTGGTAGCTCTCAATACTTGGCAGCAGCACCGC
ATTTCTCGTTTGGTGGTTCAAAAGCTTTTTGGAACGGTTACAGGTAAGCGGCTGGCACTGCTCGGCTTTGCTTTTAAGGC
AGACACCAACGACACTCGAGAAGCGCCGGCGATTCGTATTGCACATGATCTGCTGGAGGAGGGTGCTCAGCTGGCTATTT
ATGATCCGAAGGTGGATCCGCAACAGATTGCGTTTGATTTGCAGCTGGCGGCTAGTTCCCCGCCAGATGTCCAGGCAGGC
CCTACCCGTGCCGCCCTTAGCGGCGAAGGAACCTGGTGGTCCGGCACTAGCGTTGCCGATACAGTCGCTGGTGCTGATGC
TGCGCTGATCCTGACGGAGTGGCATGAGTTTAGACAGCTTGATTGGGTCGCTTTGGCTCCTTTGATGCGTCAACCTGCCT
GGGTGTTTGATGCTCGCGCTGTTGTCGATCCAGAAGCTGTGAAATCGTCTGGTTTGATGCTTTGGCGAGTTGGAGATGGT
GCTGTATGA

Upstream 100 bases:

>100_bases
CGTATAACTTGCTTCCCAGGCTGAGGTTCCACTTAATCTTTTGCCATGACTGAGCAGGTCTCTCCCCTCATCTTTTGTTG
AACTCGCTGTTTACAACGCT

Downstream 100 bases:

>100_bases
GTCGATGCGTTGTTGTTAGCGGTGCTGCAGGATTCATTGGTGCTGCCCTCGTGCAGAGGCTGTTAGCCCAGGGTGACCGT
GTTATTGGCATTGACAACCT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MTAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVNVVDLNEARIAAWNDLDLSKLPVYEPGLDAVVDRARGRNLTFSTQV
DAAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQVAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGE
LPISFSVLSNPEFLAEGTAIRDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISS
INSVAALCEHTGADVREVARAIGSDSRIGSKFLEAGPGFGGSCFQKDILNLVYLCRHFGLPDVADYWENVVALNTWQQHR
ISRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRIAHDLLEEGAQLAIYDPKVDPQQIAFDLQLAASSPPDVQAG
PTRAALSGEGTWWSGTSVADTVAGADAALILTEWHEFRQLDWVALAPLMRQPAWVFDARAVVDPEAVKSSGLMLWRVGDG
AV

Sequences:

>Translated_482_residues
MTAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVNVVDLNEARIAAWNDLDLSKLPVYEPGLDAVVDRARGRNLTFSTQV
DAAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQVAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGE
LPISFSVLSNPEFLAEGTAIRDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISS
INSVAALCEHTGADVREVARAIGSDSRIGSKFLEAGPGFGGSCFQKDILNLVYLCRHFGLPDVADYWENVVALNTWQQHR
ISRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRIAHDLLEEGAQLAIYDPKVDPQQIAFDLQLAASSPPDVQAG
PTRAALSGEGTWWSGTSVADTVAGADAALILTEWHEFRQLDWVALAPLMRQPAWVFDARAVVDPEAVKSSGLMLWRVGDG
AV
>Mature_481_residues
TAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVNVVDLNEARIAAWNDLDLSKLPVYEPGLDAVVDRARGRNLTFSTQVD
AAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQVAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGEL
PISFSVLSNPEFLAEGTAIRDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISSI
NSVAALCEHTGADVREVARAIGSDSRIGSKFLEAGPGFGGSCFQKDILNLVYLCRHFGLPDVADYWENVVALNTWQQHRI
SRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRIAHDLLEEGAQLAIYDPKVDPQQIAFDLQLAASSPPDVQAGP
TRAALSGEGTWWSGTSVADTVAGADAALILTEWHEFRQLDWVALAPLMRQPAWVFDARAVVDPEAVKSSGLMLWRVGDGA
V

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=55.8189655172414, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI296040438, Length=365, Percent_Identity=53.1506849315069, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI296040443, Length=305, Percent_Identity=55.4098360655738, Blast_Score=333, Evalue=3e-91,
Organism=Escherichia coli, GI48994968, Length=368, Percent_Identity=29.8913043478261, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788340, Length=375, Percent_Identity=24.5333333333333, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560350, Length=477, Percent_Identity=52.2012578616352, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI17136908, Length=477, Percent_Identity=53.6687631027254, Blast_Score=504, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51900; Mature: 51768

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVNVVDLNEARIAAWNDLDLSKLPVYEP
CCCCCCCCEEEECCCCCCCCHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCC
GLDAVVDRARGRNLTFSTQVDAAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQ
CHHHHHHHHCCCCCEEECCHHHHHEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
VAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGELPISFSVLSNPEFLAEGTAI
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCEE
RDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISS
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INSVAALCEHTGADVREVARAIGSDSRIGSKFLEAGPGFGGSCFQKDILNLVYLCRHFGL
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
PDVADYWENVVALNTWQQHRISRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRI
CCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHH
AHDLLEEGAQLAIYDPKVDPQQIAFDLQLAASSPPDVQAGPTRAALSGEGTWWSGTSVAD
HHHHHHCCCEEEEECCCCCHHHHEEEEEEECCCCCCCCCCCCCEEECCCCCEECCCCHHH
TVAGADAALILTEWHEFRQLDWVALAPLMRQPAWVFDARAVVDPEAVKSSGLMLWRVGDG
HHCCCCCEEEEHHHHHHHHCCHHHHHHHHHCCCCEECCHHHCCHHHHHCCCEEEEECCCC
AV
CC
>Mature Secondary Structure 
TAFPIRNICCIGAGYVGGPTMAVIADRCPQIQVNVVDLNEARIAAWNDLDLSKLPVYEP
CCCCCCCEEEECCCCCCCCHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCC
GLDAVVDRARGRNLTFSTQVDAAIAAADMVFISVNTPTKTKGLGAGQASDLRWVEACARQ
CHHHHHHHHCCCCCEEECCHHHHHEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
VAQSAQGHTIVVEKSTLPVRTAEVVRSILEAAQRQAVDGELPISFSVLSNPEFLAEGTAI
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCEE
RDLESPDRVLIGGENPVAIQSLAEIYGHWVPVEKILLTNLWSSELSKLTANAFLAQRISS
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INSVAALCEHTGADVREVARAIGSDSRIGSKFLEAGPGFGGSCFQKDILNLVYLCRHFGL
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
PDVADYWENVVALNTWQQHRISRLVVQKLFGTVTGKRLALLGFAFKADTNDTREAPAIRI
CCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHH
AHDLLEEGAQLAIYDPKVDPQQIAFDLQLAASSPPDVQAGPTRAALSGEGTWWSGTSVAD
HHHHHHCCCEEEEECCCCCHHHHEEEEEEECCCCCCCCCCCCCEEECCCCCEECCCCHHH
TVAGADAALILTEWHEFRQLDWVALAPLMRQPAWVFDARAVVDPEAVKSSGLMLWRVGDG
HHCCCCCEEEEHHHHHHHHCCHHHHHHHHHCCCCEECCHHHCCHHHHHCCCEEEEECCCC
AV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]