Click here to switch to the map view.

The map label for this gene is trpE [H]

Identifier: 124023965

GI number: 124023965

Start: 2006956

End: 2008476

Strand: Direct

Name: trpE [H]

Synonym: P9303_22721

Alternate gene names: 124023965

Gene position: 2006956-2008476 (Clockwise)

Preceding gene: 124023964

Following gene: 124023966

Centisome position: 74.81

GC content: 54.17

Gene sequence:

>1521_bases
ATGCTCAGCTCTGATCGTGACCATTTCTTTGAGATGGCTGCTAGTGGTGCCAATTTCATTCCTTTGGCCCACAGTTGGCC
AGCGGATCTGGAGACCCCTCTCACAACTTGGTTAAAAGTTGGGGCAGACCATCCCCCTGGGGTTTTACTTGAATCGGTCG
AAGGGGGTGAAACTCTTGGGCGCTGGAGTGTGGTTGCCTGCAATCCACTTTGGACTGCCACATGCCGAGGGAAACACCTC
ACACGTCGTTGGCGAGAAGGACGAACAGATGAAGCCATCGGCAACCCTTTTGAAGGCCTCAGGCAATGGCTAGCTCCTTA
TCGCACCGCAACCCTTCCAGGCCTACCCCCCCTTGGTCAGCTCTATGGAATGTGGGGTTTTGAACTGATCAAGTGGGTTG
AACCCACAGTGCCCGTTCACTTAAGGGACAACAACGATCCGCCTGATGGCATCTGGATGCTGATGGACAGCATCTTGATC
ATTGATCAAGTCAAACGCCTCATCACTGCCGTTGCATACGCAGACCTGAGTGGCGAGCAAACGGCTAACGAAGCTTGGGA
CAAGGCACAAGCACGCATTCAAGACCTAGAAAAGTGCATGGCGGAACCACTTGCACCGATTCAGCCACTGAAATGGCAAC
CAAAAGGTCAATCTCCACCTTCCACCATCAGTAACTACAGCCAAAAAGGCTTTGAGGAGGCAGTTCAAACGGCCAAGCAA
CACATCGCCGCAGGGGATGTGTTCCAGCTTGTGATCAGTCAAAGGCTGGAGACCAGAGTTCCTCAACAGCCACTTGAGCT
CTACCGAAGTCTGCGGATGGTGAATCCTTCTCCATATATGGCTTTCTTTGACTTCGGCGACTGGCAGCTGATTGGCTCAA
GCCCGGAGGTCATGGTCAAGGCGGAGCCAGTCGTCGATGGCATTAAGGCCAGCCTTCGGCCTATTGCCGGCACGCGTCCG
CGTGGCGGCAACGAACTTGAGGACCGCAATCTTGAAGCAGAGTTGATGGCAGATCCCAAGGAACGTGCCGAGCATGTGAT
GTTGGTTGATCTTGGCCGCAATGACCTTGGACGCGTTTGCAGGCCGGGCAGTGTGACGGTGAAAGAGCTGATGGTGATCG
AGAAATATTCCCACGTCATGCACATCGTCAGTGCAGTGGAAGGTGTGCTTGCCAAAGGCAAGGATGTTTGGGATCTACTC
ATGGCCTCATTCCCAGCAGGCACGGTCAGTGGCGCCCCAAAAATCAGAGCCATGCAGCTCATTCATGACCTCGAACCCGA
CTCACGAGGACCTTATTCAGGTGTTTATGGGTCCATCGATCTCAATGGTGCCCTGAATACAGCTATAACCATTCGCACAA
TGATTGTGCGGCCCCATCCTGAAGGCGGCTGGCAAGTCAAGGTTCAAGCAGGCGCTGGTGTGGTGGCCGATTCCATCCCC
ACCAAGGAATACGAAGAGACCCTCAACAAGGCAAGGGGAATGCTCACAGCCCTGGCCTGCCTCGAGTCCCACAAGTCATG
A

Upstream 100 bases:

>100_bases
TTAAAATTCAGCGGGCGCAACACCTACGACGCCTGAGTCCCTTTCGCCTGAAGGGTAGGGGGATCTTCAACCACTCGGCA
CCAGCTGCGAAGATTCCCTC

Downstream 100 bases:

>100_bases
ATACCAGGCTGCTACTTAAGGGGTTCGAAGTGGAGCTTTTCACAGGACGCTTCAGCGGTGAGCACGTCGGCGTAGCTACT
GCCGCAGCAAGCGATCTTGC

Product: anthranilate synthase component I/chorismate-binding protein

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MLSSDRDHFFEMAASGANFIPLAHSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLGRWSVVACNPLWTATCRGKHL
TRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQLYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILI
IDQVKRLITAVAYADLSGEQTANEAWDKAQARIQDLEKCMAEPLAPIQPLKWQPKGQSPPSTISNYSQKGFEEAVQTAKQ
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVKAEPVVDGIKASLRPIAGTRP
RGGNELEDRNLEAELMADPKERAEHVMLVDLGRNDLGRVCRPGSVTVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLL
MASFPAGTVSGAPKIRAMQLIHDLEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
TKEYEETLNKARGMLTALACLESHKS

Sequences:

>Translated_506_residues
MLSSDRDHFFEMAASGANFIPLAHSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLGRWSVVACNPLWTATCRGKHL
TRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQLYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILI
IDQVKRLITAVAYADLSGEQTANEAWDKAQARIQDLEKCMAEPLAPIQPLKWQPKGQSPPSTISNYSQKGFEEAVQTAKQ
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVKAEPVVDGIKASLRPIAGTRP
RGGNELEDRNLEAELMADPKERAEHVMLVDLGRNDLGRVCRPGSVTVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLL
MASFPAGTVSGAPKIRAMQLIHDLEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
TKEYEETLNKARGMLTALACLESHKS
>Mature_506_residues
MLSSDRDHFFEMAASGANFIPLAHSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLGRWSVVACNPLWTATCRGKHL
TRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQLYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILI
IDQVKRLITAVAYADLSGEQTANEAWDKAQARIQDLEKCMAEPLAPIQPLKWQPKGQSPPSTISNYSQKGFEEAVQTAKQ
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVKAEPVVDGIKASLRPIAGTRP
RGGNELEDRNLEAELMADPKERAEHVMLVDLGRNDLGRVCRPGSVTVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLL
MASFPAGTVSGAPKIRAMQLIHDLEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
TKEYEETLNKARGMLTALACLESHKS

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=386, Percent_Identity=38.860103626943, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788114, Length=456, Percent_Identity=30.2631578947368, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1786809, Length=274, Percent_Identity=28.4671532846715, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082077, Length=278, Percent_Identity=25.8992805755396, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=483, Percent_Identity=35.8178053830228, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6324361, Length=419, Percent_Identity=24.582338902148, Blast_Score=107, Evalue=5e-24,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55840; Mature: 55840

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSDRDHFFEMAASGANFIPLAHSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLG
CCCCCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCC
RWSVVACNPLWTATCRGKHLTRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQ
CEEEEEECCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
LYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILIIDQVKRLITAVAYADLSGEQ
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TANEAWDKAQARIQDLEKCMAEPLAPIQPLKWQPKGQSPPSTISNYSQKGFEEAVQTAKQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVK
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEEE
AEPVVDGIKASLRPIAGTRPRGGNELEDRNLEAELMADPKERAEHVMLVDLGRNDLGRVC
ECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHCCEEEEEECCCCCHHHHC
RPGSVTVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLLMASFPAGTVSGAPKIRAMQL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
IHDLEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
HHHCCCCCCCCCCCCEECEECCCCCCCEEEEEEEEEECCCCCCEEEEEECCCCEEECCCC
TKEYEETLNKARGMLTALACLESHKS
CHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSSDRDHFFEMAASGANFIPLAHSWPADLETPLTTWLKVGADHPPGVLLESVEGGETLG
CCCCCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCC
RWSVVACNPLWTATCRGKHLTRRWREGRTDEAIGNPFEGLRQWLAPYRTATLPGLPPLGQ
CEEEEEECCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
LYGMWGFELIKWVEPTVPVHLRDNNDPPDGIWMLMDSILIIDQVKRLITAVAYADLSGEQ
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TANEAWDKAQARIQDLEKCMAEPLAPIQPLKWQPKGQSPPSTISNYSQKGFEEAVQTAKQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HIAAGDVFQLVISQRLETRVPQQPLELYRSLRMVNPSPYMAFFDFGDWQLIGSSPEVMVK
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEEE
AEPVVDGIKASLRPIAGTRPRGGNELEDRNLEAELMADPKERAEHVMLVDLGRNDLGRVC
ECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHCCEEEEEECCCCCHHHHC
RPGSVTVKELMVIEKYSHVMHIVSAVEGVLAKGKDVWDLLMASFPAGTVSGAPKIRAMQL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
IHDLEPDSRGPYSGVYGSIDLNGALNTAITIRTMIVRPHPEGGWQVKVQAGAGVVADSIP
HHHCCCCCCCCCCCCEECEECCCCCCCEEEEEEEEEECCCCCCEEEEEECCCCEEECCCC
TKEYEETLNKARGMLTALACLESHKS
CHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 3141423 [H]