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The map label for this gene is panC [H]

Identifier: 124023940

GI number: 124023940

Start: 1985903

End: 1987369

Strand: Reverse

Name: panC [H]

Synonym: P9303_22471

Alternate gene names: 124023940

Gene position: 1987369-1985903 (Counterclockwise)

Preceding gene: 124023941

Following gene: 124023938

Centisome position: 74.08

GC content: 55.35

Gene sequence:

>1467_bases
ATGGGCGCTTTGCACCGCGCTCATGGCCAGCTGATCAAGTCAGTTCAAGGATTTGGCAGCCTTCAACCAGCCGCTGTGTT
GGTGAGTGTTTTCGTGAATCCTTTGCAGTTTGGCCCTGCTGAGGATTTCGATAGTTATCCTCGTGATCTTGAGGCCGACT
GTGAGTTGGCATCAAGATCAGGTGCTTCTGCACTCTGGGCTCCTTCAGTTGATCAGGTTTTTCCTGGAGGGGCTTCTTCC
CAGTTCAGGATTCAGGTTCCTTCTCATCTTCAGGCACATTTGTGTGGGGCGATTAGGCCCGGTCACTTTGATGGTGTGGT
CACGGTGGTGGCTCGCCTTTTGGCTCTAGTTCGGCCAGAGGTGCTTGTGCTTGGCGAAAAGGATTGGCAGCAATTGGTGA
TCCTGCGCCATTTGGTTGCCCAGTTGGGGTTGCCGGTGCGGGTGCATGGGGTCGCCACGGTGCGCGATGACGATGGCTTG
GCTTGTAGTTCCCGTAATCGTTACCTCATGACTCAACAGCGCCAGCAGGCGTTGGCCTTGCCTCAGCTACTTGCTCGAGC
TGCTCGGGAGTCTCAGGATGGACGAGCAGTTGATCTTGCAGGGCTCCGGTGCGCATGGGAGCAACTTGGCTTGGAGGTTG
AGTATGTAGAAACGGTCGATGCGTTTAACCTGCAGCCTTTGCATGCTGGCCGCAAGCTTTGCCTTCTGGCGGCGGCTGTG
CGTTGCGGGGAGACTCGTCTCATCGATCACACTTTTCTGATGTCTCGTCAGCCAATTGTTGCTATAGATGGGCCTGCCGG
TGCTGGTAAAAGCACCGTGACACGAGCCTTTGCTGAACGGCTTGGCCTGCTCTACCTCGATACGGGGGCGATGTATCGGG
CTGTCACTTGGTTGACCCAGCAACATGATGTTGATCCGCACGACCCTGTGGCAGTCAAAACCATCCTTGAGAATCTTGAG
CTTGAGCTTGAGCCATCTCAATCAGGACCACAGAAGGTTCGGATCAATGGTCACGACGTAACAGAGGCGATCAGATCGCC
GGAAGTGACGTCCTCGGTTTCAGTGGTTGCTGCTCACGGCTGTGTTCGTAAGGCTTTGACGGCTCAGCAACAGAGGATGG
GTGTACGAGGCGGTTTGGTCGCTGAAGGACGGGATATTGGTACGGCCGTTTTCCCAGATGCAGAGTTGAAGGTGTTCCTC
ACCGCCAGCCCGGCTGAACGTGCCAGGCGTCGCGCTCTGGACCTGGACAATCGTGGTTTCCCGGTTCCTGATCTGGCTGA
GTTGGAAACACAAATCGAGGAACGTGATCGAATGGATAGCACCCGCGAAGTTGCTCCTTTGCGCCAAGCTGAAGATGCCA
CTGAGTTGATCAGTGACGGTATGTCGATTGAGGAGGTGATTGAGACTTTGATCGATCTGTTTCGAGTGCAGGTTCCCGAG
GAGGTTTGGCCTACACCTGGGAGCTGA

Upstream 100 bases:

>100_bases
GTCTTGAGGTGCTGCGCTGAGGTTTTCTGTTCTCAGTTCAACGGCTGAGTTACATCGATGGCGTAAGCATCAGCAGTCTT
CGGTTTATTTTGTCCCCACC

Downstream 100 bases:

>100_bases
GTGCAATCAGTAGGCCTTCACAGGCGTCTTCAAGCAGATCGAGAACTTTCTCGAAGCCTGCATCTCCTCCGTAATAAGGG
TCTGGGACCTCTTCAAGTGA

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Pantothenate synthetase; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MGALHRAHGQLIKSVQGFGSLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRSGASALWAPSVDQVFPGGASS
QFRIQVPSHLQAHLCGAIRPGHFDGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLGLPVRVHGVATVRDDDGL
ACSSRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVETVDAFNLQPLHAGRKLCLLAAAV
RCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQQHDVDPHDPVAVKTILENLE
LELEPSQSGPQKVRINGHDVTEAIRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEGRDIGTAVFPDAELKVFL
TASPAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMSIEEVIETLIDLFRVQVPE
EVWPTPGS

Sequences:

>Translated_488_residues
MGALHRAHGQLIKSVQGFGSLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRSGASALWAPSVDQVFPGGASS
QFRIQVPSHLQAHLCGAIRPGHFDGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLGLPVRVHGVATVRDDDGL
ACSSRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVETVDAFNLQPLHAGRKLCLLAAAV
RCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQQHDVDPHDPVAVKTILENLE
LELEPSQSGPQKVRINGHDVTEAIRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEGRDIGTAVFPDAELKVFL
TASPAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMSIEEVIETLIDLFRVQVPE
EVWPTPGS
>Mature_487_residues
GALHRAHGQLIKSVQGFGSLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRSGASALWAPSVDQVFPGGASSQ
FRIQVPSHLQAHLCGAIRPGHFDGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLGLPVRVHGVATVRDDDGLA
CSSRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVETVDAFNLQPLHAGRKLCLLAAAVR
CGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQQHDVDPHDPVAVKTILENLEL
ELEPSQSGPQKVRINGHDVTEAIRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEGRDIGTAVFPDAELKVFLT
ASPAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMSIEEVIETLIDLFRVQVPEE
VWPTPGS

Specific function: Pantothenate biosynthesis; last step. [C]

COG id: COG0283

COG function: function code F; Cytidylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786325, Length=258, Percent_Identity=36.4341085271318, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1787139, Length=218, Percent_Identity=43.5779816513761, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322046, Length=200, Percent_Identity=35, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729 [H]

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase [H]

EC number: =6.3.2.1; =2.7.4.14 [H]

Molecular weight: Translated: 53156; Mature: 53025

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGALHRAHGQLIKSVQGFGSLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRS
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHCC
GASALWAPSVDQVFPGGASSQFRIQVPSHLQAHLCGAIRPGHFDGVVTVVARLLALVRPE
CCCEECCCCHHHHCCCCCCCEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
VLVLGEKDWQQLVILRHLVAQLGLPVRVHGVATVRDDDGLACSSRNRYLMTQQRQQALAL
EEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEECCCCCEEEHHHHHHHHHH
PQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVETVDAFNLQPLHAGRKLCLLAAAV
HHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCEEEEEHHHCCCCCCHHHHCHHHHHHHHHH
RCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQ
HCCCCEEEHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHH
QHDVDPHDPVAVKTILENLELELEPSQSGPQKVRINGHDVTEAIRSPEVTSSVSVVAAHG
HCCCCCCCCHHHHHHHHHCCEEECCCCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHH
CVRKALTAQQQRMGVRGGLVAEGRDIGTAVFPDAELKVFLTASPAERARRRALDLDNRGF
HHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCCEEEEEECCHHHHHHHHHCCCCCCCC
PVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMSIEEVIETLIDLFRVQVPE
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCH
EVWPTPGS
HHCCCCCC
>Mature Secondary Structure 
GALHRAHGQLIKSVQGFGSLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRS
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHCC
GASALWAPSVDQVFPGGASSQFRIQVPSHLQAHLCGAIRPGHFDGVVTVVARLLALVRPE
CCCEECCCCHHHHCCCCCCCEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
VLVLGEKDWQQLVILRHLVAQLGLPVRVHGVATVRDDDGLACSSRNRYLMTQQRQQALAL
EEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEECCCCCEEEHHHHHHHHHH
PQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVETVDAFNLQPLHAGRKLCLLAAAV
HHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCEEEEEHHHCCCCCCHHHHCHHHHHHHHHH
RCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQ
HCCCCEEEHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHH
QHDVDPHDPVAVKTILENLELELEPSQSGPQKVRINGHDVTEAIRSPEVTSSVSVVAAHG
HCCCCCCCCHHHHHHHHHCCEEECCCCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHH
CVRKALTAQQQRMGVRGGLVAEGRDIGTAVFPDAELKVFLTASPAERARRRALDLDNRGF
HHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCCEEEEEECCHHHHHHHHHCCCCCCCC
PVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMSIEEVIETLIDLFRVQVPE
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCH
EVWPTPGS
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]