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The map label for this gene is mtnC

Identifier: 124023871

GI number: 124023871

Start: 1933968

End: 1934690

Strand: Direct

Name: mtnC

Synonym: P9303_21781

Alternate gene names: 124023871

Gene position: 1933968-1934690 (Clockwise)

Preceding gene: 124023870

Following gene: 124023872

Centisome position: 72.09

GC content: 42.46

Gene sequence:

>723_bases
TTGCTGGATATTGAGGGCACCACATGCCCCACAAGTTTTGTCAGCGACACTCTCTATCCTTACGCGTATAGCCATCTAGA
AGGATTTCTAAATGAACACAGAGAAAACAATGAGATTCAATCTCTCATAGATGAAGCTTGGCGCGAATGGCAAGCCGATA
CGGATGCGAGCAGCAAAGATCTTCTAAGCAAAGCACTAAGAAAGAACAGCAGCGAAATCGTGAACATCTGCAGTTACCTT
CACCATCTAATAACAATTGATCGCAAGTCTAGTGCTTTAAAAGATCTACAAGGCAGGATCTGGCGAGAGGGTTACGAGAA
AGGTGATCTCTGCTCTTCGCTCTACCCAGAAACTATCGAGGCACTCAGAAAACTAAAACAACAAGATTATGTACTTGCTG
TATATTCATCAGGCAGCATATCAGCTCAAAAGCTCCTCTACAGACACACGGCTGATGGAGATCAAACAGCACTATTTAGC
CACTGGTTTGATACTCGTACTGGCAACAAAAAAGAGAGCAGAAGTTATAGCGACATCTCCATAGCCATGAACATTCCCGT
AGAAAAGGTGCTTTTTGTCAGTGATAGCTACGCAGAATGTAATGCCGCAGAAAAATCAGGCATGAGTGTTTTATTCAGTC
TTAGGGAAGGAAATCCAGAGCAAGATCCACATGATCACAAAGCAATCAAAGAGCTCTGTTGTCTATTTGATTATCTTCTT
TAA

Upstream 100 bases:

>100_bases
TAAACGAAGCAAGACGTCATGTAGAAATCTTGGAGTTCCTACTAGAGCTCTGCTGGCGTGAACAACTTATAGCCAGACAA
AAATCGTGATCACTCACATC

Downstream 100 bases:

>100_bases
AAATCACACTGACTTGCACATCAAAAAAGCCACCCCTGCGGGTGGCTTTTTCTTGGTAAATCAACAACTCTTTCGCAAGA
TTGATGATCTACATTCGGAA

Product: enolase-phosphatase E-1

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MLDIEGTTCPTSFVSDTLYPYAYSHLEGFLNEHRENNEIQSLIDEAWREWQADTDASSKDLLSKALRKNSSEIVNICSYL
HHLITIDRKSSALKDLQGRIWREGYEKGDLCSSLYPETIEALRKLKQQDYVLAVYSSGSISAQKLLYRHTADGDQTALFS
HWFDTRTGNKKESRSYSDISIAMNIPVEKVLFVSDSYAECNAAEKSGMSVLFSLREGNPEQDPHDHKAIKELCCLFDYLL

Sequences:

>Translated_240_residues
MLDIEGTTCPTSFVSDTLYPYAYSHLEGFLNEHRENNEIQSLIDEAWREWQADTDASSKDLLSKALRKNSSEIVNICSYL
HHLITIDRKSSALKDLQGRIWREGYEKGDLCSSLYPETIEALRKLKQQDYVLAVYSSGSISAQKLLYRHTADGDQTALFS
HWFDTRTGNKKESRSYSDISIAMNIPVEKVLFVSDSYAECNAAEKSGMSVLFSLREGNPEQDPHDHKAIKELCCLFDYLL
>Mature_240_residues
MLDIEGTTCPTSFVSDTLYPYAYSHLEGFLNEHRENNEIQSLIDEAWREWQADTDASSKDLLSKALRKNSSEIVNICSYL
HHLITIDRKSSALKDLQGRIWREGYEKGDLCSSLYPETIEALRKLKQQDYVLAVYSSGSISAQKLLYRHTADGDQTALFS
HWFDTRTGNKKESRSYSDISIAMNIPVEKVLFVSDSYAECNAAEKSGMSVLFSLREGNPEQDPHDHKAIKELCCLFDYLL

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family

Homologues:

Organism=Homo sapiens, GI10864017, Length=228, Percent_Identity=33.7719298245614, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI115533232, Length=219, Percent_Identity=36.986301369863, Blast_Score=143, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320797, Length=245, Percent_Identity=30.6122448979592, Blast_Score=112, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281360080, Length=218, Percent_Identity=34.4036697247706, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24644163, Length=218, Percent_Identity=34.4036697247706, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNC_PROM3 (A2CBQ3)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018178.1
- ProteinModelPortal:   A2CBQ3
- SMR:   A2CBQ3
- STRING:   A2CBQ3
- GeneID:   4777614
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_21781
- eggNOG:   COG4229
- HOGENOM:   HBG294242
- OMA:   TTDLNFI
- ProtClustDB:   CLSK866737
- HAMAP:   MF_01681
- InterPro:   IPR010041
- InterPro:   IPR023214
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR20371
- TIGRFAMs:   TIGR01691

Pfam domain/function: SSF56784 SSF56784

EC number: =3.1.3.77

Molecular weight: Translated: 27352; Mature: 27352

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIEGTTCPTSFVSDTLYPYAYSHLEGFLNEHRENNEIQSLIDEAWREWQADTDASSKD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHH
LLSKALRKNSSEIVNICSYLHHLITIDRKSSALKDLQGRIWREGYEKGDLCSSLYPETIE
HHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHH
ALRKLKQQDYVLAVYSSGSISAQKLLYRHTADGDQTALFSHWFDTRTGNKKESRSYSDIS
HHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHCCCCCCEE
IAMNIPVEKVLFVSDSYAECNAAEKSGMSVLFSLREGNPEQDPHDHKAIKELCCLFDYLL
EEEECCHHHEEEECCCCHHCCHHHHCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLDIEGTTCPTSFVSDTLYPYAYSHLEGFLNEHRENNEIQSLIDEAWREWQADTDASSKD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHH
LLSKALRKNSSEIVNICSYLHHLITIDRKSSALKDLQGRIWREGYEKGDLCSSLYPETIE
HHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHH
ALRKLKQQDYVLAVYSSGSISAQKLLYRHTADGDQTALFSHWFDTRTGNKKESRSYSDIS
HHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHCCCCCCEE
IAMNIPVEKVLFVSDSYAECNAAEKSGMSVLFSLREGNPEQDPHDHKAIKELCCLFDYLL
EEEECCHHHEEEECCCCHHCCHHHHCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA