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The map label for this gene is recQ [H]

Identifier: 124023866

GI number: 124023866

Start: 1929506

End: 1930999

Strand: Reverse

Name: recQ [H]

Synonym: P9303_21731

Alternate gene names: 124023866

Gene position: 1930999-1929506 (Counterclockwise)

Preceding gene: 124023867

Following gene: 124023862

Centisome position: 71.98

GC content: 59.84

Gene sequence:

>1494_bases
GTGGATCCACTGATCGAGGCCCTGCACCATCACTATGGCTGGGATGGTTTCAGGCCTGGTCAACGTCCTGTGGTGGAAGC
GATTCTTGCGGGTCAGGATGTTCTGGCGGTGCTGCCCACCGGTGGTGGTAAATCGCTTTGTTATCAGCTGCCAGCGCTGT
TGCGTGATGGTCTGGTGGTGGTGATCTCTCCCTTGGTGGCTTTGATGGAGGATCAGGTCATGCAGCTGCAACGGCGGGGG
ATTTCCGCCGCTTGTTTGCATGCTGGCCTGGATCCGTCGCGCCGTCGCGATGCGCTGGTTCGCCTGCGAGAAGAGCGCTT
GCGTTTGCTTTATCTGGCTCCCGAGCGGTTGCAGGGTGAGGCCACGCGGCAATTGATCGAGGACACAGCTGCGCAGGGAA
AGTTGGTGGCACTAGCTGTTGATGAGGCCCATTGCATCAGTGCTTGGGGCCATGATTTCCGGCCTGATTACCGTCGCCTG
GGGCAGGTGCGCCGTCTCTGCCCAGGTGTGCCTGTGGTTGCTCTCAGTGCCACTGCGGCTCCAAGGGTGCGTGCCGACAT
CATCCGCCTATTGGCTCTTCGTCGGCCGCTGGTGCAGGTTTGCTCGGCCCGGCGCAATAATCTCCACTACGCCATGCGGA
GGCGATCGAGAGATCCCTTGCCTGATGTTCTTGAGGCGTTAGGGAAATCAAGAGGGGCGAGTTTGATCTATGCCCGAACG
CGTCGCTCTGTGGAGCAATGGGCAGAGCGGTTGCAGGCGGCGGATGTTGCGGCTACTCCTTATCACGCCGGGCTTGACCC
GGAGGTGCGCCAGCAGGCGCTGGCTGATTTCCTAGATCAAGAGAAGCCTGTGCTGGTGGCCACGGTGGCCTTTGGCATGG
GTGTAGATCGCAGCGATGTGGGATTGGTTCTGCATTTGAATCTGCCTGCAACACCGGAGGGCTATTTGCAGGAGTCTGGC
CGGGCCGGGCGTGATGGACTGCCGGCCGATTGCTTGGTGTTGTTTTCTCCTGGTGATCGCACCAGCCTTGGTTGGGCGAT
GCATGCTTCAGCTCGCCGTTGTGCTGATGAGAGCGCGACGCAGGAGATTCAGATGCGGTTGGAGCTGGCGCAGCAACAGT
TGCGGCGTATCGAGGCGGTAGCAGAAGGGGAGTTTTGCCTGGAGCAAGGGCTCTTGCTTGCCGTTGGTGAATTGGTGCCG
CCTTGTGGTCGTTGCGATCGCTGCCAGCAGACTGCCCGCCGCCGTGATTGGTCTGAGCAAGCCTTTGCTGTGCTTGAGGT
GCTGGAAGATAGCAAGGGCATGAATCTTCGCAGTCTCAGTGAAAGCCTTTCGTCCACTACAGGCCGCAAGCAAGAACGTT
GGGGTTGGTTGGCTCGCAGGTTGGTGCAGGAAGAGCTGATTACGGAGAGCAATGATGGCGTCCAGCGGCTCTATTTACGT
GAGAGCGGTCGGCGCTTTTTACGCCAACCCTGGCCGCTGCACTATGCGGCCTGA

Upstream 100 bases:

>100_bases
AGGCTCCTGACCAGCTAGAGCCGCCGCCGCTGCCTTGAGTTCGAGATCGTGCCATCAGGCTTAGCGCTCGTTATCTTGAG
GGCGCTATTGGTGGTGTGAA

Downstream 100 bases:

>100_bases
GTGCAGTCCTCGATGCTCTTAGCCGCCTTTGGCTTTGCAGAGATCCTTGACGAGATCATGCTCAAAGCGCTGCTGTGGAG
CACCCCAAGTTTTCCAAGAT

Product: superfamily II DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MDPLIEALHHHYGWDGFRPGQRPVVEAILAGQDVLAVLPTGGGKSLCYQLPALLRDGLVVVISPLVALMEDQVMQLQRRG
ISAACLHAGLDPSRRRDALVRLREERLRLLYLAPERLQGEATRQLIEDTAAQGKLVALAVDEAHCISAWGHDFRPDYRRL
GQVRRLCPGVPVVALSATAAPRVRADIIRLLALRRPLVQVCSARRNNLHYAMRRRSRDPLPDVLEALGKSRGASLIYART
RRSVEQWAERLQAADVAATPYHAGLDPEVRQQALADFLDQEKPVLVATVAFGMGVDRSDVGLVLHLNLPATPEGYLQESG
RAGRDGLPADCLVLFSPGDRTSLGWAMHASARRCADESATQEIQMRLELAQQQLRRIEAVAEGEFCLEQGLLLAVGELVP
PCGRCDRCQQTARRRDWSEQAFAVLEVLEDSKGMNLRSLSESLSSTTGRKQERWGWLARRLVQEELITESNDGVQRLYLR
ESGRRFLRQPWPLHYAA

Sequences:

>Translated_497_residues
MDPLIEALHHHYGWDGFRPGQRPVVEAILAGQDVLAVLPTGGGKSLCYQLPALLRDGLVVVISPLVALMEDQVMQLQRRG
ISAACLHAGLDPSRRRDALVRLREERLRLLYLAPERLQGEATRQLIEDTAAQGKLVALAVDEAHCISAWGHDFRPDYRRL
GQVRRLCPGVPVVALSATAAPRVRADIIRLLALRRPLVQVCSARRNNLHYAMRRRSRDPLPDVLEALGKSRGASLIYART
RRSVEQWAERLQAADVAATPYHAGLDPEVRQQALADFLDQEKPVLVATVAFGMGVDRSDVGLVLHLNLPATPEGYLQESG
RAGRDGLPADCLVLFSPGDRTSLGWAMHASARRCADESATQEIQMRLELAQQQLRRIEAVAEGEFCLEQGLLLAVGELVP
PCGRCDRCQQTARRRDWSEQAFAVLEVLEDSKGMNLRSLSESLSSTTGRKQERWGWLARRLVQEELITESNDGVQRLYLR
ESGRRFLRQPWPLHYAA
>Mature_497_residues
MDPLIEALHHHYGWDGFRPGQRPVVEAILAGQDVLAVLPTGGGKSLCYQLPALLRDGLVVVISPLVALMEDQVMQLQRRG
ISAACLHAGLDPSRRRDALVRLREERLRLLYLAPERLQGEATRQLIEDTAAQGKLVALAVDEAHCISAWGHDFRPDYRRL
GQVRRLCPGVPVVALSATAAPRVRADIIRLLALRRPLVQVCSARRNNLHYAMRRRSRDPLPDVLEALGKSRGASLIYART
RRSVEQWAERLQAADVAATPYHAGLDPEVRQQALADFLDQEKPVLVATVAFGMGVDRSDVGLVLHLNLPATPEGYLQESG
RAGRDGLPADCLVLFSPGDRTSLGWAMHASARRCADESATQEIQMRLELAQQQLRRIEAVAEGEFCLEQGLLLAVGELVP
PCGRCDRCQQTARRRDWSEQAFAVLEVLEDSKGMNLRSLSESLSSTTGRKQERWGWLARRLVQEELITESNDGVQRLYLR
ESGRRFLRQPWPLHYAA

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=449, Percent_Identity=35.8574610244989, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI14591902, Length=342, Percent_Identity=38.8888888888889, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI14591904, Length=342, Percent_Identity=38.8888888888889, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI148612816, Length=422, Percent_Identity=36.4928909952607, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI51242947, Length=428, Percent_Identity=36.4485981308411, Blast_Score=259, Evalue=6e-69,
Organism=Homo sapiens, GI51242943, Length=350, Percent_Identity=40, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI110735439, Length=342, Percent_Identity=37.719298245614, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI169218196, Length=342, Percent_Identity=37.719298245614, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI284005309, Length=350, Percent_Identity=40.5714285714286, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI262118318, Length=351, Percent_Identity=25.0712250712251, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI216548263, Length=351, Percent_Identity=25.0712250712251, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI262231852, Length=351, Percent_Identity=25.0712250712251, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI13518015, Length=351, Percent_Identity=25.0712250712251, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI83700235, Length=323, Percent_Identity=22.6006191950464, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4503529, Length=325, Percent_Identity=23.3846153846154, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI148613856, Length=339, Percent_Identity=23.8938053097345, Blast_Score=65, Evalue=1e-10,
Organism=Homo sapiens, GI38201710, Length=339, Percent_Identity=23.8938053097345, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI48994977, Length=513, Percent_Identity=38.5964912280702, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI87082221, Length=356, Percent_Identity=23.876404494382, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1787016, Length=349, Percent_Identity=24.6418338108883, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32564293, Length=490, Percent_Identity=34.0816326530612, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI71987993, Length=476, Percent_Identity=33.1932773109244, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71987997, Length=476, Percent_Identity=33.1932773109244, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI25145561, Length=462, Percent_Identity=34.4155844155844, Blast_Score=257, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI17552866, Length=403, Percent_Identity=36.4764267990074, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI86570094, Length=338, Percent_Identity=25.1479289940828, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995718, Length=363, Percent_Identity=23.1404958677686, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=444, Percent_Identity=36.2612612612613, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6320224, Length=353, Percent_Identity=21.2464589235127, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324217, Length=333, Percent_Identity=25.5255255255255, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24646066, Length=343, Percent_Identity=40.5247813411079, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24664226, Length=448, Percent_Identity=32.8125, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI62472181, Length=448, Percent_Identity=32.5892857142857, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24664230, Length=448, Percent_Identity=32.5892857142857, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI21358123, Length=373, Percent_Identity=33.5120643431635, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24642151, Length=357, Percent_Identity=22.4089635854342, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 55418; Mature: 55418

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPLIEALHHHYGWDGFRPGQRPVVEAILAGQDVLAVLPTGGGKSLCYQLPALLRDGLVV
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHH
VISPLVALMEDQVMQLQRRGISAACLHAGLDPSRRRDALVRLREERLRLLYLAPERLQGE
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCHHHCCH
ATRQLIEDTAAQGKLVALAVDEAHCISAWGHDFRPDYRRLGQVRRLCPGVPVVALSATAA
HHHHHHHHHHCCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
PRVRADIIRLLALRRPLVQVCSARRNNLHYAMRRRSRDPLPDVLEALGKSRGASLIYART
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHH
RRSVEQWAERLQAADVAATPYHAGLDPEVRQQALADFLDQEKPVLVATVAFGMGVDRSDV
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCC
GLVLHLNLPATPEGYLQESGRAGRDGLPADCLVLFSPGDRTSLGWAMHASARRCADESAT
CEEEEECCCCCCCHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
QEIQMRLELAQQQLRRIEAVAEGEFCLEQGLLLAVGELVPPCGRCDRCQQTARRRDWSEQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHH
AFAVLEVLEDSKGMNLRSLSESLSSTTGRKQERWGWLARRLVQEELITESNDGVQRLYLR
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ESGRRFLRQPWPLHYAA
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDPLIEALHHHYGWDGFRPGQRPVVEAILAGQDVLAVLPTGGGKSLCYQLPALLRDGLVV
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHH
VISPLVALMEDQVMQLQRRGISAACLHAGLDPSRRRDALVRLREERLRLLYLAPERLQGE
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCHHHCCH
ATRQLIEDTAAQGKLVALAVDEAHCISAWGHDFRPDYRRLGQVRRLCPGVPVVALSATAA
HHHHHHHHHHCCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
PRVRADIIRLLALRRPLVQVCSARRNNLHYAMRRRSRDPLPDVLEALGKSRGASLIYART
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHH
RRSVEQWAERLQAADVAATPYHAGLDPEVRQQALADFLDQEKPVLVATVAFGMGVDRSDV
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCC
GLVLHLNLPATPEGYLQESGRAGRDGLPADCLVLFSPGDRTSLGWAMHASARRCADESAT
CEEEEECCCCCCCHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
QEIQMRLELAQQQLRRIEAVAEGEFCLEQGLLLAVGELVPPCGRCDRCQQTARRRDWSEQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHH
AFAVLEVLEDSKGMNLRSLSESLSSTTGRKQERWGWLARRLVQEELITESNDGVQRLYLR
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ESGRRFLRQPWPLHYAA
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]