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The map label for this gene is trpC

Identifier: 124023677

GI number: 124023677

Start: 1738168

End: 1739073

Strand: Reverse

Name: trpC

Synonym: P9303_19771

Alternate gene names: 124023677

Gene position: 1739073-1738168 (Counterclockwise)

Preceding gene: 124023678

Following gene: 124023676

Centisome position: 64.83

GC content: 52.32

Gene sequence:

>906_bases
ATGGAGATCCGCAGACGTCCGCCCAATCCAAGCGTCAAGGTGGCGCATTTGCAGTACGCCATTCCCCACGCCGATGCTGA
GCCGCGCCACATTCTTGAGAAGATTGTTTGGGAGAAGGACCGTGAAGTTGAGACGGCAAGACAGCGCGTACCTCTAGAGA
CGCTTAAATCTCAGATCGCAGACTTGCCCATCCCTCGAGATTTCATTGCTGCCTTGCGTCAGGCTTCGGTGGCTCCGGCA
GTGATTGCTGAAGTGAAGAAGGCCAGCCCAAGTCAAGGTGTGATCCGTGCGGACTTTGACCCTGTTTTGATCGCCAATGC
CTATGCGGAAGGTGGTGCTAGTTGCTTGTCTGTGCTGACCGATAAGAGCTTCTTCCAGGGTGGATTTGAGGTGCTTGTTG
AGGTGCGGCAGACGGTTGGACTACCACTGCTATGTAAGGACTTCATCCTGACGCCATATCAGCTTTATCAGGCGCGTGCT
GCAGGTGCAGATGCTGCCTTGTTGATTATGGCGATCCTCTCTGATCAGGATCTGACGTATTTGAGCAAGGTGGCCAACAG
TCTTGGACTCACTGTCTTAGTGGAAGTGCATGATGCTGAGGAACTTGAACGGGTTCTCAACCTTGGTGGTTTCCCACTGA
TTGGCATCAATAATCGTGATCTCACCACCTTTGAGACAGACCTTGAAACCACTGAAACACTGAGCAAGCAATTCGCTACT
CGATTGAAGCAGCAGGGTGTCTTGTTGGTGAGTGAATCGGGCTTGTTTAACCGTGCTGATTTGGACAGGGTTCAGGCAGT
AGGCGCTGAAGCTGTGTTGGTAGGAGAAGCCCTGATGCGTCAGTCGGATGTTTGTGCTGGCTTAAAGCAGCTGATGATTG
GAGACGAAGGAACGAGCAACAGCTGA

Upstream 100 bases:

>100_bases
GGCTAAGGCGGTTGTTGCATCGGCCAGTGCTTCCTAGGCCGCTGTTCTTCAAGCAGGTCTTAGCCCTGCGGTTCACTGTT
TTTAATTGCACTATCACCCG

Downstream 100 bases:

>100_bases
TCATTTTTTCTCTTTTATTTGAGCAATCGTTGCGATGTAGTGCCACGCCAAGAGGTTGATGTGAGCTTGCTGTGAGTGAA
GGATGAGCCGTTGCTCTTTG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIADLPIPRDFIAALRQASVAPA
VIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLTDKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARA
AGADAALLIMAILSDQDLTYLSKVANSLGLTVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSKQFAT
RLKQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLKQLMIGDEGTSNS

Sequences:

>Translated_301_residues
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIADLPIPRDFIAALRQASVAPA
VIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLTDKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARA
AGADAALLIMAILSDQDLTYLSKVANSLGLTVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSKQFAT
RLKQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLKQLMIGDEGTSNS
>Mature_301_residues
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIADLPIPRDFIAALRQASVAPA
VIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLTDKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARA
AGADAALLIMAILSDQDLTYLSKVANSLGLTVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSKQFAT
RLKQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLKQLMIGDEGTSNS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=266, Percent_Identity=41.7293233082707, Blast_Score=180, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6322638, Length=237, Percent_Identity=39.2405063291139, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_PROM3 (A2CB59)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017984.1
- ProteinModelPortal:   A2CB59
- STRING:   A2CB59
- GeneID:   4777578
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_19771
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 32800; Mature: 32800

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIA
CCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
DLPIPRDFIAALRQASVAPAVIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLT
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHH
DKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARAAGADAALLIMAILSDQDLTY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHH
LSKVANSLGLTVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSKQFAT
HHHHHHHCCCEEEEEECCHHHHHHHHCCCCCCEEECCCCCCEEEECCHHHHHHHHHHHHH
RLKQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLKQLMIGDEGTSN
HHHHCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
S
C
>Mature Secondary Structure
MEIRRRPPNPSVKVAHLQYAIPHADAEPRHILEKIVWEKDREVETARQRVPLETLKSQIA
CCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
DLPIPRDFIAALRQASVAPAVIAEVKKASPSQGVIRADFDPVLIANAYAEGGASCLSVLT
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHH
DKSFFQGGFEVLVEVRQTVGLPLLCKDFILTPYQLYQARAAGADAALLIMAILSDQDLTY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHH
LSKVANSLGLTVLVEVHDAEELERVLNLGGFPLIGINNRDLTTFETDLETTETLSKQFAT
HHHHHHHCCCEEEEEECCHHHHHHHHCCCCCCEEECCCCCCEEEECCHHHHHHHHHHHHH
RLKQQGVLLVSESGLFNRADLDRVQAVGAEAVLVGEALMRQSDVCAGLKQLMIGDEGTSN
HHHHCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA