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The map label for this gene is cobL [H]

Identifier: 124023631

GI number: 124023631

Start: 1700313

End: 1701608

Strand: Direct

Name: cobL [H]

Synonym: P9303_19311

Alternate gene names: 124023631

Gene position: 1700313-1701608 (Clockwise)

Preceding gene: 124023626

Following gene: 124023635

Centisome position: 63.38

GC content: 59.34

Gene sequence:

>1296_bases
ATGCCCGCCTCAATCAGCTCCGCAGCGATCCACGTCATCGGCACCGATGCCGCAGGCTTAGATCACCTTGCCACTCCATT
GCAAGAGCTGGTGCTCTCAGCCCAAGGGCTGGCTGCACCCCGTCGCCTTTTGCCGCAATTGCCGAGCTGGTGGCAGCAGC
AGCAAACGGATCAGCCTTTGCCAGAACTGATCGCCAGCGATCAACCAGAGGCTCTAATCGCCTGGTTGCGCCAGCGGCAG
GGCACAGCCGTCGTGCTAGCTAGCGGCGACCCGCTCTGGTTCGGCATCGGCAGGCGACTACTCGAAGCATGTTCTGCTGA
TCAGCTGCACTTTCATCCCGCACCTTCTTCGCTGCAACTTGCCTTTGCCCGGCTTGGGCGGCCTTGGCAGGATGCCGCCT
GGATCAGCCTGCATGGCCGTGACCCAGCCCCCTTAGCTCAAAAGCTGCAACAACGCCCCGCAGCTCTAGCTGTACTCACC
GATCCCAACCGCGGTGGAGCCGAAGAGGTGCGTACGATTTTGCGCTCTTCTGGCCTGGAAACTGCCTATGCAGTGTGGCT
TTGCGAACAGCTCGGACACGCCAATGAACGGGTGCAACGGCTGACGCCACAGGATGCCTTGCCATCGGATCTTCATCCCC
TACACATGGTTGTGCTGCTTGCAGAACAAGCTGCTCCACCAGGAGATCCAGCCAAGCTTCCATTGTTCGGTCTTGACGAT
GGCTTGTTCCTGCAACACGACGATCGCCCTGGCCTGATGAGCAAACGGGAGCTTCGTGTTCAGCTCCTCGCAGAGTTAGA
GCTGCCAGAACAGGGCTTACTCTGGGATTTAGGTGCCGGAGTTGGCAGCGTTGGCTTAGAGGCCTTACGCCTGCGTCCAC
AACTGCAATTACTAGCTGTTGAAAAGCGTGGCGGCGGTGCAGCGCTGATCAAGGCCAATGCTGCCCGGCTTGCCGTTCAG
CCTGCTGCAGTACTTGAAGCCGAGGCCCTCAGCCTGCTGAATGGAACAGATTTGCCACCAACCTTGAGCCGCCCCGATCG
GGTGCTGCTAGGGGGTGGCGGCCGCCAGCGAGTTGCTCTCCTCAAGGCCGTATTGCAAAAGCTTCAACCACATGGAGTCG
TCGTGATTCCACTAGTAACCATTGAGGCCATGGCAGAACTCAAACCCTTACTTCAAGATTGCGGTTGCGCCGTGAAGGTG
AGTCAACACCAGTCCTGGAGGGGCATACCGCTGGCAGACGGCACCCGCATGGCGCCGATGAACCCGGTGATGATCCTCAA
AGGCACGATGCCTTAA

Upstream 100 bases:

>100_bases
TCGTCCGCCATCTCGTCCGCCATCTTGCCCACCAACTCGCTGTTCACCATTCAAGGCAACGACAAGTCAGCCATACAACC
TCTCAGCCGAGAATGACAAC

Downstream 100 bases:

>100_bases
TGCTGCCAATCAACAGGCTTCGGCAAAGGTTGAATCTGCACAACATCACCAACCTTGATGGATAGCCTTGCTGCCTCCCC
GGCCGCCAACTCCACCACTC

Product: precorrin-6y methylase

Products: NA

Alternate protein names: Precorrin-6 methyltransferase; Precorrin-6Y methylase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MPASISSAAIHVIGTDAAGLDHLATPLQELVLSAQGLAAPRRLLPQLPSWWQQQQTDQPLPELIASDQPEALIAWLRQRQ
GTAVVLASGDPLWFGIGRRLLEACSADQLHFHPAPSSLQLAFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLT
DPNRGGAEEVRTILRSSGLETAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPPGDPAKLPLFGLDD
GLFLQHDDRPGLMSKRELRVQLLAELELPEQGLLWDLGAGVGSVGLEALRLRPQLQLLAVEKRGGGAALIKANAARLAVQ
PAAVLEAEALSLLNGTDLPPTLSRPDRVLLGGGGRQRVALLKAVLQKLQPHGVVVIPLVTIEAMAELKPLLQDCGCAVKV
SQHQSWRGIPLADGTRMAPMNPVMILKGTMP

Sequences:

>Translated_431_residues
MPASISSAAIHVIGTDAAGLDHLATPLQELVLSAQGLAAPRRLLPQLPSWWQQQQTDQPLPELIASDQPEALIAWLRQRQ
GTAVVLASGDPLWFGIGRRLLEACSADQLHFHPAPSSLQLAFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLT
DPNRGGAEEVRTILRSSGLETAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPPGDPAKLPLFGLDD
GLFLQHDDRPGLMSKRELRVQLLAELELPEQGLLWDLGAGVGSVGLEALRLRPQLQLLAVEKRGGGAALIKANAARLAVQ
PAAVLEAEALSLLNGTDLPPTLSRPDRVLLGGGGRQRVALLKAVLQKLQPHGVVVIPLVTIEAMAELKPLLQDCGCAVKV
SQHQSWRGIPLADGTRMAPMNPVMILKGTMP
>Mature_430_residues
PASISSAAIHVIGTDAAGLDHLATPLQELVLSAQGLAAPRRLLPQLPSWWQQQQTDQPLPELIASDQPEALIAWLRQRQG
TAVVLASGDPLWFGIGRRLLEACSADQLHFHPAPSSLQLAFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLTD
PNRGGAEEVRTILRSSGLETAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPPGDPAKLPLFGLDDG
LFLQHDDRPGLMSKRELRVQLLAELELPEQGLLWDLGAGVGSVGLEALRLRPQLQLLAVEKRGGGAALIKANAARLAVQP
AAVLEAEALSLLNGTDLPPTLSRPDRVLLGGGGRQRVALLKAVLQKLQPHGVVVIPLVTIEAMAELKPLLQDCGCAVKVS
QHQSWRGIPLADGTRMAPMNPVMILKGTMP

Specific function: Catalyzes the methylation of both C-5 and C-15 in precorrin-6Y to form precorrin-8X [H]

COG id: COG2241

COG function: function code H; Precorrin-6B methylase 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR012818
- InterPro:   IPR014008
- InterPro:   IPR006365 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.132 [H]

Molecular weight: Translated: 46292; Mature: 46161

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASISSAAIHVIGTDAAGLDHLATPLQELVLSAQGLAAPRRLLPQLPSWWQQQQTDQPL
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHCCCCCH
PELIASDQPEALIAWLRQRQGTAVVLASGDPLWFGIGRRLLEACSADQLHFHPAPSSLQL
HHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCEEECCCCCHHHH
AFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLTDPNRGGAEEVRTILRSSGLE
HHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCC
TAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPPGDPAKLPLFGLDD
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
GLFLQHDDRPGLMSKRELRVQLLAELELPEQGLLWDLGAGVGSVGLEALRLRPQLQLLAV
CEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEE
EKRGGGAALIKANAARLAVQPAAVLEAEALSLLNGTDLPPTLSRPDRVLLGGGGRQRVAL
EECCCCEEEEEECCHHEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHH
LKAVLQKLQPHGVVVIPLVTIEAMAELKPLLQDCGCAVKVSQHQSWRGIPLADGTRMAPM
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCC
NPVMILKGTMP
CCEEEEECCCC
>Mature Secondary Structure 
PASISSAAIHVIGTDAAGLDHLATPLQELVLSAQGLAAPRRLLPQLPSWWQQQQTDQPL
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHCCCCCH
PELIASDQPEALIAWLRQRQGTAVVLASGDPLWFGIGRRLLEACSADQLHFHPAPSSLQL
HHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCEEECCCCCHHHH
AFARLGRPWQDAAWISLHGRDPAPLAQKLQQRPAALAVLTDPNRGGAEEVRTILRSSGLE
HHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCC
TAYAVWLCEQLGHANERVQRLTPQDALPSDLHPLHMVVLLAEQAAPPGDPAKLPLFGLDD
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
GLFLQHDDRPGLMSKRELRVQLLAELELPEQGLLWDLGAGVGSVGLEALRLRPQLQLLAV
CEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEE
EKRGGGAALIKANAARLAVQPAAVLEAEALSLLNGTDLPPTLSRPDRVLLGGGGRQRVAL
EECCCCEEEEEECCHHEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHH
LKAVLQKLQPHGVVVIPLVTIEAMAELKPLLQDCGCAVKVSQHQSWRGIPLADGTRMAPM
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCC
NPVMILKGTMP
CCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732195 [H]