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The map label for this gene is menB [H]

Identifier: 124023581

GI number: 124023581

Start: 1642763

End: 1643656

Strand: Direct

Name: menB [H]

Synonym: P9303_18811

Alternate gene names: 124023581

Gene position: 1642763-1643656 (Clockwise)

Preceding gene: 124023580

Following gene: 124023582

Centisome position: 61.24

GC content: 54.92

Gene sequence:

>894_bases
ATGGCTATGGATTCCAATCGGTTTGATATGAGGCCAAGACAGGTTTTGCCTGGCAAGCCCACGATCGAATGGGAACCCTG
GGGTGAGTATCAAGACGTACTGCTCGATCGCAGTTCAGAAGGCATTGCCAGGGTTGCAATTGATCGTCCGGCCAAGCGCA
ATGCTTTCCGGCCACGCACGGTGATGGAACTCTGTGATGCGTTTACCCGAATTCGAGACGACCAACGTTTAGGCGTCGTT
TTGTTCACCGGTGTTGGACCTGCTGACGATGGCGGCTATGCCTTTTGTGCAGGTGGTGACCAAAGTGTGCGCGGCGACGG
TGGCTACCTCGATGAGGAAGGTTTGCCGCGCCTCAATGTTCTCGACCTACAGCGCATCATTCGTAGCTTGCCAAAGGTTG
TGATTGCACTTGTAGCTGGCTATGCGATCGGCGGCGGCCAAGTGCTGCACTTGTTATGTGATCTCAGTCTTGCGGCAGAG
AATGCCGTGTTTGGGCAAACCGGTCCCAAGGTGGGCAGCTTTGATGGTGGCTTTGGTGCTGGTTACCTAGCCAGGGTCGT
GGGGCAACGCAAGGCTCGTGAAATCTGGTTTCTCTGTCGTCAATACGGAGCTGAAGAAGCGCTGAAAATGGGGTTGATCA
ACGAGATTGTTCCCCTTGATGCCCTTGAAGCAGAAGGAGTGCGTTGGGCAAGAGAGGTGTTGCAGCACAGCCCCACAGCC
ATCCGCTGCCTGAAGGCCGCATTCAATGCTGAAACCGATGGCTTGGCAGGACTTCAGGAGCTAGCCGGCCAGGCCACCCA
TCTGTTCTATCGAACGGATGAAGCCCAGGAGGGCCGAAATGCTTTTCTACAAAAACGACCTCCAGATTTTTCAGGCTCAG
GCTGGCTTCCCTAA

Upstream 100 bases:

>100_bases
ATCGGGGTCAAGATTCATCGATGAGGCAACAGCTTCGCGAGGGATTGGTGATGCATCTGCAGTCGATTTCCCAAAATGGC
CACATTGATCTTTGATCCCG

Downstream 100 bases:

>100_bases
CCAGCCGCTCTAGGCAGCGTCATGATTGACGCATCGCTTGCTTTGGGGAAGGAGTTCTTGCTACCGCTTCCACTGCCGCT
GCTGCCCTCCCTGATTCATG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAMDSNRFDMRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPAKRNAFRPRTVMELCDAFTRIRDDQRLGVV
LFTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAE
NAVFGQTGPKVGSFDGGFGAGYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDALEAEGVRWAREVLQHSPTA
IRCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRPPDFSGSGWLP

Sequences:

>Translated_297_residues
MAMDSNRFDMRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPAKRNAFRPRTVMELCDAFTRIRDDQRLGVV
LFTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAE
NAVFGQTGPKVGSFDGGFGAGYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDALEAEGVRWAREVLQHSPTA
IRCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRPPDFSGSGWLP
>Mature_296_residues
AMDSNRFDMRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPAKRNAFRPRTVMELCDAFTRIRDDQRLGVVL
FTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAEN
AVFGQTGPKVGSFDGGFGAGYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDALEAEGVRWAREVLQHSPTAI
RCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRPPDFSGSGWLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=275, Percent_Identity=28, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI31542718, Length=256, Percent_Identity=29.6875, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4502327, Length=265, Percent_Identity=30.5660377358491, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI70995211, Length=231, Percent_Identity=25.974025974026, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1788597, Length=272, Percent_Identity=62.8676470588235, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI1787659, Length=253, Percent_Identity=30.8300395256917, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI221142681, Length=258, Percent_Identity=31.0077519379845, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082183, Length=213, Percent_Identity=29.1079812206573, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787660, Length=266, Percent_Identity=29.3233082706767, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788682, Length=202, Percent_Identity=28.7128712871287, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=30.2325581395349, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=273, Percent_Identity=28.9377289377289, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=234, Percent_Identity=28.2051282051282, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=214, Percent_Identity=27.1028037383178, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=196, Percent_Identity=30.1020408163265, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=257, Percent_Identity=25.2918287937743, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI20129971, Length=265, Percent_Identity=30.5660377358491, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653477, Length=265, Percent_Identity=30.5660377358491, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653139, Length=277, Percent_Identity=29.9638989169675, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21357171, Length=277, Percent_Identity=27.4368231046931, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24654903, Length=206, Percent_Identity=28.1553398058252, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32492; Mature: 32361

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMDSNRFDMRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPAKRNAFRPRT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCHHCCCCCCHH
VMELCDAFTRIRDDQRLGVVLFTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNV
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCH
LDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAENAVFGQTGPKVGSFDGGFGA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
GYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDALEAEGVRWAREVLQHSPTA
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHH
IRCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRPPDFSGSGWLP
HHHHHHHHCCCCCHHHHHHHHCCHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AMDSNRFDMRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPAKRNAFRPRT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCHHCCCCCCHH
VMELCDAFTRIRDDQRLGVVLFTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNV
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCH
LDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAENAVFGQTGPKVGSFDGGFGA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
GYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDALEAEGVRWAREVLQHSPTA
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHH
IRCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRPPDFSGSGWLP
HHHHHHHHCCCCCHHHHHHHHCCHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]