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The map label for this gene is pgi [H]

Identifier: 124023209

GI number: 124023209

Start: 1309142

End: 1310752

Strand: Reverse

Name: pgi [H]

Synonym: P9303_15071

Alternate gene names: 124023209

Gene position: 1310752-1309142 (Counterclockwise)

Preceding gene: 124023211

Following gene: 124023206

Centisome position: 48.86

GC content: 50.16

Gene sequence:

>1611_bases
GTGCATCAGCTGATGAGTTTCCCGGATTTCAGCGCCAGCGATGCCCATGTTCAGTGGCAGCGCTTTAACAATTTGCTTTG
GTATCACAACGATCTTGGAATTTGGCTGGACATCAGCCGAATGCATATCAATGCAGAAGATTTTGAGCGGCTAGGGCCAC
GCTTTGATCAGGCTTTCAAGGCCATGCAGGCTTTGGAACAGGGATCTATCGCTAATGCTGATGAACAGCGGATGGTCGGC
CACTACTGGCTGCGTCAGCCGCAGCTGGCGCCTGATCAAGAGGTCCGTGATCACATTGCCAAAGAAATTGACCTGATTGA
GACCTTTGGCAGCAATGTCGTCAATGGCCTCATCAAAGCCCCCAATGGCAAACAGTTCACCGATGTGCTTTGGATCGGGA
TTGGAGGCAGTGGCCTAGGGCCTTTATTAATGATTCGTGCTCTTCAGAATGCTGAGCAGGGATTGCGATTCCATTTTTTC
GACAATGTGGATCCTGATGGCATGAGTCGCGTTCTTGGCAATCTTGGAGATGCCCTGAGCACGACTTTGGTTGTCACGGT
AAGCAAATCTGGTGCGACTCCGGAACCACACCTCGGCATGGAGCAGGCTCGTCAACGTCTCGAAGAGATGGGAGGTCGTT
GGTCGGGTCAGGCCGTTGCCGTGACGATGCTCAATAGCCAGTTAGATCAGCTTGCACAGAAGGAATCCTGGCTTAAGCGT
TTTGACATGTTCGATTGGGTTGGCGGTAGAACAAGCATCACGAGTGCTGTTGGCCTTTTGCCGGCTGCATTGATTGGTTG
TAATACCCGCGATTTTCTTGCTGGTGCTGCCCAAATGGATGAGGCCACACGTGTGCCTGATCTGCACAGCAACCCAGCAG
CTTTGATGGCCGCTGCTTGGTTTGTTGCAGGAGATGGGCTTGGACGTCGTGACATGGTTGTTCTTCCATATAGAGATCGC
CTTGAGGTCTTTAGTCGTTACCTGCAACAGCTGGTAATGGAGTCGCTAGGCAAGCGTTTAGATCGAGATGGCAATGTTGT
TCATCAAGGCCTTGCTGTATATGGCAACAAGGGTTCAACTGATCAACATGCTTATGTACAGCAATTACGCGATGGTGTTG
ACAATTTCTTCGCCACATTTATTGAGGTGCTTGAGGATATTGAGAACATACCGGCGATCAACAATGAGCATCCAGGTGAT
TTTCTCGATGGCTTCCTGCAAGGCACTCGCGCAGCGCTCAGTCAGGGAGGTCGTCAGAGCCTCAGTATTTCAATGCGTCG
ATTTGATCCTCGTCGACTCGGCGCATTAGTTGCTTTGTTTGAGAGGGCAGTTGGTTTATATGGTGAACTTGTCAATATTA
ATGCGTATCACCAGCCTGGAGTGGAATCAGGTAAGAAAGCAGCCGCTGCCATCCTTAACTTGCAATCTCGAGTTGAAGCC
TTGCTTGCTGATGGTGTCGACCGTTCAGCTGGAGAGATCCATCAAGTGATTGGAGAAGGGTCAGAAGAAGCCATCTTTTG
GATCATGAGGCATTTAACTGCCAATAAGCGTGGTTACGTTGCAGAAGGTGATTGGGGAATTCCGACTTCACTACGTTTCA
GCAAAGGCTGA

Upstream 100 bases:

>100_bases
GGAGTCTGAAAAGAGTCTTGATCATCGCGCGAGGTTAGCCTGAGTGTCTGAGAAAATGGGCAAGCGTTTTGATCGTGGAT
AGTTTCGAGCTGTGAGCGAC

Downstream 100 bases:

>100_bases
TCGTTTCTATGGCACTAGGTTCACCAACTTGCCTGGAACAATGATGACCCGTCTAGGCGATTGACCCTCTAACCATTTAA
CGGCGATGTCACTCTTTAAG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MHQLMSFPDFSASDAHVQWQRFNNLLWYHNDLGIWLDISRMHINAEDFERLGPRFDQAFKAMQALEQGSIANADEQRMVG
HYWLRQPQLAPDQEVRDHIAKEIDLIETFGSNVVNGLIKAPNGKQFTDVLWIGIGGSGLGPLLMIRALQNAEQGLRFHFF
DNVDPDGMSRVLGNLGDALSTTLVVTVSKSGATPEPHLGMEQARQRLEEMGGRWSGQAVAVTMLNSQLDQLAQKESWLKR
FDMFDWVGGRTSITSAVGLLPAALIGCNTRDFLAGAAQMDEATRVPDLHSNPAALMAAAWFVAGDGLGRRDMVVLPYRDR
LEVFSRYLQQLVMESLGKRLDRDGNVVHQGLAVYGNKGSTDQHAYVQQLRDGVDNFFATFIEVLEDIENIPAINNEHPGD
FLDGFLQGTRAALSQGGRQSLSISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGVESGKKAAAAILNLQSRVEA
LLADGVDRSAGEIHQVIGEGSEEAIFWIMRHLTANKRGYVAEGDWGIPTSLRFSKG

Sequences:

>Translated_536_residues
MHQLMSFPDFSASDAHVQWQRFNNLLWYHNDLGIWLDISRMHINAEDFERLGPRFDQAFKAMQALEQGSIANADEQRMVG
HYWLRQPQLAPDQEVRDHIAKEIDLIETFGSNVVNGLIKAPNGKQFTDVLWIGIGGSGLGPLLMIRALQNAEQGLRFHFF
DNVDPDGMSRVLGNLGDALSTTLVVTVSKSGATPEPHLGMEQARQRLEEMGGRWSGQAVAVTMLNSQLDQLAQKESWLKR
FDMFDWVGGRTSITSAVGLLPAALIGCNTRDFLAGAAQMDEATRVPDLHSNPAALMAAAWFVAGDGLGRRDMVVLPYRDR
LEVFSRYLQQLVMESLGKRLDRDGNVVHQGLAVYGNKGSTDQHAYVQQLRDGVDNFFATFIEVLEDIENIPAINNEHPGD
FLDGFLQGTRAALSQGGRQSLSISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGVESGKKAAAAILNLQSRVEA
LLADGVDRSAGEIHQVIGEGSEEAIFWIMRHLTANKRGYVAEGDWGIPTSLRFSKG
>Mature_536_residues
MHQLMSFPDFSASDAHVQWQRFNNLLWYHNDLGIWLDISRMHINAEDFERLGPRFDQAFKAMQALEQGSIANADEQRMVG
HYWLRQPQLAPDQEVRDHIAKEIDLIETFGSNVVNGLIKAPNGKQFTDVLWIGIGGSGLGPLLMIRALQNAEQGLRFHFF
DNVDPDGMSRVLGNLGDALSTTLVVTVSKSGATPEPHLGMEQARQRLEEMGGRWSGQAVAVTMLNSQLDQLAQKESWLKR
FDMFDWVGGRTSITSAVGLLPAALIGCNTRDFLAGAAQMDEATRVPDLHSNPAALMAAAWFVAGDGLGRRDMVVLPYRDR
LEVFSRYLQQLVMESLGKRLDRDGNVVHQGLAVYGNKGSTDQHAYVQQLRDGVDNFFATFIEVLEDIENIPAINNEHPGD
FLDGFLQGTRAALSQGGRQSLSISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGVESGKKAAAAILNLQSRVEA
LLADGVDRSAGEIHQVIGEGSEEAIFWIMRHLTANKRGYVAEGDWGIPTSLRFSKG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=454, Percent_Identity=30.1762114537445, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI296080693, Length=454, Percent_Identity=26.8722466960352, Blast_Score=119, Evalue=9e-27,
Organism=Escherichia coli, GI1790457, Length=482, Percent_Identity=29.8755186721992, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71996708, Length=479, Percent_Identity=29.2275574112735, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71996703, Length=479, Percent_Identity=29.2275574112735, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319673, Length=490, Percent_Identity=28.9795918367347, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24651916, Length=496, Percent_Identity=30.241935483871, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24651914, Length=496, Percent_Identity=30.241935483871, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17737445, Length=496, Percent_Identity=30.241935483871, Blast_Score=173, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 59337; Mature: 59337

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQLMSFPDFSASDAHVQWQRFNNLLWYHNDLGIWLDISRMHINAEDFERLGPRFDQAFK
CCCCCCCCCCCCCCCEEEHHHHCCEEEEECCCCEEEEEEEEECCHHHHHHHCHHHHHHHH
AMQALEQGSIANADEQRMVGHYWLRQPQLAPDQEVRDHIAKEIDLIETFGSNVVNGLIKA
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PNGKQFTDVLWIGIGGSGLGPLLMIRALQNAEQGLRFHFFDNVDPDGMSRVLGNLGDALS
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHH
TTLVVTVSKSGATPEPHLGMEQARQRLEEMGGRWSGQAVAVTMLNSQLDQLAQKESWLKR
EEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
FDMFDWVGGRTSITSAVGLLPAALIGCNTRDFLAGAAQMDEATRVPDLHSNPAALMAAAW
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
FVAGDGLGRRDMVVLPYRDRLEVFSRYLQQLVMESLGKRLDRDGNVVHQGLAVYGNKGST
HHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEECCCCCC
DQHAYVQQLRDGVDNFFATFIEVLEDIENIPAINNEHPGDFLDGFLQGTRAALSQGGRQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
LSISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGVESGKKAAAAILNLQSRVEA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LLADGVDRSAGEIHQVIGEGSEEAIFWIMRHLTANKRGYVAEGDWGIPTSLRFSKG
HHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MHQLMSFPDFSASDAHVQWQRFNNLLWYHNDLGIWLDISRMHINAEDFERLGPRFDQAFK
CCCCCCCCCCCCCCCEEEHHHHCCEEEEECCCCEEEEEEEEECCHHHHHHHCHHHHHHHH
AMQALEQGSIANADEQRMVGHYWLRQPQLAPDQEVRDHIAKEIDLIETFGSNVVNGLIKA
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PNGKQFTDVLWIGIGGSGLGPLLMIRALQNAEQGLRFHFFDNVDPDGMSRVLGNLGDALS
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHH
TTLVVTVSKSGATPEPHLGMEQARQRLEEMGGRWSGQAVAVTMLNSQLDQLAQKESWLKR
EEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
FDMFDWVGGRTSITSAVGLLPAALIGCNTRDFLAGAAQMDEATRVPDLHSNPAALMAAAW
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
FVAGDGLGRRDMVVLPYRDRLEVFSRYLQQLVMESLGKRLDRDGNVVHQGLAVYGNKGST
HHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEECCCCCC
DQHAYVQQLRDGVDNFFATFIEVLEDIENIPAINNEHPGDFLDGFLQGTRAALSQGGRQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
LSISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGVESGKKAAAAILNLQSRVEA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LLADGVDRSAGEIHQVIGEGSEEAIFWIMRHLTANKRGYVAEGDWGIPTSLRFSKG
HHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]