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The map label for this gene is uvrC [H]

Identifier: 124023198

GI number: 124023198

Start: 1297351

End: 1299354

Strand: Reverse

Name: uvrC [H]

Synonym: P9303_14941

Alternate gene names: 124023198

Gene position: 1299354-1297351 (Counterclockwise)

Preceding gene: 124023199

Following gene: 124023197

Centisome position: 48.44

GC content: 44.76

Gene sequence:

>2004_bases
ATGCGCTTAACCTCGCTTCAACGGGTTGGTCATACGGCGGTTGAAAATAATTTGACCAACGCTTCTCAGCGCACCATCCT
TCTAAAGGATGAAAAAAGACTTGAGCAAAGGCTTAAGGAGATTCCAGCTGAACCTGGTTGTTATCTCATGCGTGATGGAG
AAGACAGGTTGTTATATGTGGGTAAATCAAAATGTTTACGAAATCGAGTAAGAAGTTATTTCCGAAGTAGCAGTGATCAT
GGGCCTCGTATTCGATTGATGGTGCGACAAATTGTTGAGATTGAATTTATCGTAACTGATAGCGAGGCTGAATCCTTAGT
TCTGGAATCTAACCTGATAAAGAATCAACAGCCACATTTCAATGTGTTGTTAAAAGATGACAAAAAATATCCCTATATTT
GCATTACATGGAGCGAGGAGTATCCACGTATCTTTATCACAAGGAGGCGACGTTTCCGAAATAAGAATGATCGCTTCTAT
GGCCCATATGTAGATGTAGGACTATTGCGTAGAACCTTATTTCTTGTCAAACGTTCGTTCCCGCTGAGACAACGACCACG
GCCATTGCACCAGGATCGTACCTGCCTTAACTATTCAATTGGACGTTGCCCTGGCGTATGCCAGCAGAAGATCACACCAA
AGGATTATCATCAAGTTCTTCGCAAAGTTGCGATGGTTTTTCAGGGCAGGAATCAAGAGCTTAAGGTTTTGCTTGAGAGG
CAAATGGAACGTTATTCAGATCGATTGGACTATGAGTCAGCCGCTAACATAAGGGATCAGATTAAAGGGTTAGAACAACT
TACAGAAGAACAGAAGATGAGCTTACCAGATTCAAGCGTAAGCCGAGATGTACTTGCTATTGCAAGCGATCATAGGGTTG
CGGCAGTTCAGCTTTTTCAGATGCGTGCAGGTAAACTTGTTAATCGTCTTGGCTTTACTGCTGATGCAGTCGATCAAACT
CTTGGAAGTGTACTTCAGCGAGTTATCGAAGAACATTACAGTCAAGTAGATGCTGTAGAAGTCCCGCCAGAAGTTCTTGT
TCAATACTCATTACCTCAGCAAGAATTACTAATTGATTGGCTCAGTGAGCAACGCGGTCGGCGTGTTCAAATCAGTTGTC
CTCAACGCCAAGCAAAAGCAGAGTTGATAGAACTTGTTGAACGCAATGCAGTATTTGAATTATCTCGTGCGAAGAGTGGG
CAGCAACAACAGGAATTGGCAACAGAGGATCTTGCCCAGTTACTTGAACTCACGACACTGCCAAGAAGAATCGAAGGATA
TGATATTAGTCATATCCAAGGAAGTGATGCTGTTGCATCACAGGTTGTATTTATCGATGGGCTACCCGCTAAACAGCATT
ACCGAAAGTATAAAATTAAAAGTAGTAGTATCAAATCTGGCCATAGCGATGACTTCATGGCGATGGCTGAGATTATGCGC
CGTCGCTTTCGTCGTTGGGCAAGGGTGAAGCAAGAAGGATCAGATTTTGAAAAACTGCAGCGCTGCAGTGGCAGCACCTT
GCAGACAGATGGTCTCAATGATTGGCCTGATGTGGTGATGATTGATGGCGGTAAGGGTCAGCTTTCATCAGTCATGGAAG
CATTACGCGAGCTTGACCTTCATGAGGATCTCGTCGTTTGTTCATTGGCTAAGAAACATGAACAGATCTTTGTACCTGGA
CAAAGCAAACCATTGGATTCTGATCCTGATCAGTTGGGTGTCGTCCTTTTAAGGCGGCTTCGGGATGAAGCACATCGCTT
TGCCGTGAGTTATCACCGCCAACAAAGAGGGGTAAGAATGAACAGATCTCGGCTTACAGACATCCCTGGACTTGGGCCTA
GGCGTGTTCGTGACCTTCTTGCACACTTTCAATCCATTGATGCTATTCAGTTGGCTAGCGTCCAGCAAATTAGTCAGGCA
CCAGGGCTTGGACCAGCACTTGCATTTCAGGTTTGGACCTATTTCCACCCTGAAGCCGATAAGGCGTTGGAGGAGGTTGC
CTGA

Upstream 100 bases:

>100_bases
ATTGGTGGAGTTGAGTGTGAACTTGTGGGCCAGGTCGTCCATGGTGATCACACTGTTTTCGTCGGAGAAGTGAGATCAGC
CCATCTAAATCAGGATGGGG

Downstream 100 bases:

>100_bases
TCAAGACGGATCACTTTTTTAAATCTCATTACTACCTCATCTCAGCAGATTGCTGATAGTTATCCATGACCTTTCCGCCC
GAGGCATACCTGTGGTTCAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MRLTSLQRVGHTAVENNLTNASQRTILLKDEKRLEQRLKEIPAEPGCYLMRDGEDRLLYVGKSKCLRNRVRSYFRSSSDH
GPRIRLMVRQIVEIEFIVTDSEAESLVLESNLIKNQQPHFNVLLKDDKKYPYICITWSEEYPRIFITRRRRFRNKNDRFY
GPYVDVGLLRRTLFLVKRSFPLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPKDYHQVLRKVAMVFQGRNQELKVLLER
QMERYSDRLDYESAANIRDQIKGLEQLTEEQKMSLPDSSVSRDVLAIASDHRVAAVQLFQMRAGKLVNRLGFTADAVDQT
LGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLIDWLSEQRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSG
QQQQELATEDLAQLLELTTLPRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
RRFRRWARVKQEGSDFEKLQRCSGSTLQTDGLNDWPDVVMIDGGKGQLSSVMEALRELDLHEDLVVCSLAKKHEQIFVPG
QSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRMNRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQA
PGLGPALAFQVWTYFHPEADKALEEVA

Sequences:

>Translated_667_residues
MRLTSLQRVGHTAVENNLTNASQRTILLKDEKRLEQRLKEIPAEPGCYLMRDGEDRLLYVGKSKCLRNRVRSYFRSSSDH
GPRIRLMVRQIVEIEFIVTDSEAESLVLESNLIKNQQPHFNVLLKDDKKYPYICITWSEEYPRIFITRRRRFRNKNDRFY
GPYVDVGLLRRTLFLVKRSFPLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPKDYHQVLRKVAMVFQGRNQELKVLLER
QMERYSDRLDYESAANIRDQIKGLEQLTEEQKMSLPDSSVSRDVLAIASDHRVAAVQLFQMRAGKLVNRLGFTADAVDQT
LGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLIDWLSEQRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSG
QQQQELATEDLAQLLELTTLPRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
RRFRRWARVKQEGSDFEKLQRCSGSTLQTDGLNDWPDVVMIDGGKGQLSSVMEALRELDLHEDLVVCSLAKKHEQIFVPG
QSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRMNRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQA
PGLGPALAFQVWTYFHPEADKALEEVA
>Mature_667_residues
MRLTSLQRVGHTAVENNLTNASQRTILLKDEKRLEQRLKEIPAEPGCYLMRDGEDRLLYVGKSKCLRNRVRSYFRSSSDH
GPRIRLMVRQIVEIEFIVTDSEAESLVLESNLIKNQQPHFNVLLKDDKKYPYICITWSEEYPRIFITRRRRFRNKNDRFY
GPYVDVGLLRRTLFLVKRSFPLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPKDYHQVLRKVAMVFQGRNQELKVLLER
QMERYSDRLDYESAANIRDQIKGLEQLTEEQKMSLPDSSVSRDVLAIASDHRVAAVQLFQMRAGKLVNRLGFTADAVDQT
LGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLIDWLSEQRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSG
QQQQELATEDLAQLLELTTLPRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
RRFRRWARVKQEGSDFEKLQRCSGSTLQTDGLNDWPDVVMIDGGKGQLSSVMEALRELDLHEDLVVCSLAKKHEQIFVPG
QSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRMNRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQA
PGLGPALAFQVWTYFHPEADKALEEVA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=646, Percent_Identity=32.1981424148607, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1788037, Length=194, Percent_Identity=27.8350515463918, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 76904; Mature: 76904

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTSLQRVGHTAVENNLTNASQRTILLKDEKRLEQRLKEIPAEPGCYLMRDGEDRLLYV
CCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCCCEEEE
GKSKCLRNRVRSYFRSSSDHGPRIRLMVRQIVEIEFIVTDSEAESLVLESNLIKNQQPHF
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCCCCE
NVLLKDDKKYPYICITWSEEYPRIFITRRRRFRNKNDRFYGPYVDVGLLRRTLFLVKRSF
EEEEECCCCCCEEEEEECCCCCEEHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHCC
PLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPKDYHQVLRKVAMVFQGRNQELKVLLER
CCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QMERYSDRLDYESAANIRDQIKGLEQLTEEQKMSLPDSSVSRDVLAIASDHRVAAVQLFQ
HHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHCCCCHHHHHHHHH
MRAGKLVNRLGFTADAVDQTLGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLIDW
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCHHHHHHHH
LSEQRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSGQQQQELATEDLAQLLELTTL
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
PRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
CHHHCCCCCCCCCCCHHHHHEEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
RRFRRWARVKQEGSDFEKLQRCSGSTLQTDGLNDWPDVVMIDGGKGQLSSVMEALRELDL
HHHHHHHHHHHCCCHHHHHHHCCCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCC
HEDLVVCSLAKKHEQIFVPGQSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRM
HHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQAPGLGPALAFQVWTYFHPEAD
CHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHH
KALEEVA
HHHHHCC
>Mature Secondary Structure
MRLTSLQRVGHTAVENNLTNASQRTILLKDEKRLEQRLKEIPAEPGCYLMRDGEDRLLYV
CCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCCCEEEE
GKSKCLRNRVRSYFRSSSDHGPRIRLMVRQIVEIEFIVTDSEAESLVLESNLIKNQQPHF
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCCCCE
NVLLKDDKKYPYICITWSEEYPRIFITRRRRFRNKNDRFYGPYVDVGLLRRTLFLVKRSF
EEEEECCCCCCEEEEEECCCCCEEHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHCC
PLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPKDYHQVLRKVAMVFQGRNQELKVLLER
CCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QMERYSDRLDYESAANIRDQIKGLEQLTEEQKMSLPDSSVSRDVLAIASDHRVAAVQLFQ
HHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHCCCCHHHHHHHHH
MRAGKLVNRLGFTADAVDQTLGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLIDW
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCHHHHHHHH
LSEQRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSGQQQQELATEDLAQLLELTTL
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
PRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
CHHHCCCCCCCCCCCHHHHHEEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
RRFRRWARVKQEGSDFEKLQRCSGSTLQTDGLNDWPDVVMIDGGKGQLSSVMEALRELDL
HHHHHHHHHHHCCCHHHHHHHCCCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCC
HEDLVVCSLAKKHEQIFVPGQSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRM
HHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQAPGLGPALAFQVWTYFHPEAD
CHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHH
KALEEVA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]