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The map label for this gene is ahpC [C]

Identifier: 124023166

GI number: 124023166

Start: 1258385

End: 1258987

Strand: Reverse

Name: ahpC [C]

Synonym: P9303_14621

Alternate gene names: 124023166

Gene position: 1258987-1258385 (Counterclockwise)

Preceding gene: 124023168

Following gene: 124023164

Centisome position: 46.93

GC content: 43.28

Gene sequence:

>603_bases
ATGACGACCAACGAATGCCTAAGGGTGGGTCAGCAGGCCCCAGACTTCAGTGCTACAGCTGTTGTTGATCAAGAGTTTAA
GGAAATAAGCCTTTCCCAGTACAGGGGTAAGTATGTGGTTTTATTCTTTTATCCTCTAGATTTCACTTTTGTATGCCCAA
CAGAAATTACAGCATTTAGTGATCGGTACACTGATTTCTCAAGCCGAAATACAGAGGTCTTAGGGGTTTCAGTTGATAGT
CAATTCAGCCATCTTGCATGGATCCAGACATCACGTAAGGAGGGAGGGCTCGGTGACATTAACTATCCATTAATAGCTGA
TCTCAAGAAAGAGATATCTACGGCCTATAACGTTTTAGATGATGCTGCTGGAGTAGCCCTCCGTGGTTTGTTTATCATTG
ACCCAGATGGAGTAATAATGCATTCAACAATCAACAACTTACCGGTAGGAAGGAACGTGGATGAGACATTACGTGTACTG
CAGGCCTTTCAGTATGTACAGTCACATCCAGATGAGGTATGCCCAGCTAATTGGACACCAGGAGAGAAAACAATGAAACC
AGACCCAGTTGGAAGTAAGGAGTTCTTCGCCTCAATAAATTAA

Upstream 100 bases:

>100_bases
GCATGATAAATTTGAGAAGCCAACTAGAAGTCATAACGACTTCATTATAGCTCTGATTAAGCACATCTCTTGCAGAGCCA
TCAACTCTTAACTCTCCATC

Downstream 100 bases:

>100_bases
TCATTAATCTATCAATACATCATTAATTTGATTGATCTGCTGCCTTAATCGGTGGCAGATCATTTCTATTTAAATACACT
GCTTTTTTGCTTGATCCGTC

Product: thioredoxin peroxidase

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MTTNECLRVGQQAPDFSATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYTDFSSRNTEVLGVSVDS
QFSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLDDAAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVL
QAFQYVQSHPDEVCPANWTPGEKTMKPDPVGSKEFFASIN

Sequences:

>Translated_200_residues
MTTNECLRVGQQAPDFSATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYTDFSSRNTEVLGVSVDS
QFSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLDDAAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVL
QAFQYVQSHPDEVCPANWTPGEKTMKPDPVGSKEFFASIN
>Mature_199_residues
TTNECLRVGQQAPDFSATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYTDFSSRNTEVLGVSVDSQ
FSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLDDAAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVLQ
AFQYVQSHPDEVCPANWTPGEKTMKPDPVGSKEFFASIN

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=192, Percent_Identity=63.0208333333333, Blast_Score=262, Evalue=2e-70,
Organism=Homo sapiens, GI32483377, Length=198, Percent_Identity=61.6161616161616, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=63.7305699481865, Blast_Score=256, Evalue=7e-69,
Organism=Homo sapiens, GI5453549, Length=193, Percent_Identity=58.0310880829015, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI4505591, Length=192, Percent_Identity=58.3333333333333, Blast_Score=240, Evalue=7e-64,
Organism=Homo sapiens, GI32455266, Length=192, Percent_Identity=58.3333333333333, Blast_Score=240, Evalue=7e-64,
Organism=Homo sapiens, GI32455264, Length=192, Percent_Identity=58.3333333333333, Blast_Score=240, Evalue=7e-64,
Organism=Homo sapiens, GI33188454, Length=87, Percent_Identity=70.1149425287356, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI4758638, Length=189, Percent_Identity=30.1587301587302, Blast_Score=84, Evalue=9e-17,
Organism=Escherichia coli, GI1786822, Length=172, Percent_Identity=37.7906976744186, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193204376, Length=188, Percent_Identity=61.1702127659574, Blast_Score=239, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI32565831, Length=188, Percent_Identity=61.1702127659574, Blast_Score=239, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17554494, Length=187, Percent_Identity=56.6844919786096, Blast_Score=231, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI25153706, Length=190, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=193, Percent_Identity=57.5129533678757, Blast_Score=221, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6320661, Length=193, Percent_Identity=54.4041450777202, Blast_Score=213, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319407, Length=197, Percent_Identity=32.48730964467, Blast_Score=105, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17738015, Length=195, Percent_Identity=59.4871794871795, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24656348, Length=192, Percent_Identity=59.8958333333333, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17864676, Length=192, Percent_Identity=59.8958333333333, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17157991, Length=191, Percent_Identity=57.0680628272251, Blast_Score=233, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24641739, Length=191, Percent_Identity=57.0680628272251, Blast_Score=233, Evalue=8e-62,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=51.0526315789474, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17975518, Length=188, Percent_Identity=36.1702127659575, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24652434, Length=188, Percent_Identity=36.1702127659575, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24652436, Length=188, Percent_Identity=36.1702127659575, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24581278, Length=192, Percent_Identity=32.2916666666667, Blast_Score=103, Evalue=7e-23,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22287; Mature: 22156

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNECLRVGQQAPDFSATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFS
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCHHHHHC
DRYTDFSSRNTEVLGVSVDSQFSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLD
CCCCCCCCCCCEEEEEECCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DAAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVLQAFQYVQSHPDEVCPANWTP
HHCCCEEEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GEKTMKPDPVGSKEFFASIN
CCCCCCCCCCCCHHHEEECC
>Mature Secondary Structure 
TTNECLRVGQQAPDFSATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFS
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCHHHHHC
DRYTDFSSRNTEVLGVSVDSQFSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLD
CCCCCCCCCCCEEEEEECCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DAAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVLQAFQYVQSHPDEVCPANWTP
HHCCCEEEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GEKTMKPDPVGSKEFFASIN
CCCCCCCCCCCCHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]