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The map label for this gene is clcA [H]

Identifier: 124023155

GI number: 124023155

Start: 1247948

End: 1249315

Strand: Reverse

Name: clcA [H]

Synonym: P9303_14511

Alternate gene names: 124023155

Gene position: 1249315-1247948 (Counterclockwise)

Preceding gene: 124023156

Following gene: 124023154

Centisome position: 46.57

GC content: 50.29

Gene sequence:

>1368_bases
ATGAGTTTTGATCTACGACGGCTCGACCAATTAATCCCAGGAGTGATTGGAAGAAAACAATCTGAGATTATTCAGCTCTT
TCAACATCTTCTATGTCTTTTGATTATTGGCCTTCTAATCGGCCTTGCATGCCTGCCACTCAACCTGATTGATGGAATTC
AAAAGTCTCTATTTCAGCAGTTACCAGCAACAGCAGGAGGTGCCTGGCGGCCAATTGGTCTGATATTGGCACTGTTGCCG
ATAGGAGTGATGCCAATCCTCTTGTTACTGCAGCGGGGGCCATGGCGAGATGCAGCCGGCTCTGGGATACCTCAGACAAT
GAATGCTCTTGAAGATCACTCACAGCTAGCCCCTGCTCTCGCTGCCCCAAGAACGATTCAACGTGGTCTTCTCTGGACTA
TTGCAACGGTTGCTCTGTTCCCGCTTGGACGGGAGGGGCCAGTGGTGCATGTAGGAGCAGCTGTTGCACGAGCTATTCAC
AAACGTTTTAAGCGTTGGCTCCCTTCACTAAATGAGCGTCAGATTGTGGCTATTGGTGGCGGTGCCGGACTTGCAGGAGG
CTTCAACACCCCTCTACTAGCACCAATATTCATGATTGAGGAACTCACAACTGAATATTCCCTCACTCTGATTTGGCCTG
CTCTTGTGATTGGAATCTCCGCGGCTTGGTTTAGCAGCATTGGCGGAGAACCAATCTTCGGTCTTGGCATGATCAATGTG
ATGGCCCCAGAATCCGAGCAGCTCTTAATTGCTATTCCAATTGGGATTTTAGCTGGGCTTGTGGGGGGATTCTTTAATCG
AGGCCTTGTCTGGTGCTCTTCATTTCTTGAGCCATGGGTGCGTCAACGACCAATCCGCACTGGTCTATTACTTGGAATTT
CCCTCAGCGCCTTGGCTCTGGCCAGCTGGGGGACAAGCACAGGTGATGGAGAGGGGCTTCTGCAATTGTTGATTCAGGAA
GGAATGCCAAACCATTTCCCTGAAGGTGGCTCTATTTCACAAGGACTAACTTCTATATGGATCATCTTGGTTCGTGTCTT
AGCTCCGATGATTGCACTTTCACCTGGGGTACCTGGAGGCCTTATTGACCCTTCACTCGCATTCGGAGGCCTCCTCGGTT
ACACATTCTGTGCATTGATCGGTTCAAGCACTCATCTCGGCCTAGCACTAGGAATGGCCGCTGGTTTGGCTGGTGCCACA
CAGCTTCCACTGGTCTCGATTGTGTTCGCCTGGAGACTAGTTGGCGATCAACAACTAGTTGCAGGTGTAGTTCTTTGTTC
AGTACTGGCCGCCTACATAGGACGGCTGGTAGCACGTAAGCCCGTCTATCACGCTCTTGCCGAACTTCAAAGACCTAATC
GATTTTGA

Upstream 100 bases:

>100_bases
TGTCAAGCAATGGAAAGCTTAAATGCACTGACAGTCGAGCTAGGCATCCTTACATTCATAACCTGATCGAAGAGGGATTA
ATAGGTCTGGGACTTCGCCC

Downstream 100 bases:

>100_bases
TAAAAACATAAGAATATGATTGCTGGACCGGCCAGGGCAACTGCGCCAAGCGGCCCAAAGATCTCGAGAATGCGGATGGC
AGTGTCCATAGCGACTTAGA

Product: chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSFDLRRLDQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQLPATAGGAWRPIGLILALLP
IGVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPALAAPRTIQRGLLWTIATVALFPLGREGPVVHVGAAVARAIH
KRFKRWLPSLNERQIVAIGGGAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSIGGEPIFGLGMINV
MAPESEQLLIAIPIGILAGLVGGFFNRGLVWCSSFLEPWVRQRPIRTGLLLGISLSALALASWGTSTGDGEGLLQLLIQE
GMPNHFPEGGSISQGLTSIWIILVRVLAPMIALSPGVPGGLIDPSLAFGGLLGYTFCALIGSSTHLGLALGMAAGLAGAT
QLPLVSIVFAWRLVGDQQLVAGVVLCSVLAAYIGRLVARKPVYHALAELQRPNRF

Sequences:

>Translated_455_residues
MSFDLRRLDQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQLPATAGGAWRPIGLILALLP
IGVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPALAAPRTIQRGLLWTIATVALFPLGREGPVVHVGAAVARAIH
KRFKRWLPSLNERQIVAIGGGAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSIGGEPIFGLGMINV
MAPESEQLLIAIPIGILAGLVGGFFNRGLVWCSSFLEPWVRQRPIRTGLLLGISLSALALASWGTSTGDGEGLLQLLIQE
GMPNHFPEGGSISQGLTSIWIILVRVLAPMIALSPGVPGGLIDPSLAFGGLLGYTFCALIGSSTHLGLALGMAAGLAGAT
QLPLVSIVFAWRLVGDQQLVAGVVLCSVLAAYIGRLVARKPVYHALAELQRPNRF
>Mature_454_residues
SFDLRRLDQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQLPATAGGAWRPIGLILALLPI
GVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPALAAPRTIQRGLLWTIATVALFPLGREGPVVHVGAAVARAIHK
RFKRWLPSLNERQIVAIGGGAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSIGGEPIFGLGMINVM
APESEQLLIAIPIGILAGLVGGFFNRGLVWCSSFLEPWVRQRPIRTGLLLGISLSALALASWGTSTGDGEGLLQLLIQEG
MPNHFPEGGSISQGLTSIWIILVRVLAPMIALSPGVPGGLIDPSLAFGGLLGYTFCALIGSSTHLGLALGMAAGLAGATQ
LPLVSIVFAWRLVGDQQLVAGVVLCSVLAAYIGRLVARKPVYHALAELQRPNRF

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=441, Percent_Identity=25.6235827664399, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 48187; Mature: 48056

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDLRRLDQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQ
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPATAGGAWRPIGLILALLPIGVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AAPRTIQRGLLWTIATVALFPLGREGPVVHVGAAVARAIHKRFKRWLPSLNERQIVAIGG
HCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSIGGEPIFGLGMINV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHE
MAPESEQLLIAIPIGILAGLVGGFFNRGLVWCSSFLEPWVRQRPIRTGLLLGISLSALAL
ECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ASWGTSTGDGEGLLQLLIQEGMPNHFPEGGSISQGLTSIWIILVRVLAPMIALSPGVPGG
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LIDPSLAFGGLLGYTFCALIGSSTHLGLALGMAAGLAGATQLPLVSIVFAWRLVGDQQLV
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHH
AGVVLCSVLAAYIGRLVARKPVYHALAELQRPNRF
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SFDLRRLDQLIPGVIGRKQSEIIQLFQHLLCLLIIGLLIGLACLPLNLIDGIQKSLFQQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPATAGGAWRPIGLILALLPIGVMPILLLLQRGPWRDAAGSGIPQTMNALEDHSQLAPAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AAPRTIQRGLLWTIATVALFPLGREGPVVHVGAAVARAIHKRFKRWLPSLNERQIVAIGG
HCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GAGLAGGFNTPLLAPIFMIEELTTEYSLTLIWPALVIGISAAWFSSIGGEPIFGLGMINV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHE
MAPESEQLLIAIPIGILAGLVGGFFNRGLVWCSSFLEPWVRQRPIRTGLLLGISLSALAL
ECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ASWGTSTGDGEGLLQLLIQEGMPNHFPEGGSISQGLTSIWIILVRVLAPMIALSPGVPGG
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LIDPSLAFGGLLGYTFCALIGSSTHLGLALGMAAGLAGATQLPLVSIVFAWRLVGDQQLV
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHH
AGVVLCSVLAAYIGRLVARKPVYHALAELQRPNRF
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA