Click here to switch to the map view.

The map label for this gene is pmbA [C]

Identifier: 124023145

GI number: 124023145

Start: 1239475

End: 1240860

Strand: Reverse

Name: pmbA [C]

Synonym: P9303_14411

Alternate gene names: 124023145

Gene position: 1240860-1239475 (Counterclockwise)

Preceding gene: 124023146

Following gene: 124023144

Centisome position: 46.25

GC content: 47.76

Gene sequence:

>1386_bases
ATGTCCGAAATAAAAAGAGCAAATGCAATCGAACTCGATACTCATTCCCTACGGGACAAGCTCAGTCAACTTGCTAGCCG
CGAGAGTATCCACCAATGGGATTTAGGAGCAGCGTGCAGCACAGATAGCTCTGTTCAAATTGATCGTGGCGAAGCCAAGC
AAATGAAAGCTGCGCAGCGCAGCTCAATCACAGTACGTGTATGGAACAACAAAGGACTTGTAGGCATCACAAGCACGTCA
GATCTTTCAGAAAAAGGAATAGAGAAAGCGCTTATTGGTGCTCGTCAGGCAAGTGACTTTGGCAACGCCGATGACGTGCC
TGCCTTCTCAACACTCGCTAAATCTCCGTTACCAAAACTAGATCGACCTCTAAGACCAGCGCAGGGAATTCAACGAATGC
TTGAGGTTCTTAAAGAGGCCGAAGCTGATCTTCTTAGTCGACATCCTTCTATACAGAGCATTCCTTACAACGGTCTAGGG
GAAGCAACCTACGAACGAGTTTATCTCAATAGCGATGGTGCGCTTCGTCAAATGAAGCGTAGTCAAGCCAGCCTTTACCT
TTTTGCCCGCGCAGAAGAAAGTGGACGTAAACCACGCAGTGGTGGTGCAATTCGCCTTGCTCTAGGTAGTCACGATCTGG
ATGTTGATGGATGTATCGATGAAGCAGCAGAACGAACAATCAGCCATCTTGACTATCAGCCAATCGACACTGGGTGCTAT
CTCGTCTGCTTCACACCAGAGGCTTTCCTAGACTTGATCGGTGCCTTCAGCAGCATGTTCAATGCCAGATCAGTACTCGA
TGGCGTCAGCCTCAGCCAGCGAGATACACTCGGCAAAAATATTGCCGTTCCATTCTTCTCTCTTCATGATAATGGCCTAC
ATCCTGCACATGTAGGGGCCTCAAGTTTCGATGGTGAAGGCACACCTACTAAAAAACTTTGCTTAATCAACGGTGGAAGA
CTCGAGAATTTCCTGCACTCGGAAGCTACCGCAAGGGCATTCGGCTTACCACCAACTGGCCATGCCGGACTGGGAGCAAA
GGTATCAGTGGGACCAGATTGGTTTGAAGTGAACAAAACTGAAGGTCAAAACAGCGCAAATACTCATCTGCAACACAGCA
AGAGCAAAGAAACCTTCGTGTTAATTGAAGGGTTAAATGCTCTACACGCTGGGGTTAAAGCAAGTCAGGGTTCATTTTCT
CTTCCATTTAATGGTTGGTTAGTAATGAAAGGGGAAAAGGTGTCGATCGAAGCAGCGACAGTTGCTGGAGACATCCGTAC
AGTGTTGAATAGCATTGTGAATATGGAAGCTGAACAGGTGATCACACCTGGCGGGGTATCTCCTCATGTGTGGGTCGAAG
GGTTATCAATTACTGGTGAAGCGTGA

Upstream 100 bases:

>100_bases
TGGCAGCCGGTTTCTGCGGGTCAATAAGCGGCAACATTTTTGTCACCGTAGGGCAGCCACATATCAAAGTCGATTCAATT
ACCGTGGGAGGCCGCTGATT

Downstream 100 bases:

>100_bases
AGGTGCTGTTCTGGGGTACACCCAGCTATGCAGTGCCAACTCTGGATGCCCTAAATGATTCAGGCTATGAAATTGTAGGA
GTGGTGAGCCAGCCTGATCG

Product: modulator of DNA gyrase

Products: NA

Alternate protein names: Modulator Of DNA Gyrase; PmbA Protein; TldD/PmbA Family Protein; Zn-Dependent Protease; Peptidase PmbA; PmbA-Related Protein; Protein PmbA; TldD/PmbA Family; Peptide Maturation; PmbA/TldD Related Protein; Pmba-Related Protein; Inactivated Zn-Dependent Peptidase PMBA Ortholog; Modulator Of DNA Gyrase Protein; PmbA/TldD Protein; Peptidase U; DNA Gyrase Modulator Peptidase U; Zn-Dependent Protease TLDE Protein; Protease PmbA; Protease; Zn-Dependent Protease PmbA-Like Protein; Modulator Of DNA Gyrase Family; Zinc Protease PmbA; Pmba/Tldd Protein; Regulatory Protease; Zn-Dependent Protease-Like Protein; Antibiotic/Peptide Maturation Related Protein

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSEIKRANAIELDTHSLRDKLSQLASRESIHQWDLGAACSTDSSVQIDRGEAKQMKAAQRSSITVRVWNNKGLVGITSTS
DLSEKGIEKALIGARQASDFGNADDVPAFSTLAKSPLPKLDRPLRPAQGIQRMLEVLKEAEADLLSRHPSIQSIPYNGLG
EATYERVYLNSDGALRQMKRSQASLYLFARAEESGRKPRSGGAIRLALGSHDLDVDGCIDEAAERTISHLDYQPIDTGCY
LVCFTPEAFLDLIGAFSSMFNARSVLDGVSLSQRDTLGKNIAVPFFSLHDNGLHPAHVGASSFDGEGTPTKKLCLINGGR
LENFLHSEATARAFGLPPTGHAGLGAKVSVGPDWFEVNKTEGQNSANTHLQHSKSKETFVLIEGLNALHAGVKASQGSFS
LPFNGWLVMKGEKVSIEAATVAGDIRTVLNSIVNMEAEQVITPGGVSPHVWVEGLSITGEA

Sequences:

>Translated_461_residues
MSEIKRANAIELDTHSLRDKLSQLASRESIHQWDLGAACSTDSSVQIDRGEAKQMKAAQRSSITVRVWNNKGLVGITSTS
DLSEKGIEKALIGARQASDFGNADDVPAFSTLAKSPLPKLDRPLRPAQGIQRMLEVLKEAEADLLSRHPSIQSIPYNGLG
EATYERVYLNSDGALRQMKRSQASLYLFARAEESGRKPRSGGAIRLALGSHDLDVDGCIDEAAERTISHLDYQPIDTGCY
LVCFTPEAFLDLIGAFSSMFNARSVLDGVSLSQRDTLGKNIAVPFFSLHDNGLHPAHVGASSFDGEGTPTKKLCLINGGR
LENFLHSEATARAFGLPPTGHAGLGAKVSVGPDWFEVNKTEGQNSANTHLQHSKSKETFVLIEGLNALHAGVKASQGSFS
LPFNGWLVMKGEKVSIEAATVAGDIRTVLNSIVNMEAEQVITPGGVSPHVWVEGLSITGEA
>Mature_460_residues
SEIKRANAIELDTHSLRDKLSQLASRESIHQWDLGAACSTDSSVQIDRGEAKQMKAAQRSSITVRVWNNKGLVGITSTSD
LSEKGIEKALIGARQASDFGNADDVPAFSTLAKSPLPKLDRPLRPAQGIQRMLEVLKEAEADLLSRHPSIQSIPYNGLGE
ATYERVYLNSDGALRQMKRSQASLYLFARAEESGRKPRSGGAIRLALGSHDLDVDGCIDEAAERTISHLDYQPIDTGCYL
VCFTPEAFLDLIGAFSSMFNARSVLDGVSLSQRDTLGKNIAVPFFSLHDNGLHPAHVGASSFDGEGTPTKKLCLINGGRL
ENFLHSEATARAFGLPPTGHAGLGAKVSVGPDWFEVNKTEGQNSANTHLQHSKSKETFVLIEGLNALHAGVKASQGSFSL
PFNGWLVMKGEKVSIEAATVAGDIRTVLNSIVNMEAEQVITPGGVSPHVWVEGLSITGEA

Specific function: May Facilitate The Secretion Of The Peptide Antibiotic Microcin B17 (Mccb17) By Completing Its Maturation. Suppresses The Inhibitory Activity Of The Carbon Storage Regulator (Csra). [C]

COG id: COG0312

COG function: function code R; Predicted Zn-dependent proteases and their inactivated homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790682, Length=409, Percent_Identity=23.960880195599, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 49511; Mature: 49380

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIKRANAIELDTHSLRDKLSQLASRESIHQWDLGAACSTDSSVQIDRGEAKQMKAAQR
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHH
SSITVRVWNNKGLVGITSTSDLSEKGIEKALIGARQASDFGNADDVPAFSTLAKSPLPKL
CCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCC
DRPLRPAQGIQRMLEVLKEAEADLLSRHPSIQSIPYNGLGEATYERVYLNSDGALRQMKR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHH
SQASLYLFARAEESGRKPRSGGAIRLALGSHDLDVDGCIDEAAERTISHLDYQPIDTGCY
CCCEEEEEEECHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
LVCFTPEAFLDLIGAFSSMFNARSVLDGVSLSQRDTLGKNIAVPFFSLHDNGLHPAHVGA
EEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEECEEEEECCCCCCHHHCCC
SSFDGEGTPTKKLCLINGGRLENFLHSEATARAFGLPPTGHAGLGAKVSVGPDWFEVNKT
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEECC
EGQNSANTHLQHSKSKETFVLIEGLNALHAGVKASQGSFSLPFNGWLVMKGEKVSIEAAT
CCCCCCCCCHHCCCCCCEEEEEECCHHHHCCCCCCCCCEECCCCCEEEEECCEEEEEEHH
VAGDIRTVLNSIVNMEAEQVITPGGVSPHVWVEGLSITGEA
HHHHHHHHHHHHHCCCHHHEECCCCCCCCEEEEEEEECCCC
>Mature Secondary Structure 
SEIKRANAIELDTHSLRDKLSQLASRESIHQWDLGAACSTDSSVQIDRGEAKQMKAAQR
CCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHH
SSITVRVWNNKGLVGITSTSDLSEKGIEKALIGARQASDFGNADDVPAFSTLAKSPLPKL
CCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCC
DRPLRPAQGIQRMLEVLKEAEADLLSRHPSIQSIPYNGLGEATYERVYLNSDGALRQMKR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHH
SQASLYLFARAEESGRKPRSGGAIRLALGSHDLDVDGCIDEAAERTISHLDYQPIDTGCY
CCCEEEEEEECHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
LVCFTPEAFLDLIGAFSSMFNARSVLDGVSLSQRDTLGKNIAVPFFSLHDNGLHPAHVGA
EEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEECEEEEECCCCCCHHHCCC
SSFDGEGTPTKKLCLINGGRLENFLHSEATARAFGLPPTGHAGLGAKVSVGPDWFEVNKT
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEECC
EGQNSANTHLQHSKSKETFVLIEGLNALHAGVKASQGSFSLPFNGWLVMKGEKVSIEAAT
CCCCCCCCCHHCCCCCCEEEEEECCHHHHCCCCCCCCCEECCCCCEEEEECCEEEEEEHH
VAGDIRTVLNSIVNMEAEQVITPGGVSPHVWVEGLSITGEA
HHHHHHHHHHHHHCCCHHHEECCCCCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA