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The map label for this gene is fmt

Identifier: 124023144

GI number: 124023144

Start: 1238444

End: 1239472

Strand: Reverse

Name: fmt

Synonym: P9303_14401

Alternate gene names: 124023144

Gene position: 1239472-1238444 (Counterclockwise)

Preceding gene: 124023145

Following gene: 124023143

Centisome position: 46.2

GC content: 48.49

Gene sequence:

>1029_bases
GTGCTGTTCTGGGGTACACCCAGCTATGCAGTGCCAACTCTGGATGCCCTAAATGATTCAGGCTATGAAATTGTAGGAGT
GGTGAGCCAGCCTGATCGTCGTCGTGGGCGTGGTAATCAGCAAATGGCCTCCCCCGTCAAACAACGAGCAATGGATCAGG
GGTTGCGTGTTTTCACCCCTGAACGGATTAGAGATGAGGGCAACGTTCAAGCAGAATTAAAATCACTAAAGGCTGATATT
TCTGTTGTAGTCGCCTTTGGGCAGCTTCTTCCTTCAACAGTTCTCAATCAACCTCCTCTCGGTTGCTGGAACGGTCACGC
TTCACTGCTACCCCGCTGGCGTGGAGCAGGACCTATTCAATGGAGTCTGCTAAGTGGTGACAGCGTGACAGGCGTTGGAA
TCATGGCTATGGAAGAGGGGCTTGATACCGGCCCCGTTTTAGCCAATCAGCGGGTTTCTATCGGCTTACTGGAAAATGCG
AATCAGCTGTCTAATCGTTTGAGCTCAATAACAGCAAAATTATTTTTAGAATCAATACCAAGAATTGCAGCAGCAGGCCC
TGGAGTCGAATCGGAACGTTGGAAACAATTGGAAGTCATCAAACAGGAAGAGATTGGAGGTGACCCGACATATGCCCGAA
TGCTGTCGAAAAAAGACCACATTCTTGATTGGAATCAATCTGCAATGGATTTGCATCGCAGGGTTATGGGCCTTTATCCA
AACGCATTCAGCAGCTGGAACAACAAGAGGCTAAAAGTGCAAGCCACTGAACCTCTTGATGAGGAATTGAAATCCAAGCT
TTCTGAAAGAGTAAGGCCACTGCTCGGACGCTGGCAAGATGGAGAACATGAACCAGGAAAGATCCTCGCTTGCGAATCCG
ATCTGGGCCTAGTCGTAAGTACAAAAACGTGCCCTTTACTCATTCGACAAGGCCAATTGGAAGGCAAAAGCAAGGCGCTT
GGAGAGGTGTTAATACAACAATTGCAAGCGACTGTTGGCCAGAATCTTGGGGTGGTGTGCAACATCTAA

Upstream 100 bases:

>100_bases
ATAGCATTGTGAATATGGAAGCTGAACAGGTGATCACACCTGGCGGGGTATCTCCTCATGTGTGGGTCGAAGGGTTATCA
ATTACTGGTGAAGCGTGAAG

Downstream 100 bases:

>100_bases
CTCAAGGGTCCCCATTTCCAGATGTACTCCTTTAGCGTGTTTGATCAATTGTCCTACATTCAAACCAAGACTTAACCAAT
CCTTATAGGGTCATGCTTAG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRVFTPERIRDEGNVQAELKSLKADI
SVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQWSLLSGDSVTGVGIMAMEEGLDTGPVLANQRVSIGLLENA
NQLSNRLSSITAKLFLESIPRIAAAGPGVESERWKQLEVIKQEEIGGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
NAFSSWNNKRLKVQATEPLDEELKSKLSERVRPLLGRWQDGEHEPGKILACESDLGLVVSTKTCPLLIRQGQLEGKSKAL
GEVLIQQLQATVGQNLGVVCNI

Sequences:

>Translated_342_residues
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRVFTPERIRDEGNVQAELKSLKADI
SVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQWSLLSGDSVTGVGIMAMEEGLDTGPVLANQRVSIGLLENA
NQLSNRLSSITAKLFLESIPRIAAAGPGVESERWKQLEVIKQEEIGGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
NAFSSWNNKRLKVQATEPLDEELKSKLSERVRPLLGRWQDGEHEPGKILACESDLGLVVSTKTCPLLIRQGQLEGKSKAL
GEVLIQQLQATVGQNLGVVCNI
>Mature_342_residues
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRVFTPERIRDEGNVQAELKSLKADI
SVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQWSLLSGDSVTGVGIMAMEEGLDTGPVLANQRVSIGLLENA
NQLSNRLSSITAKLFLESIPRIAAAGPGVESERWKQLEVIKQEEIGGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
NAFSSWNNKRLKVQATEPLDEELKSKLSERVRPLLGRWQDGEHEPGKILACESDLGLVVSTKTCPLLIRQGQLEGKSKAL
GEVLIQQLQATVGQNLGVVCNI

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=253, Percent_Identity=27.6679841897233, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI21614513, Length=225, Percent_Identity=30.2222222222222, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI164663775, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1789683, Length=256, Percent_Identity=41.015625, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1788589, Length=331, Percent_Identity=25.6797583081571, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI133930964, Length=262, Percent_Identity=24.8091603053435, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319458, Length=270, Percent_Identity=27.037037037037, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45550868, Length=241, Percent_Identity=29.8755186721992, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28571984, Length=163, Percent_Identity=34.3558282208589, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585660, Length=241, Percent_Identity=29.045643153527, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_PROM3 (A2C9M6)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017451.1
- ProteinModelPortal:   A2C9M6
- SMR:   A2C9M6
- STRING:   A2C9M6
- GeneID:   4778989
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_14401
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   WRGAGPI
- ProtClustDB:   CLSK825991
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 37529; Mature: 37529

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRVFTP
CCEECCCCCCCCCHHHCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCEEECH
ERIRDEGNVQAELKSLKADISVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCEE
WSLLSGDSVTGVGIMAMEEGLDTGPVLANQRVSIGLLENANQLSNRLSSITAKLFLESIP
EEEECCCCCCCEEEEEHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCC
RIAAAGPGVESERWKQLEVIKQEEIGGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
HHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
NAFSSWNNKRLKVQATEPLDEELKSKLSERVRPLLGRWQDGEHEPGKILACESDLGLVVS
CHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEE
TKTCPLLIRQGQLEGKSKALGEVLIQQLQATVGQNLGVVCNI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
>Mature Secondary Structure
MLFWGTPSYAVPTLDALNDSGYEIVGVVSQPDRRRGRGNQQMASPVKQRAMDQGLRVFTP
CCEECCCCCCCCCHHHCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCEEECH
ERIRDEGNVQAELKSLKADISVVVAFGQLLPSTVLNQPPLGCWNGHASLLPRWRGAGPIQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCEE
WSLLSGDSVTGVGIMAMEEGLDTGPVLANQRVSIGLLENANQLSNRLSSITAKLFLESIP
EEEECCCCCCCEEEEEHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCC
RIAAAGPGVESERWKQLEVIKQEEIGGDPTYARMLSKKDHILDWNQSAMDLHRRVMGLYP
HHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
NAFSSWNNKRLKVQATEPLDEELKSKLSERVRPLLGRWQDGEHEPGKILACESDLGLVVS
CHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEE
TKTCPLLIRQGQLEGKSKALGEVLIQQLQATVGQNLGVVCNI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA