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The map label for this gene is lysA [H]

Identifier: 124022700

GI number: 124022700

Start: 904953

End: 906320

Strand: Direct

Name: lysA [H]

Synonym: P9303_09931

Alternate gene names: 124022700

Gene position: 904953-906320 (Clockwise)

Preceding gene: 124022694

Following gene: 124022701

Centisome position: 33.73

GC content: 52.85

Gene sequence:

>1368_bases
ATGATTTCATCCAGCCCCTATGAGCCTGGGCGGGATCTCCTTAGCCCCAATTGCAACCTCGCGCCGATTACAACCGAACT
TGATGCGCAATCACGCTTGATCGTAGGAGGCTGTCAACTGAGCAAATTGGCTGAGTGCTATGGCACCCCTCTCTATGTGC
TTGATGAAGCCACTTTGAGGGCAGCTTGTCAGTCTTACCGTGGGGCATTACAGCGTCACTATCCAGGCCCATCTCTTCCT
ATCTATGCCTCTAAGGCCAATAGCTCATTGATGATGAGCAGCCTGGTGGCTTCAGAAGGTTTTGGGCTGGATGTGGTCTC
AGCAGGTGAGTTGCTTACCGCTTTGAAGGGAGGTGTGCCAGGCGATTGCATTGTGCTTCATGGCAACAACAAATCTGATC
AGGAGCTGCTGCTTGCCTATCGCAATGGCGTCACAATCGTTGCTGATAATCAGCATGATCTAGATCGCCTCTCACAACTG
GTGCCGGTTGGGGCAGATCCTGCAAACTTGATGTTGCGTTTCACTCCGGGCATCGAATGCCATACCCATGAGTACATCCG
CACCGGCCATCTTGATAGCAAGTTTGGTTTTGATCCAGATCAGCTTGAATCGGTTCTGAATCAGTTACTCGGCTGTCGGT
GGGCACGGTTAACCGGACTCCACGCTCATATTGGATCGCAGATCTTTGAATTGGAACCTCATCAGGATCTGGCAGATGTG
ATGGCTGGTGCTCTGCAACTGGCTAGGCGCCTGGGTCATCCAGTCATGGATCTCAACGTTGGAGGAGGCCTAGGTGTCAG
ATATGTCAGCTCTGATGATCCACCTTCAATTGACAACTGGGTCAAGGTGGTTGCCGAGGCAGTGAATCAAGCCTGTCGTT
CTCGCAATCTGGATTTGCCCCGGTTGATGTGTGAGCCGGGTCGCTCTCTGGTCGCTGCTGCCGGAGTCACCCTTTATCGG
GTTGGATCACGCAAGACCATCCCAGGGCTGCGCACCTATCTTTCTGTCGATGGAGGCATGAGTGACAACCCCCGCCCAAT
CACATATCAATCTCTCTATACGGCTTGCCTTGCTGACCGCCCTTTGGACTCGCCAGACGAGACGATCACTCTGGTTGGCA
AGCATTGTGAATCTGGGGATGTTCTGCTTAAGGACCTTGCCTTGCCATATGCCAGCAGTGGAGAAGTCTTGGTCGTGTTT
GCGACAGGGGCTTACAACGTCTCAATGAGTTCTAACTACAACCGCATCCCACGACCTGCAGCGGTACTTGTTCATTCAGG
CCACTCAGAGTTGGTGCAGAGGCGGGAGCAGCCAGAAGATCTTCTGCGATATGACGTTATGCCGGAACGATTTGTAGCGT
TAGGCTGA

Upstream 100 bases:

>100_bases
CTTCCATTGCTTGGATGTCGTGCTTCAACATGCCTAACCCCCTCCTTGGGGGGATTGATCCCTACATTGATCCCTCTAAC
TAATTTCCTCGTCCATCGCC

Downstream 100 bases:

>100_bases
GGGGGCAAGGCTGGGGAGTGGGAGTGAACTTGTGGGGGGTGGTAGATCCGCGCCTGCTCGATGTTTTGTTTGCTTCGGCC
CTTGGCGTCTTGCTTTTTTC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MISSSPYEPGRDLLSPNCNLAPITTELDAQSRLIVGGCQLSKLAECYGTPLYVLDEATLRAACQSYRGALQRHYPGPSLP
IYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVPGDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQL
VPVGADPANLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLPRLMCEPGRSLVAAAGVTLYR
VGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADRPLDSPDETITLVGKHCESGDVLLKDLALPYASSGEVLVVF
ATGAYNVSMSSNYNRIPRPAAVLVHSGHSELVQRREQPEDLLRYDVMPERFVALG

Sequences:

>Translated_455_residues
MISSSPYEPGRDLLSPNCNLAPITTELDAQSRLIVGGCQLSKLAECYGTPLYVLDEATLRAACQSYRGALQRHYPGPSLP
IYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVPGDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQL
VPVGADPANLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLPRLMCEPGRSLVAAAGVTLYR
VGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADRPLDSPDETITLVGKHCESGDVLLKDLALPYASSGEVLVVF
ATGAYNVSMSSNYNRIPRPAAVLVHSGHSELVQRREQPEDLLRYDVMPERFVALG
>Mature_455_residues
MISSSPYEPGRDLLSPNCNLAPITTELDAQSRLIVGGCQLSKLAECYGTPLYVLDEATLRAACQSYRGALQRHYPGPSLP
IYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVPGDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQL
VPVGADPANLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLPRLMCEPGRSLVAAAGVTLYR
VGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADRPLDSPDETITLVGKHCESGDVLLKDLALPYASSGEVLVVF
ATGAYNVSMSSNYNRIPRPAAVLVHSGHSELVQRREQPEDLLRYDVMPERFVALG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=416, Percent_Identity=30.0480769230769, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24586472, Length=412, Percent_Identity=23.5436893203883, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24586474, Length=356, Percent_Identity=25.2808988764045, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49229; Mature: 49229

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSSPYEPGRDLLSPNCNLAPITTELDAQSRLIVGGCQLSKLAECYGTPLYVLDEATLR
CCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCEEEECHHHHH
AACQSYRGALQRHYPGPSLPIYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVP
HHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCC
GDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQLVPVGADPANLMLRFTPGIEC
CCEEEEECCCCCCHHHEEEEECCEEEEECCCHHHHHHHHHCCCCCCHHHEEEEECCCCCC
HTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
CCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCHHHHHH
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLP
HHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RLMCEPGRSLVAAAGVTLYRVGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADR
HHHHCCCCHHHHHCCEEEEEECCCCCCCCHHHEEEECCCCCCCCCCEEHHHHHHHHHHCC
PLDSPDETITLVGKHCESGDVLLKDLALPYASSGEVLVVFATGAYNVSMSSNYNRIPRPA
CCCCCCCEEEEEECCCCCCCEEHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCE
AVLVHSGHSELVQRREQPEDLLRYDVMPERFVALG
EEEEECCHHHHHHHHCCHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MISSSPYEPGRDLLSPNCNLAPITTELDAQSRLIVGGCQLSKLAECYGTPLYVLDEATLR
CCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCEEEECHHHHH
AACQSYRGALQRHYPGPSLPIYASKANSSLMMSSLVASEGFGLDVVSAGELLTALKGGVP
HHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCC
GDCIVLHGNNKSDQELLLAYRNGVTIVADNQHDLDRLSQLVPVGADPANLMLRFTPGIEC
CCEEEEECCCCCCHHHEEEEECCEEEEECCCHHHHHHHHHCCCCCCHHHEEEEECCCCCC
HTHEYIRTGHLDSKFGFDPDQLESVLNQLLGCRWARLTGLHAHIGSQIFELEPHQDLADV
CCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCHHHHHH
MAGALQLARRLGHPVMDLNVGGGLGVRYVSSDDPPSIDNWVKVVAEAVNQACRSRNLDLP
HHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RLMCEPGRSLVAAAGVTLYRVGSRKTIPGLRTYLSVDGGMSDNPRPITYQSLYTACLADR
HHHHCCCCHHHHHCCEEEEEECCCCCCCCHHHEEEECCCCCCCCCCEEHHHHHHHHHHCC
PLDSPDETITLVGKHCESGDVLLKDLALPYASSGEVLVVFATGAYNVSMSSNYNRIPRPA
CCCCCCCEEEEEECCCCCCCEEHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCE
AVLVHSGHSELVQRREQPEDLLRYDVMPERFVALG
EEEEECCHHHHHHHHCCHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]