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The map label for this gene is prsA [H]

Identifier: 124022683

GI number: 124022683

Start: 887254

End: 888267

Strand: Reverse

Name: prsA [H]

Synonym: P9303_09761

Alternate gene names: 124022683

Gene position: 888267-887254 (Counterclockwise)

Preceding gene: 124022685

Following gene: 124022682

Centisome position: 33.11

GC content: 53.94

Gene sequence:

>1014_bases
TTGCTCGCTGTCGACGTGACGAGTTTTCTGACCGCAGCCCGTACCGAACAAGAGAGCATCAGCTATGACATGCAGCGTCT
GCGCTTGTTCAGCGGCACCTCAAATCCAGCTCTTGCAAGAGAGATTGCGGCCTACCTAGGTGTTCCCGATGGTCCAAGGA
TCTGCAAACGGTTCGCAGATGGTGAGCTCTATGTACAAATCCAGGAATCGATCCGAGGTTGTGACGTCTTCCTGATTCAG
CCCACCTGCGCGCCAGTGAACGACAATTTGATGGAGCTGCTGATCATGGTTGATGCCTGTCAGCGCGCCTCTGCCAGGCA
GATCACGGCTGTAGTTCCCTACTACGGCTATGCAAGAGCCGACCGCAAAACGGCTGGTCGCGAGTCAATCACTGCCAAGC
TCACCGCAAACCTGCTGGTGAAATCTGGCGTGAACAGGGTCCTCGCCATGGATCTGCATTCCGCCCAAATCCAGGGCTAC
TTTGACATCCCTTGCGATCACATCTACGGCTCACCAGTCCTGGTTGATTACCTCGCAGCACAAGAACTTAACGAAGTCGT
GGTGGTGTCTCCAGATGTGGGAGGAGTCGCACGAGCACGAGCCTTTGCGAAACAAATGAGGGATGCGCCACTGGCAATTA
TTGATAAGCGCCGATCAGGTCACAACGTTGCCGAAAGTCTCACAGTGATCGGCGATGTGGCAGGGAAAACAGCCATCCTG
ATCGACGACATGATCGACACTGGGGGAACCATTTGCTCAGGAGCTCGTCTGCTTCGACAAGAAGGGGCTAAACGGGTGAT
TGCCTGTGCCTCCCATGCCGTGTTTTCGCCCCCCGCCTGCGAACGATTATCCGAAGAAGGATTATTCGAACAAGTCTTGG
TTACCAACAGCATTCCCATCGCTGCGGAACGACGCTTCCCTCAATTACAGGTACTTTCAGTGGCCAATATGCTTGGCGAA
GCGATTTGGCGCATCCATGAGGAAAGCTCTGTGAGCTCAATGTTTAGAGGATAA

Upstream 100 bases:

>100_bases
CCAACCAGAAAAGGGATGGGAGCAATCATCAGGCGACCCTACATAGAGAAGAAGTTGAGATGAGAGCCTTTGCAGCACTA
GCATCGGAGTACAGCTGATA

Downstream 100 bases:

>100_bases
CGCTGAGATTAAGTCTAAAATGAAGTACTACGCGATTAAGCGCCTGTTCTTAGAGGCTCTTGTGAATAGTTTTAGGCACT
AAAATCCAAGCAAAATCAAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MLAVDVTSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFADGELYVQIQESIRGCDVFLIQ
PTCAPVNDNLMELLIMVDACQRASARQITAVVPYYGYARADRKTAGRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGY
FDIPCDHIYGSPVLVDYLAAQELNEVVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAIL
IDDMIDTGGTICSGARLLRQEGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPIAAERRFPQLQVLSVANMLGE
AIWRIHEESSVSSMFRG

Sequences:

>Translated_337_residues
MLAVDVTSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFADGELYVQIQESIRGCDVFLIQ
PTCAPVNDNLMELLIMVDACQRASARQITAVVPYYGYARADRKTAGRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGY
FDIPCDHIYGSPVLVDYLAAQELNEVVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAIL
IDDMIDTGGTICSGARLLRQEGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPIAAERRFPQLQVLSVANMLGE
AIWRIHEESSVSSMFRG
>Mature_337_residues
MLAVDVTSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFADGELYVQIQESIRGCDVFLIQ
PTCAPVNDNLMELLIMVDACQRASARQITAVVPYYGYARADRKTAGRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGY
FDIPCDHIYGSPVLVDYLAAQELNEVVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAIL
IDDMIDTGGTICSGARLLRQEGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPIAAERRFPQLQVLSVANMLGE
AIWRIHEESSVSSMFRG

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=42.5396825396825, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=42.2222222222222, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=41.9047619047619, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=42.1383647798742, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI4506133, Length=347, Percent_Identity=35.1585014409222, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194018537, Length=346, Percent_Identity=34.1040462427746, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=50.6369426751592, Blast_Score=327, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI17554702, Length=328, Percent_Identity=41.4634146341463, Blast_Score=253, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=42.2222222222222, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71989924, Length=328, Percent_Identity=41.4634146341463, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=42.5806451612903, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=30.1775147928994, Blast_Score=164, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=39.873417721519, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=41.3461538461538, Blast_Score=238, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=38.7301587301587, Blast_Score=226, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6322667, Length=199, Percent_Identity=40.2010050251256, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=96, Percent_Identity=39.5833333333333, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=43.1746031746032, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=40.8284023668639, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=30.6179775280899, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=30.6179775280899, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=30.6179775280899, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=30.6179775280899, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24651462, Length=183, Percent_Identity=36.6120218579235, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24651464, Length=183, Percent_Identity=36.6120218579235, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552010, Length=183, Percent_Identity=36.6120218579235, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36631; Mature: 36631

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAVDVTSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFAD
CEEEEHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCC
GELYVQIQESIRGCDVFLIQPTCAPVNDNLMELLIMVDACQRASARQITAVVPYYGYARA
CEEEEEEEHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHC
DRKTAGRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGYFDIPCDHIYGSPVLVDYLAA
CHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCEEECCCHHHHCCCHHHHHHHHH
QELNEVVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAIL
HCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEE
IDDMIDTGGTICSGARLLRQEGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPI
EEHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCC
AAERRFPQLQVLSVANMLGEAIWRIHEESSVSSMFRG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLAVDVTSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFAD
CEEEEHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCC
GELYVQIQESIRGCDVFLIQPTCAPVNDNLMELLIMVDACQRASARQITAVVPYYGYARA
CEEEEEEEHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHC
DRKTAGRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGYFDIPCDHIYGSPVLVDYLAA
CHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCEEECCCHHHHCCCHHHHHHHHH
QELNEVVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAIL
HCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEE
IDDMIDTGGTICSGARLLRQEGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPI
EEHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCC
AAERRFPQLQVLSVANMLGEAIWRIHEESSVSSMFRG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]