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The map label for this gene is folD

Identifier: 124022641

GI number: 124022641

Start: 845021

End: 845929

Strand: Direct

Name: folD

Synonym: P9303_09321

Alternate gene names: 124022641

Gene position: 845021-845929 (Clockwise)

Preceding gene: 124022639

Following gene: 124022642

Centisome position: 31.5

GC content: 55.56

Gene sequence:

>909_bases
ATGGCCCTTAGGCTTGATGGCAAACAACTGGCCGCAGAATTGGAGCAGCGTCTCCAAGCTGAAATTGCGGCTGGCTTGGT
GCAAGCGGGAAGGCCGCCAGGGTTAGCTGTGGTGCGTATCGGGGACGACCCCGCCAGTGGGGTGTATGTGGCCAACAAGC
AGAAAGCTTGTGGGCGTATCGGTATGGCTAGTTATCTGTCACATCTGCCTGCAAAGGTTCCTGCGGCAGAGGTGTTGGCC
ACGATTCAGTCTTTGAATCTTGATGAGCGAGTGGACGGCATTCTTTTGCAATTGCCTCTACCCAAGGGCCTTGATGAAGG
GCCTTTGCTTGCTGCGATTGATCCCGAGAAAGATGCCGATGGTCTGCATACACTCAACCTTGGCCGATTGTTGAAAGGTG
AGCCTGGGCCGCGTAGTTGTACACCTGGGGGTGTGATGGCCTTGTTGGCACGCCACCAGATTCCTTTGGCGGGAAAAAGG
GCTGTTGTGATTGGGCGCAGCATCCTGGTAGGCCAACCAATGGCATTGATGCTTCAGGCTGCAAATGCCACCGTGAGCGT
GGCCCATTCTCATACCGATGATCTGGCCTCGTTAACTCAGCAGGCTGATGTGTTGGTGGTAGCGGCCGGGCGAGCGCGGA
TGATTGGTTCAGAGCATGTCAAGCCAGGAGCAGTGGTTGTCGATGTTGGCATTCATCGCCTTCCCGCAGATCCTGAACTG
GGGCCGCAAGTTAAGGCCAGGTTGTGTGGAGATGTACGAGCGCAAGAAGTTGAACCTTTAGCAAGTGCATTGACCCCTGT
TCCTGGTGGTGTAGGTCCGATGACCGTGACCATGCTCTTGGTGAATACCGTGGCTAGATGGCAGCAGCATTGCGGTTTGC
CCTTCGGCCTGAGAGATTTGCTGGTTTGA

Upstream 100 bases:

>100_bases
GAGCCTGTTTAAGGTTGGAAGACGGACCACAGAAGCTGGCACTTGTCCTAAACGCTAGCTCTCTTCTGCGTGCATGCTTG
GGGAAGCATCGGATCGGTGA

Downstream 100 bases:

>100_bases
GACTGGTTGGCCTGAGAGAATCCCATGAACGAGACAAGGTTCATGGCGGCGGCGGTCAGCACCTTCTTCGATTTCCCCGC
CTATTTGGCTGCGGCCAAAG

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MALRLDGKQLAAELEQRLQAEIAAGLVQAGRPPGLAVVRIGDDPASGVYVANKQKACGRIGMASYLSHLPAKVPAAEVLA
TIQSLNLDERVDGILLQLPLPKGLDEGPLLAAIDPEKDADGLHTLNLGRLLKGEPGPRSCTPGGVMALLARHQIPLAGKR
AVVIGRSILVGQPMALMLQAANATVSVAHSHTDDLASLTQQADVLVVAAGRARMIGSEHVKPGAVVVDVGIHRLPADPEL
GPQVKARLCGDVRAQEVEPLASALTPVPGGVGPMTVTMLLVNTVARWQQHCGLPFGLRDLLV

Sequences:

>Translated_302_residues
MALRLDGKQLAAELEQRLQAEIAAGLVQAGRPPGLAVVRIGDDPASGVYVANKQKACGRIGMASYLSHLPAKVPAAEVLA
TIQSLNLDERVDGILLQLPLPKGLDEGPLLAAIDPEKDADGLHTLNLGRLLKGEPGPRSCTPGGVMALLARHQIPLAGKR
AVVIGRSILVGQPMALMLQAANATVSVAHSHTDDLASLTQQADVLVVAAGRARMIGSEHVKPGAVVVDVGIHRLPADPEL
GPQVKARLCGDVRAQEVEPLASALTPVPGGVGPMTVTMLLVNTVARWQQHCGLPFGLRDLLV
>Mature_301_residues
ALRLDGKQLAAELEQRLQAEIAAGLVQAGRPPGLAVVRIGDDPASGVYVANKQKACGRIGMASYLSHLPAKVPAAEVLAT
IQSLNLDERVDGILLQLPLPKGLDEGPLLAAIDPEKDADGLHTLNLGRLLKGEPGPRSCTPGGVMALLARHQIPLAGKRA
VVIGRSILVGQPMALMLQAANATVSVAHSHTDDLASLTQQADVLVVAAGRARMIGSEHVKPGAVVVDVGIHRLPADPELG
PQVKARLCGDVRAQEVEPLASALTPVPGGVGPMTVTMLLVNTVARWQQHCGLPFGLRDLLV

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=293, Percent_Identity=40.9556313993174, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI222136639, Length=285, Percent_Identity=40.7017543859649, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI94721354, Length=293, Percent_Identity=39.2491467576792, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI36796743, Length=209, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786741, Length=284, Percent_Identity=45.7746478873239, Blast_Score=234, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17568735, Length=260, Percent_Identity=38.8461538461538, Blast_Score=167, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319558, Length=283, Percent_Identity=41.696113074205, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6321643, Length=293, Percent_Identity=39.5904436860068, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17136816, Length=301, Percent_Identity=43.5215946843854, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17136818, Length=301, Percent_Identity=43.5215946843854, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI62472483, Length=284, Percent_Identity=44.0140845070423, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI45551871, Length=284, Percent_Identity=44.0140845070423, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24645718, Length=284, Percent_Identity=44.0140845070423, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI17137370, Length=284, Percent_Identity=44.0140845070423, Blast_Score=208, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_PROM3 (A2C873)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016948.1
- ProteinModelPortal:   A2C873
- SMR:   A2C873
- STRING:   A2C873
- GeneID:   4778825
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_09321
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   DVVYETA
- ProtClustDB:   PRK14186
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 31453; Mature: 31322

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRLDGKQLAAELEQRLQAEIAAGLVQAGRPPGLAVVRIGDDPASGVYVANKQKACGRI
CEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCHHHHHHC
GMASYLSHLPAKVPAAEVLATIQSLNLDERVDGILLQLPLPKGLDEGPLLAAIDPEKDAD
CHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHCCEEEEECCCCCCCCCCEEEEECCCCCCC
GLHTLNLGRLLKGEPGPRSCTPGGVMALLARHQIPLAGKRAVVIGRSILVGQPMALMLQA
CCEEECHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECHHHHCCCHHHHEEC
ANATVSVAHSHTDDLASLTQQADVLVVAAGRARMIGSEHVKPGAVVVDVGIHRLPADPEL
CCCEEEEECCCHHHHHHHHHHCCEEEEECCCHHHCCCCCCCCCEEEEECCCCCCCCCCCC
GPQVKARLCGDVRAQEVEPLASALTPVPGGVGPMTVTMLLVNTVARWQQHCGLPFGLRDL
CHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LV
CC
>Mature Secondary Structure 
ALRLDGKQLAAELEQRLQAEIAAGLVQAGRPPGLAVVRIGDDPASGVYVANKQKACGRI
EEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCHHHHHHC
GMASYLSHLPAKVPAAEVLATIQSLNLDERVDGILLQLPLPKGLDEGPLLAAIDPEKDAD
CHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHCCEEEEECCCCCCCCCCEEEEECCCCCCC
GLHTLNLGRLLKGEPGPRSCTPGGVMALLARHQIPLAGKRAVVIGRSILVGQPMALMLQA
CCEEECHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECHHHHCCCHHHHEEC
ANATVSVAHSHTDDLASLTQQADVLVVAAGRARMIGSEHVKPGAVVVDVGIHRLPADPEL
CCCEEEEECCCHHHHHHHHHHCCEEEEECCCHHHCCCCCCCCCEEEEECCCCCCCCCCCC
GPQVKARLCGDVRAQEVEPLASALTPVPGGVGPMTVTMLLVNTVARWQQHCGLPFGLRDL
CHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA