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The map label for this gene is guaB [C]

Identifier: 124022622

GI number: 124022622

Start: 826990

End: 828156

Strand: Reverse

Name: guaB [C]

Synonym: P9303_09131

Alternate gene names: 124022622

Gene position: 828156-826990 (Counterclockwise)

Preceding gene: 124022623

Following gene: 124022621

Centisome position: 30.87

GC content: 56.98

Gene sequence:

>1167_bases
GTGGTGAACATTCAGCTCGGACGCACCAAGGTCGTTCGCCGGGCCTATGGCATCGACGAAACCGCCCTTGTTCCGGGTGG
ACGAACCGTAGACCCGGAGATCACTGACACCTGCTGGAACCTCGCAGGCATCGAACGTGAGATACCGATCATTGCGAGCG
CTATGGATAGCGTTGTCAATGTCGATATGGCTGTTGCCCTATCTCGCCTTGGAGCCCTCGGCGTAATCAATCTGGAAGGA
GTCCAAACCCGCTACAAAGACCCCAACCCAGTACTGGATCGGATCTCTGCAATCGGAAAGGACGCCTTCGTGCCACTGAT
GCAGGAGATCTACAGCAAACCTGTACAAGAAGACCTGATCTATCAACGCATTAAAGAGATCAAAAATCAGGGGGGCATTG
CTGCTGTGAGTGGCACACCCGTTGCAGCAATGCGCTTTAGCAAAACCATTGCAGAAGCGGGTGCTGACCTCTTCTTTGTG
CAGGCGACAGTGGTCTCAACCGAACACATTGGTCCTGAAGGTCAACAAACTCTCGACCTAGAGGCCCTTTGTCAAGGCAT
GGGGGTCCCTGTGGTGATGGGTAATTGCGTCACCTACGAGGTTGCTCTGCAACTCATGCGTGCAGGTGCCGCAGGGGTGA
TGGTTGGCATCGGCCCTGGTGCTGCCTGCACCTCCCGTGGGGTTCTTGGCGTGGGCATCCCCCAAGCCACCGCCGTAGCA
GACTGCGCTGCCGCCCGTGAGGACTACGAGCGAGAGAGTGGTCGCTACGTTCCGATCGTCGCAGATGGCGGCATCATCAC
AGGAGGCGACATCTGTAAATGCATTGCCTGCGGTGCCGATGCGGTCATGATCGGCTCTCCGATCGCCCGAGCAGTGGAGG
CCCCTGGTCGTGGCTTCCACTGGGGCATGGCCACTCCCAGTCCAGTACTGCCAAGGGGCACAAGAATCAAGGTGGGCAGC
ACAGGCAGCCTGGAACGCATCCTTAGAGGGCCTGCTCTGCTAGACGATGGCACCCATAACCTTCTAGGAGCTCTAAAAAC
ATCCATGGGCACTCTTGGGGCCCGTACGATCAAAGAGATGCAACAGGTTGAAGTCGTCATCGCCCCATCTCTGCTGACCG
AAGGGAAGGTTTATCAGAAAGCCCAGCAACTAGGTATGGGCAAGTAA

Upstream 100 bases:

>100_bases
CCGTGGAACCACTGACAACAAGCCCTAGCTAAAGCTCCTTTCCCTCAAGGCAAAATTTGAATCACCCCAGTTGGTAACTT
GGCGTGACTTTATTTGGTCT

Downstream 100 bases:

>100_bases
ACATTCCGATCGCAGACGAAAACCAATTGGATCCGAGAGAGGCCATGGCTAGTATGTATTGGTGAGGGCTACGGCCCACA
CACTCCTCACACACACCGGC

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MVNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVNVDMAVALSRLGALGVINLEG
VQTRYKDPNPVLDRISAIGKDAFVPLMQEIYSKPVQEDLIYQRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFV
QATVVSTEHIGPEGQQTLDLEALCQGMGVPVVMGNCVTYEVALQLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVA
DCAAAREDYERESGRYVPIVADGGIITGGDICKCIACGADAVMIGSPIARAVEAPGRGFHWGMATPSPVLPRGTRIKVGS
TGSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK

Sequences:

>Translated_388_residues
MVNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVNVDMAVALSRLGALGVINLEG
VQTRYKDPNPVLDRISAIGKDAFVPLMQEIYSKPVQEDLIYQRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFV
QATVVSTEHIGPEGQQTLDLEALCQGMGVPVVMGNCVTYEVALQLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVA
DCAAAREDYERESGRYVPIVADGGIITGGDICKCIACGADAVMIGSPIARAVEAPGRGFHWGMATPSPVLPRGTRIKVGS
TGSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK
>Mature_388_residues
MVNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVNVDMAVALSRLGALGVINLEG
VQTRYKDPNPVLDRISAIGKDAFVPLMQEIYSKPVQEDLIYQRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFV
QATVVSTEHIGPEGQQTLDLEALCQGMGVPVVMGNCVTYEVALQLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVA
DCAAAREDYERESGRYVPIVADGGIITGGDICKCIACGADAVMIGSPIARAVEAPGRGFHWGMATPSPVLPRGTRIKVGS
TGSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. [C

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI217035150, Length=111, Percent_Identity=45.045045045045, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI217035148, Length=142, Percent_Identity=39.4366197183099, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI217035152, Length=109, Percent_Identity=45.8715596330275, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI217035146, Length=111, Percent_Identity=45.045045045045, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI34328930, Length=109, Percent_Identity=45.8715596330275, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI34328928, Length=109, Percent_Identity=45.8715596330275, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI156616279, Length=109, Percent_Identity=45.8715596330275, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI66933016, Length=112, Percent_Identity=43.75, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI50541954, Length=197, Percent_Identity=29.4416243654822, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI50541952, Length=197, Percent_Identity=29.4416243654822, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI50541948, Length=197, Percent_Identity=29.4416243654822, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI50541956, Length=197, Percent_Identity=29.4416243654822, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI156104880, Length=197, Percent_Identity=29.4416243654822, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786293, Length=334, Percent_Identity=28.1437125748503, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788855, Length=236, Percent_Identity=33.4745762711864, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994385, Length=184, Percent_Identity=35.8695652173913, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994389, Length=184, Percent_Identity=35.8695652173913, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560440, Length=192, Percent_Identity=32.2916666666667, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322012, Length=113, Percent_Identity=38.9380530973451, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323464, Length=112, Percent_Identity=35.7142857142857, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323585, Length=112, Percent_Identity=36.6071428571429, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641071, Length=168, Percent_Identity=39.2857142857143, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24641073, Length=168, Percent_Identity=39.2857142857143, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571163, Length=170, Percent_Identity=38.8235294117647, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40623; Mature: 40623

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVN
CEEEECCHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VDMAVALSRLGALGVINLEGVQTRYKDPNPVLDRISAIGKDAFVPLMQEIYSKPVQEDLI
HHHHHHHHHHCCCEEEEECCCHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHH
YQRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFVQATVVSTEHIGPEGQQTLDL
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEEEHHCCCCCCCCEECH
EALCQGMGVPVVMGNCVTYEVALQLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVA
HHHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHH
DCAAAREDYERESGRYVPIVADGGIITGGDICKCIACGADAVMIGSPIARAVEAPGRGFH
HHHHHHHHHHHCCCCEEEEEECCCEEECHHHHHHHHCCCCEEEECCHHHHHHCCCCCCEE
WGMATPSPVLPRGTRIKVGSTGSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEM
CCCCCCCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QQVEVVIAPSLLTEGKVYQKAQQLGMGK
HHHEEEEECHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MVNIQLGRTKVVRRAYGIDETALVPGGRTVDPEITDTCWNLAGIEREIPIIASAMDSVVN
CEEEECCHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VDMAVALSRLGALGVINLEGVQTRYKDPNPVLDRISAIGKDAFVPLMQEIYSKPVQEDLI
HHHHHHHHHHCCCEEEEECCCHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHH
YQRIKEIKNQGGIAAVSGTPVAAMRFSKTIAEAGADLFFVQATVVSTEHIGPEGQQTLDL
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEEEHHCCCCCCCCEECH
EALCQGMGVPVVMGNCVTYEVALQLMRAGAAGVMVGIGPGAACTSRGVLGVGIPQATAVA
HHHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHH
DCAAAREDYERESGRYVPIVADGGIITGGDICKCIACGADAVMIGSPIARAVEAPGRGFH
HHHHHHHHHHHCCCCEEEEEECCCEEECHHHHHHHHCCCCEEEECCHHHHHHCCCCCCEE
WGMATPSPVLPRGTRIKVGSTGSLERILRGPALLDDGTHNLLGALKTSMGTLGARTIKEM
CCCCCCCCCCCCCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QQVEVVIAPSLLTEGKVYQKAQQLGMGK
HHHEEEEECHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA