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The map label for this gene is trxA [H]

Identifier: 124022621

GI number: 124022621

Start: 826442

End: 826765

Strand: Reverse

Name: trxA [H]

Synonym: P9303_09121

Alternate gene names: 124022621

Gene position: 826765-826442 (Counterclockwise)

Preceding gene: 124022622

Following gene: 124022620

Centisome position: 30.82

GC content: 53.09

Gene sequence:

>324_bases
ATGTCCAATGCCGCCGCAGTTACCGACGCCTCCTTCGAGCAGGACGTCCTTCAAAGCGACGTGCCTGTGCTAGTTGATTT
CTGGGCGCCTTGGTGTGGCCCATGTCGCATGGTTGCTCCGATCGTCGATGAGATTGCCAAGGAATTCGAGAGCAAGATCA
AAGTCTTCAAGCTCAACACTGACGAAAACCCCAACGTCGCCAGCCAATACGGTATTCGCAGTATCCCCACCCTGATGGTG
TTCAAGGGAGGTCAAAAAGTCGACACAGTTGTTGGTGCAGTGCCCAAAGCCACGCTTTCTGGAACCATTTCAAAGTACCT
CTGA

Upstream 100 bases:

>100_bases
TCTGTGCAAGAGACCGTCACAGTTCCTACCTTTGCAGGCTCTTAAGCCTGAATAAAATACAAACGATTGCTAAATTTCCG
CAAAATCAACGACCTAAGGA

Downstream 100 bases:

>100_bases
AGCTTGATCCAACTTCGATTCCAGCCCTCCTAGATCACCATTGGCCTGATTCAATGCCACACATGGCTAAAAGGCCAGAT
TGCTGAGGGTTTCTTTGAAC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSNAAAVTDASFEQDVLQSDVPVLVDFWAPWCGPCRMVAPIVDEIAKEFESKIKVFKLNTDENPNVASQYGIRSIPTLMV
FKGGQKVDTVVGAVPKATLSGTISKYL

Sequences:

>Translated_107_residues
MSNAAAVTDASFEQDVLQSDVPVLVDFWAPWCGPCRMVAPIVDEIAKEFESKIKVFKLNTDENPNVASQYGIRSIPTLMV
FKGGQKVDTVVGAVPKATLSGTISKYL
>Mature_106_residues
SNAAAVTDASFEQDVLQSDVPVLVDFWAPWCGPCRMVAPIVDEIAKEFESKIKVFKLNTDENPNVASQYGIRSIPTLMVF
KGGQKVDTVVGAVPKATLSGTISKYL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=31.25, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI5031973, Length=83, Percent_Identity=36.144578313253, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI50592994, Length=88, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=9e-12,
Organism=Homo sapiens, GI42794771, Length=85, Percent_Identity=34.1176470588235, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI224493972, Length=85, Percent_Identity=34.1176470588235, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI38505222, Length=78, Percent_Identity=38.4615384615385, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=93, Percent_Identity=58.0645161290323, Blast_Score=124, Evalue=2e-30,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=50, Blast_Score=110, Evalue=2e-26,
Organism=Escherichia coli, GI87081747, Length=108, Percent_Identity=29.6296296296296, Blast_Score=68, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=111, Percent_Identity=35.1351351351351, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=43.0555555555556, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=84, Percent_Identity=38.0952380952381, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=43.0555555555556, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=72, Percent_Identity=40.2777777777778, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=43.0555555555556, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=37.3333333333333, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=86, Percent_Identity=39.5348837209302, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=35.8974358974359, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=84, Percent_Identity=36.9047619047619, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=95, Percent_Identity=30.5263157894737, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=81, Percent_Identity=38.2716049382716, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=40.9090909090909, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=40, Blast_Score=77, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=100, Percent_Identity=26, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=40, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=38.8235294117647, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=40.5405405405405, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=40.5405405405405, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664269, Length=82, Percent_Identity=37.8048780487805, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921434, Length=83, Percent_Identity=33.7349397590361, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=29.0322580645161, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11592; Mature: 11461

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAAAVTDASFEQDVLQSDVPVLVDFWAPWCGPCRMVAPIVDEIAKEFESKIKVFKLNT
CCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEECC
DENPNVASQYGIRSIPTLMVFKGGQKVDTVVGAVPKATLSGTISKYL
CCCCCHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SNAAAVTDASFEQDVLQSDVPVLVDFWAPWCGPCRMVAPIVDEIAKEFESKIKVFKLNT
CCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEECC
DENPNVASQYGIRSIPTLMVFKGGQKVDTVVGAVPKATLSGTISKYL
CCCCCHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]