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The map label for this gene is dnaA [H]

Identifier: 124022539

GI number: 124022539

Start: 755354

End: 756745

Strand: Direct

Name: dnaA [H]

Synonym: P9303_08301

Alternate gene names: 124022539

Gene position: 755354-756745 (Clockwise)

Preceding gene: 124022534

Following gene: 124022540

Centisome position: 28.16

GC content: 51.87

Gene sequence:

>1392_bases
GTGGTGCTAACGGGCAATGAGCTGTGGTCCAAGGTGCAGCAGGCCCTTCAGCACAATCTCAGCAAACCTACCTTTGAGAC
ATGGATTCGTCCTGCCATTTGCAGTGGTTTTCGGGACGGGGAGTTGACTCTGATTGCTCCAAATAGCTTTGCAAGTAACT
GGCTTCGCAAGAATTACGTTCAAACAATCGAGGCGGCTGCGGCGAAGATTTACGGCCAGCCAGTGAGGGTGTCTGTTCAG
GCGCAGGAGGAAGACTCTGCTGAGAGGGTGTTGCCACCAATGGCATCGGCGCCCGTACCTTTGCCTGCTGCAGAAGCAAC
CACTGCTTCTGCAGCCCCTTCTAGTGGTCCGCGACGGATTCTTCCAGGCCTGAACCTGCGCTATGTCTTCAATCGGTTCG
TCGTGGGGCCGAACAGTCGCATGGCCCATGCTGCTGCGCTAGCCGTTGCAGAAGCTCCTGGACGAGAGTTCAATCCTTTA
TTCATTTGCGGCGGTGTTGGCCTGGGCAAGACTCATCTGATGCAGGCCATTGGTCACTACAGGCTTGAGATCAATCCCGA
AGCAAAGGTGGCTTATGTTTCTACAGAGACCTTCACAAATGACTTAATTCAAGCTATTCGGAAGGATGGTATGCAAGCTT
TCCGAGATCGATATCGGGCCACTGATTTGATTTTGGTTGATGATATTCAGTTTATTGAAGGCAAGGAATACACCCAGGAA
GAGTTCTTTCATACCTTTAATGCTCTCCATGAAGCAGGTAGGCAGATTGTGATCGCTAGTGATAGACCTCCAAGTCAGAT
TCCAAAGCTTCAAGAACGCCTAATCTCTCGATTCTCTATGGGCTTGATCGCTGATATTCAGTCGCCTGACCTTGAGACTC
GCATGGCAATTTTGCAGAAGAAGGCGGAACAGGAACGCATGATGCTGCCTCGCGATTTAATTCAGTACATCGCTGGTCGC
TTCACATCCAATATCCGTGAACTTGAGGGGGCTCTTACCAGGGCAGTTGCCTTCGCTTCGATCACGGGGCTGCCTATGAC
AGTTGAATCGGTGGCACCAATGCTTGACCCTAATGGTCAAGGTGTGGACGTTACCCCACAACAAGTGATTGATAAGGTCT
CTGAGGTTTTTGACGTGACTCCTCAAGACATGCGTAGCAGCAGTCGTAGGCGGGCCGTTAGCCATGCTCGGCAGGTGGGC
ATGTATCTGATGCGTCAGGGCACGGATTTGAGCTTGCCTCGTATCGGTGAAACTTTTGGGGGAAAGGACCACACCACAGT
GATGTATGCCATCGAGCAAGTGGAGAAAAGGTTGTCCAGTGATCCTCAGTTGGCTAGTCAGGTTCGGCGTGTGAGGGATC
TGCTGCAGATCGATTCACGCCGTCGGCGATAG

Upstream 100 bases:

>100_bases
TGACAAACGCAGGTGCCAGGGAACGTGAACATCAGGGTCTTATTAAAGACTGCTTGCTCGATAGAAGTTGCGTAGATTCA
GCCATCGCAGGGGAAAGGAT

Downstream 100 bases:

>100_bases
GTTTCAACAATTTGATCATTTGACAAGATCAGATGAGGTGTATGAGATTTTGTTTGCATCAACATCAGCCTTTCAATGCC
TTCCCTTCAAAGCGTTCCAG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MVLTGNELWSKVQQALQHNLSKPTFETWIRPAICSGFRDGELTLIAPNSFASNWLRKNYVQTIEAAAAKIYGQPVRVSVQ
AQEEDSAERVLPPMASAPVPLPAAEATTASAAPSSGPRRILPGLNLRYVFNRFVVGPNSRMAHAAALAVAEAPGREFNPL
FICGGVGLGKTHLMQAIGHYRLEINPEAKVAYVSTETFTNDLIQAIRKDGMQAFRDRYRATDLILVDDIQFIEGKEYTQE
EFFHTFNALHEAGRQIVIASDRPPSQIPKLQERLISRFSMGLIADIQSPDLETRMAILQKKAEQERMMLPRDLIQYIAGR
FTSNIRELEGALTRAVAFASITGLPMTVESVAPMLDPNGQGVDVTPQQVIDKVSEVFDVTPQDMRSSSRRRAVSHARQVG
MYLMRQGTDLSLPRIGETFGGKDHTTVMYAIEQVEKRLSSDPQLASQVRRVRDLLQIDSRRRR

Sequences:

>Translated_463_residues
MVLTGNELWSKVQQALQHNLSKPTFETWIRPAICSGFRDGELTLIAPNSFASNWLRKNYVQTIEAAAAKIYGQPVRVSVQ
AQEEDSAERVLPPMASAPVPLPAAEATTASAAPSSGPRRILPGLNLRYVFNRFVVGPNSRMAHAAALAVAEAPGREFNPL
FICGGVGLGKTHLMQAIGHYRLEINPEAKVAYVSTETFTNDLIQAIRKDGMQAFRDRYRATDLILVDDIQFIEGKEYTQE
EFFHTFNALHEAGRQIVIASDRPPSQIPKLQERLISRFSMGLIADIQSPDLETRMAILQKKAEQERMMLPRDLIQYIAGR
FTSNIRELEGALTRAVAFASITGLPMTVESVAPMLDPNGQGVDVTPQQVIDKVSEVFDVTPQDMRSSSRRRAVSHARQVG
MYLMRQGTDLSLPRIGETFGGKDHTTVMYAIEQVEKRLSSDPQLASQVRRVRDLLQIDSRRRR
>Mature_463_residues
MVLTGNELWSKVQQALQHNLSKPTFETWIRPAICSGFRDGELTLIAPNSFASNWLRKNYVQTIEAAAAKIYGQPVRVSVQ
AQEEDSAERVLPPMASAPVPLPAAEATTASAAPSSGPRRILPGLNLRYVFNRFVVGPNSRMAHAAALAVAEAPGREFNPL
FICGGVGLGKTHLMQAIGHYRLEINPEAKVAYVSTETFTNDLIQAIRKDGMQAFRDRYRATDLILVDDIQFIEGKEYTQE
EFFHTFNALHEAGRQIVIASDRPPSQIPKLQERLISRFSMGLIADIQSPDLETRMAILQKKAEQERMMLPRDLIQYIAGR
FTSNIRELEGALTRAVAFASITGLPMTVESVAPMLDPNGQGVDVTPQQVIDKVSEVFDVTPQDMRSSSRRRAVSHARQVG
MYLMRQGTDLSLPRIGETFGGKDHTTVMYAIEQVEKRLSSDPQLASQVRRVRDLLQIDSRRRR

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=455, Percent_Identity=38.021978021978, Blast_Score=312, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 51612; Mature: 51612

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLTGNELWSKVQQALQHNLSKPTFETWIRPAICSGFRDGELTLIAPNSFASNWLRKNYV
CEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHH
QTIEAAAAKIYGQPVRVSVQAQEEDSAERVLPPMASAPVPLPAAEATTASAAPSSGPRRI
HHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LPGLNLRYVFNRFVVGPNSRMAHAAALAVAEAPGREFNPLFICGGVGLGKTHLMQAIGHY
CCCCCHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCE
RLEINPEAKVAYVSTETFTNDLIQAIRKDGMQAFRDRYRATDLILVDDIQFIEGKEYTQE
EEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHCCCCHHHH
EFFHTFNALHEAGRQIVIASDRPPSQIPKLQERLISRFSMGLIADIQSPDLETRMAILQK
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHH
KAEQERMMLPRDLIQYIAGRFTSNIRELEGALTRAVAFASITGLPMTVESVAPMLDPNGQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCC
GVDVTPQQVIDKVSEVFDVTPQDMRSSSRRRAVSHARQVGMYLMRQGTDLSLPRIGETFG
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCC
GKDHTTVMYAIEQVEKRLSSDPQLASQVRRVRDLLQIDSRRRR
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVLTGNELWSKVQQALQHNLSKPTFETWIRPAICSGFRDGELTLIAPNSFASNWLRKNYV
CEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHH
QTIEAAAAKIYGQPVRVSVQAQEEDSAERVLPPMASAPVPLPAAEATTASAAPSSGPRRI
HHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LPGLNLRYVFNRFVVGPNSRMAHAAALAVAEAPGREFNPLFICGGVGLGKTHLMQAIGHY
CCCCCHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCE
RLEINPEAKVAYVSTETFTNDLIQAIRKDGMQAFRDRYRATDLILVDDIQFIEGKEYTQE
EEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHCCCCHHHH
EFFHTFNALHEAGRQIVIASDRPPSQIPKLQERLISRFSMGLIADIQSPDLETRMAILQK
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHH
KAEQERMMLPRDLIQYIAGRFTSNIRELEGALTRAVAFASITGLPMTVESVAPMLDPNGQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCC
GVDVTPQQVIDKVSEVFDVTPQDMRSSSRRRAVSHARQVGMYLMRQGTDLSLPRIGETFG
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCC
GKDHTTVMYAIEQVEKRLSSDPQLASQVRRVRDLLQIDSRRRR
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]