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The map label for this gene is folE [H]

Identifier: 124022493

GI number: 124022493

Start: 719615

End: 720388

Strand: Direct

Name: folE [H]

Synonym: P9303_07841

Alternate gene names: 124022493

Gene position: 719615-720388 (Clockwise)

Preceding gene: 124022492

Following gene: 124022494

Centisome position: 26.82

GC content: 44.06

Gene sequence:

>774_bases
ATGACTTCCATAATCCCAGCATCATCTAAAGACCTAGGTCAGCATCGCAATCGCAATGGCTTGCCTGGGAATGGTCAGCC
AAAAAATGAAAATAAGATCTCTGAACGTATACGTGCCCGCCTTGTTGCAGAAGATGTTTCCTTCCTCGCCAACGACAATA
TTGCAGAACACATTCAACCTGGAGAGCTGAAGGAACTTGAAGTAGAAGTTGCCGATCGCGTGCGAGAACTGCTCCAAAGC
CTAGTGATTGATATTGATAATGACCACAACACACAAGAGACTGCCGAGCGGGTTGCTCGCATGTATTTAAATGAAGTATT
TAAAGGTCGATTCTATGAGCAGCCAGATGTTACTAGCTTTCCAAATACAAAAGATTTAGATGAAATTTATACTGTTGGCC
CCATAACTGTTCGTTCTGCTTGCTCTCATCATTTGGTTCCTATCCTTGGTAACTGTTGGATTGGCATTAAGCCTGGCAGC
CGTGTAATTGGGCTCTCAAAGTTTGCGAGAGTGGCTGACTGGGTCTTTTCAAGGCCACATATCCAGGAAGAAGCTGTAAT
GATTCTTGCTGATGAAATAGAGCGTTTATGTGAGCCTAAGGGTTTAGGGATAATAGTAAAAGCACAACATTATTGTATGA
AATGGCGAGGAGTGAAAGAGCCAAATACCAGCATGGTGAACTCAGTTGTCAGAGGAGTTTTTCGTCATGACCCTAGCCTT
AAGCAGGAATTTTTCGAGCTTGTTCGCCAGCAGGAGTCCACGCTAGGAGCTTAA

Upstream 100 bases:

>100_bases
GCGGCCGCCGCCCTTCTACACTTGGCTCAGCAGCCACCATCACAGGTGATTGAAGATCTCACTCTAATGCCAGCCACTGG
CGCCTTTTAACCAGCCTTTA

Downstream 100 bases:

>100_bases
AAGTTCTTTCTAGGTCTTTTAGAGGTATAAGGCTTAATAATGGCCAGCTCTGATTAACATGTGTGTATCAGCTTGGCTTG
TTACTGGCCAAGTCGATAAA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTSIIPASSKDLGQHRNRNGLPGNGQPKNENKISERIRARLVAEDVSFLANDNIAEHIQPGELKELEVEVADRVRELLQS
LVIDIDNDHNTQETAERVARMYLNEVFKGRFYEQPDVTSFPNTKDLDEIYTVGPITVRSACSHHLVPILGNCWIGIKPGS
RVIGLSKFARVADWVFSRPHIQEEAVMILADEIERLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMVNSVVRGVFRHDPSL
KQEFFELVRQQESTLGA

Sequences:

>Translated_257_residues
MTSIIPASSKDLGQHRNRNGLPGNGQPKNENKISERIRARLVAEDVSFLANDNIAEHIQPGELKELEVEVADRVRELLQS
LVIDIDNDHNTQETAERVARMYLNEVFKGRFYEQPDVTSFPNTKDLDEIYTVGPITVRSACSHHLVPILGNCWIGIKPGS
RVIGLSKFARVADWVFSRPHIQEEAVMILADEIERLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMVNSVVRGVFRHDPSL
KQEFFELVRQQESTLGA
>Mature_256_residues
TSIIPASSKDLGQHRNRNGLPGNGQPKNENKISERIRARLVAEDVSFLANDNIAEHIQPGELKELEVEVADRVRELLQSL
VIDIDNDHNTQETAERVARMYLNEVFKGRFYEQPDVTSFPNTKDLDEIYTVGPITVRSACSHHLVPILGNCWIGIKPGSR
VIGLSKFARVADWVFSRPHIQEEAVMILADEIERLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMVNSVVRGVFRHDPSLK
QEFFELVRQQESTLGA

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=126, Percent_Identity=41.2698412698413, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4503949, Length=126, Percent_Identity=41.2698412698413, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1788476, Length=183, Percent_Identity=31.6939890710383, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=33.7078651685393, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321706, Length=190, Percent_Identity=29.4736842105263, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656782, Length=161, Percent_Identity=33.5403726708075, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656796, Length=158, Percent_Identity=34.1772151898734, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656791, Length=125, Percent_Identity=38.4, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 29064; Mature: 28933

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIIPASSKDLGQHRNRNGLPGNGQPKNENKISERIRARLVAEDVSFLANDNIAEHIQP
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
GELKELEVEVADRVRELLQSLVIDIDNDHNTQETAERVARMYLNEVFKGRFYEQPDVTSF
CCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PNTKDLDEIYTVGPITVRSACSHHLVPILGNCWIGIKPGSRVIGLSKFARVADWVFSRPH
CCCCCHHHHHHCCCHHHHHHHHHCCHHHHCCCEEEECCCCCEECHHHHHHHHHHHHCCCC
IQEEAVMILADEIERLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMVNSVVRGVFRHDPSL
CHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCH
KQEFFELVRQQESTLGA
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSIIPASSKDLGQHRNRNGLPGNGQPKNENKISERIRARLVAEDVSFLANDNIAEHIQP
CCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
GELKELEVEVADRVRELLQSLVIDIDNDHNTQETAERVARMYLNEVFKGRFYEQPDVTSF
CCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PNTKDLDEIYTVGPITVRSACSHHLVPILGNCWIGIKPGSRVIGLSKFARVADWVFSRPH
CCCCCHHHHHHCCCHHHHHHHHHCCHHHHCCCEEEECCCCCEECHHHHHHHHHHHHCCCC
IQEEAVMILADEIERLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMVNSVVRGVFRHDPSL
CHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCH
KQEFFELVRQQESTLGA
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA