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The map label for this gene is ftsI [H]

Identifier: 124022465

GI number: 124022465

Start: 695690

End: 697444

Strand: Direct

Name: ftsI [H]

Synonym: P9303_07561

Alternate gene names: 124022465

Gene position: 695690-697444 (Clockwise)

Preceding gene: 124022464

Following gene: 124022466

Centisome position: 25.93

GC content: 55.56

Gene sequence:

>1755_bases
GTGATTGCGTTGGAATCAGTTCCTGCTCATCGGATGCGATGGGTGTTTTCCATCCTCTGCGTTGGGCTGATTGGACTTGT
GGGCCGGATGGCTTGGCTGCAGGTTCTGCAAGCACCGCAACTTGAAGCCCGTGCAAGGGCTTTGCAGACCCAGCGAACCC
AACCGATTGGGACACGGCGTTCAATTGTGGACCGCAATGGACGGCTGGTCGCTCTCGATGAGGAACGCTTTCGGCTTTGG
GCTCATCCTCGTTATTTTAATTTCCCCGGGGATGATCCCGGTTTGATACGTAAGCCACTGGATGTTGCTCGCAAGCTCTC
CGGGGTGTTGGCGATTCCTGTTGCCGAATTGGTGCAGCGATTTGGTGACCGTCCTTCTGGTGTGAAGCTTGCTGAAGGAT
TGGATCAGGACATCGTCAATGAAATCCGCAACCTTGGTATCAGTGGTTTAGATCTTGAGGCTTATCCACAGCGGCTCTAT
CCGCAGGGTTCTCTATTTGCCAACGTGGTGGGCTTTCTTAATTTGGATCGCGTCCCACAGGCGGGATTGGAGCAAAGTCG
TCACGAGGATTTGCTGCGTCATGAACAGGTTCGCAGCCTGCGCCGAGGAGCGGATGGCACCCCCCTTCCTGACGACCTGG
CTCCGGGAGTGTTTTATGGCGATCATCTAAGCCTGCAGCTCACTTTGGATGCTCGTTTGCAGGAGCTGGCGGGGCAGGCA
CTTGTGGCCCAGGTCAAAGAGTGGAAGGCCAAGAAGGGAGTGGCCATCGTGATTGATGTCACCAATGGGGAGTTGCTGGC
GCTGGCGTCCACACCCACATATGACCCGAACAAGTATTGGAAATATTCGCCCTCTCGCTTTCGCGAGTGGTCCGTTCAGG
ACCTTTATGAACCTGGTTCTACCTTAAAGCCGATCAACCTTGCCCTTGCTCTTCAGGAAGGTGTGATTCAGCCGGGGGGA
ATGGTGAACGACAACGGATCACTGAAGATCGGTGGGTGGCCAATTTCCAACCATGATCGTCAGAGCCATGGGGTGATCGA
CTACGCCACGGTGCTGCAAGTTTCTAGCAACGTCGGCATGGTGAAGATCATGCGTCAGCTCAAACCCTCGCTTTACTGGG
ATTGGTTGCGTCGGCTAGGACTTGATGTCAAGCCCGATACCGATCTGCCGGGGGCTATTGCAGGTCAGTTAAAGACGAAG
GAGCAATTCGTGGCTCAGCCAATTGAGCCGGCCACGGCGGCATTTGGACAGGGACTGTCGCTCACGCCACTGAAGCTGGC
TCAGTTGCATGCCTTGATTGCCAATGGTGGCCGGCTGGTGAGTCCCCACATCACCAGGGGATTGCGGGCGGGAGAAGCGA
TGGCTCCACGCGCCGCCGCAACAACCGGACATCAACTACTGCGCCCAGATGTCACCAGGATTGTGCGGGACTGGATGGAA
TCGGTTGTAGAGAAAGGGAGTGGGAAAGGGGCGAAAACGCCTGGTTATCGCATTGGTGGCAAGACCGGCACTGCTCAGAA
AGCACTGAATGGGGTCTATCTATCAGGAGCAAAGATTTGCAGCTTTGTTGCCCATCTGCCGGTTGATAACCCTCGCTATG
TGGTGGTGGTCGTGGTGGATGAACCCCAGGGGGGCAATGCTTATGGGTCCACGGTGGCGGTGCCTGTAGCGAAACAGATC
ATTGATGCTTTGCTGGTGCTTGAAAAAATTCCACCTAGCACTGAGCAGACCTATCCTCAGCCGGCCAAAGGCTAA

Upstream 100 bases:

>100_bases
AAATGCTTAGCCAATTGATGGGCCAACCCATTAATCACGGCTACTGATGCCTGCCTCAAAGGCTCGTCGCTCACGAAGCT
CCAGGAGGCGTGCCCAGGAT

Downstream 100 bases:

>100_bases
GTCTTGGCAAAGCTTCGATGGTGAGTTCTGAACCTGGGCTGTCAGCAAAAAAAACGCCGCTAGCTTAAAGATCTTGCGAG
ACGTTCTGCTTTATGGCCAC

Product: peptidoglycan synthetase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MIALESVPAHRMRWVFSILCVGLIGLVGRMAWLQVLQAPQLEARARALQTQRTQPIGTRRSIVDRNGRLVALDEERFRLW
AHPRYFNFPGDDPGLIRKPLDVARKLSGVLAIPVAELVQRFGDRPSGVKLAEGLDQDIVNEIRNLGISGLDLEAYPQRLY
PQGSLFANVVGFLNLDRVPQAGLEQSRHEDLLRHEQVRSLRRGADGTPLPDDLAPGVFYGDHLSLQLTLDARLQELAGQA
LVAQVKEWKAKKGVAIVIDVTNGELLALASTPTYDPNKYWKYSPSRFREWSVQDLYEPGSTLKPINLALALQEGVIQPGG
MVNDNGSLKIGGWPISNHDRQSHGVIDYATVLQVSSNVGMVKIMRQLKPSLYWDWLRRLGLDVKPDTDLPGAIAGQLKTK
EQFVAQPIEPATAAFGQGLSLTPLKLAQLHALIANGGRLVSPHITRGLRAGEAMAPRAAATTGHQLLRPDVTRIVRDWME
SVVEKGSGKGAKTPGYRIGGKTGTAQKALNGVYLSGAKICSFVAHLPVDNPRYVVVVVVDEPQGGNAYGSTVAVPVAKQI
IDALLVLEKIPPSTEQTYPQPAKG

Sequences:

>Translated_584_residues
MIALESVPAHRMRWVFSILCVGLIGLVGRMAWLQVLQAPQLEARARALQTQRTQPIGTRRSIVDRNGRLVALDEERFRLW
AHPRYFNFPGDDPGLIRKPLDVARKLSGVLAIPVAELVQRFGDRPSGVKLAEGLDQDIVNEIRNLGISGLDLEAYPQRLY
PQGSLFANVVGFLNLDRVPQAGLEQSRHEDLLRHEQVRSLRRGADGTPLPDDLAPGVFYGDHLSLQLTLDARLQELAGQA
LVAQVKEWKAKKGVAIVIDVTNGELLALASTPTYDPNKYWKYSPSRFREWSVQDLYEPGSTLKPINLALALQEGVIQPGG
MVNDNGSLKIGGWPISNHDRQSHGVIDYATVLQVSSNVGMVKIMRQLKPSLYWDWLRRLGLDVKPDTDLPGAIAGQLKTK
EQFVAQPIEPATAAFGQGLSLTPLKLAQLHALIANGGRLVSPHITRGLRAGEAMAPRAAATTGHQLLRPDVTRIVRDWME
SVVEKGSGKGAKTPGYRIGGKTGTAQKALNGVYLSGAKICSFVAHLPVDNPRYVVVVVVDEPQGGNAYGSTVAVPVAKQI
IDALLVLEKIPPSTEQTYPQPAKG
>Mature_584_residues
MIALESVPAHRMRWVFSILCVGLIGLVGRMAWLQVLQAPQLEARARALQTQRTQPIGTRRSIVDRNGRLVALDEERFRLW
AHPRYFNFPGDDPGLIRKPLDVARKLSGVLAIPVAELVQRFGDRPSGVKLAEGLDQDIVNEIRNLGISGLDLEAYPQRLY
PQGSLFANVVGFLNLDRVPQAGLEQSRHEDLLRHEQVRSLRRGADGTPLPDDLAPGVFYGDHLSLQLTLDARLQELAGQA
LVAQVKEWKAKKGVAIVIDVTNGELLALASTPTYDPNKYWKYSPSRFREWSVQDLYEPGSTLKPINLALALQEGVIQPGG
MVNDNGSLKIGGWPISNHDRQSHGVIDYATVLQVSSNVGMVKIMRQLKPSLYWDWLRRLGLDVKPDTDLPGAIAGQLKTK
EQFVAQPIEPATAAFGQGLSLTPLKLAQLHALIANGGRLVSPHITRGLRAGEAMAPRAAATTGHQLLRPDVTRIVRDWME
SVVEKGSGKGAKTPGYRIGGKTGTAQKALNGVYLSGAKICSFVAHLPVDNPRYVVVVVVDEPQGGNAYGSTVAVPVAKQI
IDALLVLEKIPPSTEQTYPQPAKG

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=579, Percent_Identity=32.8151986183074, Blast_Score=245, Evalue=7e-66,
Organism=Escherichia coli, GI1786854, Length=621, Percent_Identity=23.0273752012882, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63758; Mature: 63758

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALESVPAHRMRWVFSILCVGLIGLVGRMAWLQVLQAPQLEARARALQTQRTQPIGTRR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHH
SIVDRNGRLVALDEERFRLWAHPRYFNFPGDDPGLIRKPLDVARKLSGVLAIPVAELVQR
HHHCCCCCEEEEEHHHEEEEECCEECCCCCCCCCHHHHHHHHHHHHCCEEECCHHHHHHH
FGDRPSGVKLAEGLDQDIVNEIRNLGISGLDLEAYPQRLYPQGSLFANVVGFLNLDRVPQ
HCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
AGLEQSRHEDLLRHEQVRSLRRGADGTPLPDDLAPGVFYGDHLSLQLTLDARLQELAGQA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEECCCEEEEEEHHHHHHHHHHHH
LVAQVKEWKAKKGVAIVIDVTNGELLALASTPTYDPNKYWKYSPSRFREWSVQDLYEPGS
HHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHCCCHHHHHCCCC
TLKPINLALALQEGVIQPGGMVNDNGSLKIGGWPISNHDRQSHGVIDYATVLQVSSNVGM
CCCCHHHEEEHHHCCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCH
VKIMRQLKPSLYWDWLRRLGLDVKPDTDLPGAIAGQLKTKEQFVAQPIEPATAAFGQGLS
HHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
LTPLKLAQLHALIANGGRLVSPHITRGLRAGEAMAPRAAATTGHQLLRPDVTRIVRDWME
CCHHHHHHHHHHHHCCCEEECHHHHHCCCCCCCCCCCHHHHCCHHHHCHHHHHHHHHHHH
SVVEKGSGKGAKTPGYRIGGKTGTAQKALNGVYLSGAKICSFVAHLPVDNPRYVVVVVVD
HHHHCCCCCCCCCCCEEECCCCCHHHHHHCCEEECHHHHHHHHHHCCCCCCCEEEEEEEE
EPQGGNAYGSTVAVPVAKQIIDALLVLEKIPPSTEQTYPQPAKG
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIALESVPAHRMRWVFSILCVGLIGLVGRMAWLQVLQAPQLEARARALQTQRTQPIGTRR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHH
SIVDRNGRLVALDEERFRLWAHPRYFNFPGDDPGLIRKPLDVARKLSGVLAIPVAELVQR
HHHCCCCCEEEEEHHHEEEEECCEECCCCCCCCCHHHHHHHHHHHHCCEEECCHHHHHHH
FGDRPSGVKLAEGLDQDIVNEIRNLGISGLDLEAYPQRLYPQGSLFANVVGFLNLDRVPQ
HCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
AGLEQSRHEDLLRHEQVRSLRRGADGTPLPDDLAPGVFYGDHLSLQLTLDARLQELAGQA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEECCCEEEEEEHHHHHHHHHHHH
LVAQVKEWKAKKGVAIVIDVTNGELLALASTPTYDPNKYWKYSPSRFREWSVQDLYEPGS
HHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHCCCHHHHHCCCC
TLKPINLALALQEGVIQPGGMVNDNGSLKIGGWPISNHDRQSHGVIDYATVLQVSSNVGM
CCCCHHHEEEHHHCCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCH
VKIMRQLKPSLYWDWLRRLGLDVKPDTDLPGAIAGQLKTKEQFVAQPIEPATAAFGQGLS
HHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
LTPLKLAQLHALIANGGRLVSPHITRGLRAGEAMAPRAAATTGHQLLRPDVTRIVRDWME
CCHHHHHHHHHHHHCCCEEECHHHHHCCCCCCCCCCCHHHHCCHHHHCHHHHHHHHHHHH
SVVEKGSGKGAKTPGYRIGGKTGTAQKALNGVYLSGAKICSFVAHLPVDNPRYVVVVVVD
HHHHCCCCCCCCCCCEEECCCCCHHHHHHCCEEECHHHHHHHHHHCCCCCCCEEEEEEEE
EPQGGNAYGSTVAVPVAKQIIDALLVLEKIPPSTEQTYPQPAKG
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]