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The map label for this gene is cyoB [H]

Identifier: 124022351

GI number: 124022351

Start: 604240

End: 605916

Strand: Reverse

Name: cyoB [H]

Synonym: P9303_06411

Alternate gene names: 124022351

Gene position: 605916-604240 (Counterclockwise)

Preceding gene: 124022352

Following gene: 124022350

Centisome position: 22.59

GC content: 52.24

Gene sequence:

>1677_bases
ATGACGGTTGCTATCTCTCCTCCTAGCAAAAAGCAATCAGATGGTCTTCAACCAACTGGCTGGTTGCGTTACTTCAGCTT
CAGCCTTGACCACAAGGTCATCGGTCTGCAGTACTTGGTTTGCGGATTCATCTTCTACCTAATCGGTGGAGTGCTTGGTG
GCGCCATCCGCATCGAACTAGCCAGCCCCATCGCCGACTTCATGGCCAGGGATGTCTACAACCAGGTGCTAACTCTGCAC
GGCACAGTGATGATCTTCCTGTGGATCGTGCCGGTCGTGAACGGTGCCTTCGGCAACTATCTCATTCCGTTTTATGTGGG
AGCCCGTGATATGGCCTTCCCTCGACTCAATGCCGTGGCGTTCTGGATGATCCCTCCAGCTGGCCTGCTGCTGATCAGTA
GCTACTTCATTACCGGTGCTGCTCAATCCGGCTGGACGGCCTATCCACCTCTAAGTATCACCACCCCCGCCGCAGGACAG
ATCTTATGGATTCTCAGTGTTCTCTTGCTTGGCGGTAGCTCAATCTTTGGTGGCATCAACTTCATCGCCACCATCCTCAA
GCTGCGGCAGCCCGGGCTCAAGCTGATGCAACTACCCATGTACTGCTGGGCGATGCTCGGTACAAGCATCCTGGTGGTGC
TCTCCACGCCAGTACTGGCTGGAACACTGGTTCTTTTAAGTTTCGACATCGTTGCCCATACAGGATTCTTCAACCCCAGC
CTGGGCGGAAACGCAGTCGTCTACCAACATCTTTTCTGGTTTTATTCCCACCCAGCTGTATACATCATGGTGCTGCCAGC
CTTCGGATTGGTCAGTGAAATCCTTCCTGTTCACTGCCGCAAACCACTTTTTGGCTACACCTCAATGGTGTATTCAATCA
TGACCATCGTGATCCTTGGCCTCGTGGTTTGGGCACATCACATGTTCACCAGTGGAACACCTCCTTGGATGCGCCTCTTT
TTCACCATTGCCACATCCTTCATCGCCGTACCAACAGGAATTAAGTTCTTCAACTGGCTAGCAACACTCTGGGGAGGGCG
CATCTCTCTAAACAGTGCTGTGCTTTTCTCCTGTGGCTTCATTGTTAACTTTGTGCTTGGCGGCATTACTGGCGTAGCGC
TTGCACAAGTTCCATTCGATATTCACGTGCATGATACCTACTTTGTTGTTGCCCATTTTCACTACATCGTCTATGGAGGT
TCGGTGTTTGTGATCTTTGCCTCTATTTATCACTGGTATCCAAAATTCACTGGGCGCATGCTCAATGAGTCTCTGGGGCG
GTTTCATTTTTTAATCACTTTCATCGGCTTCAATCTCTGCTTTGCCCCACAGCATTGGCTAGGCCTCAACGGCATGCCCC
GCCGTGTAGCGGAATACGACCCGCAATTCACCGTAATCAATCAAATCAGCAGTGTTGGGGCCTTGCTGATGGCCATCAGC
ACGCTGCCCTTTCTCTGGAACGTCGTGCAGAGTGCATTGAGCGGCCCCATTGCCGGAGACAACCCCTGGAGGGCGCTGAC
TCCTGAATGGCTCACCAGCTCCCCACCACCAGTGGAAAACTGGAGCGGCAAAGCCCCTCTGGTAACAGAGCCCTATGGCT
ATGGCGTACCTGAGGAGCAGCTCAACCTAGAAAAAACCAACAACATTGATAGTGATCTAGGGAGCAAAAGCCAATGA

Upstream 100 bases:

>100_bases
GTCCATACCACGGGAACATGCATACGAAAGTGATTGTCGAAGCGCCCGGTGACTACGACACCTGGTTCAACAACAACGCC
AAAACAACGGTTTCAGAAGC

Downstream 100 bases:

>100_bases
CATCCCTTCCAACGATCGACCATGACTATGAGGAGCAGGCTGATCTAGCAGATGAACATGCTGAGCTTGGCGAGGAACAT
GCTGATCACCGCATGTTCGG

Product: cytochrome C oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MTVAISPPSKKQSDGLQPTGWLRYFSFSLDHKVIGLQYLVCGFIFYLIGGVLGGAIRIELASPIADFMARDVYNQVLTLH
GTVMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWMIPPAGLLLISSYFITGAAQSGWTAYPPLSITTPAAGQ
ILWILSVLLLGGSSIFGGINFIATILKLRQPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLVLLSFDIVAHTGFFNPS
LGGNAVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHCRKPLFGYTSMVYSIMTIVILGLVVWAHHMFTSGTPPWMRLF
FTIATSFIAVPTGIKFFNWLATLWGGRISLNSAVLFSCGFIVNFVLGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGG
SVFVIFASIYHWYPKFTGRMLNESLGRFHFLITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFTVINQISSVGALLMAIS
TLPFLWNVVQSALSGPIAGDNPWRALTPEWLTSSPPPVENWSGKAPLVTEPYGYGVPEEQLNLEKTNNIDSDLGSKSQ

Sequences:

>Translated_558_residues
MTVAISPPSKKQSDGLQPTGWLRYFSFSLDHKVIGLQYLVCGFIFYLIGGVLGGAIRIELASPIADFMARDVYNQVLTLH
GTVMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWMIPPAGLLLISSYFITGAAQSGWTAYPPLSITTPAAGQ
ILWILSVLLLGGSSIFGGINFIATILKLRQPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLVLLSFDIVAHTGFFNPS
LGGNAVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHCRKPLFGYTSMVYSIMTIVILGLVVWAHHMFTSGTPPWMRLF
FTIATSFIAVPTGIKFFNWLATLWGGRISLNSAVLFSCGFIVNFVLGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGG
SVFVIFASIYHWYPKFTGRMLNESLGRFHFLITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFTVINQISSVGALLMAIS
TLPFLWNVVQSALSGPIAGDNPWRALTPEWLTSSPPPVENWSGKAPLVTEPYGYGVPEEQLNLEKTNNIDSDLGSKSQ
>Mature_557_residues
TVAISPPSKKQSDGLQPTGWLRYFSFSLDHKVIGLQYLVCGFIFYLIGGVLGGAIRIELASPIADFMARDVYNQVLTLHG
TVMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWMIPPAGLLLISSYFITGAAQSGWTAYPPLSITTPAAGQI
LWILSVLLLGGSSIFGGINFIATILKLRQPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLVLLSFDIVAHTGFFNPSL
GGNAVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHCRKPLFGYTSMVYSIMTIVILGLVVWAHHMFTSGTPPWMRLFF
TIATSFIAVPTGIKFFNWLATLWGGRISLNSAVLFSCGFIVNFVLGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGS
VFVIFASIYHWYPKFTGRMLNESLGRFHFLITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFTVINQISSVGALLMAIST
LPFLWNVVQSALSGPIAGDNPWRALTPEWLTSSPPPVENWSGKAPLVTEPYGYGVPEEQLNLEKTNNIDSDLGSKSQ

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=500, Percent_Identity=44, Blast_Score=385, Evalue=1e-107,
Organism=Escherichia coli, GI1786634, Length=522, Percent_Identity=40.4214559386973, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6226519, Length=525, Percent_Identity=37.9047619047619, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6226524, Length=318, Percent_Identity=39.937106918239, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6226523, Length=246, Percent_Identity=35.3658536585366, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 61495; Mature: 61364

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAISPPSKKQSDGLQPTGWLRYFSFSLDHKVIGLQYLVCGFIFYLIGGVLGGAIRIEL
CEEECCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
ASPIADFMARDVYNQVLTLHGTVMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEE
FWMIPPAGLLLISSYFITGAAQSGWTAYPPLSITTPAAGQILWILSVLLLGGSSIFGGIN
EEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHH
FIATILKLRQPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLVLLSFDIVAHTGFFNPS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCC
LGGNAVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHCRKPLFGYTSMVYSIMTIVILG
CCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LVVWAHHMFTSGTPPWMRLFFTIATSFIAVPTGIKFFNWLATLWGGRISLNSAVLFSCGF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHH
IVNFVLGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGSVFVIFASIYHWYPKFTGRM
HHHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LNESLGRFHFLITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFTVINQISSVGALLMAIS
HHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
TLPFLWNVVQSALSGPIAGDNPWRALTPEWLTSSPPPVENWSGKAPLVTEPYGYGVPEEQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEECCCCCCCCHHH
LNLEKTNNIDSDLGSKSQ
CCCHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TVAISPPSKKQSDGLQPTGWLRYFSFSLDHKVIGLQYLVCGFIFYLIGGVLGGAIRIEL
EEECCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
ASPIADFMARDVYNQVLTLHGTVMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEE
FWMIPPAGLLLISSYFITGAAQSGWTAYPPLSITTPAAGQILWILSVLLLGGSSIFGGIN
EEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHH
FIATILKLRQPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLVLLSFDIVAHTGFFNPS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCC
LGGNAVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHCRKPLFGYTSMVYSIMTIVILG
CCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LVVWAHHMFTSGTPPWMRLFFTIATSFIAVPTGIKFFNWLATLWGGRISLNSAVLFSCGF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHH
IVNFVLGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGSVFVIFASIYHWYPKFTGRM
HHHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LNESLGRFHFLITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFTVINQISSVGALLMAIS
HHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
TLPFLWNVVQSALSGPIAGDNPWRALTPEWLTSSPPPVENWSGKAPLVTEPYGYGVPEEQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEECCCCCCCCHHH
LNLEKTNNIDSDLGSKSQ
CCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8387368; 8905231 [H]