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The map label for this gene is nblS [H]

Identifier: 124022255

GI number: 124022255

Start: 526341

End: 528398

Strand: Reverse

Name: nblS [H]

Synonym: P9303_05451

Alternate gene names: 124022255

Gene position: 528398-526341 (Counterclockwise)

Preceding gene: 124022256

Following gene: 124022252

Centisome position: 19.7

GC content: 52.67

Gene sequence:

>2058_bases
ATGGCCAGCAGTACTTCGCAAGCCATCGCAGAGTGGGCTCCCCCAGGAGATGGCCAACCCCCACCAGAGCCACCCGGCTG
GGGGGAACGCATCTATCTCTGGTGGGCAGAATTCAGCCTGCAAACCAAGTTGTTGGCAATCGCCACACTGGTGGTGAGCC
TGCTGATGACAGGCATCACCTTCTTCGTCCTCAACGGCATCCAAAGGGATGCAGGGATGAATGACACGCGTTACGCCAGG
GATCTAGGACTCCTCCTTTCCGGAAACGTCACTGAACTTGTCGCCCAAGGACGTGACAGGGAGCTGGCAACTGTTGCCGA
ACAATTCTGGCGCTCGCGCAGCCTTCGTTACATCTTCTTCGCCGACCCAGATGGCTTGATCTATCTAGGAATCCCCATTA
GCGCTTCCCCTGTCAGCGGTGATAACGACCTGCAGCTCAACCATCGCTTGGAACTGCCAGCAGAGCTGCCATCACGACCA
GAAAACGCACTGATTCGCCAGCACCTCACCCCTCAAGGTCAACTCACCGATGTCTTCGTTCCACTGGTGTGGAAAGGCGA
TTATCTGGGGACCCTGGCTCTGGGGGTCAACCCCAACGACACAGCTCTTGCCAGCGCGGCTCTCACGCGACAGGTGACGA
TTGCCGTCTTCATCTCCATCTGGGTGCTTGTGATTCTTGGCGCCGTCTTCAATGCTCTAACGATCACGCAGCCTGTAAAG
GAGCTTCTGCGCGGTGTAAGGGCCATTGCTTCCGGCAATTTCGAAGCTCGAATCGCTCTACCGATGGGAGGAGAACTGGG
AGAACTCCTGAATGGCTTCAACGCCATGGCCTCCCAACTTGAGGCCTATGACGCCGCCAATATTGAAGAGCTCACTGCCG
CCCAAGTAAAGCAGCAATCGCTGATTGCCACGATGGCCGATGGCGCTTTACTGCTCGATGAAGTTGGACAAATCGTGCTG
GCCAATCCAACAGCACGGCGGCTATTTCGCTGGGAAGGTCGCAATCTTGAGGGTCAGGAACTGCTCAATGAGTTGCCGGA
GATCATCGCAAACGAACTGCATGATCCCCTTCAATCTCTGCTGCGCAATATCGGTGAAAGCAACGATCTGCGTTGCAGTC
TTGAAGAACCAACACGCACACTTCGCATCGTGTTGCAGTCAGTGCGCGATCAAAGCGGTGAAACCCTTAAAGGCATCGCA
ATCACAGTGCAGGACCTCACCAGAGAAGTGGAGCTCAATGCAGCCCAAAGCCGCTTCATCAGCAACGTTTCACATGAACT
TAGAACACCACTGTTCAACATCAAAAGCTATGTAGAAACACTGCATGATCTCGGTGATCAACTCAGCGAAGAGGAAAAGA
AAGAATTTTTAGGTGTTGCTAATTCCGAAACCGATAGGCTGGCTCGACTCGTTAATGATGTGCTCGACCTTTCGCGCTTG
GAATCCGGACGGACCGTGCAGTTCGAGCCCATGGATCTTCGCCCTGCCATCGAGCAAACCCTACGCAACTATCGACTTAA
TGCAGATGACAAGCAGATTCATATTGAGCTCAATACGGATGATGAGCTACCAACAATCCTTGGAAATTGGGATCTACTAC
TCCAAGTGCTTGACAATTTAGTTGGCAATGGGCTCAAGTTTAGTCGTGCTGGTGGAAGCCTGATGGTGCGAGCCTACACA
TGGCCTGATAGCTGCAAAATGTCTCCAATCGAGAGCAGCAAATCAGCACCACATTGCGAATTTTTCTCACCACTCCCCAA
GCTCCGCGTAGAAGTTGCGGACACCGGCCATGGCATCAATCAGGATGACCAACAGCATATTTTTGACCGCTTCTATCGTG
TGGAAAATGCCGTGCATACAGAAGCTGGCACCGGTCTTGGGCTATCAATCGTGCGCGGCATCATCGAAAAGCATGGCGGC
CAAATACGAATGGCCAGTGAGGTTGACCTGGGCACAACCTTTTGGTTTGATCTACCTCTTGAGCAAACAGATGCAGATGA
GCTTATCGTTCAATCAGTACGAACAACTCGGCAACAAGAACAAGGTTTAGAACTCTAA

Upstream 100 bases:

>100_bases
CCAAGGTCTTGATCAGGTGTATTTCGAAGGGATCACTTACCGTCGGGACATCGGTCACCAAGTGCGCCAGTCCTAGGGTG
AAGAGACGCTGAATGGGTTG

Downstream 100 bases:

>100_bases
TTCAGCCAATAACCTGAATCAGCTAGCATTTTAAAGGCCCTTGGCATCGAAGCAACATTAAGAGCGTTCGTCGTCAGCAA
TACGATGAGGAGCACCACTG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MASSTSQAIAEWAPPGDGQPPPEPPGWGERIYLWWAEFSLQTKLLAIATLVVSLLMTGITFFVLNGIQRDAGMNDTRYAR
DLGLLLSGNVTELVAQGRDRELATVAEQFWRSRSLRYIFFADPDGLIYLGIPISASPVSGDNDLQLNHRLELPAELPSRP
ENALIRQHLTPQGQLTDVFVPLVWKGDYLGTLALGVNPNDTALASAALTRQVTIAVFISIWVLVILGAVFNALTITQPVK
ELLRGVRAIASGNFEARIALPMGGELGELLNGFNAMASQLEAYDAANIEELTAAQVKQQSLIATMADGALLLDEVGQIVL
ANPTARRLFRWEGRNLEGQELLNELPEIIANELHDPLQSLLRNIGESNDLRCSLEEPTRTLRIVLQSVRDQSGETLKGIA
ITVQDLTREVELNAAQSRFISNVSHELRTPLFNIKSYVETLHDLGDQLSEEEKKEFLGVANSETDRLARLVNDVLDLSRL
ESGRTVQFEPMDLRPAIEQTLRNYRLNADDKQIHIELNTDDELPTILGNWDLLLQVLDNLVGNGLKFSRAGGSLMVRAYT
WPDSCKMSPIESSKSAPHCEFFSPLPKLRVEVADTGHGINQDDQQHIFDRFYRVENAVHTEAGTGLGLSIVRGIIEKHGG
QIRMASEVDLGTTFWFDLPLEQTDADELIVQSVRTTRQQEQGLEL

Sequences:

>Translated_685_residues
MASSTSQAIAEWAPPGDGQPPPEPPGWGERIYLWWAEFSLQTKLLAIATLVVSLLMTGITFFVLNGIQRDAGMNDTRYAR
DLGLLLSGNVTELVAQGRDRELATVAEQFWRSRSLRYIFFADPDGLIYLGIPISASPVSGDNDLQLNHRLELPAELPSRP
ENALIRQHLTPQGQLTDVFVPLVWKGDYLGTLALGVNPNDTALASAALTRQVTIAVFISIWVLVILGAVFNALTITQPVK
ELLRGVRAIASGNFEARIALPMGGELGELLNGFNAMASQLEAYDAANIEELTAAQVKQQSLIATMADGALLLDEVGQIVL
ANPTARRLFRWEGRNLEGQELLNELPEIIANELHDPLQSLLRNIGESNDLRCSLEEPTRTLRIVLQSVRDQSGETLKGIA
ITVQDLTREVELNAAQSRFISNVSHELRTPLFNIKSYVETLHDLGDQLSEEEKKEFLGVANSETDRLARLVNDVLDLSRL
ESGRTVQFEPMDLRPAIEQTLRNYRLNADDKQIHIELNTDDELPTILGNWDLLLQVLDNLVGNGLKFSRAGGSLMVRAYT
WPDSCKMSPIESSKSAPHCEFFSPLPKLRVEVADTGHGINQDDQQHIFDRFYRVENAVHTEAGTGLGLSIVRGIIEKHGG
QIRMASEVDLGTTFWFDLPLEQTDADELIVQSVRTTRQQEQGLEL
>Mature_684_residues
ASSTSQAIAEWAPPGDGQPPPEPPGWGERIYLWWAEFSLQTKLLAIATLVVSLLMTGITFFVLNGIQRDAGMNDTRYARD
LGLLLSGNVTELVAQGRDRELATVAEQFWRSRSLRYIFFADPDGLIYLGIPISASPVSGDNDLQLNHRLELPAELPSRPE
NALIRQHLTPQGQLTDVFVPLVWKGDYLGTLALGVNPNDTALASAALTRQVTIAVFISIWVLVILGAVFNALTITQPVKE
LLRGVRAIASGNFEARIALPMGGELGELLNGFNAMASQLEAYDAANIEELTAAQVKQQSLIATMADGALLLDEVGQIVLA
NPTARRLFRWEGRNLEGQELLNELPEIIANELHDPLQSLLRNIGESNDLRCSLEEPTRTLRIVLQSVRDQSGETLKGIAI
TVQDLTREVELNAAQSRFISNVSHELRTPLFNIKSYVETLHDLGDQLSEEEKKEFLGVANSETDRLARLVNDVLDLSRLE
SGRTVQFEPMDLRPAIEQTLRNYRLNADDKQIHIELNTDDELPTILGNWDLLLQVLDNLVGNGLKFSRAGGSLMVRAYTW
PDSCKMSPIESSKSAPHCEFFSPLPKLRVEVADTGHGINQDDQQHIFDRFYRVENAVHTEAGTGLGLSIVRGIIEKHGGQ
IRMASEVDLGTTFWFDLPLEQTDADELIVQSVRTTRQQEQGLEL

Specific function: Member Of The Two-Component Regulatory System Atos/Atoc; May Activate Atoc By Phosphorylation. [C]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=408, Percent_Identity=26.2254901960784, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789149, Length=298, Percent_Identity=27.8523489932886, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=28.8321167883212, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=27.2373540856031, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=409, Percent_Identity=27.1393643031785, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790436, Length=264, Percent_Identity=28.4090909090909, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI87082128, Length=249, Percent_Identity=26.5060240963855, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87081816, Length=250, Percent_Identity=28.4, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=268, Percent_Identity=29.8507462686567, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=244, Percent_Identity=29.5081967213115, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=311, Percent_Identity=24.4372990353698, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=27.3809523809524, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 75884; Mature: 75753

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSTSQAIAEWAPPGDGQPPPEPPGWGERIYLWWAEFSLQTKLLAIATLVVSLLMTGIT
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
FFVLNGIQRDAGMNDTRYARDLGLLLSGNVTELVAQGRDRELATVAEQFWRSRSLRYIFF
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEE
ADPDGLIYLGIPISASPVSGDNDLQLNHRLELPAELPSRPENALIRQHLTPQGQLTDVFV
ECCCCEEEEEECCCCCCCCCCCCEEECEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEE
PLVWKGDYLGTLALGVNPNDTALASAALTRQVTIAVFISIWVLVILGAVFNALTITQPVK
EEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLRGVRAIASGNFEARIALPMGGELGELLNGFNAMASQLEAYDAANIEELTAAQVKQQS
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIATMADGALLLDEVGQIVLANPTARRLFRWEGRNLEGQELLNELPEIIANELHDPLQSL
HHHHHCCCHHHHHHCCCEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRNIGESNDLRCSLEEPTRTLRIVLQSVRDQSGETLKGIAITVQDLTREVELNAAQSRFI
HHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEHHEEEHHHHHHHHHHHHHHHHHH
SNVSHELRTPLFNIKSYVETLHDLGDQLSEEEKKEFLGVANSETDRLARLVNDVLDLSRL
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
ESGRTVQFEPMDLRPAIEQTLRNYRLNADDKQIHIELNTDDELPTILGNWDLLLQVLDNL
CCCCEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHH
VGNGLKFSRAGGSLMVRAYTWPDSCKMSPIESSKSAPHCEFFSPLPKLRVEVADTGHGIN
HCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHCCCCHHEEEEECCCCCCC
QDDQQHIFDRFYRVENAVHTEAGTGLGLSIVRGIIEKHGGQIRMASEVDLGTTFWFDLPL
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCC
EQTDADELIVQSVRTTRQQEQGLEL
CCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ASSTSQAIAEWAPPGDGQPPPEPPGWGERIYLWWAEFSLQTKLLAIATLVVSLLMTGIT
CCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
FFVLNGIQRDAGMNDTRYARDLGLLLSGNVTELVAQGRDRELATVAEQFWRSRSLRYIFF
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEE
ADPDGLIYLGIPISASPVSGDNDLQLNHRLELPAELPSRPENALIRQHLTPQGQLTDVFV
ECCCCEEEEEECCCCCCCCCCCCEEECEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEE
PLVWKGDYLGTLALGVNPNDTALASAALTRQVTIAVFISIWVLVILGAVFNALTITQPVK
EEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLRGVRAIASGNFEARIALPMGGELGELLNGFNAMASQLEAYDAANIEELTAAQVKQQS
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIATMADGALLLDEVGQIVLANPTARRLFRWEGRNLEGQELLNELPEIIANELHDPLQSL
HHHHHCCCHHHHHHCCCEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRNIGESNDLRCSLEEPTRTLRIVLQSVRDQSGETLKGIAITVQDLTREVELNAAQSRFI
HHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEHHEEEHHHHHHHHHHHHHHHHHH
SNVSHELRTPLFNIKSYVETLHDLGDQLSEEEKKEFLGVANSETDRLARLVNDVLDLSRL
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
ESGRTVQFEPMDLRPAIEQTLRNYRLNADDKQIHIELNTDDELPTILGNWDLLLQVLDNL
CCCCEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHH
VGNGLKFSRAGGSLMVRAYTWPDSCKMSPIESSKSAPHCEFFSPLPKLRVEVADTGHGIN
HCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHCCCCHHEEEEECCCCCCC
QDDQQHIFDRFYRVENAVHTEAGTGLGLSIVRGIIEKHGGQIRMASEVDLGTTFWFDLPL
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCC
EQTDADELIVQSVRTTRQQEQGLEL
CCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8535519; 8905231; 3141423 [H]