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The map label for this gene is serA [H]

Identifier: 124022234

GI number: 124022234

Start: 511898

End: 513484

Strand: Direct

Name: serA [H]

Synonym: P9303_05241

Alternate gene names: 124022234

Gene position: 511898-513484 (Clockwise)

Preceding gene: 124022230

Following gene: 124022235

Centisome position: 19.08

GC content: 56.58

Gene sequence:

>1587_bases
ATGACGAAAGTTCTGGTTTCAGACCCTATCGACCAAGCGGGAATTGACATCCTCGCTCAGGTTGCACAGGTGGATCAGCG
TGTGGGCCTGTCAGAGGATGACCTCAAGGCGATGATCGGCGACTACGACGCGCTGATGATCCGTTCTGGCACGCAGGTCA
CGGCGGATGTGATCAAAGCCGGCGGACGTTTGCGCATCATTGGTCGGGCGGGTGTTGGCGTCGATAATGTTGATGTGCCG
ACGGCCACCCAACAGGGTGTTCTGGTGGTGAATTCGCCGGAAGGCAACACTATTGCTGCTGCTGAACAGGCGTTGGCTTT
AATGCTTTCGCTCTCTCGGCATGTGCCTCAGGCCCATGCCAGCACGATGGCTGGGGGTTGGGATCGCAAGAAATATGTAG
GGAACGAGCTCTATAAGAAAGTTCTTGGCGTGGTTGGGCTCGGCAAGATCGGCTCCCATGTGGCCCGCGTCTGCAATGCC
ATGGGTATGGAGGTCATCGCTTACGACCCCTTCATCTCTGCGGACCGTGCTCAACAGATGCAGGTGCGACTCTCAAGCTT
GGAGAATCTTTTTGAGCAAGCCGACTACATCACCTTGCATCTCCCTCGTACTCCCGATACCGAGAATTTGGTCAATGAGG
AATTGCTGGGCAAGATGAAGTCCACAGCAAGGCTCGTGAACTGTGCTCGCGGTGGCATCATCGATGAGTCAGCTCTGGCT
GATGCCTTGAAGGCTGGAGTGATTGGCGGGGCTGCGTTGGATGTTTATGCCCAGGAGCCATTGGCTACCGATTCGCCGCT
GCGCTCTGTGCAGGAGCGCTTGATCCTTACGCCCCATCTCGGTGCCTCGACGACGGAGGCGCAAGAGAACGTGGCTGTTG
ATGTGGCGGAACAGATCCGAGATGTCCTGCTTGGCCTGCCTGCCCGTAGTGCCGTGAACATCCCTGGCCTCAGTGCAGAG
ATCATGGAGCGGCTTAAGCCTCATTTGCAATTAGCCGAGACCCTTGGGCTGTTGGTGAGCCAGCTCTCCGGAGGACAGTT
GCAGGAGCTTGAAGTTCGTCTTCAGGGGGAGTTCGCTCAGCATCCCTCTCAGCCTCTGGTGATTGCTGCTCTCAAGGGCG
TGCTGACCAGTGCCCTTGGCGATCGGATCAATTACGTGAATGCGTCCTTAGAAGCCAAGGGCCGTGGCATTCGTGTCTTG
GAGGTCAAGGACGAGACAAGTAAGGATTTTGCCGGGGGGTCCTTGCAACTAACGACTCGTGGTGACCAGGGCGGTCACAG
CGTGACGGGTGCAGTGTTTGCCAATGGCGATCTGCGCATCACCACCATTGATGAATTCCCGGTCAACGTGTCGCCTAGTC
GACACATGCTGTTGACCAGGCACAGGGATATGCCAGGGATCATCGGTCAGTTGGGCTCCGTGCTTGGTGAACACAACGTC
AACATCGCATCAATGCAGGTGGGGCGTCGCATTGTTCGCGGTGATGCGGTGATGGTGCTGAGCATTGATGATCCAATCCC
ACCAAGTTTGCTGGTCACCATCCATGCGATCAATGGCATTAAGGAAGCTCATCCGGTCACCCTCTGA

Upstream 100 bases:

>100_bases
ACACACCTCAATCGTTTGAATTCTGAACCCTGTTTTGTGGTCTGCAGGGCTTGGAGCCTGTAGATCTCTACAGTGCCCTG
CTGCAGTCTTGCGCCGGTTG

Downstream 100 bases:

>100_bases
TCGAGGCTGATGAGATGAACTCTGCTTCTGCTTGTTGCTGGTGGCGTCTTGCCCTGCCCATTGCAGATGAACTGGAAGAG
TCGCTCATCTGGAAGCTGAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTADVIKAGGRLRIIGRAGVGVDNVDVP
TATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVPQAHASTMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVARVCNA
MGMEVIAYDPFISADRAQQMQVRLSSLENLFEQADYITLHLPRTPDTENLVNEELLGKMKSTARLVNCARGGIIDESALA
DALKAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVAEQIRDVLLGLPARSAVNIPGLSAE
IMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQGEFAQHPSQPLVIAALKGVLTSALGDRINYVNASLEAKGRGIRVL
EVKDETSKDFAGGSLQLTTRGDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLGEHNV
NIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL

Sequences:

>Translated_528_residues
MTKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTADVIKAGGRLRIIGRAGVGVDNVDVP
TATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVPQAHASTMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVARVCNA
MGMEVIAYDPFISADRAQQMQVRLSSLENLFEQADYITLHLPRTPDTENLVNEELLGKMKSTARLVNCARGGIIDESALA
DALKAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVAEQIRDVLLGLPARSAVNIPGLSAE
IMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQGEFAQHPSQPLVIAALKGVLTSALGDRINYVNASLEAKGRGIRVL
EVKDETSKDFAGGSLQLTTRGDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLGEHNV
NIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL
>Mature_527_residues
TKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTADVIKAGGRLRIIGRAGVGVDNVDVPT
ATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVPQAHASTMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVARVCNAM
GMEVIAYDPFISADRAQQMQVRLSSLENLFEQADYITLHLPRTPDTENLVNEELLGKMKSTARLVNCARGGIIDESALAD
ALKAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVAEQIRDVLLGLPARSAVNIPGLSAEI
MERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQGEFAQHPSQPLVIAALKGVLTSALGDRINYVNASLEAKGRGIRVLE
VKDETSKDFAGGSLQLTTRGDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLGEHNVN
IASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=401, Percent_Identity=41.1471321695761, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI61743967, Length=272, Percent_Identity=35.2941176470588, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=35.2941176470588, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI6912396, Length=326, Percent_Identity=29.4478527607362, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI145580578, Length=310, Percent_Identity=32.5806451612903, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI4557499, Length=310, Percent_Identity=32.5806451612903, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI145580575, Length=301, Percent_Identity=32.5581395348837, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1789279, Length=327, Percent_Identity=32.7217125382263, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=32.3529411764706, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1787645, Length=210, Percent_Identity=34.7619047619048, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788660, Length=265, Percent_Identity=30.5660377358491, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081824, Length=159, Percent_Identity=32.0754716981132, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=324, Percent_Identity=45.3703703703704, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=31.496062992126, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=34.0490797546012, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=32.9268292682927, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324964, Length=250, Percent_Identity=29.2, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=27.1604938271605, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=156, Percent_Identity=34.6153846153846, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=28.1081081081081, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=30.2325581395349, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=46.5116279069767, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24646446, Length=253, Percent_Identity=35.9683794466403, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646448, Length=253, Percent_Identity=35.9683794466403, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646452, Length=253, Percent_Identity=35.9683794466403, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646450, Length=253, Percent_Identity=35.9683794466403, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI62472511, Length=270, Percent_Identity=35.5555555555556, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=27.1565495207668, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=29.8076923076923, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=29.2490118577075, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56121; Mature: 55990

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTADVIKA
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHC
GGRLRIIGRAGVGVDNVDVPTATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVPQAHA
CCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCHHHH
STMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVARVCNAMGMEVIAYDPFISADRAQQM
HHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHH
QVRLSSLENLFEQADYITLHLPRTPDTENLVNEELLGKMKSTARLVNCARGGIIDESALA
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
DALKAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVAEQIR
HHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHH
DVLLGLPARSAVNIPGLSAEIMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQGEFAQ
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHEEEECHHHC
HPSQPLVIAALKGVLTSALGDRINYVNASLEAKGRGIRVLEVKDETSKDFAGGSLQLTTR
CCCCCCHHHHHHHHHHHHHHCHHHEECCEEECCCCCEEEEEECCCCCCCCCCCEEEEEEC
GDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLGEHNV
CCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL
EEEHHHHHHHHCCCCEEEEEECCCCCCCHHEEEEEHHCCCCCCCCCCC
>Mature Secondary Structure 
TKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTADVIKA
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHC
GGRLRIIGRAGVGVDNVDVPTATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVPQAHA
CCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCHHHH
STMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVARVCNAMGMEVIAYDPFISADRAQQM
HHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHH
QVRLSSLENLFEQADYITLHLPRTPDTENLVNEELLGKMKSTARLVNCARGGIIDESALA
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
DALKAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVAEQIR
HHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHH
DVLLGLPARSAVNIPGLSAEIMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQGEFAQ
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHEEEECHHHC
HPSQPLVIAALKGVLTSALGDRINYVNASLEAKGRGIRVLEVKDETSKDFAGGSLQLTTR
CCCCCCHHHHHHHHHHHHHHCHHHEECCEEECCCCCEEEEEECCCCCCCCCCCEEEEEEC
GDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLGEHNV
CCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL
EEEHHHHHHHHCCCCEEEEEECCCCCCCHHEEEEEHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]