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The map label for this gene is putP [H]

Identifier: 124022152

GI number: 124022152

Start: 447714

End: 449483

Strand: Direct

Name: putP [H]

Synonym: P9303_04421

Alternate gene names: 124022152

Gene position: 447714-449483 (Clockwise)

Preceding gene: 124022151

Following gene: 124022153

Centisome position: 16.69

GC content: 56.55

Gene sequence:

>1770_bases
ATGGCTGCCATTGATTGGATAATCCTCGTTGGTTATCTCGCCATCACTCTCGTGATTGGGCTTTGGTTGTCTCGTCGCAA
TCGAAGTGAGGATGATTACTTTGTTGCGGGACGTCGACTCAGTGGTTGGTTGGCTGGGGCTTCGATGGCCGCAACGACAT
TTTCGATTGATACCCCTCTTTATGTAGCCGGTCTGGTTGGCACACGAGGATTGGCCGGCAATTGGGAATGGTGGAGCTTC
GGCCTGGCGCATGTTGCCATGGCAGTTGTCTTTGCTCCGCTCTGGCGACGGAGTGGGGTGCTGACCGATGCTGCATTCAC
CGAGCTGCGTTATGGCGGAGCGCCTGCCGCCTGGCTGCGTGGGATTAAAGCATTTTTGCTCGCACTGCCGGTGAATTGCA
TCGGTATCGGCTATGCCTTCCTGGCCATGCGCAAGGTCGTAGAAGCCCTGGGCATAGTGTCTGGCAGCCCTGTGGCAGTG
CTTGGCGGTACCCCTGACACTGTTGTGCTGTTGGCAGTCGTGGCTGTGATGGTGCTTGTTTACACAGTTGCTGGCGGCCT
CTGGGCTGTCGTGATCACCGATTTCGTGCAGTTGCTGTTGGCTCTTTTGGGAGCGGTGGCGGTGGCGTGGGCCGCCGTTC
ATGCAGCCGGAGGGATGGACGCCATGCTCGATCAACTGAGGGGGTTAGAGCGACCTGAACTGCTGGCGATCGTGCCCTGG
CAATGGAATGGTGATGGCTTTGATTGGATTGGTGGCGCCGAGATCAGTGTGGCCACATTCCTTTCTTATCTCACTGTCCA
ATGGTGGAGTTTCCGTCGCAGCGACGGTGGTGGTGAGTTCATTCAGAGAATGTTGGCCACGCGGGACGAGCGTCAGGCTC
AACTGGCTGGCTGGGTGTTTCTGGTGGTCAACTATCTGGTGCGCAGTTGGTTGTGGGTTGTGGTTGCTCTTGCCGCTTTA
GTGCTGTTGCCAGCTCAGGCCGACTGGGAACTCAGTTACCCAACCTTGGCTGTGACCTACCTGCCACCGGTGGTGCTTGG
TCTTGTCGTGGTCTCTCTGGTGGCGGCTTTCATGAGTACGGTCAGTACCGCAGTGAACTGGGGTGCTAGCTATCTCACCC
ACGATCTTTACCAGCGTTTTATAAGGCCGGATGCTGATCAGAGAGAGCTGTTGCTGGTCGGTCAATTCACCAGTGTTTTG
CTGCTAGTTCTCGGGGTGATCACCGCATTAATTAGCGACAGCATCGGCACAGTGTTTCGTCTGGTGATTGCTATTGGTAC
CGGGCCCGGAGTGGTGCTTGTGCTGCGTTGGTTCTGGTGGCGGATCAATGCTGCTGCCGAATTGGCGGCGATGGTTTGTG
GTTTTGTGGTGGGCCTTTGTACATCCGTTGTGCCCTTGGTGACAATTCCTGATTACGGCACCAGGTTGATGATCACCACA
GCGATTACTGCTGTGGTCTGGGTTGTAGTGATGCTGGTGACTCCGCCTGAATCGCCGCAAGTGCTCGAGCGCTTTGTGAA
CCAGGTGCAGCCACCAGGCCCAGGCTGGAGTCGCTTGCGTCAACGCCTGGATATAACACCGGTGGATTCCCTGGTGAGTT
TGTGTTTGCGCTTCATTCTTAGTGTCGGTGTTCTGTTTGGCGGTCTGCTCGGCACTGGCGCGTTTCTGTTACATCAGCAG
CTAGGCGGTTGGATCGGTTTGGTGGTCACCGTGGTCTGTGTGCTGCCTTTAACCCGTGGTTGGCTGCGTAGTCGGATGGG
CGTCGCATGA

Upstream 100 bases:

>100_bases
GCTGGATCAGAATGCCGCCTGTGGCCAGCTCCGCCGCCAGCACGCAGCCATCGGCTGAGATGGACTAGCTGAGCCACACT
GAGATCAACCGCCTAGGGAT

Downstream 100 bases:

>100_bases
TCTACAAGGTCTTGGCTTGGGCGGCAGAATGAGAGAAAGTGTTGATAAACCTTGGATTTCTTACGTTCCACCGTGTTGCC
GGCTCTGATTGTGGCTTTAT

Product: sodium/solute symporter family protein glucose transporter

Products: NA

Alternate protein names: Na(+)/glucose symporter [H]

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MAAIDWIILVGYLAITLVIGLWLSRRNRSEDDYFVAGRRLSGWLAGASMAATTFSIDTPLYVAGLVGTRGLAGNWEWWSF
GLAHVAMAVVFAPLWRRSGVLTDAAFTELRYGGAPAAWLRGIKAFLLALPVNCIGIGYAFLAMRKVVEALGIVSGSPVAV
LGGTPDTVVLLAVVAVMVLVYTVAGGLWAVVITDFVQLLLALLGAVAVAWAAVHAAGGMDAMLDQLRGLERPELLAIVPW
QWNGDGFDWIGGAEISVATFLSYLTVQWWSFRRSDGGGEFIQRMLATRDERQAQLAGWVFLVVNYLVRSWLWVVVALAAL
VLLPAQADWELSYPTLAVTYLPPVVLGLVVVSLVAAFMSTVSTAVNWGASYLTHDLYQRFIRPDADQRELLLVGQFTSVL
LLVLGVITALISDSIGTVFRLVIAIGTGPGVVLVLRWFWWRINAAAELAAMVCGFVVGLCTSVVPLVTIPDYGTRLMITT
AITAVVWVVVMLVTPPESPQVLERFVNQVQPPGPGWSRLRQRLDITPVDSLVSLCLRFILSVGVLFGGLLGTGAFLLHQQ
LGGWIGLVVTVVCVLPLTRGWLRSRMGVA

Sequences:

>Translated_589_residues
MAAIDWIILVGYLAITLVIGLWLSRRNRSEDDYFVAGRRLSGWLAGASMAATTFSIDTPLYVAGLVGTRGLAGNWEWWSF
GLAHVAMAVVFAPLWRRSGVLTDAAFTELRYGGAPAAWLRGIKAFLLALPVNCIGIGYAFLAMRKVVEALGIVSGSPVAV
LGGTPDTVVLLAVVAVMVLVYTVAGGLWAVVITDFVQLLLALLGAVAVAWAAVHAAGGMDAMLDQLRGLERPELLAIVPW
QWNGDGFDWIGGAEISVATFLSYLTVQWWSFRRSDGGGEFIQRMLATRDERQAQLAGWVFLVVNYLVRSWLWVVVALAAL
VLLPAQADWELSYPTLAVTYLPPVVLGLVVVSLVAAFMSTVSTAVNWGASYLTHDLYQRFIRPDADQRELLLVGQFTSVL
LLVLGVITALISDSIGTVFRLVIAIGTGPGVVLVLRWFWWRINAAAELAAMVCGFVVGLCTSVVPLVTIPDYGTRLMITT
AITAVVWVVVMLVTPPESPQVLERFVNQVQPPGPGWSRLRQRLDITPVDSLVSLCLRFILSVGVLFGGLLGTGAFLLHQQ
LGGWIGLVVTVVCVLPLTRGWLRSRMGVA
>Mature_588_residues
AAIDWIILVGYLAITLVIGLWLSRRNRSEDDYFVAGRRLSGWLAGASMAATTFSIDTPLYVAGLVGTRGLAGNWEWWSFG
LAHVAMAVVFAPLWRRSGVLTDAAFTELRYGGAPAAWLRGIKAFLLALPVNCIGIGYAFLAMRKVVEALGIVSGSPVAVL
GGTPDTVVLLAVVAVMVLVYTVAGGLWAVVITDFVQLLLALLGAVAVAWAAVHAAGGMDAMLDQLRGLERPELLAIVPWQ
WNGDGFDWIGGAEISVATFLSYLTVQWWSFRRSDGGGEFIQRMLATRDERQAQLAGWVFLVVNYLVRSWLWVVVALAALV
LLPAQADWELSYPTLAVTYLPPVVLGLVVVSLVAAFMSTVSTAVNWGASYLTHDLYQRFIRPDADQRELLLVGQFTSVLL
LVLGVITALISDSIGTVFRLVIAIGTGPGVVLVLRWFWWRINAAAELAAMVCGFVVGLCTSVVPLVTIPDYGTRLMITTA
ITAVVWVVVMLVTPPESPQVLERFVNQVQPPGPGWSRLRQRLDITPVDSLVSLCLRFILSVGVLFGGLLGTGAFLLHQQL
GGWIGLVVTVVCVLPLTRGWLRSRMGVA

Specific function: Actively transports glucose into cells by Na(+) cotransport [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI4507033, Length=429, Percent_Identity=25.8741258741259, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4507031, Length=557, Percent_Identity=23.3393177737882, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI14140236, Length=513, Percent_Identity=24.1715399610136, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI17941285, Length=481, Percent_Identity=24.5322245322245, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI110835708, Length=550, Percent_Identity=22.9090909090909, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI206597483, Length=547, Percent_Identity=23.0347349177331, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790113, Length=509, Percent_Identity=23.7721021611002, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790503, Length=480, Percent_Identity=21.6666666666667, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 63683; Mature: 63552

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIDWIILVGYLAITLVIGLWLSRRNRSEDDYFVAGRRLSGWLAGASMAATTFSIDTPL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHCCHHHHEEEECCCCH
YVAGLVGTRGLAGNWEWWSFGLAHVAMAVVFAPLWRRSGVLTDAAFTELRYGGAPAAWLR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHH
GIKAFLLALPVNCIGIGYAFLAMRKVVEALGIVSGSPVAVLGGTPDTVVLLAVVAVMVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
YTVAGGLWAVVITDFVQLLLALLGAVAVAWAAVHAAGGMDAMLDQLRGLERPELLAIVPW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEE
QWNGDGFDWIGGAEISVATFLSYLTVQWWSFRRSDGGGEFIQRMLATRDERQAQLAGWVF
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
LVVNYLVRSWLWVVVALAALVLLPAQADWELSYPTLAVTYLPPVVLGLVVVSLVAAFMST
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VSTAVNWGASYLTHDLYQRFIRPDADQRELLLVGQFTSVLLLVLGVITALISDSIGTVFR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVIAIGTGPGVVLVLRWFWWRINAAAELAAMVCGFVVGLCTSVVPLVTIPDYGTRLMITT
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHH
AITAVVWVVVMLVTPPESPQVLERFVNQVQPPGPGWSRLRQRLDITPVDSLVSLCLRFIL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
SVGVLFGGLLGTGAFLLHQQLGGWIGLVVTVVCVLPLTRGWLRSRMGVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AAIDWIILVGYLAITLVIGLWLSRRNRSEDDYFVAGRRLSGWLAGASMAATTFSIDTPL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHCCHHHHEEEECCCCH
YVAGLVGTRGLAGNWEWWSFGLAHVAMAVVFAPLWRRSGVLTDAAFTELRYGGAPAAWLR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHH
GIKAFLLALPVNCIGIGYAFLAMRKVVEALGIVSGSPVAVLGGTPDTVVLLAVVAVMVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
YTVAGGLWAVVITDFVQLLLALLGAVAVAWAAVHAAGGMDAMLDQLRGLERPELLAIVPW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEE
QWNGDGFDWIGGAEISVATFLSYLTVQWWSFRRSDGGGEFIQRMLATRDERQAQLAGWVF
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
LVVNYLVRSWLWVVVALAALVLLPAQADWELSYPTLAVTYLPPVVLGLVVVSLVAAFMST
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VSTAVNWGASYLTHDLYQRFIRPDADQRELLLVGQFTSVLLLVLGVITALISDSIGTVFR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVIAIGTGPGVVLVLRWFWWRINAAAELAAMVCGFVVGLCTSVVPLVTIPDYGTRLMITT
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHH
AITAVVWVVVMLVTPPESPQVLERFVNQVQPPGPGWSRLRQRLDITPVDSLVSLCLRFIL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
SVGVLFGGLLGTGAFLLHQQLGGWIGLVVTVVCVLPLTRGWLRSRMGVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8652595; 10835424; 10757971 [H]