Click here to switch to the map view.

The map label for this gene is tolC [C]

Identifier: 124021936

GI number: 124021936

Start: 240486

End: 242219

Strand: Direct

Name: tolC [C]

Synonym: P9303_02231

Alternate gene names: 124021936

Gene position: 240486-242219 (Clockwise)

Preceding gene: 124021935

Following gene: 124021937

Centisome position: 8.96

GC content: 46.94

Gene sequence:

>1734_bases
GTGCGTCTGATTACCGCAAGACTGTTTCTCCTTGCAGGCGTATTGGCTCAAGGGTGCACTGGTGTTCTAGCTCAACAGTC
GCTTGAGGTTCAACAGCATGGCAGCAGCACTGATCAAGCGCCTGCCTCGCAAGACGCTGAGGCTGATGGTTCAGCTTTAA
TCGATCAGTCGACGCTTCCTAGCGCCATTGAGTTGAAGGGATCTCGCCCCAGGGTTGATCCTTCAGCAGTGAAGCCTGCA
GCAACGAGTTTGCCTGAGCCGCTTTCTTCGCTTGGGGCCACGCCAAGTCTTGCGCTGCCAAATAAAACTTCAGAGGTGAG
GATTAGGGAGCTTCGCCCTCTCAGCTTGTCTGAAGTAGAGCAATTAGCTGAAGTCAATAGTCCCAGTCTCAAAGCTGCAG
CTAGTGTTGTCGAGCAAGCAAAATCAAACCTTTTAGCTGCTCTTTCAGCCTGGTATCCAACTTTAAGTCTTAAATCTAGT
GTTAATTTCGCAGGGGATGAGGGGCGCAGCAACTCTGAGAATTATCAGCAAATCACTGAGGAATATACTTTTAGGGAGGA
ATGGATTACAAATTTTGATGCCACTTTGAACTGGAATCTTATTGATCCTGCAAGAGTTCCTCAAATTGCATCAGCTAGAG
ATACCTTTGAAAAGCAGAGAGATACTTACCTGATTGCACTTCGCGACTTACGTTTAAATGCGGCAGATCTTTATTTTAGA
TTGCAGCGAGCTGATGAAGGTGTGGGCATTGGTCAAAATGCTGTTCGTGCTTCTCTCGTGAGTTTGCGTGATGCTCAGTC
TCGCCTGCAGGCAGGGGTCGCGACTAAGCTTGAAGTGCTCGAGGCGGAGACTCAGCTTGCTCGAGATACTCAGTCTTTAA
CTCTTGCTCTGGCTCAGCAGAATACGCGACGCAGAAATCTTGCTCAATTGTTAGACTTGCCCCAAGATGTAACTCCTACA
GCGGCTGATCCTGTCCAAATTATTGGTATCTGGCAGCCCTCGCTTGAGGAGAGTATTGTTGCAGCTTATGCCTTTCGTGA
GGAACTTGACAGCTTAATACTTGATATCTCTATTAATAATAGTAATGCCAATGCTGCTCTTGCCGCAGTGCAGCCAGTCA
TTAATCTCACTAACACTTATCAAGCCATTCGAAGAGAGGGTCAATCTGGCGTAACCATTGATAACTCTGTCGACTGGACG
CAACATTCATGGACGTCTGCCAACACAGTTGGTTTGGGCTTCACCTGGAATATTTTTGATGGAGGGAGAGCATGGGCTCA
ATATCGCCAGAACAAACAGAAGGCTCAGCAAAGTGAGTTTGAATTCGCATCAAAGCGTGATCAGGTTCGCCTAGAAGTTG
AGCAAAGCTTTTTTAATCTTCGTGCCTCTAACCAAGATATCAAGACAACGAGTATTGGAGTTTTATCTTCAAGAGAATCA
CTTCGATTGGCGCGTTTGAGATTCCAGGCAGGAGTGACAACGCAAAGAGAGGTTGTAAATAATCAGCGTGATCTTAAACA
GGCCAAGACTCTCTATGCAGATGCAATGCTTAAATACAATCAAAGCATGATCCAGCTTAGTCGCCGTACAGGTCTGGATC
AGATTGCGGCTTGTGATTCCTTAGAGCTTTCCAATAAGAAGCCGAAAGATGATCTCTTTGACTCGGCCGAAGTTCCTATC
AAACCTTCTCCGCTCAATCCAGCGTGCAAGGCTTCCATCCTGCAAGCTGAGTGA

Upstream 100 bases:

>100_bases
GATCTCGATACGTATCGTGCATGGGGCGGCTGACATCGTGGCCGCTGCGATGGGAGATGGCCAGGAAATTCATTAAGCTC
CCCGCAGTTTTCAAATTGCT

Downstream 100 bases:

>100_bases
TGAGTAGTGGGCCTTTGCCTGAATCTCTTGGTTCTTTGCAACTGAGCGCAGTTCATCAACTCCTTGATCGAGTTGCAGAT
CGTCAACGTCAAGACTTTGG

Product: RND family outer membrane efflux protein

Products: NA

Alternate protein names: RND Family Outer Membrane Efflux Protein; Outer Membrane Protein-Like; RND Family Outer Membrane Efflux Protein-Like; Tranporter Outer Membrane Factor Family; Outer Membrane Efflux Family Protein

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MRLITARLFLLAGVLAQGCTGVLAQQSLEVQQHGSSTDQAPASQDAEADGSALIDQSTLPSAIELKGSRPRVDPSAVKPA
ATSLPEPLSSLGATPSLALPNKTSEVRIRELRPLSLSEVEQLAEVNSPSLKAAASVVEQAKSNLLAALSAWYPTLSLKSS
VNFAGDEGRSNSENYQQITEEYTFREEWITNFDATLNWNLIDPARVPQIASARDTFEKQRDTYLIALRDLRLNAADLYFR
LQRADEGVGIGQNAVRASLVSLRDAQSRLQAGVATKLEVLEAETQLARDTQSLTLALAQQNTRRRNLAQLLDLPQDVTPT
AADPVQIIGIWQPSLEESIVAAYAFREELDSLILDISINNSNANAALAAVQPVINLTNTYQAIRREGQSGVTIDNSVDWT
QHSWTSANTVGLGFTWNIFDGGRAWAQYRQNKQKAQQSEFEFASKRDQVRLEVEQSFFNLRASNQDIKTTSIGVLSSRES
LRLARLRFQAGVTTQREVVNNQRDLKQAKTLYADAMLKYNQSMIQLSRRTGLDQIAACDSLELSNKKPKDDLFDSAEVPI
KPSPLNPACKASILQAE

Sequences:

>Translated_577_residues
MRLITARLFLLAGVLAQGCTGVLAQQSLEVQQHGSSTDQAPASQDAEADGSALIDQSTLPSAIELKGSRPRVDPSAVKPA
ATSLPEPLSSLGATPSLALPNKTSEVRIRELRPLSLSEVEQLAEVNSPSLKAAASVVEQAKSNLLAALSAWYPTLSLKSS
VNFAGDEGRSNSENYQQITEEYTFREEWITNFDATLNWNLIDPARVPQIASARDTFEKQRDTYLIALRDLRLNAADLYFR
LQRADEGVGIGQNAVRASLVSLRDAQSRLQAGVATKLEVLEAETQLARDTQSLTLALAQQNTRRRNLAQLLDLPQDVTPT
AADPVQIIGIWQPSLEESIVAAYAFREELDSLILDISINNSNANAALAAVQPVINLTNTYQAIRREGQSGVTIDNSVDWT
QHSWTSANTVGLGFTWNIFDGGRAWAQYRQNKQKAQQSEFEFASKRDQVRLEVEQSFFNLRASNQDIKTTSIGVLSSRES
LRLARLRFQAGVTTQREVVNNQRDLKQAKTLYADAMLKYNQSMIQLSRRTGLDQIAACDSLELSNKKPKDDLFDSAEVPI
KPSPLNPACKASILQAE
>Mature_577_residues
MRLITARLFLLAGVLAQGCTGVLAQQSLEVQQHGSSTDQAPASQDAEADGSALIDQSTLPSAIELKGSRPRVDPSAVKPA
ATSLPEPLSSLGATPSLALPNKTSEVRIRELRPLSLSEVEQLAEVNSPSLKAAASVVEQAKSNLLAALSAWYPTLSLKSS
VNFAGDEGRSNSENYQQITEEYTFREEWITNFDATLNWNLIDPARVPQIASARDTFEKQRDTYLIALRDLRLNAADLYFR
LQRADEGVGIGQNAVRASLVSLRDAQSRLQAGVATKLEVLEAETQLARDTQSLTLALAQQNTRRRNLAQLLDLPQDVTPT
AADPVQIIGIWQPSLEESIVAAYAFREELDSLILDISINNSNANAALAAVQPVINLTNTYQAIRREGQSGVTIDNSVDWT
QHSWTSANTVGLGFTWNIFDGGRAWAQYRQNKQKAQQSEFEFASKRDQVRLEVEQSFFNLRASNQDIKTTSIGVLSSRES
LRLARLRFQAGVTTQREVVNNQRDLKQAKTLYADAMLKYNQSMIQLSRRTGLDQIAACDSLELSNKKPKDDLFDSAEVPI
KPSPLNPACKASILQAE

Specific function: Required For Proper Expression Of Outer Membrane Protein Genes Such As Ompf, Nmpc, Protein 2, Hemolysin, Colicin V, Or Colicin E1. May Be Specialized For Signal Sequence Independent, Extracellular Secretion In Gram-Negative Bacteria. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Outer Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 63380; Mature: 63380

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLITARLFLLAGVLAQGCTGVLAQQSLEVQQHGSSTDQAPASQDAEADGSALIDQSTLP
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCC
SAIELKGSRPRVDPSAVKPAATSLPEPLSSLGATPSLALPNKTSEVRIRELRPLSLSEVE
CCEEECCCCCCCCHHHCCCCHHCCCHHHHHHCCCCCCCCCCCCCCEEHHHCCCCCHHHHH
QLAEVNSPSLKAAASVVEQAKSNLLAALSAWYPTLSLKSSVNFAGDEGRSNSENYQQITE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHH
EYTFREEWITNFDATLNWNLIDPARVPQIASARDTFEKQRDTYLIALRDLRLNAADLYFR
HHHHHHHHHCCCCCEEEECCCCHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHH
LQRADEGVGIGQNAVRASLVSLRDAQSRLQAGVATKLEVLEAETQLARDTQSLTLALAQQ
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTRRRNLAQLLDLPQDVTPTAADPVQIIGIWQPSLEESIVAAYAFREELDSLILDISINN
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEEECC
SNANAALAAVQPVINLTNTYQAIRREGQSGVTIDNSVDWTQHSWTSANTVGLGFTWNIFD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCEEEECEEEEECC
GGRAWAQYRQNKQKAQQSEFEFASKRDQVRLEVEQSFFNLRASNQDIKTTSIGVLSSRES
CHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCEEEEEECCCHHH
LRLARLRFQAGVTTQREVVNNQRDLKQAKTLYADAMLKYNQSMIQLSRRTGLDQIAACDS
HHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
LELSNKKPKDDLFDSAEVPIKPSPLNPACKASILQAE
CCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MRLITARLFLLAGVLAQGCTGVLAQQSLEVQQHGSSTDQAPASQDAEADGSALIDQSTLP
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCC
SAIELKGSRPRVDPSAVKPAATSLPEPLSSLGATPSLALPNKTSEVRIRELRPLSLSEVE
CCEEECCCCCCCCHHHCCCCHHCCCHHHHHHCCCCCCCCCCCCCCEEHHHCCCCCHHHHH
QLAEVNSPSLKAAASVVEQAKSNLLAALSAWYPTLSLKSSVNFAGDEGRSNSENYQQITE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHH
EYTFREEWITNFDATLNWNLIDPARVPQIASARDTFEKQRDTYLIALRDLRLNAADLYFR
HHHHHHHHHCCCCCEEEECCCCHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHH
LQRADEGVGIGQNAVRASLVSLRDAQSRLQAGVATKLEVLEAETQLARDTQSLTLALAQQ
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTRRRNLAQLLDLPQDVTPTAADPVQIIGIWQPSLEESIVAAYAFREELDSLILDISINN
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEEECC
SNANAALAAVQPVINLTNTYQAIRREGQSGVTIDNSVDWTQHSWTSANTVGLGFTWNIFD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCEEEECEEEEECC
GGRAWAQYRQNKQKAQQSEFEFASKRDQVRLEVEQSFFNLRASNQDIKTTSIGVLSSRES
CHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCEEEEEECCCHHH
LRLARLRFQAGVTTQREVVNNQRDLKQAKTLYADAMLKYNQSMIQLSRRTGLDQIAACDS
HHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
LELSNKKPKDDLFDSAEVPIKPSPLNPACKASILQAE
CCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA