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The map label for this gene is mpg1 [H]

Identifier: 124021830

GI number: 124021830

Start: 116758

End: 117720

Strand: Reverse

Name: mpg1 [H]

Synonym: P9303_01171

Alternate gene names: 124021830

Gene position: 117720-116758 (Counterclockwise)

Preceding gene: 124021832

Following gene: 124021829

Centisome position: 4.39

GC content: 36.24

Gene sequence:

>963_bases
ATGGTTGTAGTAGTTGATGATAAGAAGCGAATGCTTGGCTCTATAACTGATGGAGATGTAAGGAGGGGATTGCTTCGTGG
TGAATCATTGCAATCGAAGGCTTATAAAATAATGAATCATAATTATAGGTTTATGTACAACGATAGTGATGAATCTAATG
CATACGAGATCATGAAAAAGGAATCACTACGATATATACCAATACTAGACAAAGACGGAGTAATTAAAAGAATTATATCA
TTAAATGAATTTTTAGAACCTGAGAAAATAAGAAACCCTGTTGTGATTATGGCAGGCGGAAAAGGGATGCGATTACGGCC
ACTTACAGAGGATTGTCCTAAACCAATGCTCTTGGTTGGAGGCAAGCCGATGTTAAAAATCCTATTAGAACAGTTTATAG
CTAGTGGATTTGAAGAGTTTTACTTTTCAGTAAATTATTTAAAAGATAAGATAATTAATCATTTTGAAAATGGAGAAAGG
TGGGGTGTCAATATAAGATACATAAATGAAGACAAGCCGTTAGGGACTGCTGGTTCTTTGAAGTTACTACCAAGTAATAT
TAAAAGGCCTTTTATAGTTATAAATGGAGATGTTCTTACTAGGCTAAATACAATTCAATTGCTACGGTTTCATATAGATC
ATGATGCCTTAGCGACGATATGTGTACGCGAATATGAAATGAAAGTACCATTTGGTGTAGTTCAGGTTGACGGGGTAGAA
CTTAAAGGGTTCAAAGAAAAGCCAAGAATACGACAACTTGTCAATGCGGGTATATATGTCATTAACCCTGCATTGATAGA
GTCTATTAAGGACGGCCAAGTAATAGATATGCCTGAACTACTGCTCAATGAAAGTAATGAATCAAGACGCGTCACTGTTT
ACCCTATTCATGAATATTGGTTAGACGTAGGAAGACCAGAGAGTCTAGAAGAGGCTCATGCGACCTGGGAAGAATTAAAG
TGA

Upstream 100 bases:

>100_bases
ACATAATTTGTTTGAAGTGGACGACATTTGTGAGCTAATGGTTTCTTCTGAAACTGTTGTGGAAAGGATCCTCCAAAAGC
TTGACAGCTCAGGAGCGCAA

Downstream 100 bases:

>100_bases
ATAGTAATATGAAATCAAAAAGAGTAGTTGCAAGGGTCTTAGTTTGTGGACTAGGAAGTATAGGGAAACAACATATTAAA
GTCATTAAGAAGTATTGGCC

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MVVVVDDKKRMLGSITDGDVRRGLLRGESLQSKAYKIMNHNYRFMYNDSDESNAYEIMKKESLRYIPILDKDGVIKRIIS
LNEFLEPEKIRNPVVIMAGGKGMRLRPLTEDCPKPMLLVGGKPMLKILLEQFIASGFEEFYFSVNYLKDKIINHFENGER
WGVNIRYINEDKPLGTAGSLKLLPSNIKRPFIVINGDVLTRLNTIQLLRFHIDHDALATICVREYEMKVPFGVVQVDGVE
LKGFKEKPRIRQLVNAGIYVINPALIESIKDGQVIDMPELLLNESNESRRVTVYPIHEYWLDVGRPESLEEAHATWEELK

Sequences:

>Translated_320_residues
MVVVVDDKKRMLGSITDGDVRRGLLRGESLQSKAYKIMNHNYRFMYNDSDESNAYEIMKKESLRYIPILDKDGVIKRIIS
LNEFLEPEKIRNPVVIMAGGKGMRLRPLTEDCPKPMLLVGGKPMLKILLEQFIASGFEEFYFSVNYLKDKIINHFENGER
WGVNIRYINEDKPLGTAGSLKLLPSNIKRPFIVINGDVLTRLNTIQLLRFHIDHDALATICVREYEMKVPFGVVQVDGVE
LKGFKEKPRIRQLVNAGIYVINPALIESIKDGQVIDMPELLLNESNESRRVTVYPIHEYWLDVGRPESLEEAHATWEELK
>Mature_320_residues
MVVVVDDKKRMLGSITDGDVRRGLLRGESLQSKAYKIMNHNYRFMYNDSDESNAYEIMKKESLRYIPILDKDGVIKRIIS
LNEFLEPEKIRNPVVIMAGGKGMRLRPLTEDCPKPMLLVGGKPMLKILLEQFIASGFEEFYFSVNYLKDKIINHFENGER
WGVNIRYINEDKPLGTAGSLKLLPSNIKRPFIVINGDVLTRLNTIQLLRFHIDHDALATICVREYEMKVPFGVVQVDGVE
LKGFKEKPRIRQLVNAGIYVINPALIESIKDGQVIDMPELLLNESNESRRVTVYPIHEYWLDVGRPESLEEAHATWEELK

Specific function: Lipopolysaccharide biosynthesis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=221, Percent_Identity=31.2217194570136, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI11761619, Length=222, Percent_Identity=31.0810810810811, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI31881779, Length=210, Percent_Identity=29.0476190476191, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI45447090, Length=210, Percent_Identity=29.0476190476191, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=223, Percent_Identity=29.5964125560538, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320148, Length=229, Percent_Identity=31.0043668122271, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI21355443, Length=220, Percent_Identity=31.3636363636364, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24644084, Length=220, Percent_Identity=31.3636363636364, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 36805; Mature: 36805

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVVVDDKKRMLGSITDGDVRRGLLRGESLQSKAYKIMNHNYRFMYNDSDESNAYEIMKK
CEEEEECHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
ESLRYIPILDKDGVIKRIISLNEFLEPEKIRNPVVIMAGGKGMRLRPLTEDCPKPMLLVG
CCCEEEEEECCCHHHHHHHHHHHHCCHHHHCCCEEEEECCCCCEECCCHHHCCCCEEEEC
GKPMLKILLEQFIASGFEEFYFSVNYLKDKIINHFENGERWGVNIRYINEDKPLGTAGSL
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCE
KLLPSNIKRPFIVINGDVLTRLNTIQLLRFHIDHDALATICVREYEMKVPFGVVQVDGVE
EECCCCCCCCEEEECCHHHHHHHHEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCEE
LKGFKEKPRIRQLVNAGIYVINPALIESIKDGQVIDMPELLLNESNESRRVTVYPIHEYW
ECCCCCCHHHHHHHHCCEEEECHHHHHHCCCCCEECCHHHHHCCCCCCCEEEEEEHHHHH
LDVGRPESLEEAHATWEELK
HCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVVVVDDKKRMLGSITDGDVRRGLLRGESLQSKAYKIMNHNYRFMYNDSDESNAYEIMKK
CEEEEECHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
ESLRYIPILDKDGVIKRIISLNEFLEPEKIRNPVVIMAGGKGMRLRPLTEDCPKPMLLVG
CCCEEEEEECCCHHHHHHHHHHHHCCHHHHCCCEEEEECCCCCEECCCHHHCCCCEEEEC
GKPMLKILLEQFIASGFEEFYFSVNYLKDKIINHFENGERWGVNIRYINEDKPLGTAGSL
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCE
KLLPSNIKRPFIVINGDVLTRLNTIQLLRFHIDHDALATICVREYEMKVPFGVVQVDGVE
EECCCCCCCCEEEECCHHHHHHHHEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCEE
LKGFKEKPRIRQLVNAGIYVINPALIESIKDGQVIDMPELLLNESNESRRVTVYPIHEYW
ECCCCCCHHHHHHHHCCEEEECHHHHHHCCCCCEECCHHHHHCCCCCCCEEEEEEHHHHH
LDVGRPESLEEAHATWEELK
HCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]