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The map label for this gene is ptmB [H]

Identifier: 124021828

GI number: 124021828

Start: 115033

End: 115749

Strand: Reverse

Name: ptmB [H]

Synonym: P9303_01151

Alternate gene names: 124021828

Gene position: 115749-115033 (Counterclockwise)

Preceding gene: 124021829

Following gene: 124021827

Centisome position: 4.31

GC content: 36.4

Gene sequence:

>717_bases
ATGAATGGATCTACTCATGCTTTTATATTTGCAAGAGGTGGTTCTAAAGGACTTCCAGGGAAGAATATAATGAAAATTAG
TGGAATACCTCTTATAGCTCATGCGATACTATTAGCTAAAAAAATTAAAGTGGTTGATAGAATATTTGTGTCTACTGATT
CTGATGAGATTGAGTCAATAGCAAAGAATTACGGCGCAGAAATAATTCAGCGCCCTAAAGAATTAGCCACTGACCAGGCT
CCTGAATGGAAGGCTTGGCAACATGCTGTTAGCTATGTAAGAACCAAATATGGAAATTTTGACACATTCTTGAGTCTTCC
TTGTACATCGCCACTAAGAACAATTAATGACGTAGAAAGATGTCTAAACGGATTAGATGCTGAAACTGATATTGTCATAA
CGATAAGTCCTTCAAGTAGAAATCCTTGGTTTAATATGGTGAAAATTACAGATAAGCACAAAGTTAAAAGAATAATGGAA
GAACACTCAATATCGAGAAGACAGGATGCTCCTCAATGCTTTGATATAGCCACTATTGCGTATGTCTCAAGACCTGAGTA
TATTCTAAGAGCAAGCAATGTCTGGGATGGTGTGGTAGTGGGTGTAGAGGTACTAAAAGAACACGCAATTGATATAGACA
CTGAATTTGATTTTGCTATGGCGAAATTTATATTTGAAGAATATCGTCCCTCGTTAAAGGTTAGAGAAGATGGATAA

Upstream 100 bases:

>100_bases
GGAGAGAGCTCTCCAATATGCACAGTTGAAGATGGGGTAGAAGTTTTAAAAGTAATCAAAGAGGCAAAATTAATGGCAAG
TATATATGGTGAGATTTAGG

Downstream 100 bases:

>100_bases
GTCTCTAAGTCTGAAGGATGAATGTATTTTAATAACAGGAGCGGCAGGAAGAATAGGTTCAGCTGTCGCTAAAATTGCTT
TTCACGCGGGAGCAAATATA

Product: CMP-N-acetylneuraminic acid synthetase

Products: diphosphate; CMP-N-acylneuraminate

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNGSTHAFIFARGGSKGLPGKNIMKISGIPLIAHAILLAKKIKVVDRIFVSTDSDEIESIAKNYGAEIIQRPKELATDQA
PEWKAWQHAVSYVRTKYGNFDTFLSLPCTSPLRTINDVERCLNGLDAETDIVITISPSSRNPWFNMVKITDKHKVKRIME
EHSISRRQDAPQCFDIATIAYVSRPEYILRASNVWDGVVVGVEVLKEHAIDIDTEFDFAMAKFIFEEYRPSLKVREDG

Sequences:

>Translated_238_residues
MNGSTHAFIFARGGSKGLPGKNIMKISGIPLIAHAILLAKKIKVVDRIFVSTDSDEIESIAKNYGAEIIQRPKELATDQA
PEWKAWQHAVSYVRTKYGNFDTFLSLPCTSPLRTINDVERCLNGLDAETDIVITISPSSRNPWFNMVKITDKHKVKRIME
EHSISRRQDAPQCFDIATIAYVSRPEYILRASNVWDGVVVGVEVLKEHAIDIDTEFDFAMAKFIFEEYRPSLKVREDG
>Mature_238_residues
MNGSTHAFIFARGGSKGLPGKNIMKISGIPLIAHAILLAKKIKVVDRIFVSTDSDEIESIAKNYGAEIIQRPKELATDQA
PEWKAWQHAVSYVRTKYGNFDTFLSLPCTSPLRTINDVERCLNGLDAETDIVITISPSSRNPWFNMVKITDKHKVKRIME
EHSISRRQDAPQCFDIATIAYVSRPEYILRASNVWDGVVVGVEVLKEHAIDIDTEFDFAMAKFIFEEYRPSLKVREDG

Specific function: Required for biosynthesis of LAH modification in the post-translational modification of Campylobacter coli flagellin [H]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=223, Percent_Identity=27.3542600896861, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: 2.7.7.43

Molecular weight: Translated: 26872; Mature: 26872

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGSTHAFIFARGGSKGLPGKNIMKISGIPLIAHAILLAKKIKVVDRIFVSTDSDEIESI
CCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AKNYGAEIIQRPKELATDQAPEWKAWQHAVSYVRTKYGNFDTFLSLPCTSPLRTINDVER
HHHHCHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHH
CLNGLDAETDIVITISPSSRNPWFNMVKITDKHKVKRIMEEHSISRRQDAPQCFDIATIA
HHHCCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YVSRPEYILRASNVWDGVVVGVEVLKEHAIDIDTEFDFAMAKFIFEEYRPSLKVREDG
HHCCCHHEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MNGSTHAFIFARGGSKGLPGKNIMKISGIPLIAHAILLAKKIKVVDRIFVSTDSDEIESI
CCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AKNYGAEIIQRPKELATDQAPEWKAWQHAVSYVRTKYGNFDTFLSLPCTSPLRTINDVER
HHHHCHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHH
CLNGLDAETDIVITISPSSRNPWFNMVKITDKHKVKRIMEEHSISRRQDAPQCFDIATIA
HHHCCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YVSRPEYILRASNVWDGVVVGVEVLKEHAIDIDTEFDFAMAKFIFEEYRPSLKVREDG
HHCCCHHEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; N-acylneuraminate

Specific reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8825781 [H]