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The map label for this gene is neuC [H]

Identifier: 124021822

GI number: 124021822

Start: 109329

End: 110489

Strand: Reverse

Name: neuC [H]

Synonym: P9303_01091

Alternate gene names: 124021822

Gene position: 110489-109329 (Counterclockwise)

Preceding gene: 124021823

Following gene: 124021821

Centisome position: 4.12

GC content: 37.81

Gene sequence:

>1161_bases
TTGACTAGTAATAAAACAAAGATCGGAATATTTACTGGCACAAGGGCAGAATATGGACTAATGAGAACCCTGATCAGGAA
ATTAGTTGATCATCCTGATTATGATACGAAGTTAATAGTCAGTGGATCTCACCTAAGTAAAAGGTATGGCAAAACTATAG
CCGAAATAAAATCTGATGGCATAAAAACAATTGAGAAAGTAAAAACAAGTCTGGATCATACACCTATGCCTGGAATGGCA
TTAATCACAGGGGAAGTGCTCGTTGGAGTAAGTACTTTTCTTGAAAGGTTTGAACCAGAACTATTATTTATCTTAGGAGA
TCGTTATGAATGTTTTGCTGCTGCCACAGCAGCACACTTATTGGGTATTCCTATCGTACATTTACATGGTGGAGAAAAAA
CATCAGGAGCCATCGATGATCGGCTTAGGAATGCTATTTCGCAGCTGAGTACATGGCACTTTACTGCTGCTGAATTATAT
CGAGAAAACATCATCCTTATGGGTCATCCAGCCAAAAATGTTATTTGTGTAGGGCCCATGGTACTTGACATGATATTAGA
TTTTAAGCCTTGTTCGAGATCTATATTTGAAGCAAAAACAGGATTTCGATTCTCGGGAAAAAATATTCTTGTTACTTATC
ATCCAGAAACCCTAACAAAAGATCATGGGATGAAAGGTCTTTTGACTTTGCTTGAAGCAATCGATAGGGTGGAGTGCAAT
ATTCTCTTTACCTACCCAAATGCAGATCAAGGAAGTATAGAGATAAAGGAAGCAATATTGGATTACGTGCATACTCATAA
TGAAAAATGTTATGCTATTCCTTCATTAGGTCAAATCCAATATTTAAATGCATTATATCTATTTGATGTTGTTGCAGGGA
ATTCATCTAGCGGAATCATTGAAGCACCACTGCTTGGCGTGCCAGTAATTAATATTGGTACTAGACAAGGTGGCCGTCTC
CGGTTTGGGAAGGTGCATGATGTAGAAGATAGTGTAAATCGTATCTATACTCTTTTAAAGGAGCTTCTAGCCTTAAGTCC
TAGGAGTACATCACAGCAATATGGGAAGGAGGAATTACTGAGCAGATATCCATCAGCGCCTAGTGATATAATATTAGGTT
GGCTTGACAGTAGAAAATATGTGAATGATTCTCAAATCTGA

Upstream 100 bases:

>100_bases
AATCTGATATGCAAGCGCCCTAATGATGGGATAAGTCCTATGAATTATCCGCAAATATTAGGTAAACGTGCAAAGCGCGA
ATACGAAATTGGTGAATGTA

Downstream 100 bases:

>100_bases
CTTATAATGTAAAATATGAAAACTAACTTGGAGATATGACTCGCTACCCCTTCCCAAAAGAAACGGATAAAGCTCTCTAC
AGAGATGCAGTAAGTAATGA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTSNKTKIGIFTGTRAEYGLMRTLIRKLVDHPDYDTKLIVSGSHLSKRYGKTIAEIKSDGIKTIEKVKTSLDHTPMPGMA
LITGEVLVGVSTFLERFEPELLFILGDRYECFAAATAAHLLGIPIVHLHGGEKTSGAIDDRLRNAISQLSTWHFTAAELY
RENIILMGHPAKNVICVGPMVLDMILDFKPCSRSIFEAKTGFRFSGKNILVTYHPETLTKDHGMKGLLTLLEAIDRVECN
ILFTYPNADQGSIEIKEAILDYVHTHNEKCYAIPSLGQIQYLNALYLFDVVAGNSSSGIIEAPLLGVPVINIGTRQGGRL
RFGKVHDVEDSVNRIYTLLKELLALSPRSTSQQYGKEELLSRYPSAPSDIILGWLDSRKYVNDSQI

Sequences:

>Translated_386_residues
MTSNKTKIGIFTGTRAEYGLMRTLIRKLVDHPDYDTKLIVSGSHLSKRYGKTIAEIKSDGIKTIEKVKTSLDHTPMPGMA
LITGEVLVGVSTFLERFEPELLFILGDRYECFAAATAAHLLGIPIVHLHGGEKTSGAIDDRLRNAISQLSTWHFTAAELY
RENIILMGHPAKNVICVGPMVLDMILDFKPCSRSIFEAKTGFRFSGKNILVTYHPETLTKDHGMKGLLTLLEAIDRVECN
ILFTYPNADQGSIEIKEAILDYVHTHNEKCYAIPSLGQIQYLNALYLFDVVAGNSSSGIIEAPLLGVPVINIGTRQGGRL
RFGKVHDVEDSVNRIYTLLKELLALSPRSTSQQYGKEELLSRYPSAPSDIILGWLDSRKYVNDSQI
>Mature_385_residues
TSNKTKIGIFTGTRAEYGLMRTLIRKLVDHPDYDTKLIVSGSHLSKRYGKTIAEIKSDGIKTIEKVKTSLDHTPMPGMAL
ITGEVLVGVSTFLERFEPELLFILGDRYECFAAATAAHLLGIPIVHLHGGEKTSGAIDDRLRNAISQLSTWHFTAAELYR
ENIILMGHPAKNVICVGPMVLDMILDFKPCSRSIFEAKTGFRFSGKNILVTYHPETLTKDHGMKGLLTLLEAIDRVECNI
LFTYPNADQGSIEIKEAILDYVHTHNEKCYAIPSLGQIQYLNALYLFDVVAGNSSSGIIEAPLLGVPVINIGTRQGGRLR
FGKVHDVEDSVNRIYTLLKELLALSPRSTSQQYGKEELLSRYPSAPSDIILGWLDSRKYVNDSQI

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=333, Percent_Identity=28.8288288288288, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI298566312, Length=333, Percent_Identity=28.8288288288288, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4885285, Length=333, Percent_Identity=28.8288288288288, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI298566325, Length=296, Percent_Identity=29.7297297297297, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42867; Mature: 42736

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNKTKIGIFTGTRAEYGLMRTLIRKLVDHPDYDTKLIVSGSHLSKRYGKTIAEIKSDG
CCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHCH
IKTIEKVKTSLDHTPMPGMALITGEVLVGVSTFLERFEPELLFILGDRYECFAAATAAHL
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
LGIPIVHLHGGEKTSGAIDDRLRNAISQLSTWHFTAAELYRENIILMGHPAKNVICVGPM
HCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECHH
VLDMILDFKPCSRSIFEAKTGFRFSGKNILVTYHPETLTKDHGMKGLLTLLEAIDRVECN
HHHHHHCCCCCCHHHHHHCCCCEECCCEEEEEECCCHHCCCCCHHHHHHHHHHHCCCEEE
ILFTYPNADQGSIEIKEAILDYVHTHNEKCYAIPSLGQIQYLNALYLFDVVAGNSSSGII
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHEEHHEEECCCCCCEE
EAPLLGVPVINIGTRQGGRLRFGKVHDVEDSVNRIYTLLKELLALSPRSTSQQYGKEELL
ECCCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHH
SRYPSAPSDIILGWLDSRKYVNDSQI
HHCCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TSNKTKIGIFTGTRAEYGLMRTLIRKLVDHPDYDTKLIVSGSHLSKRYGKTIAEIKSDG
CCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHCH
IKTIEKVKTSLDHTPMPGMALITGEVLVGVSTFLERFEPELLFILGDRYECFAAATAAHL
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
LGIPIVHLHGGEKTSGAIDDRLRNAISQLSTWHFTAAELYRENIILMGHPAKNVICVGPM
HCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECHH
VLDMILDFKPCSRSIFEAKTGFRFSGKNILVTYHPETLTKDHGMKGLLTLLEAIDRVECN
HHHHHHCCCCCCHHHHHHCCCCEECCCEEEEEECCCHHCCCCCHHHHHHHHHHHCCCEEE
ILFTYPNADQGSIEIKEAILDYVHTHNEKCYAIPSLGQIQYLNALYLFDVVAGNSSSGII
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHEEHHEEECCCCCCEE
EAPLLGVPVINIGTRQGGRLRFGKVHDVEDSVNRIYTLLKELLALSPRSTSQQYGKEELL
ECCCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHH
SRYPSAPSDIILGWLDSRKYVNDSQI
HHCCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]