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The map label for this gene is pdhB [H]

Identifier: 124021817

GI number: 124021817

Start: 103928

End: 105007

Strand: Direct

Name: pdhB [H]

Synonym: P9303_01041

Alternate gene names: 124021817

Gene position: 103928-105007 (Clockwise)

Preceding gene: 124021816

Following gene: 124021818

Centisome position: 3.87

GC content: 38.8

Gene sequence:

>1080_bases
ATGAGTAGTTTAATGAAGGATAAATTATCCATGAAACATGGTGAATTAATCAGAGAACAGACCTATGAATTTCTAAATAA
ATCGCCTAACCATATTCTCCTATGTGAAGGGATAGATGATGGATTTTACGGCACAATTGCTGAGCTTTCAACCCATTTTT
CCTCTCAATGCTATGAACTTCCTTGTTCAGAGAATGCTTCAGTTGGCTTAGCAATTAGTGCCTCAGCATATGAAGTTACA
ACGATCCTCTGTTTCCAGCGCGTAGAATTTGCCTTGCTTGCACTCGAGCAATTTATTAACAATGCAGCCAAAAATAATTT
TCTTGCTGGTGGCAGACGACCTAATCCATGTCTTTTTAGATTTGTGATTGGACGTGGCTGGGGACAAGGTCCAAGTCATT
CTCAGAGTCTCGAAACAATCTTTGCTCAAATTCCAAACATAAATGTTTTGATGCCTGTTTTCCCAAGAGACTCAGAATTT
ATATTTAAGAATTTTGTCAACCTTACTGCTCCAACTATTTCTTTGGAGCATCGCTGGACTCATTTCTCTAGAGACTTGCA
GGATATAAATCTCAGACCTCACTCATTAAGTCCTTATGTAGTCAAGGAAGGTTTAGACATAACTATAGTAGCAACATCAT
ATAATACCTGTATTGCGCTAAAGGCTGCTCACATATTGGAGGATGCAGACGTATCGGTTGAGGTCATTAATATGTTTTGC
ATAGCCCCATTTGAATTTTCTATTATAAGGGATTCCATCATTAAAACGCAACACCTTATAGTGATTGACTTAGATCATAG
TTTATACTCTATTTCATCAGAGGTTTTAGCAAGAGTAATCCTAGATGGAGTAGATCTCAAGTTGCCACCTGTAAGAATGG
CAAATCATGGTGATTATTCACCGTCATCAGCGACATTAGCCAGTGAATATTATCTTAATTGCAGTGATGTCGTCCAAGCA
GTTACTCGTATGATGCATTGCTCACCTATTGAAAGCATTAGGCTGGTGGACGAAGCAGATGCCTTTGATAAGAAATTCCA
ATCAGATGTTCCTAACCAGGACTTTCACGGCCCGTTCTGA

Upstream 100 bases:

>100_bases
CAACGTATAGACCCTGTCAATCAAATGCTATCCATCTACCCGAACTTAAAAAACGATGAAACTATTTGGAAGAAATATTA
TATTGACTTGATTCGTAAGT

Downstream 100 bases:

>100_bases
TAAAATTAAATAAATGAGAATGATTGCTTTGCTCAAGGTGCCTGATAACTTTGTCCAGTTAGTTGAAATAACTAACGTCT
CTGAGGACTCTTCTGGCGTT

Product: pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSSLMKDKLSMKHGELIREQTYEFLNKSPNHILLCEGIDDGFYGTIAELSTHFSSQCYELPCSENASVGLAISASAYEVT
TILCFQRVEFALLALEQFINNAAKNNFLAGGRRPNPCLFRFVIGRGWGQGPSHSQSLETIFAQIPNINVLMPVFPRDSEF
IFKNFVNLTAPTISLEHRWTHFSRDLQDINLRPHSLSPYVVKEGLDITIVATSYNTCIALKAAHILEDADVSVEVINMFC
IAPFEFSIIRDSIIKTQHLIVIDLDHSLYSISSEVLARVILDGVDLKLPPVRMANHGDYSPSSATLASEYYLNCSDVVQA
VTRMMHCSPIESIRLVDEADAFDKKFQSDVPNQDFHGPF

Sequences:

>Translated_359_residues
MSSLMKDKLSMKHGELIREQTYEFLNKSPNHILLCEGIDDGFYGTIAELSTHFSSQCYELPCSENASVGLAISASAYEVT
TILCFQRVEFALLALEQFINNAAKNNFLAGGRRPNPCLFRFVIGRGWGQGPSHSQSLETIFAQIPNINVLMPVFPRDSEF
IFKNFVNLTAPTISLEHRWTHFSRDLQDINLRPHSLSPYVVKEGLDITIVATSYNTCIALKAAHILEDADVSVEVINMFC
IAPFEFSIIRDSIIKTQHLIVIDLDHSLYSISSEVLARVILDGVDLKLPPVRMANHGDYSPSSATLASEYYLNCSDVVQA
VTRMMHCSPIESIRLVDEADAFDKKFQSDVPNQDFHGPF
>Mature_358_residues
SSLMKDKLSMKHGELIREQTYEFLNKSPNHILLCEGIDDGFYGTIAELSTHFSSQCYELPCSENASVGLAISASAYEVTT
ILCFQRVEFALLALEQFINNAAKNNFLAGGRRPNPCLFRFVIGRGWGQGPSHSQSLETIFAQIPNINVLMPVFPRDSEFI
FKNFVNLTAPTISLEHRWTHFSRDLQDINLRPHSLSPYVVKEGLDITIVATSYNTCIALKAAHILEDADVSVEVINMFCI
APFEFSIIRDSIIKTQHLIVIDLDHSLYSISSEVLARVILDGVDLKLPPVRMANHGDYSPSSATLASEYYLNCSDVVQAV
TRMMHCSPIESIRLVDEADAFDKKFQSDVPNQDFHGPF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=323, Percent_Identity=25.6965944272446, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI291084858, Length=323, Percent_Identity=23.5294117647059, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4557353, Length=252, Percent_Identity=25.7936507936508, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI34101272, Length=252, Percent_Identity=25.7936507936508, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17538422, Length=297, Percent_Identity=28.956228956229, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=26.6871165644172, Blast_Score=115, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21358145, Length=294, Percent_Identity=25.5102040816327, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24650940, Length=294, Percent_Identity=25.5102040816327, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40202; Mature: 40071

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLMKDKLSMKHGELIREQTYEFLNKSPNHILLCEGIDDGFYGTIAELSTHFSSQCYEL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHEEC
PCSENASVGLAISASAYEVTTILCFQRVEFALLALEQFINNAAKNNFLAGGRRPNPCLFR
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEE
FVIGRGWGQGPSHSQSLETIFAQIPNINVLMPVFPRDSEFIFKNFVNLTAPTISLEHRWT
EEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEECHHHH
HFSRDLQDINLRPHSLSPYVVKEGLDITIVATSYNTCIALKAAHILEDADVSVEVINMFC
HHHCCHHHCCCCCCCCCCHHHHCCCEEEEEEECCCCEEEEHHHHHHCCCCCCEEEEEEEE
IAPFEFSIIRDSIIKTQHLIVIDLDHSLYSISSEVLARVILDGVDLKLPPVRMANHGDYS
ECCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCC
PSSATLASEYYLNCSDVVQAVTRMMHCSPIESIRLVDEADAFDKKFQSDVPNQDFHGPF
CCCCEEHHHHEECHHHHHHHHHHHHCCCCHHHEEEHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SSLMKDKLSMKHGELIREQTYEFLNKSPNHILLCEGIDDGFYGTIAELSTHFSSQCYEL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHEEC
PCSENASVGLAISASAYEVTTILCFQRVEFALLALEQFINNAAKNNFLAGGRRPNPCLFR
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEE
FVIGRGWGQGPSHSQSLETIFAQIPNINVLMPVFPRDSEFIFKNFVNLTAPTISLEHRWT
EEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEECHHHH
HFSRDLQDINLRPHSLSPYVVKEGLDITIVATSYNTCIALKAAHILEDADVSVEVINMFC
HHHCCHHHCCCCCCCCCCHHHHCCCEEEEEEECCCCEEEEHHHHHHCCCCCCEEEEEEEE
IAPFEFSIIRDSIIKTQHLIVIDLDHSLYSISSEVLARVILDGVDLKLPPVRMANHGDYS
ECCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCC
PSSATLASEYYLNCSDVVQAVTRMMHCSPIESIRLVDEADAFDKKFQSDVPNQDFHGPF
CCCCEEHHHHEECHHHHHHHHHHHHCCCCHHHEEEHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]