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The map label for this gene is gmhA [H]

Identifier: 124021812

GI number: 124021812

Start: 98662

End: 99330

Strand: Direct

Name: gmhA [H]

Synonym: P9303_00991

Alternate gene names: 124021812

Gene position: 98662-99330 (Clockwise)

Preceding gene: 124021811

Following gene: 124021813

Centisome position: 3.68

GC content: 37.37

Gene sequence:

>669_bases
ATGTCAAGACTAGAACAAATGAACCATTTCGGACGGAGAGGCGGTGAATATCTCGAAAAATTGTGTGGATCCTTCAACAA
TGAAATTTACCAGAAGATTGATGAATTATGTAATGATCTAATTGGTGCATGGAAGAATCATAAAGTTGTTTACATCTGTG
GCAATGGTGGCAGCGCTGCAAATGCTCTACATATCTCTAATGATTTTTTATATGGTGCCGGCGCTTGCGGAGAAGGTTTA
CCAACCAATGGTTTGCGAATAGAGGCATTGACTGCTAACAATTCGGTAATGACTTGTCTGGCCAATGACACTGGATATGA
GAATATCTTTTCACGTCAACTTGAAGTCAAGGCAAATGAAGAGGATATATTAATAGTATTAAGTGGAAGTGGTAATTCCT
CCAATGTGGTCAAAGCAATTCAAGCAGCAAAGTCTTTAAATATGAAATCATATTCAATCGTGGCATTTGATGGTGGGCAG
TGCAAGAAATTATCTGATGCGTGCATTCATTTCCAAGTGAATGATATGCAGATTGCAGAAGATACTCAACTTATTGTGGG
GCATCTGCTAATGCAATTCTTAGTTGAAGCACGATCTAACATATTTAACCATGACTTTATATCCTCAGCTGTAAATACAG
TAGATTCTTCAGCTAATATAAAAAAATGA

Upstream 100 bases:

>100_bases
CCCAAATTATTAGGTAAAATACAGACTGTTCATACAATGGATAAGTTGGTAGACATAGGCACTTTGGAGCGGCTTAACAA
GCTAGAATTGGAATTGAACG

Downstream 100 bases:

>100_bases
CTGAAAATATGACAGACACCATTAGCATTAGGGATATAGGAACAGTTCTTGACTCTGTTCTAGCTTATGGCCATTTTAAC
TCTGTACACCCTGGTCATAT

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSRLEQMNHFGRRGGEYLEKLCGSFNNEIYQKIDELCNDLIGAWKNHKVVYICGNGGSAANALHISNDFLYGAGACGEGL
PTNGLRIEALTANNSVMTCLANDTGYENIFSRQLEVKANEEDILIVLSGSGNSSNVVKAIQAAKSLNMKSYSIVAFDGGQ
CKKLSDACIHFQVNDMQIAEDTQLIVGHLLMQFLVEARSNIFNHDFISSAVNTVDSSANIKK

Sequences:

>Translated_222_residues
MSRLEQMNHFGRRGGEYLEKLCGSFNNEIYQKIDELCNDLIGAWKNHKVVYICGNGGSAANALHISNDFLYGAGACGEGL
PTNGLRIEALTANNSVMTCLANDTGYENIFSRQLEVKANEEDILIVLSGSGNSSNVVKAIQAAKSLNMKSYSIVAFDGGQ
CKKLSDACIHFQVNDMQIAEDTQLIVGHLLMQFLVEARSNIFNHDFISSAVNTVDSSANIKK
>Mature_221_residues
SRLEQMNHFGRRGGEYLEKLCGSFNNEIYQKIDELCNDLIGAWKNHKVVYICGNGGSAANALHISNDFLYGAGACGEGLP
TNGLRIEALTANNSVMTCLANDTGYENIFSRQLEVKANEEDILIVLSGSGNSSNVVKAIQAAKSLNMKSYSIVAFDGGQC
KKLSDACIHFQVNDMQIAEDTQLIVGHLLMQFLVEARSNIFNHDFISSAVNTVDSSANIKK

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate [H]

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1786416, Length=158, Percent_Identity=32.9113924050633, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789539, Length=125, Percent_Identity=31.2, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020620
- InterPro:   IPR001347 [H]

Pfam domain/function: PF01380 SIS [H]

EC number: =5.3.1.28 [H]

Molecular weight: Translated: 24192; Mature: 24060

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLEQMNHFGRRGGEYLEKLCGSFNNEIYQKIDELCNDLIGAWKNHKVVYICGNGGSAA
CCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
NALHISNDFLYGAGACGEGLPTNGLRIEALTANNSVMTCLANDTGYENIFSRQLEVKANE
CEEEECCCEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHEEEECCC
EDILIVLSGSGNSSNVVKAIQAAKSLNMKSYSIVAFDGGQCKKLSDACIHFQVNDMQIAE
CCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEECCEEECH
DTQLIVGHLLMQFLVEARSNIFNHDFISSAVNTVDSSANIKK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRLEQMNHFGRRGGEYLEKLCGSFNNEIYQKIDELCNDLIGAWKNHKVVYICGNGGSAA
CHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
NALHISNDFLYGAGACGEGLPTNGLRIEALTANNSVMTCLANDTGYENIFSRQLEVKANE
CEEEECCCEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHEEEECCC
EDILIVLSGSGNSSNVVKAIQAAKSLNMKSYSIVAFDGGQCKKLSDACIHFQVNDMQIAE
CCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEECCEEECH
DTQLIVGHLLMQFLVEARSNIFNHDFISSAVNTVDSSANIKK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11279237; 12101286 [H]