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The map label for this gene is uvrB

Identifier: 124021794

GI number: 124021794

Start: 77670

End: 79709

Strand: Direct

Name: uvrB

Synonym: P9303_00791

Alternate gene names: 124021794

Gene position: 77670-79709 (Clockwise)

Preceding gene: 124021793

Following gene: 124021795

Centisome position: 2.9

GC content: 47.5

Gene sequence:

>2040_bases
ATGCCGAAGTATCACCTCAAGGCGCCCTATAGCCCGAAGGGGGATCAGCCCACTGCGATTGCGCGGTTGGTGGAGGGGGT
CAATCAGGGCCAGCGTTATCAGACGCTTTTAGGAGCGACCGGTACGGGTAAGACATTCACGATTGCCAATTTGATTGCTC
AGACTGGCCGTCCGGCTCTTGTCTTGGCTCATAACAAGACGCTTGCTGCGCAACTTTGCAATGAGTTTAGGGAGTTCTTT
CCTGATAATTCTGTTGAATATTTTATTTCTTACTATGATTATTATCAGCCAGAGGCTTACGTGCCTGTTAGTGATACCTA
CATAGCCAAGACAGCTTCAATCAATGAAGAGATTGATATGCTGCGTCATTCAGCAACGCGTTCCTTATTTGAGCGTAATG
ATGTCATTGTAGTAGCTTCAATCAGCTGCATTTATGGTCTAGGCATTCCTAGCGAATATCTAAAGGCTGCTGTTAAATTT
AAAGTTGGTGAAACACTCAACCTTCGCAGTTCATTGCGGGAGTTGGTTGATAATCAATATAGTCGAAATGACTTTGACAT
TACGCGGGGTCGCTTTCGAGTGAGAGGGGATGTTTTGGAGATTGGCCCTGCTTATGAAGATCGGCTAGTACGGATTGAGC
TTTTTGGTGATGAGGTAGAGGCAATCCGTTATCTGGATCCAACAACAGGTGAGATTTTGCAAAGCTTGGAAGCCATTAAT
ATTTATCCGGCCAAACATTTTGTAACTCCTAAAGAGCGATTGAATGTTGCAGTTCAAGCGATTCGTGATGAACTGCGTGA
GCGTTTGCAGGTGCTCAATGAACAAGGCAAGCTTTTGGAAGCGCAGCGTTTAGAGCAACGCACTGCCTACGACTTGGAGA
TGTTGCGGGAGGTTGGTTATTGCAATGGTGTTGAAAACTATGCTCGCCATCTTGCTGGCCGTTCCGCGGGAACGCCTCCT
GAATGCTTGATTGACTATTTCCCTGATGATTGGTTACTGGTGGTGGATGAAAGTCATGTGACATGTTCTCAGCTTAAGGC
GATGTACAACGGCGATCAAGCTCGTAAGAAAGTTTTAATTGAGCATGGTTTTCGATTGCCTAGTGCTGCTGATAATCGTC
CTCTCAAGAGTGAGGAATTCTGGAGGAAGGCGAGGCAAACTGTATTTGTTAGTGCGACGCCAGGTGATTGGGAGCTCACG
CAGAGTGATGGTCAGCTGGCTGAACAGGTGATTCGGCCCACAGGGGTTCTTGATCCCTTGGTGGAAGTGCGCCCGACGCA
AGGCCAGGTCGACGACTTGTTGGCGGAAATCCGTATCAGAGCAAAGAAGCAGGAGAGAGTGTTAATCACCACCCTGACCA
AACGTATGGCGGAAGATCTTACCGATTATCTGGCTGAGAATGATGTGCGCGTTCGTTATCTACACTCGGAAATCCATTCA
ATCGAGCGGATTGAGATTATTCAGGATTTGAGATTGGGCGAATATGATGTTCTTGTGGGTGTCAATCTTCTTCGAGAAGG
TTTGGATCTTCCGGAGGTGTCGTTAGTGGTCATTCTTGATGCTGATAAGGAAGGTTTCTTGCGAGCAGAGCGGTCGCTGA
TTCAGACCATTGGTCGTGCGGCTAGGCATGTGGATGGGATGGCACTTCTTTATGCAGATAACTTGACAGATTCGATGGCA
AGAGCGATTAGTGAAACTGAGCGAAGACGCGAGATTCAAAAGGCTTACAACGAATTGAATGGCATCGTGCCAAGGCCAGC
GGGTAAGAGAGCGAGCAATTCGATCCTCTCGTTTCTGGAGTTGTCAAGGCGCTTACAGACGGATGGTAAAGATGCTGACT
TGGTGCAGATTACTGGGCGGGCTGTTGATGCGCTTGATTCAGATCAGGATTCTGGCTTAGCCCTTGATGCTTTGCCTGAG
TTGATCGATCAGCTCGAAACAAAGATGAAAGAAGCTGCCAAGAATCTTAATTTTGAGGAAGCAGCAAGCCTTCGCGATCG
CATCAAGAAGTTCAGGCAGAAGCTGATTCGCAATACTTGA

Upstream 100 bases:

>100_bases
TCAAGGCATTGGTTAGAAGGTCATCAGCTTTGGAGGCAGTCTGGAATAGCCCGTTCATGGCATCTGCTCATAGGCTAAGC
AGCTGCCCGTTACGGCCCTA

Downstream 100 bases:

>100_bases
TCATGTGCCATTGTTCATGCGATCACCTTTTGTATAAAGTACCTTTTGTTTGCATTCCATCTGATACTTGTAGTTGTCGG
AAGTTTCATCCTTGTTCATT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MPKYHLKAPYSPKGDQPTAIARLVEGVNQGQRYQTLLGATGTGKTFTIANLIAQTGRPALVLAHNKTLAAQLCNEFREFF
PDNSVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERNDVIVVASISCIYGLGIPSEYLKAAVKF
KVGETLNLRSSLRELVDNQYSRNDFDITRGRFRVRGDVLEIGPAYEDRLVRIELFGDEVEAIRYLDPTTGEILQSLEAIN
IYPAKHFVTPKERLNVAVQAIRDELRERLQVLNEQGKLLEAQRLEQRTAYDLEMLREVGYCNGVENYARHLAGRSAGTPP
ECLIDYFPDDWLLVVDESHVTCSQLKAMYNGDQARKKVLIEHGFRLPSAADNRPLKSEEFWRKARQTVFVSATPGDWELT
QSDGQLAEQVIRPTGVLDPLVEVRPTQGQVDDLLAEIRIRAKKQERVLITTLTKRMAEDLTDYLAENDVRVRYLHSEIHS
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAERSLIQTIGRAARHVDGMALLYADNLTDSMA
RAISETERRREIQKAYNELNGIVPRPAGKRASNSILSFLELSRRLQTDGKDADLVQITGRAVDALDSDQDSGLALDALPE
LIDQLETKMKEAAKNLNFEEAASLRDRIKKFRQKLIRNT

Sequences:

>Translated_679_residues
MPKYHLKAPYSPKGDQPTAIARLVEGVNQGQRYQTLLGATGTGKTFTIANLIAQTGRPALVLAHNKTLAAQLCNEFREFF
PDNSVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERNDVIVVASISCIYGLGIPSEYLKAAVKF
KVGETLNLRSSLRELVDNQYSRNDFDITRGRFRVRGDVLEIGPAYEDRLVRIELFGDEVEAIRYLDPTTGEILQSLEAIN
IYPAKHFVTPKERLNVAVQAIRDELRERLQVLNEQGKLLEAQRLEQRTAYDLEMLREVGYCNGVENYARHLAGRSAGTPP
ECLIDYFPDDWLLVVDESHVTCSQLKAMYNGDQARKKVLIEHGFRLPSAADNRPLKSEEFWRKARQTVFVSATPGDWELT
QSDGQLAEQVIRPTGVLDPLVEVRPTQGQVDDLLAEIRIRAKKQERVLITTLTKRMAEDLTDYLAENDVRVRYLHSEIHS
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAERSLIQTIGRAARHVDGMALLYADNLTDSMA
RAISETERRREIQKAYNELNGIVPRPAGKRASNSILSFLELSRRLQTDGKDADLVQITGRAVDALDSDQDSGLALDALPE
LIDQLETKMKEAAKNLNFEEAASLRDRIKKFRQKLIRNT
>Mature_678_residues
PKYHLKAPYSPKGDQPTAIARLVEGVNQGQRYQTLLGATGTGKTFTIANLIAQTGRPALVLAHNKTLAAQLCNEFREFFP
DNSVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERNDVIVVASISCIYGLGIPSEYLKAAVKFK
VGETLNLRSSLRELVDNQYSRNDFDITRGRFRVRGDVLEIGPAYEDRLVRIELFGDEVEAIRYLDPTTGEILQSLEAINI
YPAKHFVTPKERLNVAVQAIRDELRERLQVLNEQGKLLEAQRLEQRTAYDLEMLREVGYCNGVENYARHLAGRSAGTPPE
CLIDYFPDDWLLVVDESHVTCSQLKAMYNGDQARKKVLIEHGFRLPSAADNRPLKSEEFWRKARQTVFVSATPGDWELTQ
SDGQLAEQVIRPTGVLDPLVEVRPTQGQVDDLLAEIRIRAKKQERVLITTLTKRMAEDLTDYLAENDVRVRYLHSEIHSI
ERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAERSLIQTIGRAARHVDGMALLYADNLTDSMAR
AISETERRREIQKAYNELNGIVPRPAGKRASNSILSFLELSRRLQTDGKDADLVQITGRAVDALDSDQDSGLALDALPEL
IDQLETKMKEAAKNLNFEEAASLRDRIKKFRQKLIRNT

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=675, Percent_Identity=57.3333333333333, Blast_Score=758, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_PROM3 (A2C5S6)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016101.1
- ProteinModelPortal:   A2C5S6
- STRING:   A2C5S6
- GeneID:   4778160
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_00791
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76902; Mature: 76771

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYHLKAPYSPKGDQPTAIARLVEGVNQGQRYQTLLGATGTGKTFTIANLIAQTGRPAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNEFREFFPDNSVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHHHH
LRHSATRSLFERNDVIVVASISCIYGLGIPSEYLKAAVKFKVGETLNLRSSLRELVDNQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
SRNDFDITRGRFRVRGDVLEIGPAYEDRLVRIELFGDEVEAIRYLDPTTGEILQSLEAIN
CCCCCCCCCCEEEEECCEEECCCCCCCCEEEEEEECCHHHHHHHCCCCHHHHHHHHHHHE
IYPAKHFVTPKERLNVAVQAIRDELRERLQVLNEQGKLLEAQRLEQRTAYDLEMLREVGY
EECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
CNGVENYARHLAGRSAGTPPECLIDYFPDDWLLVVDESHVTCSQLKAMYNGDQARKKVLI
CCCHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHH
EHGFRLPSAADNRPLKSEEFWRKARQTVFVSATPGDWELTQSDGQLAEQVIRPTGVLDPL
HCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCEEECCCHHHHHHHHCCCCCCCCH
VEVRPTQGQVDDLLAEIRIRAKKQERVLITTLTKRMAEDLTDYLAENDVRVRYLHSEIHS
HHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVDGMALLYADNLTDSMARAISETERRREIQKAYNELNGIVPRPAGKRASNSILSFLE
HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LSRRLQTDGKDADLVQITGRAVDALDSDQDSGLALDALPELIDQLETKMKEAAKNLNFEE
HHHHHHCCCCCCCEEEECCHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHH
AASLRDRIKKFRQKLIRNT
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PKYHLKAPYSPKGDQPTAIARLVEGVNQGQRYQTLLGATGTGKTFTIANLIAQTGRPAL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEE
VLAHNKTLAAQLCNEFREFFPDNSVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHHHH
LRHSATRSLFERNDVIVVASISCIYGLGIPSEYLKAAVKFKVGETLNLRSSLRELVDNQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
SRNDFDITRGRFRVRGDVLEIGPAYEDRLVRIELFGDEVEAIRYLDPTTGEILQSLEAIN
CCCCCCCCCCEEEEECCEEECCCCCCCCEEEEEEECCHHHHHHHCCCCHHHHHHHHHHHE
IYPAKHFVTPKERLNVAVQAIRDELRERLQVLNEQGKLLEAQRLEQRTAYDLEMLREVGY
EECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
CNGVENYARHLAGRSAGTPPECLIDYFPDDWLLVVDESHVTCSQLKAMYNGDQARKKVLI
CCCHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHH
EHGFRLPSAADNRPLKSEEFWRKARQTVFVSATPGDWELTQSDGQLAEQVIRPTGVLDPL
HCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCEEECCCHHHHHHHHCCCCCCCCH
VEVRPTQGQVDDLLAEIRIRAKKQERVLITTLTKRMAEDLTDYLAENDVRVRYLHSEIHS
HHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVVILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVDGMALLYADNLTDSMARAISETERRREIQKAYNELNGIVPRPAGKRASNSILSFLE
HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LSRRLQTDGKDADLVQITGRAVDALDSDQDSGLALDALPELIDQLETKMKEAAKNLNFEE
HHHHHHCCCCCCCEEEECCHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHH
AASLRDRIKKFRQKLIRNT
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA