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The map label for this gene is dapA

Identifier: 124021787

GI number: 124021787

Start: 71142

End: 72050

Strand: Direct

Name: dapA

Synonym: P9303_00721

Alternate gene names: 124021787

Gene position: 71142-72050 (Clockwise)

Preceding gene: 124021786

Following gene: 124021789

Centisome position: 2.65

GC content: 55.67

Gene sequence:

>909_bases
ATGAGCTCTGCTGCTGAGTCGTCTCCAACTCCTTTTGGCCGTTTGCTGACGGCCATGGTTACACCTTTTGACGCTGATGG
ATGCGTTGATCTGGCTTTGGCTGGTCGTCTTGCTCGCTATCTCGTAGATGAGGGATCTGATGGGCTGGTTGTCTGCGGCA
CGACTGGGGAATCGCCCACTTTGAGCTGGCAGGAGCAGCATCAATTGCTTGGGGTGGTCCGTCAGGCAGTGGGGCCAGGT
GTGAAGGTTCTTGCCGGTACTGGTAGCAATAGCACCGCTGAGGCGATAGAGGCCACCACTCAGGCAGCTGCGGTGGGTGC
TGATGGGGCATTGGTGGTTGTTCCTTATTACAACAAGCCTCCGCAGGAAGGTCTTGAAGCCCATTTCAGGGCTATTGCCC
AGGCTGCCCCTGAGTTGCCGCTGATGCTCTACAACATTCCTGGGCGGACTGGCTGTTCGCTTGCTCCAGCAACAGTTGCA
AGGTTGATGGAATGTCCGAATGTGGTGAGTTTCAAAGCCGCCAGTGGCACCACGGATGAGGTGACGCAGTTGAGGTTGCA
GTGTGGTTCAAAACTGGCTGTTTACAGCGGCGACGATGGCTTGCTTTTGCCCATGATGTCGGTGGGGGCTGTTGGGGTGG
TGAGTGTCGCAAGTCACCTTGTAGGTCGTCGGCTTAAGGCGATGATTGAGGCCTATCTCAATGGTCAGGGTGCTCTTGCC
CTCAGTTATCACGAGCAGTTGCAACCTTTGTTCAAGGCTCTATTTGTCACCACCAATCCGATTCCTGTTAAAGCAGCCCT
CGAGCTCAGCGGTTGGCCGGTCGGATCCCCCCGCCTCCCTTTGCTTCCACTTGATCCCGTTATGCGAGATGCTCTTTCAA
ACACCTTGACTGCCTTGTGTCAGACCTGA

Upstream 100 bases:

>100_bases
GTGATCCCAATGCTCTCGAGCTTTGGCTATGCGGGGATCAGATCCGTAAAGGTGCCGCTCTAAATGCGATCCAAATTGCA
GAATTGTTGTTGTCGTCATC

Downstream 100 bases:

>100_bases
CGCCACGGCTGTTTCCCACATTGATGGCTTGACGCTTTAGCTTTTCGCAATGAGCGCTCGCTTCATTTCAGTCCCCAAAT
AGTTTTCGTACGCTTTTGTC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSSAAESSPTPFGRLLTAMVTPFDADGCVDLALAGRLARYLVDEGSDGLVVCGTTGESPTLSWQEQHQLLGVVRQAVGPG
VKVLAGTGSNSTAEAIEATTQAAAVGADGALVVVPYYNKPPQEGLEAHFRAIAQAAPELPLMLYNIPGRTGCSLAPATVA
RLMECPNVVSFKAASGTTDEVTQLRLQCGSKLAVYSGDDGLLLPMMSVGAVGVVSVASHLVGRRLKAMIEAYLNGQGALA
LSYHEQLQPLFKALFVTTNPIPVKAALELSGWPVGSPRLPLLPLDPVMRDALSNTLTALCQT

Sequences:

>Translated_302_residues
MSSAAESSPTPFGRLLTAMVTPFDADGCVDLALAGRLARYLVDEGSDGLVVCGTTGESPTLSWQEQHQLLGVVRQAVGPG
VKVLAGTGSNSTAEAIEATTQAAAVGADGALVVVPYYNKPPQEGLEAHFRAIAQAAPELPLMLYNIPGRTGCSLAPATVA
RLMECPNVVSFKAASGTTDEVTQLRLQCGSKLAVYSGDDGLLLPMMSVGAVGVVSVASHLVGRRLKAMIEAYLNGQGALA
LSYHEQLQPLFKALFVTTNPIPVKAALELSGWPVGSPRLPLLPLDPVMRDALSNTLTALCQT
>Mature_301_residues
SSAAESSPTPFGRLLTAMVTPFDADGCVDLALAGRLARYLVDEGSDGLVVCGTTGESPTLSWQEQHQLLGVVRQAVGPGV
KVLAGTGSNSTAEAIEATTQAAAVGADGALVVVPYYNKPPQEGLEAHFRAIAQAAPELPLMLYNIPGRTGCSLAPATVAR
LMECPNVVSFKAASGTTDEVTQLRLQCGSKLAVYSGDDGLLLPMMSVGAVGVVSVASHLVGRRLKAMIEAYLNGQGALAL
SYHEQLQPLFKALFVTTNPIPVKAALELSGWPVGSPRLPLLPLDPVMRDALSNTLTALCQT

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI13540533, Length=301, Percent_Identity=31.2292358803987, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI31543060, Length=291, Percent_Identity=31.2714776632302, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788823, Length=286, Percent_Identity=39.1608391608392, Blast_Score=191, Evalue=5e-50,
Organism=Escherichia coli, GI1789620, Length=221, Percent_Identity=31.2217194570136, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082415, Length=297, Percent_Identity=29.96632996633, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1786463, Length=288, Percent_Identity=31.5972222222222, Blast_Score=107, Evalue=8e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PROM3 (A2C5R9)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016094.1
- ProteinModelPortal:   A2C5R9
- SMR:   A2C5R9
- STRING:   A2C5R9
- GeneID:   4778731
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_00721
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31380; Mature: 31248

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 172-172 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAAESSPTPFGRLLTAMVTPFDADGCVDLALAGRLARYLVDEGSDGLVVCGTTGESPT
CCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
LSWQEQHQLLGVVRQAVGPGVKVLAGTGSNSTAEAIEATTQAAAVGADGALVVVPYYNKP
CCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
PQEGLEAHFRAIAQAAPELPLMLYNIPGRTGCSLAPATVARLMECPNVVSFKAASGTTDE
CHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCHHH
VTQLRLQCGSKLAVYSGDDGLLLPMMSVGAVGVVSVASHLVGRRLKAMIEAYLNGQGALA
HHHHHHHCCCEEEEEECCCCEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LSYHEQLQPLFKALFVTTNPIPVKAALELSGWPVGSPRLPLLPLDPVMRDALSNTLTALC
EHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QT
CC
>Mature Secondary Structure 
SSAAESSPTPFGRLLTAMVTPFDADGCVDLALAGRLARYLVDEGSDGLVVCGTTGESPT
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
LSWQEQHQLLGVVRQAVGPGVKVLAGTGSNSTAEAIEATTQAAAVGADGALVVVPYYNKP
CCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
PQEGLEAHFRAIAQAAPELPLMLYNIPGRTGCSLAPATVARLMECPNVVSFKAASGTTDE
CHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCHHH
VTQLRLQCGSKLAVYSGDDGLLLPMMSVGAVGVVSVASHLVGRRLKAMIEAYLNGQGALA
HHHHHHHCCCEEEEEECCCCEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LSYHEQLQPLFKALFVTTNPIPVKAALELSGWPVGSPRLPLLPLDPVMRDALSNTLTALC
EHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA