Click here to switch to the map view.

The map label for this gene is clpP1 [H]

Identifier: 124021784

GI number: 124021784

Start: 67780

End: 68454

Strand: Reverse

Name: clpP1 [H]

Synonym: P9303_00691

Alternate gene names: 124021784

Gene position: 68454-67780 (Counterclockwise)

Preceding gene: 124021785

Following gene: 124021783

Centisome position: 2.55

GC content: 55.11

Gene sequence:

>675_bases
GTGATCGATTCCTGCTGCTACCACCCCATCCACAATCGCTGGCCGGGCATTCGTCCTGTCTCATCACCAGGGATCCTGCC
CACAGTGGTGGAACAGTCGGGCCGAGGAGAACGGGCATTCGACATTTACTCACGCTTGCTACGTGAGCGAATCATCTTTC
TTGGCACTGGTGTCGACGATCAAGTGGCAGATGCCCTCGTTGCTCAGATGCTCTTCCTTGAAGCCGAAGATCCCGAAAAG
GACATCCAGATCTATATCAACTCCCCAGGTGGTTCAGTGACCGCTGGTTTGGCTATCTATGACACCATGCAGCAGGTCGC
TCCAGACGTCGTGACCATCTGTTATGGCCTTGCTGCCAGCATGGGGGCTTTCCTTCTCTGCGGAGGTACCAAAGGCAAGC
GACTGGCACTACCCAATGCACGGATCATGATTCATCAGCCCCTGGGTGGTGCCCAGGGCCAAGCAGTAGACATCGAAATC
CAGGCCAAGGAGATCCTCTTCTTAAAAGAAACCCTCAACGGCCTTCTCGCCGAGCACACTGGCCAACCCCTCAACAAAAT
CGCTGAAGACACTGACCGCGACCACTTCCTTTCTCCAGCAAAAGCGGTTGAATACGGACTGATCGATCGGGTTGTGGATA
GCCTCACAGGCGGTGGAATCGTTACGGAAGGGTGA

Upstream 100 bases:

>100_bases
AAGACCAACAAAGCCAAGACTGAAAAACCTGCCTCGGACAAAACCAAGTCCTGAATGGCACCAATAGATTGATAAAAGTG
CTCCCCTAAAGCCCAAACGA

Downstream 100 bases:

>100_bases
CGCAACCCTGATCTGACACGATCCTGAGCGTTCAGGCTGGCCAACATTCGTCAGATCCTGTCTGCCCGTTTGCAGTGATC
ACAGCCCGATGGCCAAATTC

Product: Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIDSCCYHPIHNRWPGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDDQVADALVAQMLFLEAEDPEK
DIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAASMGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEI
QAKEILFLKETLNGLLAEHTGQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVTEG

Sequences:

>Translated_224_residues
MIDSCCYHPIHNRWPGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDDQVADALVAQMLFLEAEDPEK
DIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAASMGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEI
QAKEILFLKETLNGLLAEHTGQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVTEG
>Mature_224_residues
MIDSCCYHPIHNRWPGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDDQVADALVAQMLFLEAEDPEK
DIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAASMGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEI
QAKEILFLKETLNGLLAEHTGQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVTEG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=57.4468085106383, Blast_Score=223, Evalue=7e-59,
Organism=Escherichia coli, GI1786641, Length=201, Percent_Identity=63.18407960199, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=55.3763440860215, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=53.0927835051546, Blast_Score=214, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 24113; Mature: 24113

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSCCYHPIHNRWPGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDD
CCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCH
QVADALVAQMLFLEAEDPEKDIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
MGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEIQAKEILFLKETLNGLLAEHT
HCCEEEECCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVTEG
CCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure
MIDSCCYHPIHNRWPGIRPVSSPGILPTVVEQSGRGERAFDIYSRLLRERIIFLGTGVDD
CCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCH
QVADALVAQMLFLEAEDPEKDIQIYINSPGGSVTAGLAIYDTMQQVAPDVVTICYGLAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
MGAFLLCGGTKGKRLALPNARIMIHQPLGGAQGQAVDIEIQAKEILFLKETLNGLLAEHT
HCCEEEECCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GQPLNKIAEDTDRDHFLSPAKAVEYGLIDRVVDSLTGGGIVTEG
CCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]