Click here to switch to the map view.

The map label for this gene is pdxA [H]

Identifier: 124021747

GI number: 124021747

Start: 35239

End: 36270

Strand: Reverse

Name: pdxA [H]

Synonym: P9303_00321

Alternate gene names: 124021747

Gene position: 36270-35239 (Counterclockwise)

Preceding gene: 124021749

Following gene: 124021744

Centisome position: 1.35

GC content: 53.97

Gene sequence:

>1032_bases
ATGGCTATGCCTTCTGAAGGCTTTGACGCTAATCAACTGATCGTTATCGCCATCGGCGATCCCGCTGGCATAGGGATGGA
GGTCACCCTAAAGGCCCTCGCTTCACCAAGCTTGCCATCAAAGCTGCATCCCCAGCTGGTTGGCTGTCGAAAAAGCCTGG
AACTGACCTATGCCCAATTACAAGCTCAAGGAATCTCTCCCCTAGCCAATCCAAAGAACCTCGATATCAAAGATCTACCC
CTGAAGAGCACACTTAAGCCTGGATACCCCACAGCACAGAGTGGAGCCGCAAGCTTTCTATGGTTGACAAAGGCAACAGA
ACTCCTCTTGAAGGGTCGAGCCCGCGCCCTTGTTACCGCTCCCATTGCCAAGCATGCCTGGCATGCAGCAGGCCATCACT
ATCCGGGTCAAACCGAACGACTTAAAGAACTGGTGGGCGCTGATCAAGCCTCCATGCTCTTCACCGCGATCTCACCTCAA
AACGGCTGGCGGTTAAACACTCTGCTAGCAACAACCCATATCCCGCTAGCAGCAGTCCCAAAAGTTCTTACCCCTGAGTT
GGTTAGAGCGAAGCTCAACGTACTCAAGGCATTCTGCCAAAGATTCAAAACCGATCCATCCATTGCAGTCGCAGGCCTCA
ATCCCCACGCTGGCGAGCAAGGCCAACTTGGCCATGAAGAGCTGAAATGGTTGATCCCAATGCTGAACAAATGGAAAACC
GAGCACCCTGAGATCCAACTAGACGGTCCTTTACCTCCCGACACATGTTGGCTTTCAGCTGCAAAGGCTTGGCATGGCAA
CCCATGCGCCCAAACCCCAGACGGCATCCTGGCCTTGTACCACGATCAGGGTCTAATTCCAATGAAGCTGCTGGCTTTCG
ACTCTGCCGTCAACACCACCCTTGGGCTTCCATTTCTGCGTACCTCACCTGATCACGGCACCGCCTTTGACATTGCCGGA
AAGGGATGTGCCAGAGCCGACAGCATGTTGGCCGCCCTCAAAGCAGCCTGGGAACTCACGGAATCACGCTGA

Upstream 100 bases:

>100_bases
GGCATCGCGCAAAAACTGACTCCAATGCACCACCAACCAACCATTCCGCAACCCGGTACCAAGACCAAACAACATCAAAC
CAAGCAGCAACCAGCGCATC

Downstream 100 bases:

>100_bases
TCAGCCAGGCTTAACACGCATCAAAACCTGACCGAACTCAACTGGTGTGCCGTTATCTACAAGGATTTCAACCACCTCGC
CACTGACTTCAGATTCCAAC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MAMPSEGFDANQLIVIAIGDPAGIGMEVTLKALASPSLPSKLHPQLVGCRKSLELTYAQLQAQGISPLANPKNLDIKDLP
LKSTLKPGYPTAQSGAASFLWLTKATELLLKGRARALVTAPIAKHAWHAAGHHYPGQTERLKELVGADQASMLFTAISPQ
NGWRLNTLLATTHIPLAAVPKVLTPELVRAKLNVLKAFCQRFKTDPSIAVAGLNPHAGEQGQLGHEELKWLIPMLNKWKT
EHPEIQLDGPLPPDTCWLSAAKAWHGNPCAQTPDGILALYHDQGLIPMKLLAFDSAVNTTLGLPFLRTSPDHGTAFDIAG
KGCARADSMLAALKAAWELTESR

Sequences:

>Translated_343_residues
MAMPSEGFDANQLIVIAIGDPAGIGMEVTLKALASPSLPSKLHPQLVGCRKSLELTYAQLQAQGISPLANPKNLDIKDLP
LKSTLKPGYPTAQSGAASFLWLTKATELLLKGRARALVTAPIAKHAWHAAGHHYPGQTERLKELVGADQASMLFTAISPQ
NGWRLNTLLATTHIPLAAVPKVLTPELVRAKLNVLKAFCQRFKTDPSIAVAGLNPHAGEQGQLGHEELKWLIPMLNKWKT
EHPEIQLDGPLPPDTCWLSAAKAWHGNPCAQTPDGILALYHDQGLIPMKLLAFDSAVNTTLGLPFLRTSPDHGTAFDIAG
KGCARADSMLAALKAAWELTESR
>Mature_342_residues
AMPSEGFDANQLIVIAIGDPAGIGMEVTLKALASPSLPSKLHPQLVGCRKSLELTYAQLQAQGISPLANPKNLDIKDLPL
KSTLKPGYPTAQSGAASFLWLTKATELLLKGRARALVTAPIAKHAWHAAGHHYPGQTERLKELVGADQASMLFTAISPQN
GWRLNTLLATTHIPLAAVPKVLTPELVRAKLNVLKAFCQRFKTDPSIAVAGLNPHAGEQGQLGHEELKWLIPMLNKWKTE
HPEIQLDGPLPPDTCWLSAAKAWHGNPCAQTPDGILALYHDQGLIPMKLLAFDSAVNTTLGLPFLRTSPDHGTAFDIAGK
GCARADSMLAALKAAWELTESR

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=342, Percent_Identity=34.5029239766082, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 36847; Mature: 36716

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMPSEGFDANQLIVIAIGDPAGIGMEVTLKALASPSLPSKLHPQLVGCRKSLELTYAQL
CCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHH
QAQGISPLANPKNLDIKDLPLKSTLKPGYPTAQSGAASFLWLTKATELLLKGRARALVTA
HHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCEEEEC
PIAKHAWHAAGHHYPGQTERLKELVGADQASMLFTAISPQNGWRLNTLLATTHIPLAAVP
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHEEEEEECCCCCCEEEEEEEECCCCHHHCC
KVLTPELVRAKLNVLKAFCQRFKTDPSIAVAGLNPHAGEQGQLGHEELKWLIPMLNKWKT
HHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC
EHPEIQLDGPLPPDTCWLSAAKAWHGNPCAQTPDGILALYHDQGLIPMKLLAFDSAVNTT
CCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
LGLPFLRTSPDHGTAFDIAGKGCARADSMLAALKAAWELTESR
HCCCEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AMPSEGFDANQLIVIAIGDPAGIGMEVTLKALASPSLPSKLHPQLVGCRKSLELTYAQL
CCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHH
QAQGISPLANPKNLDIKDLPLKSTLKPGYPTAQSGAASFLWLTKATELLLKGRARALVTA
HHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCEEEEC
PIAKHAWHAAGHHYPGQTERLKELVGADQASMLFTAISPQNGWRLNTLLATTHIPLAAVP
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHEEEEEECCCCCCEEEEEEEECCCCHHHCC
KVLTPELVRAKLNVLKAFCQRFKTDPSIAVAGLNPHAGEQGQLGHEELKWLIPMLNKWKT
HHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC
EHPEIQLDGPLPPDTCWLSAAKAWHGNPCAQTPDGILALYHDQGLIPMKLLAFDSAVNTT
CCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
LGLPFLRTSPDHGTAFDIAGKGCARADSMLAALKAAWELTESR
HCCCEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA