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The map label for this gene is tetA [H]

Identifier: 123969437

GI number: 123969437

Start: 1641064

End: 1642335

Strand: Direct

Name: tetA [H]

Synonym: A9601_19051

Alternate gene names: 123969437

Gene position: 1641064-1642335 (Clockwise)

Preceding gene: 123969435

Following gene: 123969438

Centisome position: 98.27

GC content: 31.29

Gene sequence:

>1272_bases
GTGAAAGAAAGTTTATTAAAACCAAATAAAAAATTTACTCTCCTTAGTGCCTTTATCACTCTTCTAAATGATCGTTTAAG
TGAAAGCATATTACTACCTATATTACCCTCCTTTGTTTTACTTTTTGATTCTAAAGCAAGTACATATGGTTTATTATCAT
GCACTTACCAATTAGCTCAATTTACAGCTTCTCCTTTTATAGGACTTATGAGCGATAGATATGGAAGAAGACCTGTCACT
CTTTTTTGTATTACTGGTTCAGTCATAGGAATATCAATATTATCTTTTACGGTTCTATTTAACTGGTCAAATTCAATAGC
CTCTATCCCTTTATTTTTATTATTTTTAGCAAGACTAATTGACGGTTTAAGTGGGGGAACTGCAGCTACTGCAACAACAA
TTCTTGCAGATATTTCAAGCCCTGAAAAAAGAGCAAAAACATTTGGACTTATTGGTGTAGCTTTTGGTTTAAGTTTTTTC
TTAGGTAATATTTTTGTTGTTATTTTTGCCAAAAATACAAATAATAATTTTATTATTCCAGTTTTGATAGCCTCAATCAT
TCCAATAATAAATTTCCTCCTTGTATTTTTTTACTTACCGGAAACCAAGCCTAATAGTGACTCAAATAAATCAAAACCTT
TTATAAGAAACCCTTTAAAAAACCTATTTACAGTTTTCAAAGAAGAAAAGATTAAAAAATTATCATTAGCTTTTTTTATT
TACTTTATTGCCTTTACTGGATTGACCAATATACTTATATTCTTCCTTCAAGAATCTTTAAACTGGACGACAAAAGCATC
AAGTGGAACTCTTGTTGTAGTAGGAATAATTGCAATTATCGTTCAGGGAGGACTAATTGGGCCTCTTGTAAAACAATTTG
GAGAAATGCGATTAACACTTATCGGATCAGGCTTCATTCTTGTTGCATGTGCTCTTTTAATAACTGCTCCAAAAGAAAAT
GCGACAATTAATATTTATTCAGCTGTATCATTTTTAGCCGTTGGGGCAGGATTAATTACGCCCACCTTAAGAGCACTAAT
ATCAAAGAAATTAGACATTGATAAACAAGGATCAATTTTAAGTAATCTTCAAGGTCTACAGAGTCTTGGGGGGGTTTTAG
GAATTGCAATGGCAGGAAGGGTTTATGATAGTTTTGGTCCTAAATCTCCTTTTATAGCTGGTTCCGTTATCTTGCTTTTC
ATGATATATCTTATTGCAGAGGGTAAAAGTAATAATTCTTTTAATAATCAAAAATCAAAAGTATTGAAATGA

Upstream 100 bases:

>100_bases
GGTCACCAGGACCTGCTCCAACTAAATAAACAATGCCGGGCACAATAATCTCCATTAACAAGTATGGTAGTAGAAGTTAA
TGGTAATGAAGGTAAATATT

Downstream 100 bases:

>100_bases
AACGCCAGGCTGATGTTTTTATTAATAGAGAATTAAGTTGGATTGAATTTAATAAGAGAGTTCTCCTTACTGGAATGGAA
AAGGAGTACAAAATCCTAGA

Product: major facilitator superfamily multidrug-efflux transporter

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGLMSDRYGRRPVT
LFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVLIASIIPIINFLLVFFYLPETKPNSDSNKSKPFIRNPLKNLFTVFKEEKIKKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTLIGSGFILVACALLITAPKEN
ATINIYSAVSFLAVGAGLITPTLRALISKKLDIDKQGSILSNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILLF
MIYLIAEGKSNNSFNNQKSKVLK

Sequences:

>Translated_423_residues
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGLMSDRYGRRPVT
LFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVLIASIIPIINFLLVFFYLPETKPNSDSNKSKPFIRNPLKNLFTVFKEEKIKKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTLIGSGFILVACALLITAPKEN
ATINIYSAVSFLAVGAGLITPTLRALISKKLDIDKQGSILSNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILLF
MIYLIAEGKSNNSFNNQKSKVLK
>Mature_423_residues
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGLMSDRYGRRPVT
LFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVLIASIIPIINFLLVFFYLPETKPNSDSNKSKPFIRNPLKNLFTVFKEEKIKKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTLIGSGFILVACALLITAPKEN
ATINIYSAVSFLAVGAGLITPTLRALISKKLDIDKQGSILSNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILLF
MIYLIAEGKSNNSFNNQKSKVLK

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=256, Percent_Identity=28.515625, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI225703102, Length=256, Percent_Identity=28.515625, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI39753965, Length=361, Percent_Identity=21.3296398891967, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551570, Length=366, Percent_Identity=24.5901639344262, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71996331, Length=338, Percent_Identity=21.301775147929, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17738085, Length=376, Percent_Identity=25.7978723404255, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45881; Mature: 45881

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FTASPFIGLMSDRYGRRPVTLFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLI
HHHCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHH
DGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFFLGNIFVVIFAKNTNNNFIIP
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCEEHH
VLIASIIPIINFLLVFFYLPETKPNSDSNKSKPFIRNPLKNLFTVFKEEKIKKLSLAFFI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTL
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEEEE
IGSGFILVACALLITAPKENATINIYSAVSFLAVGAGLITPTLRALISKKLDIDKQGSIL
ECCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
SNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILLFMIYLIAEGKSNNSFNNQKSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
VLK
CCC
>Mature Secondary Structure
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FTASPFIGLMSDRYGRRPVTLFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLI
HHHCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHH
DGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFFLGNIFVVIFAKNTNNNFIIP
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCEEHH
VLIASIIPIINFLLVFFYLPETKPNSDSNKSKPFIRNPLKNLFTVFKEEKIKKLSLAFFI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTL
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEEEE
IGSGFILVACALLITAPKENATINIYSAVSFLAVGAGLITPTLRALISKKLDIDKQGSIL
ECCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
SNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILLFMIYLIAEGKSNNSFNNQKSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
VLK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]