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The map label for this gene is tktA [H]

Identifier: 123969352

GI number: 123969352

Start: 1552173

End: 1554179

Strand: Direct

Name: tktA [H]

Synonym: A9601_18201

Alternate gene names: 123969352

Gene position: 1552173-1554179 (Clockwise)

Preceding gene: 123969351

Following gene: 123969358

Centisome position: 92.95

GC content: 37.72

Gene sequence:

>2007_bases
ATGGTCGCTGCATCTGTTTCATTAGAATCACTTTGTGTAAATAGTATAAGAATGCTTGCTGTAGATGCAGTAAATAAATC
TAATAGTGGTCATCCTGGATTGCCAATGGGATGTGCACCTATGGGTTATGCATTATGGCAAAACATACTTAATCACAACC
CTAACAACCCTAAATGGTTCAATAGAGACCGTTTTGTTTTATCAGCTGGTCATGGCTGTATGCTGTTGTATTCCTTGCTT
CATTTGACAGGATATAAATCAGTTTCCATAGAAGATATTAAAGAATTTAGGCAATGGGGATCAAAAACTCCTGGACATCC
AGAAACATTCGAAACTGAAGGTGTTGAAGTTACAGCTGGGCCTCTTGGAGCAGGAATTTCAAATGCAGTTGGTTTAGCAA
TAGCTGAAACACACTTAGCAGCTAAATTTAATAAGCCTGATTGCAATATTGTTGATCACTATACTTACGTAATAATGGGT
GATGGCTGTAATCAAGAAGGTATCGCATCAGAGGCCTGCTCATTAGCTGGTCATCTTAAGCTTGGGAAATTAATTGCACT
TTATGACGATAATCAAATTACAATTGATGGACGGACCGACGTTTCTTTTACTGAAGATGTCTTAAAAAGATACGAAGCTT
ATGGATGGCATGTGCAACATGTTGAAGATGGGAATCATGATGTTAAAGGAATCACCGAAGCTATCGAAAAAGCGAAATTA
ATTACAGACAAGCCTTCAATTATAAAAATTTCTACAACCATAGGTTACGGTTCTCCAAATAAATCAGATACTGCTGGAAT
TCATGGAGCAGCTGTCGGAGAAGAAGAAGCTGCATTAACTAGAGAGTTTCTAAACTGGGAATATCCTCCTTTTAAAATAC
CCGATGAAGTATATACGCATTTTAGAAAATCAATAAACAAAGGTGAAAATTTAGAGCAAGAATGGGATTCTAAATTTGAA
GAATATCAAAAAAAATATCCCTCTGAAGGAGCCGAATTAAAAAGAATGTTAGAGGGTCAATTACCTGAGAATTGGGACTC
AGACCTCCCCTCTTATTCGCCTAATGATAAAGGTTTAGCCACAAGAAAGCATTCACAAATATGTTTGGGTGCTCTAGGTC
CTAACCTACCTGAATTAATTGGCGGATCAGCAGATTTAACTCACTCTAATTACACAGATATAAAAGGAGAAACTGGATCA
TTCCAGCCACATAGCCCTGAAAAAAGATATTTACATTTTGGTGTACGAGAGCATGCAATGGCAGCTGTACTTAATGGTAT
TGCCTATCACAATAGTGGTCTTATCCCTTATGGTGGAACCTTCCTTGTTTTCGCCGATTATATGAGGGGCTCAATGAGGC
TTTCAGCACTTAGCGAATTAGGAGTAATCTATGTCTTAACACATGATTCAATTGGTGTAGGAGAAGATGGGCCAACACAT
CAACCTATTGAGACTATCCCTTCTCTTCGCGCAATGCCTAACATGCTAGTTTTCAGACCTGGAGATGGCAACGAGACGAG
TGGGGCTTATAAGCTTGCTATTCAAAATCGAAAAAGACCTTCTGCCCTTTGTTTAAGTAGACAAGGTATGCCAAATCAAG
AAAATACTTCGATAGACAAAGTTGCTCTAGGAGGATATGTAGTTTCCGATTGTGAAGGAACACCAGACTTAATATTTATT
GGTACTGGAAGCGAACTGAATCTTTGCATTGAAGCAAGTAAGGAACTTTCAAGCTTGGGTAAAAAAATTAGAGTTGTCTC
TATGCCTTGTGTAGAACTTTTTGAAGAGCAAGAAGAATCTTATAAAGAAAGTGTTTTACCTAGTAGTGTGAAAAAGAGAG
TTGTAGTAGAAGCAGCTCATTCATTTGGTTGGCATAAATATACAGGTTTTGATGGTCTTTGTATCACTATGGATAGGTTT
GGTGCATCAGCACCAGGTGGAGAATGTATGAAAAATTTTGGATTTACAGTAGAAAACGTAGTTAATAAGACTAAGGAAAT
TCTATAA

Upstream 100 bases:

>100_bases
AATTCTTTCGGCTTTGGTGGTCACAATGTTTGCCTTGCTTTCAGCAAAATGAATTGAAGACAACCAATTCTGTATTTCCA
ACTTAACTTAATTTAAAACA

Downstream 100 bases:

>100_bases
CTTGTAATTGATAACTAAACTGAAGTATTACATTCTTCAAGTTTATCTTTTAGTTGATCTAGTGATTCATCTGAAATCTT
TGAATTCATTGGACAATGTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFKIPDEVYTHFRKSINKGENLEQEWDSKFE
EYQKKYPSEGAELKRMLEGQLPENWDSDLPSYSPNDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDKVALGGYVVSDCEGTPDLIFI
GTGSELNLCIEASKELSSLGKKIRVVSMPCVELFEEQEESYKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGLCITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL

Sequences:

>Translated_668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFKIPDEVYTHFRKSINKGENLEQEWDSKFE
EYQKKYPSEGAELKRMLEGQLPENWDSDLPSYSPNDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDKVALGGYVVSDCEGTPDLIFI
GTGSELNLCIEASKELSSLGKKIRVVSMPCVELFEEQEESYKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGLCITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL
>Mature_668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFKIPDEVYTHFRKSINKGENLEQEWDSKFE
EYQKKYPSEGAELKRMLEGQLPENWDSDLPSYSPNDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDKVALGGYVVSDCEGTPDLIFI
GTGSELNLCIEASKELSSLGKKIRVVSMPCVELFEEQEESYKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGLCITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=581, Percent_Identity=26.5060240963855, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI205277463, Length=581, Percent_Identity=25.9896729776248, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI4507521, Length=581, Percent_Identity=25.9896729776248, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI225637459, Length=583, Percent_Identity=22.8130360205832, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI225637463, Length=482, Percent_Identity=24.2738589211618, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI225637461, Length=482, Percent_Identity=24.2738589211618, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=51.3595166163142, Blast_Score=688, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=50.9803921568627, Blast_Score=676, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=583, Percent_Identity=24.5283018867925, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=53.2934131736527, Blast_Score=686, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=50.3725782414307, Blast_Score=658, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=678, Percent_Identity=26.2536873156342, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45550715, Length=678, Percent_Identity=26.2536873156342, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24645119, Length=649, Percent_Identity=26.1941448382126, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24666278, Length=584, Percent_Identity=24.8287671232877, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73118; Mature: 73118

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWF
CEECCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYSLLHLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECC
PLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHHHHHHHHHEECCCCCCCEEECEEEEEECCCCCCCCHHHHHHHHHCCCC
LGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFKIPDEVYTH
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
FRKSINKGENLEQEWDSKFEEYQKKYPSEGAELKRMLEGQLPENWDSDLPSYSPNDKGLA
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGSFQPHSPEKRYLHFGVREHAM
ECCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCHHHHHH
AAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCCE
VALGGYVVSDCEGTPDLIFIGTGSELNLCIEASKELSSLGKKIRVVSMPCVELFEEQEES
EEECCEEEECCCCCCCEEEEECCCCEEEEEECHHHHHHHCCEEEEEECHHHHHHHHHHHH
YKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGLCITMDRFGASAPGGECMKNFGFTVENV
HHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHCCCCCCCHHHHHHCCCCHHHH
VNKTKEIL
HHHHHHCC
>Mature Secondary Structure
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWF
CEECCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYSLLHLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECC
PLGAGISNAVGLAIAETHLAAKFNKPDCNIVDHYTYVIMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHHHHHHHHHEECCCCCCCEEECEEEEEECCCCCCCCHHHHHHHHHCCCC
LGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFKIPDEVYTH
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
FRKSINKGENLEQEWDSKFEEYQKKYPSEGAELKRMLEGQLPENWDSDLPSYSPNDKGLA
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGSFQPHSPEKRYLHFGVREHAM
ECCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCHHHHHH
AAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCCE
VALGGYVVSDCEGTPDLIFIGTGSELNLCIEASKELSSLGKKIRVVSMPCVELFEEQEES
EEECCEEEECCCCCCCEEEEECCCCEEEEEECHHHHHHHCCEEEEEECHHHHHHHHHHHH
YKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGLCITMDRFGASAPGGECMKNFGFTVENV
HHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHCCCCCCCHHHHHHCCCCHHHH
VNKTKEIL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]